Navigation Links
A protein sequence associated with Huntington’s disease may become life-saving vaccine component
Date:6/10/2008

al adjuvants formed with antigenic peptides exposed on their surface. Dr. Shneider hypothesized that these polyQ containing aggregates were easily taken up by antigen-presenting cells, as is the case with adjuvant droplets, triggering the immune response.

Another hypothesis was proposed by Michael Sherman, professor at Boston University Medical School and scientific consultant at Cure Lab. "We knew- said Michael Sherman- that polyQ aggregates are destroyed in cells by a special degradation system, called autophagy. Interestingly, autophagy plays a key role in the processing of certain antigens, which is critical for the immune response. So, attachment of a polyQ tail should specifically target the antigen to autophagy, which in turn should facilitate the response. Thus, polyQ would serve as a molecular adjuvant".

There are two branches to the immune system. One is responsible for developing antibodies against bacteria, viruses and toxins freely circulating in the organism. Another is aimed at eliminating virus-infected or cancer cells. Cure Lab's paper demonstrates that the new polyQ-based adjuvant efficiently enhances both branches of the immune response to a poor model antigen. Importantly, the adjuvant caused no apparent toxicity in mice.

Many questions remain to be answered. The adjuvant properties of the polyQ tail will have to be tested for each individual antigen of medical and veterinary importance. However, this work may launch a new era in vaccine development, the era of molecular adjuvants.


'/>"/>

Contact: Alex Shneider
ashneider@curelab.com
609-841-1201
Cure Lab, Inc.
Source:Eurekalert

Page: 1 2

Related biology news :

1. Fruit fly helps identify protein critical to eggshell formation that may be pesticide target
2. Protein fibrils as alternative plastics?
3. Montana State University researchers map iron transport protein
4. Plant biologists discover unexpected proteins affecting small RNAs
5. New clues to how proteins dissolve and crystallize
6. Ancient protein offers clues to killer condition
7. New discovery on role of vital protein that fights meningitis
8. Researchers report the cloning of a key group of human genes, the protein kinases
9. Genetic sequencing of protein from T. rex bone confirms dinosaurs link to birds
10. Proteins that stop a major signaling pathway can also generate new proteins
11. Researchers reveal structure of protein that repairs damage to cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... UC Davis have made some surprising discoveries about ... simian immunodeficiency virus (SIV), the team found that ... are early responders to viral invasion and are ... cytokine called interleukin-1 beta (IL-1β). , Though ... breakdown of the gut epithelium that provides a ...
(Date:8/29/2014)... ANTONIO (Aug. 29, 2014) Scientists at the Barshop ... School of Medicine at the UT Health Science Center ... in the tissues of the longest-lived rodent, the naked ... in the cells of naked mole rats protects and ... for damaged and obsolete proteins. , The factor also ...
(Date:8/29/2014)... Until recently, little has been known about what ... international team of scientists, one of whom is a ... by showing that genes controlling the development of the ... rabbit domestication., The study was published Aug. 28 in ... questions. It is online at http://www.sciencemag.org/ ., The ...
Breaking Biology News(10 mins):The early cost of HIV 2Factor in naked mole rat's cells enhances protein integrity 2New research reveals how wild rabbits were genetically transformed into tame rabbits 2New research reveals how wild rabbits were genetically transformed into tame rabbits 3
... determined the structure of an enzyme complex that modifies one ... levels in numerous forms of cancer. A study in ... The Wistar Institute, depicts the structure and the means of ... they believe, will allow them to create an inhibitora potential ...
... , Aug. 2, 2013  /PRNewswire-iReach/ -- This market ... of human embryonic stem cell products, providing clear guidance ... collaborating with WARF to less costly alternatives - such ... embryonic stem cell products for other species. The report ...
... confirm, the initial three months of pregnancy are the most ... friends or colleagues that they are pregnant until after this ... suffer from similar problems, with a considerable number of pregnancies ... is still unclear but may relate to a problem with ...
Cached Biology News:Wistar scientists decipher structure of NatA, an enzyme complex that modifies most human proteins 2hESC Products Market: Human Embryonic Stem Cell Patent IP Landscape Opportunity Analysis in New Research Report 2hESC Products Market: Human Embryonic Stem Cell Patent IP Landscape Opportunity Analysis in New Research Report 3Helping horses come to term 2
(Date:8/29/2014)... Aug. 29, 2014  Pfenex Inc. (NYSE MKT: ... development of high-value and difficult to manufacture proteins ... and reported financial results for the second quarter ... successful completion of our initial public offering, we ... biosimilar product candidates, derived from our proprietary protein ...
(Date:8/29/2014)... on electrons, but one of the most promising technologies ... based on light (photons) instead of electrons. First, it ... of single photons and control their direction. Researchers around ... achieve this control, but now scientists at the Niels ... of photons emitted one at a time and in ...
(Date:8/29/2014)... New York (PRWEB) August 29, 2014 ... valued at $5.6 billion in 2019. It is ... from 2013 to 2019, and was valued at ... report published by Transparency Market Research. , For ... visit: http://www.transparencymarketresearch.com/companion-diagnostics-market.html . , The research report, ...
(Date:8/29/2014)... New York (PRWEB) August 29, 2014 According ... “Global Orthobiologics Market” the global orthobiologics market was valued at ... a market worth USD 5,519.9million in 2019at a CAGR of ... population aged 50 years and above is afflicted by bone ... double by the year 2020. This has and will continue ...
Breaking Biology Technology:Pfenex Reports Second Quarter 2014 Results and Provides Business Update 2Pfenex Reports Second Quarter 2014 Results and Provides Business Update 3Pfenex Reports Second Quarter 2014 Results and Provides Business Update 4Pfenex Reports Second Quarter 2014 Results and Provides Business Update 5Pfenex Reports Second Quarter 2014 Results and Provides Business Update 6Pfenex Reports Second Quarter 2014 Results and Provides Business Update 7Pfenex Reports Second Quarter 2014 Results and Provides Business Update 8Breakthrough in light sources for new quantum technology 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 2Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 3
... LAKE FOREST, Ill., May 14 - Bioniche ... pharmaceuticals, announced the launch of Enlon (R) ... USP and atropine sulfate, USP) Injection. (Logo: ... (R) represent Bioniche,s continued growth and a ...
... 14 Dendreon Corporation today announced that Chief Executive ... the Ernst & Young Entrepreneur Of The Year (R) ... to Ernst & Young LLP, the awards program recognizes ... innovation, financial performance and personal commitment to their businesses ...
... the 2009 BIO International Convention at the Georgia International Convention Center in Atlanta, Georgia, on Tuesday, May 19th ... ... CTI Presentation: Tuesday, May 19, 2009, ... Pacific, ...
Cached Biology Technology:Dendreon Corporation CEO Mitchell H. Gold, M.D. Named Ernst & Young Entrepreneur of the Year(R) 2009 Award Finalist in the Pacific Northwest 2