Navigation Links
A radar for ADAR: Altered gene tracks RNA editing in neurons
Date:12/25/2011

ide variation in ADAR activity in the brains of flies of similar ages from individual to individual. This was a surprise, Reenan said, because all the flies were essentially genetically identical.

A versatile new tool?

Reenan said he is confident that the ADAR reporter could be useful in more organisms than the fruit fly. The idea of creating the reporter grew out of his lab's studies of comparative genomics in a number of species. ADAR, meanwhile, is found in both invertebrates and vertebrates. In fact, in the paper the researchers describe testing the flexibility of their engineering by inserting into their engineered jellyfish gene destined as it was for a fruit fly the splicing intron of a moth.

"Thus it was, a jellyfish-moth gene chimera was crippled by mutation, and repaired by a fruit fly enzyme," Reenan said. "Rube Goldberg would be proud."

Reenan said he plans to use the ADAR reporter in flies to continue the investigation of the genes associated with Fragile X and is eager for someone who works on the disorder in mice to give it a try.

The idea of adapting this method to direct ADAR to fix mistranscribed RNA or reverse DNA damage at the RNA level in a therapeutic fashion is farther into the future. But in a sense, at least ADAR is now on the radar.


'/>"/>
Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. TEEB report puts worlds natural assets on the global political radar
2. New boreal forest biomass maps produced from radar satellite data
3. SRI International announces findings from new upper atmospheric radar system for scientific research
4. A glimpse of future GMES Sentinel-1 radar images
5. New pollution radar developed to provide unprecedented picture of urban smog
6. Researcher finds altered cerebella in those with Down syndrome
7. Clinical study suggests estrogen levels and breast health can be altered
8. Altered gene protects some African-Americans from coronary artery disease
9. Most river flows across the US are altered by land and water management
10. 1st census shows life in planet ocean is richer, more connected, more altered than expected
11. New data on the regulation of a protein that is altered in all cancers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A radar for ADAR: Altered gene tracks RNA editing in neurons
(Date:9/21/2014)... Diego, have developed a program that predicts the placement ... based on sequences of DNA. They describe their analysis ... cells in a paper published in Nature Methods ... have the same blueprint, the same DNA, although they ... the report. "Skin cells protect, nerve cells send signals, ...
(Date:9/19/2014)... Durante of dinosaurs a newly discovered hadrosaur ... dinosaur, named Rhinorex condrupus by paleontologists ... University, lived in what is now Utah approximately ... period. , Rhinorex, which translates roughly into "King ... of other Cretaceous hadrosaurs like Parasaurolophus and Edmontosaurus. ...
(Date:9/19/2014)... over thousands of years has adapted to the arctic cold, ... the cold dangerous for you. , This is happening to ... cold provoking substance, called nonylphenol, comes from the use of ... being a endocrine disruptor, but when entering the worm it ... protect the cells in its body from cold damage. , ...
Breaking Biology News(10 mins):Program predicts placement of chemical tags that control gene activity 2New hadrosaur noses into spotlight 2Environmental pollutants make worms susceptible to cold 2Environmental pollutants make worms susceptible to cold 3
... female fertility by directly affecting the uterus ?making it ... implant, according to research published on line (Thursday 9 ... , The finding, from a team of fertility ... of comparing the pregnancy rates between non-heavy smokers and ...
... malaria remains the subject of "best guesses," and as ... by perceptions and politics, rather than an objective assessment ... Medicine. , Simon Hay and Robert Snow (Kenya Medical ... has been almost 40 years since the last global ...
... a few square meters in size, where fluid is ... volcanoes which are active areas of fluid seepage, are ... conditions give rise to some of the most extreme ... the planet. , Extensive fields of hydrocarbon-rich gas ...
Cached Biology News:Heavy smoking cuts women's chance of pregnancy -- even with donated oocytes 2Heavy smoking cuts women's chance of pregnancy -- even with donated oocytes 3Life in the extreme 2
(Date:9/19/2014)... NC (PRWEB) September 19, 2014 ... Biobased Product Label for its Organic Cotton . ... product’s amount of renewable biobased ingredients meets or exceeds ... intermediate materials composed in whole or in significant part ... logo/label will allow our Organic cotton to be immediately ...
(Date:9/19/2014)... 2014 Dublin ... has announced the addition of the  "Micro Market ... their offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ... the fastest-growing segments in the chromatography market. The ... and expected to reach $2.0 billion by 2019, ...
(Date:9/19/2014)... September 19, 2014 The new , ... , available today on PharmaBoardroom.com for ... crisis that rocked the Spanish economy in 2009, and the ... community has remained pragmatic in times of trouble. ... the fifth biggest European market, and the general conditions to ...
(Date:9/18/2014)... September 18, 2014 HealthTronics, ... and interventional radiology products and services, announced that ... cryotherapy and cryoablation) versus external beam radiotherapy (EBRT) ... the American Urological Association (MAAUA) Annual Meeting in ... Relative Effectiveness of Cryosurgery and External Beam Radiation ...
Breaking Biology Technology:Barnhardt Manufacturing Company Earns USDA Certified Biobased Product Certification and Label for Organic Cotton 2Micro Market Monitor : Global Pre-packed Chromatography Columns 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2
... Blood America, Inc . ( www.cordblood-america.com ) (OTC Bulletin Board: ... cell preservation company focused on bringing the life saving ... announced revenues of $2.89 million for the first six months ... million in the same period in 2010.  Revenues for the ...
... IQ is pioneering new compound management discussion platform with launch of ... Integrity Online event, which will take an innovative form of ... 31 st   of October 2011. ... the agenda for many organisations and this was recently recognised by ...
... ALBUQUERQUE, N.M., Aug. 10, 2011 Exagen Diagnostics, ... discovers, develops and markets proprietary tests for rheumatologists and ... President and Chief Operating Officer. Tornoe has ... sales, sales management and marketing, making him a key ...
Cached Biology Technology:Cord Blood America Six Month Revenues Up 61 Percent; Gross Profit Up 100 Percent 2Cord Blood America Six Month Revenues Up 61 Percent; Gross Profit Up 100 Percent 3Compound Management and Integrity Goes Online 2Compound Management and Integrity Goes Online 3Eric Tornoe Joins Exagen Diagnostics as President and COO 2
... high durability and capacity with unequalled ease ... prevents vibration, allowing the unit to run ... part, from the large rubber block vibration ... platform is designed to last through years ...
The Holten mini vertical flow workbench provides a particle-free environment for sample protection against airborne contaminants....
The Holten Horizontal series of laminar airflow work benches offers comfort and ease of use....
The Holten Horizontal series of laminar airflow work benches offers comfort and ease of use....
Biology Products: