Navigation Links
A protein sequence associated with Huntington’s disease may become life-saving vaccine component
Date:6/10/2008

al adjuvants formed with antigenic peptides exposed on their surface. Dr. Shneider hypothesized that these polyQ containing aggregates were easily taken up by antigen-presenting cells, as is the case with adjuvant droplets, triggering the immune response.

Another hypothesis was proposed by Michael Sherman, professor at Boston University Medical School and scientific consultant at Cure Lab. "We knew- said Michael Sherman- that polyQ aggregates are destroyed in cells by a special degradation system, called autophagy. Interestingly, autophagy plays a key role in the processing of certain antigens, which is critical for the immune response. So, attachment of a polyQ tail should specifically target the antigen to autophagy, which in turn should facilitate the response. Thus, polyQ would serve as a molecular adjuvant".

There are two branches to the immune system. One is responsible for developing antibodies against bacteria, viruses and toxins freely circulating in the organism. Another is aimed at eliminating virus-infected or cancer cells. Cure Lab's paper demonstrates that the new polyQ-based adjuvant efficiently enhances both branches of the immune response to a poor model antigen. Importantly, the adjuvant caused no apparent toxicity in mice.

Many questions remain to be answered. The adjuvant properties of the polyQ tail will have to be tested for each individual antigen of medical and veterinary importance. However, this work may launch a new era in vaccine development, the era of molecular adjuvants.


'/>"/>

Contact: Alex Shneider
ashneider@curelab.com
609-841-1201
Cure Lab, Inc.
Source:Eurekalert

Page: 1 2

Related biology news :

1. Fruit fly helps identify protein critical to eggshell formation that may be pesticide target
2. Protein fibrils as alternative plastics?
3. Montana State University researchers map iron transport protein
4. Plant biologists discover unexpected proteins affecting small RNAs
5. New clues to how proteins dissolve and crystallize
6. Ancient protein offers clues to killer condition
7. New discovery on role of vital protein that fights meningitis
8. Researchers report the cloning of a key group of human genes, the protein kinases
9. Genetic sequencing of protein from T. rex bone confirms dinosaurs link to birds
10. Proteins that stop a major signaling pathway can also generate new proteins
11. Researchers reveal structure of protein that repairs damage to cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... 2014 How does oxygen control insect body size? What ... in the first issue of Current Opinion in Insect ... and more questions. , Current Opinion in Insect Science ... series. It is a review journal that aims to provide ... expanding volume of information published in the field of insect ...
(Date:7/14/2014)... The Biogerontology Research Foundation (BGRF), a UK-based charity ... challenges of a rapidly ageing population, hosted the ... 30th, with Aging Analytics, a company supporting financial ... , The speakers at the forum included: , ... Kong on ,Impact Investment to Advance Longevity Research, ...
(Date:7/14/2014)... discovery and description of Rhipidocyrtus muiri - a ... to represent a new genus and species. The long and ... is discussed in a recent paper published in the open ... male, and only known specimen of Rhipidocyrtus muiri , ... this it was transferred among several researchers in the early ...
Breaking Biology News(10 mins):BGRF hosts inaugural 21st Century Medicine Forum 2Serendipity at the Smithsonian: The 107-year journey of the beetle Rhipidocyrtus muiri 2Serendipity at the Smithsonian: The 107-year journey of the beetle Rhipidocyrtus muiri 3
... the National Institutes of Health will explore the role ... by NIH,s National Institute of Environmental Health Sciences (NIEHS), ... people more vulnerable to heat exposure; changing weather patterns; ... toxic chemicals; and the negative effects of climate change ...
... discovered in the 16-23 million years old sediments of the ... Helophorus sibiricus , a member of the water scavenger ... in Eurasia and reaches even North America. The species was ... based on specimens collected at Lake Baikal. It is aquatic ...
... 2011. In the central Arctic the proportion of old, thick ... largely consists of thin, one-year-old floes. This is one of ... Polar and Marine Research in the Helmholtz Association brought back ... The ship arrived at its home port of Bremerhaven ...
Cached Biology News:NIH launches research program to explore health effects from climate change 2NIH launches research program to explore health effects from climate change 3A living species of aquatic beetle found in 20-million-year-old sediments 2Young and thin instead of old and bulky 2Young and thin instead of old and bulky 3Young and thin instead of old and bulky 4
(Date:7/10/2014)... July 10, 2014 Unraveling life’s mysteries ... The Archer Family purchased a DNA test ... but ended up with a lifetime of memories, sharing, ... the family members’ DNA genuinely brought the family closer ... search deeper into genetic history and prior to taking ...
(Date:7/10/2014)... CROWN POINT, Ind. , July 10, ... recently expanded its use of capnography for ... a growing group of healthcare leaders in ... Capnography measures how effectively patients are breathing ... respiratory depression occurs. By measuring the amount ...
(Date:7/10/2014)... THOUSAND OAKS, Calif., July 10, 2014   Ceres, ... biotechnology and seed company, announced today financial results for ... an update on its business. Ceres reported ... progress in product performance this growing season in Brazil, ... that affected the company,s sorghum evaluation areas for part ...
(Date:7/10/2014)... been extremely challenging because there are many genetic variants ... disease. Now investigators reporting in the July 3rd issue ... describe a strategy that may help reveal how ... or environmental exposures to affect the development of the ... may predispose individuals to schizophrenia. , The work ...
Breaking Biology Technology:Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9New strategy could uncover genes at the root of psychiatric illnesses 2
... , Most Basic Recommended Cecil Instrumentation: , ... 500 l loop , Fraction collector , Column ... : , Researchers need to understand ... protein expression in healthy and diseased cells. , Hence the ...
... reliable and accurate long-range PCR and RT-PCR , ... RT-PCR Kits provide dedicated and highly reliable solutions for long-range,amplification from genomic DNA and cDNA. ... , QIAGEN LongRange PCR ... Amplification of extremely long PCR products up to 40 kb DNA or,12.5 kb ...
... LOS ANGELES, CA (August 10, 2006) - DoveBid, Inc., ( http://www.dovebid.com ... auction and valuation services, announced , today it ... Exchange auction online, on August 15, 2006. The event marks a milestone ... practice, and is expected , to bring to-date ...
Cached Biology Technology:Semi Preparative Purification of Proteins 2QIAGEN LongRange PCR and 2Step RT-PCR Kits 2World Class Life Science and Pharmaceutical Companies Leverage DoveBid s Global Reach for Asset Management and Disposition 2World Class Life Science and Pharmaceutical Companies Leverage DoveBid s Global Reach for Asset Management and Disposition 3
Biotin-OSu is used to label proteins, immunological agents, DNA and synthetic oligonucleotides. Biotin labeling is detected through enzymatically labeled avidin or streptavidin proteins that conforma...
Cross reactivity to St. Louis encephalitis (MSI-7) is determined by ELISA....
ANTI K. AEROGENES...
casein kinase 2, alpha 1 polypeptide, transcript variant 2, mRNA (cDNA clone MGC:15232 IMAGE:4121882), complete cds...
Biology Products: