Navigation Links
A protein sequence associated with Huntington’s disease may become life-saving vaccine component
Date:6/10/2008

On June 10, 2008 the scientific journal "Vaccine" published a paper by the Massachusetts based biotech company Cure Lab, Inc., demonstrating that a protein sequence important in neurodegenerative Huntington's disease can be safely used as a new generation of vaccine adjuvants.

The major component of every vaccine is an antigen that elicits specific immunity to a particular virus, bacteria or even cancer cells. Search for better antigens is one of the most pressing medical and public health necessities, and the biotech industry invests heavily in this research. However, antigens are able to generate a limited immune response if administered alone. In order to be protective or therapeutic, vaccine compositions have to be supplemented with adjuvants, strong facilitators of the immune response. In the search for efficient adjuvants that are also non-toxic, scientists at Cure Lab, Inc. discovered a novel paradigm that capitalizes on insights from recent breakthroughs in understanding the fatal neurodegenerative disorder, Huntington's.

Huntington's disease results from mutations in the protein huntingtin, which contains a sequence of polyglutamine residues (polyQ). In healthy individuals, huntingtin contains less than 35 glutamines in the polyQ segment. However, in neurons of Huntington's patients, the number of glutamine residues in the sequence expands to more than 36. This induces protein self-aggregation, or formation of big protein "chunks", and eventually causes neuronal dysfunction. Recent research findings indicate that attachment of a prolonged polyQ segment to almost any protein promotes its aggregation.

"There were two ideas - said Alex Shneider, Cure Lab's founder and CEO- which stimulated us to test if attachment of a long polyQ "tail" to an antigen can enhance immune response to vaccination". First, he noticed that small aggregates formed by an antigen fused to a polyQ tail resembled the droplets that convention
'/>"/>

Contact: Alex Shneider
ashneider@curelab.com
609-841-1201
Cure Lab, Inc.
Source:Eurekalert

Page: 1 2

Related biology news :

1. Fruit fly helps identify protein critical to eggshell formation that may be pesticide target
2. Protein fibrils as alternative plastics?
3. Montana State University researchers map iron transport protein
4. Plant biologists discover unexpected proteins affecting small RNAs
5. New clues to how proteins dissolve and crystallize
6. Ancient protein offers clues to killer condition
7. New discovery on role of vital protein that fights meningitis
8. Researchers report the cloning of a key group of human genes, the protein kinases
9. Genetic sequencing of protein from T. rex bone confirms dinosaurs link to birds
10. Proteins that stop a major signaling pathway can also generate new proteins
11. Researchers reveal structure of protein that repairs damage to cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... April 14, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces ... the 2015 New York Design Awards under the category  ... York City Design Awards are part of a global ... 2,500 ratings from the marketplace, industry and judging panel. ...
(Date:4/13/2015)... 2015  higi, a leading cloud-based consumer engagement platform ... engage with their communities around health and wellness, announced ... secure API.  ... affordable, and convenient vehicle to receive validated health information ... The API will allow higi,s trusted partners, on ...
(Date:4/9/2015)... SAN JOSE, Calif. , April 9, 2015 /PRNewswire/ ... of human interface solutions, announced today that it will ... 2015 on Thursday, April 23, 2015, after the close ... call for analysts and investors at 2:00 p.m. PT ... information.    To participate on the live ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3Synaptics to Report Third Quarter Results on April 23 2
... Lecture has been awarded to John Ellis for his ... sciences. Ellis, an Emeritus Professor in the Department of ... UK, is the author of the Springer book How ... 1960 from King,s College, London, and completed postdoctoral studies ...
... hospitalized each year due to hyperemesis gravidarum (HG), an extreme ... often forces them to reluctantly terminate their pregnancies. ... on either side of the family who have experienced extreme ... heightened, according to a new study led by researchers from ...
... The Brazilian Instituto Nacional de Pesquisas Espaciais (INPE, ... auspices of the Ministrio da Cincia e Tecnologia ... installation of a supercomputer to be used for ... Climate System Model. The model is designed to ...
Cached Biology News:Study shows extreme form of pregnancy-related morning sickness could be genetic 2Supercomputer makes it possible to develop a Brazilian Global Climate System Model 2
(Date:4/16/2015)... Proove Biosciences , Inc. is pleased to ... for the 2015 BIO International Convention. Hosted by the ... will take place June 15-18 at the Pennsylvania Convention ... contest, industry leaders will be voting for companies they ... community voting period began on April 14, 2015 and ...
(Date:4/16/2015)... Ohio (PRWEB) April 16, 2015 ... Index, overexertion involving an outside source was ranked ... This includes injuries related to lifting, pushing, pulling, ... billion in direct costs. The David Round Company ... is committed to working hard to develop and ...
(Date:4/16/2015)... WESTON, Mass. , April 16, 2015  In recognition ... has collaborated with hemophilia advocacy groups to illuminate more than ... , including Boston,s Zakim Bridge ... New Orleans, Mercedes-Benz Superdome and ... will occur during the evening of April 17, and coincide ...
(Date:4/16/2015)... April 16, 2015 /CNW/ - Bioenterprise Corporation is pleased to ... in Charlottetown , PEI.  Bioenterprise has ... Island ADAPT Council for the commercialization of agricultural technologies ... working with PEI ADAPT.  They have been at the ... a decade," explains Dave Smardon , President & ...
Breaking Biology Technology:Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 2Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 3The David Round Company Helps Companies Meet OSHA Standards by Combining Safety, Ergonomics, and Productivity 2Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 2Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 3Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 4Bioenterprise Corporation Expands into the Maritimes 2
... Michael Su, M.S., ... , INTRODUCTION , Adenosine triphosphate ... assay of ATP can be used as a indicator of viable ... planthygiene for bacterial contamination in the food, drug, health care and ...
... INTRODUCTION , ... necessary to produce accurate results for dissolution testing of pharmaceutical ... laboratories. USP requirements for calibration are given in the Apparatus ... Each individual apparatus (i.e. spindle or basket) must be tested ...
... 1311 Orleans Dr., Sunnyvale, CA 94089., , , ... Introduction , ... Quantitation Kit from Molecular Probes in the Gemini XS, Gemini EM ... Pro software from Molecular Devices. Single-stranded DNA and oligonucleotides are traditionally ...
Cached Biology Technology:ATP Quantitation in the LMax Microplate Luminometer (MaxLine Application Note #40) 2ATP Quantitation in the LMax Microplate Luminometer (MaxLine Application Note #40) 3ATP Quantitation in the LMax Microplate Luminometer (MaxLine Application Note #40) 4Using the SpectraMax Plus for USP Dissolution Calibration (MaxLine Application Note #27) 2Using the SpectraMax Plus for USP Dissolution Calibration (MaxLine Application Note #27) 3Using the SpectraMax Plus for USP Dissolution Calibration (MaxLine Application Note #27) 4Using the SpectraMax Plus for USP Dissolution Calibration (MaxLine Application Note #27) 5Using the SpectraMax Plus for USP Dissolution Calibration (MaxLine Application Note #27) 6Using the SpectraMax Plus for USP Dissolution Calibration (MaxLine Application Note #27) 7Using the SpectraMax Plus for USP Dissolution Calibration (MaxLine Application Note #27) 8Using the SpectraMax Plus for USP Dissolution Calibration (MaxLine Application Note #27) 9Using the OligoGreen Oligonucleotide Quantitation Reagent in the Gemini XS, Gemini EM and SpectraMax M2 Microplate Readers (MaxLine Application Note #21) 2Using the OligoGreen Oligonucleotide Quantitation Reagent in the Gemini XS, Gemini EM and SpectraMax M2 Microplate Readers (MaxLine Application Note #21) 3Using the OligoGreen Oligonucleotide Quantitation Reagent in the Gemini XS, Gemini EM and SpectraMax M2 Microplate Readers (MaxLine Application Note #21) 4
Applications: Immunohistochemistry, ISH, FISH, CISH....
... TempliPhi 100 Amplification Kit, 100 reactions. ... sequencing in 4-6 h.Generate microgram quantities ... of starting material.Use amplified DNA directly ... from bacterial or M13 liquid cultures, ...
Immunogen: Synthetic peptide (KLH conjugated): L(506) S K S S S Q I R M S G L P A D N L A T(525) Storage: -20 C, Avoid Freeze/Thaw Cycles...
Polypropylene test tube racks, used in Thermo Forma's line of Test Tube Rack holders...
Biology Products: