Navigation Links
A protein couple controls flow of information into the brain's memory center
Date:7/24/2014

ut remains largely stable for a certain amount of time. "This condition may last for hours, days or even longer. This long-term effect is essential for the creation of memories. We can only remember things if the connections between neurons undergo a long-lasting change," says the scientist.

Fast sequence of signals

However, CKAMP44 and TARP Gamma-8 also act over shorter periods of time. The research team discovered that the molecules affect how quickly the AMPA receptors return to a receptive state. "If glutamate has docked on to a receptor, it takes a while until the receptor can react to the next neurotransmitter. CKAMP44 lengthens this period. In contrast, TARP Gamma-8 helps the receptor to recover more quickly," says von Engelhardt.

Hence, CKAMP44 temporarily weakens the synaptic connection, while TARP Gamma-8 strengthens it. Through the interplay of these proteins the synapse is able to tune its sensitivity to a specific level. This condition can last from milliseconds to a few seconds before the strength of the connection is again adapted. Specialists refer to this as "short-term plasticity".

"These molecules ultimately influence how well the nerve cell is able to react to a rapid succession of signals," the scientist summarises the findings. "Such a rapid firing enables neuronal networks to synchronize their activity, which is a common process in the brain."

Sensitive balance

Much to the researchers' surprise, it turned out that the two proteins influence not only the synapse but also the shape of the nerve cells. In the absence of these auxiliary molecules, the neurons have fewer dendrites to establish contact with other nerve cells. "The organism can use CKAMP44 and TARP Gamma-8 molecules to regulate neuronal connections in a number of ways," von Engelhardt says. "This ability depends on the balance between the partners, as to some extent they have a contrary effect. T
'/>"/>

Contact: Dirk Förger
dirk.foerger@dzne.de
0049-228-433-02260
DZNE - German Center for Neurodegenerative Diseases
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Protein evolution follows a modular principle
2. High matrix metalloproteinase-9 expression induces microangiogenesis after cerebral infarction
3. Scientists map one of most important proteins in life -- and cancer
4. Measuring the number of protein molecules inside cells
5. National Xenopus resource at the MBL innovates new way to study proteins
6. Cell membrane proteins give up their secrets
7. Proteins hands enable bacteria to establish infection, research finds
8. SLU scientists hit delete: Removing regions of shape-shifting protein explains how blood clots
9. CNIO scientists develop technology to redirect proteins towards specific areas of the genome
10. Research reveals how key controller protein is switched on
11. Cellular defence against fatal associations between proteins and DNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2015)... According to a recently ... & Opportunities, 2020", the global biometrics market is ... till 2020. The biometrics market is garnering attention ... review of biometric management systems. The constant development ... greater efficiency, are resulting in increasing installation of ...
(Date:4/6/2015)... Apr. 6, 2015 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce ... patent 62/143028 for MINIATURE, MULTI-PURPOSE ANTENNA ... NXT-ID introduces a new revolutionary method ... surrounds the use of miniature antenna modules for ...
(Date:4/1/2015)... , Apr. 1, 2015  NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces ... smart wallets is underway to early access pre-order customers. ... includes usage at retail outlets including Walmart, Target, AT&T, ... report Wocket was accepted at all outlets and very ...
Breaking Biology News(10 mins):Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4
... Just as inhaling cigarette smoke can cause lung cancer, inhaling ... College of Medicine of Yeshiva University have received a ... to clinically develop an inhaled therapy for lung cancer ... The grant recipients are Roman Perez-Soler, M.D., professor of ...
... Institute for Brain Science has released the world,s ... a previously unthinkable feat made possible through leading-edge ... studies and documentation. The unprecedented mappings are the ... online public resource developed to advance the Institute,s ...
... biological material available to identify persons or find next of ... cases, the kits usually employed to carry out DNA identifications ... DNA is not available, and that which is available is ... identifying persons from these small fragments of DNA. His thesis, ...
Cached Biology News:NIH funds investigation of inhaled lung cancer treatment 2Allen Institute for Brain Science announces first comprehensive gene map of the human brain 2Allen Institute for Brain Science announces first comprehensive gene map of the human brain 3Developing a tool for identification -- even using very degraded DNA samples 2Developing a tool for identification -- even using very degraded DNA samples 3
(Date:4/28/2015)... Cambridge, MA (PRWEB) April 28, 2015 ... Safety (ACRES), a Massachusetts-based multi-stakeholder, non-profit organization dedicated ... creation of a shared global system for clinical ... SYNERGY , an innovative new type of clinical ... “The future of clinical research is changing,” said ...
(Date:4/27/2015)... 2015 /PRNewswire/ - iCo Therapeutics ("iCo" or "the Company") ... for the year ended December 31, 2014. Amounts, ... and presented under International Financial Reporting Standards ("IFRS"). ... did not provide the outcome management and investors ... at iCo Therapeutics", said Andrew Rae , ...
(Date:4/27/2015)... 27, 2015 Dr. Robert Hanzlik, whose ... toxicity carries implications for advancing the creation of safer ... National University , the second-largest private, nonprofit university ... Hanzlik, a professor at the University of Kansas School ... design, starts at 5 p.m. and takes place at ...
(Date:4/27/2015)... Deadly viruses such as Ebola are the target ... University City Science Center's Port business incubator at ... $4.5 million Phase 2 SBIR grant from the National ... is focused on therapies for unmet medical needs while ... first-in-class protease inhibitors based on a technology platform inspired ...
Breaking Biology Technology:ACRES Announces Innovative Clinical Research Event--SYNERGY 2ACRES Announces Innovative Clinical Research Event--SYNERGY 3ACRES Announces Innovative Clinical Research Event--SYNERGY 4iCo Therapeutics Announces Year End 2014 Financial Results 2iCo Therapeutics Announces Year End 2014 Financial Results 3iCo Therapeutics Announces Year End 2014 Financial Results 4Dr. Robert Hanzlik Discusses Pharmaceutical Testing Models at Event Hosted by National University 2Dr. Robert Hanzlik Discusses Pharmaceutical Testing Models at Event Hosted by National University 3New Resident of Science Center’s Port Business Incubator Targets SARS and Ebola 2
... YORK, June 15, 2011 NeoStem, Inc. ("NeoStem" or ... international biopharmaceutical company with product and service revenues, global ... business units – U.S. adult stem cells, China adult ... Kolbert, Vice President of Strategic Business Development, will present ...
... Vermillion, Inc. (NASDAQ: VRML ), a molecular ... Microcap Index when Russell Investments reconstitutes its family of U.S. ... additions posted on June 10, available at www.russell.com/indexes . ... in place for one year, means automatic inclusion in the ...
... June 15, 2011 , Pharma IQ is ... HTA Online event - ,Global HTA and CER Forum ... over the course of August. Health Technology Assessment ... assessed for pharmaceuticals in Australia, Canada,and the UK, while clinical ...
Cached Biology Technology:NeoStem to Present at Two Investor Events This Month 2NeoStem to Present at Two Investor Events This Month 3NeoStem to Present at Two Investor Events This Month 4Vermillion Announces Joining Russell Microcap® Index 2Vermillion Announces Joining Russell Microcap® Index 3Health Technology Assessment Goes Online 2Health Technology Assessment Goes Online 3
... C-1-tetrahydrofolate synthase, ... [Includes: Methylenetetrahydrofolate dehydrogenase ... cyclohydrolase (EC 3.5.4.9); ... 6.3.4.3)]. [Source:Uniprot/SWISSPROT;Acc:P11586] ...
Request Info...
Request Info...
Whole rabbit blood (any breed, either sex) is collected at the time of slaughter and processed immediately at 4C, bottled, frozen and stored at -70C....
Biology Products: