Navigation Links
A protein sequence associated with Huntington’s disease may become life-saving vaccine component
Date:6/10/2008

al adjuvants formed with antigenic peptides exposed on their surface. Dr. Shneider hypothesized that these polyQ containing aggregates were easily taken up by antigen-presenting cells, as is the case with adjuvant droplets, triggering the immune response.

Another hypothesis was proposed by Michael Sherman, professor at Boston University Medical School and scientific consultant at Cure Lab. "We knew- said Michael Sherman- that polyQ aggregates are destroyed in cells by a special degradation system, called autophagy. Interestingly, autophagy plays a key role in the processing of certain antigens, which is critical for the immune response. So, attachment of a polyQ tail should specifically target the antigen to autophagy, which in turn should facilitate the response. Thus, polyQ would serve as a molecular adjuvant".

There are two branches to the immune system. One is responsible for developing antibodies against bacteria, viruses and toxins freely circulating in the organism. Another is aimed at eliminating virus-infected or cancer cells. Cure Lab's paper demonstrates that the new polyQ-based adjuvant efficiently enhances both branches of the immune response to a poor model antigen. Importantly, the adjuvant caused no apparent toxicity in mice.

Many questions remain to be answered. The adjuvant properties of the polyQ tail will have to be tested for each individual antigen of medical and veterinary importance. However, this work may launch a new era in vaccine development, the era of molecular adjuvants.


'/>"/>

Contact: Alex Shneider
ashneider@curelab.com
609-841-1201
Cure Lab, Inc.
Source:Eurekalert

Page: 1 2

Related biology news :

1. Fruit fly helps identify protein critical to eggshell formation that may be pesticide target
2. Protein fibrils as alternative plastics?
3. Montana State University researchers map iron transport protein
4. Plant biologists discover unexpected proteins affecting small RNAs
5. New clues to how proteins dissolve and crystallize
6. Ancient protein offers clues to killer condition
7. New discovery on role of vital protein that fights meningitis
8. Researchers report the cloning of a key group of human genes, the protein kinases
9. Genetic sequencing of protein from T. rex bone confirms dinosaurs link to birds
10. Proteins that stop a major signaling pathway can also generate new proteins
11. Researchers reveal structure of protein that repairs damage to cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... Prediabetes and Diabetes increasingly consume the healthcare ... immediate attention. , To address the ... impacting low-and middle-income countries, global leaders in ... research in diabetes prevention and development of ... important text. , This book on ...
(Date:7/25/2014)... tractography (DTT), which is derived from diffusion tensor ... motor tracts, such as the corticospinal tract, the ... The corticospinal tract is known to be a ... human brain. Several studies have reported on injury ... addition, some studies have demonstrated recovery of a ...
(Date:7/25/2014)... the first time, Spanish researchers have detected an unknown ... cells are introduced into a droplet of salt ... sodium chloride crystallisation to create biomineralogical biosaline 3D morphologically ... the material, bacteria are revived. The discovery was made ... the cover of the Astrobiology journal and ...
Breaking Biology News(10 mins):What constitutes an effective response to the global 'diabesity' tsunami? 2Bacteria manipulate salt to build shelters to hibernate 2
... University of Michigan researchers and their colleagues recently hastened ... trees in a large-scale, long-term experiment to glimpse the ... bark was stripped from each tree to kill it ... the federally funded experiment Forest Accelerated Succession Experiment (FASET) ...
... of Pacific Islands Forestry have submitted a proposal to ... strawberry guava, a South American tree that has invaded ... in 1825 as a garden plant. The scientists are ... and Natural Resources, and Hawai Department of Agriculture, agencies ...
... May 25, 2008, approaching 5 p.m. PDT, NASA scientists will ... because at that time the Phoenix Mars Mission space vehicle ... a soft landing onto the northern Mars terrain called Green ... the Red Planet. The place got its name after analysis ...
Cached Biology News:U-M scientists remove thousands of aspens to glimpse forest's future 2U-M scientists remove thousands of aspens to glimpse forest's future 3Insect release proposed to control exotic strawberry guava 2Phoenix mission to Mars will search for climate clues 2Phoenix mission to Mars will search for climate clues 3
(Date:7/24/2014)... Calabasas, CA (PRWEB) July 24, 2014 ... advancing the Global Supply Chain of the biotech ... annual SCM Innovation Awards, brought to you by ... premiere global organization of supply chain management professionals ... be given to stakeholders of the Biotech industry ...
(Date:7/24/2014)... BURLINGAME, Calif. , July 24, 2014  ECC ... Denver, Colorado with University College Hospital ... of a development project to finance, design, construct, and ... Ibadan, Nigeria . Under the first ... and prepare scoping documents and funding applications. UCH Ibadan ...
(Date:7/24/2014)... scientists are making progress in devising suitable means ... relies on quantum dotsa kind of artificial atom, ... new study demonstrates that changing the coupling of ... impulses can help better control them. This has ... quantum information units, which would produce faster quantum ...
(Date:7/24/2014)... , July 24, 2014 Research and ... "Global Cell Culture Market 2014-2018" report to their ... Cell culture is the in vitro growth of ... research, cell studies, and biopharmaceutical production. Cell culture is ... Cell culture instruments and cell culture consumables are necessary ...
Breaking Biology Technology:Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3ECC Signs a Contract for the Finance, Design, and Construction of a Premier Cancer Institute in Ibadan, Nigeria 2Global Cell Culture Market 2014-2018: Key Vendors are Becton, Dickinson and Co, EMD, GE Healthcare, Lonza Group, Sigma Aldrich and Thermo Fisher Scientific 2
... , Multiporator / Electroporator 2510 , , , , , , ... , Protocol No. 4308 915.534 01/2002 , , ... , , Microorganism , ... Cell type , Bacteria, gram positive, , ...
... , , , , , , Multiporator / Electroporator 2510 , , , ... , Transformation Protocol , Protocol No. 4308 915.532 ... , , , , , , ... , Cell type , ...
... , , , , , , Multiporator / Electroporator 2510 , , , ... , Transformation Protocol , Protocol No. 4308 915.528 ... , , , , , , ... , Cell type , ...
Cached Biology Technology:Staphylococcus epidermidis 2Salmonella typhimurium 2Pseudomonas aeruginosa 2