Navigation Links
A protein sequence associated with Huntington’s disease may become life-saving vaccine component
Date:6/10/2008

On June 10, 2008 the scientific journal "Vaccine" published a paper by the Massachusetts based biotech company Cure Lab, Inc., demonstrating that a protein sequence important in neurodegenerative Huntington's disease can be safely used as a new generation of vaccine adjuvants.

The major component of every vaccine is an antigen that elicits specific immunity to a particular virus, bacteria or even cancer cells. Search for better antigens is one of the most pressing medical and public health necessities, and the biotech industry invests heavily in this research. However, antigens are able to generate a limited immune response if administered alone. In order to be protective or therapeutic, vaccine compositions have to be supplemented with adjuvants, strong facilitators of the immune response. In the search for efficient adjuvants that are also non-toxic, scientists at Cure Lab, Inc. discovered a novel paradigm that capitalizes on insights from recent breakthroughs in understanding the fatal neurodegenerative disorder, Huntington's.

Huntington's disease results from mutations in the protein huntingtin, which contains a sequence of polyglutamine residues (polyQ). In healthy individuals, huntingtin contains less than 35 glutamines in the polyQ segment. However, in neurons of Huntington's patients, the number of glutamine residues in the sequence expands to more than 36. This induces protein self-aggregation, or formation of big protein "chunks", and eventually causes neuronal dysfunction. Recent research findings indicate that attachment of a prolonged polyQ segment to almost any protein promotes its aggregation.

"There were two ideas - said Alex Shneider, Cure Lab's founder and CEO- which stimulated us to test if attachment of a long polyQ "tail" to an antigen can enhance immune response to vaccination". First, he noticed that small aggregates formed by an antigen fused to a polyQ tail resembled the droplets that convention
'/>"/>

Contact: Alex Shneider
ashneider@curelab.com
609-841-1201
Cure Lab, Inc.
Source:Eurekalert

Page: 1 2

Related biology news :

1. Fruit fly helps identify protein critical to eggshell formation that may be pesticide target
2. Protein fibrils as alternative plastics?
3. Montana State University researchers map iron transport protein
4. Plant biologists discover unexpected proteins affecting small RNAs
5. New clues to how proteins dissolve and crystallize
6. Ancient protein offers clues to killer condition
7. New discovery on role of vital protein that fights meningitis
8. Researchers report the cloning of a key group of human genes, the protein kinases
9. Genetic sequencing of protein from T. rex bone confirms dinosaurs link to birds
10. Proteins that stop a major signaling pathway can also generate new proteins
11. Researchers reveal structure of protein that repairs damage to cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2015)... , Feb. 24, 2015 This report analyzes the ... provides separate comprehensive analytics for the US, Canada ... , Asia-Pacific , Middle ... Annual estimates and forecasts are provided for the period 2013 ... these markets. Market data and analytics are derived from primary ...
(Date:2/18/2015)... (NASDAQ: CPHD ) today announced that its executives ... to participate via webcast. , Cowen and Company Health ... 3, 2015 at 11.20 a.m. Eastern Time , Raymond ... Wednesday, March 4, 2015 at 10.25 a.m. Eastern Time ... these events, please visit Cepheid,s website at http://ir.cepheid.com ...
(Date:2/10/2015)... -- Alere Inc. (NYSE: ALR), a global leader in ... quarter ended December 31, 2014. Namal ... said, "We made substantial progress in the fourth ... in rapid diagnostics and delivering against our financial ... early January enabled us to substantially reduce our ...
Breaking Biology News(10 mins):World Iris Biometrics Industry 2World Iris Biometrics Industry 3World Iris Biometrics Industry 4World Iris Biometrics Industry 5World Iris Biometrics Industry 6World Iris Biometrics Industry 7World Iris Biometrics Industry 8World Iris Biometrics Industry 9World Iris Biometrics Industry 10World Iris Biometrics Industry 11Cepheid to Webcast Upcoming Financial Presentations 2Alere Inc. Announces Fourth Quarter 2014 Results 2Alere Inc. Announces Fourth Quarter 2014 Results 3Alere Inc. Announces Fourth Quarter 2014 Results 4Alere Inc. Announces Fourth Quarter 2014 Results 5Alere Inc. Announces Fourth Quarter 2014 Results 6Alere Inc. Announces Fourth Quarter 2014 Results 7Alere Inc. Announces Fourth Quarter 2014 Results 8Alere Inc. Announces Fourth Quarter 2014 Results 9Alere Inc. Announces Fourth Quarter 2014 Results 10Alere Inc. Announces Fourth Quarter 2014 Results 11Alere Inc. Announces Fourth Quarter 2014 Results 12Alere Inc. Announces Fourth Quarter 2014 Results 13Alere Inc. Announces Fourth Quarter 2014 Results 14Alere Inc. Announces Fourth Quarter 2014 Results 15Alere Inc. Announces Fourth Quarter 2014 Results 16Alere Inc. Announces Fourth Quarter 2014 Results 17Alere Inc. Announces Fourth Quarter 2014 Results 18Alere Inc. Announces Fourth Quarter 2014 Results 19Alere Inc. Announces Fourth Quarter 2014 Results 20Alere Inc. Announces Fourth Quarter 2014 Results 21Alere Inc. Announces Fourth Quarter 2014 Results 22Alere Inc. Announces Fourth Quarter 2014 Results 23Alere Inc. Announces Fourth Quarter 2014 Results 24Alere Inc. Announces Fourth Quarter 2014 Results 25
... and reuse of data has become a vital part of ... pace of scientific discovery is not unnecessarily hindered by data ... lab drawers. BioMed Central, a long supporter of ... with LabArchives, LLC to shed further light on science,s "dark ...
... of Adelaide could help protect one of the world,s ... - from extinction. Big leaf mahogany ( Swietenia macrophylla ... It is at risk of extinction in its native ... South America. To better understand how such a threatened ...
... a Simon Fraser University professor and Canada Research Chair ... a hefty financial boost in their efforts to develop ... Institutes of Health (NIH) has awarded the four researchers ... a DNA-based vaccine that Marinieve Montero first conceived of ...
Cached Biology News:Linking and lightening: New partnership connects and reveals dark data 2Pollen can protect mahogany from extinction 2SFU HIV/AIDS vaccine research gets financial boost 2
(Date:2/27/2015)... COLUMBIA, Md. (PRWEB) February 27, 2015 ... Unified Chromatography system (Nexera UC) can sequentially analyze ... chromatographic separation combined with high-sensitivity detection of targets ... system is designed to fulfill the measurement requirements ... pesticides in food products, drug delivery and search ...
(Date:2/27/2015)... -- Steep Hill, the industry leader in cannabis testing and ... a full service medical cannabis quality assurance laboratory in ... scientific tools and methodology to the state, for regulatory ... the only laboratory licensed by the New Mexico Department ... order to meet the recently adopted regulatory requirements pertaining ...
(Date:2/26/2015)... TORONTO , Feb. 26, 2015 /PRNewswire/ - SQI ... SQIDF), a life sciences company that develops and commercializes ... reported its financial and operational results for the fiscal ... this press release are in Canadian dollars (CAD), unless ... Company continued to win new business from our existing ...
(Date:2/26/2015)... Angeles, CA (PRWEB) February 26, 2015 ... an online demonstration to support life extension technologies and ... 8pm UTC, Universal Coordinated Time, on March 21st 2015, ... the world. , Eric Schulke, Founder of MILE, ... must act with urgency. The Movement for Indefinite Life ...
Breaking Biology Technology:Shimadzu Corporation Launches Nexera UC - The World’s Foremost Unified Chromatography System 2Shimadzu Corporation Launches Nexera UC - The World’s Foremost Unified Chromatography System 3Steep Hill First to Receive Provisional Approval to Establish Laboratory Services for Cannabis Testing in State of New Mexico 2SQI Diagnostics Reports First Quarter Financial Results 2SQI Diagnostics Reports First Quarter Financial Results 3SQI Diagnostics Reports First Quarter Financial Results 4SQI Diagnostics Reports First Quarter Financial Results 5SQI Diagnostics Reports First Quarter Financial Results 6Indefinite Life Extension Activists Organize Online Demonstration 2Indefinite Life Extension Activists Organize Online Demonstration 3
... Research Park Center. ZyStor will have labs at the research ... syndicate has drawn a St. Louis niche-market biotech company to ... Milwaukee County Research Park . , ,The company is targeting ... sometimes in young children, using a new technique. , , ...
... Madison, Wis. The University of Wisconsin-Madison plans to ... by June 2006, according to the Division of Information ... that 46 percent of students said they were likely to ... across the campus, DoIT announced on November 2 that it ...
... The University of Wisconsin-Madison Board of Regents has approved ... near UW Hospital and Clinics and the ... spring 2008, awaits approval from the State Building Commission on ... include laboratory facilities, offices, an imaging center and animal quarters. ...
Cached Biology Technology:Wisconsin VCs draw Missouri biotech firm to state 2Wisconsin VCs draw Missouri biotech firm to state 3Wisconsin VCs draw Missouri biotech firm to state 4UW-Madison working to extend wireless access to entire campus 2
... Enzyme concentration - 5 units/µL ,• High ... yields ,• Leaves an 'A' overhang ,• ... which exhibits very high activity in primer ... ensure the quality of the enzyme, each ...
... Gold® DNA Polymerase is a chemically modified ... chemical moiety is attached to the enzyme, ... the first ramp of thermal cycling (when ... temperatures), the enzyme is inactive. The result ...
Ps-Aeruginosa (IgG) -Ab EIA Sample Size: 100 l...
Request Info...
Biology Products: