Navigation Links
A protein couple controls flow of information into the brain's memory center
Date:7/24/2014

de of the hippocampus. It was already known that these proteins form protein complexes with AMPA receptors. "We have now found out that they exert a significant influence on the functioning of glutamate receptors. Each in its own way, as chemically they are completely different," says the neuroscientist. "We identified that the ability of a nerve cell to receive signals doesn't depend solely on the actual receptors; CKAMP44 and TARP Gamma-8 are just as important. Their function cannot be separated from that of the receptors."

This was the result of an analysis in which the researchers compared brain tissue from mice with a natural genotype with brain tissue from genetically modified mice. Neurons in the genetically modified animals were not able to produce either CKAMP44 or TARP Gamma-8 or both.

Long-term effect

The researchers discovered, among other things, that both proteins promote the transportation of glutamate receptors to the cell surface. "This means they influence how receptive the nerve cell is to incoming signals," says von Engelhardt.

However, the number of receptors and thus the signal reception can be altered by neuronal activity. The von Engelhardt group found that in this regard the auxiliary molecules have different effects: TARP Gamma-8 is essential to ensure that more AMPA receptors are integrated into the synapse following a plasticity induction protocol, whereas CKAMP44 plays no role in this context. "Synapses alter their communication depending on their activity. This ability is called plasticity. Some of the changes involved are only temporary, others may last longer," explains von Engelhardt. "TARP Gamma-8 influences long-term plasticity. It makes the cell able to strengthen synaptic communication for a prolonged time-period. The larger the number of receptors on the receiving side of the synapse, the better the neuronal connection."

The number of receptors doesn't change suddenly, b
'/>"/>

Contact: Dirk Förger
dirk.foerger@dzne.de
0049-228-433-02260
DZNE - German Center for Neurodegenerative Diseases
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Protein evolution follows a modular principle
2. High matrix metalloproteinase-9 expression induces microangiogenesis after cerebral infarction
3. Scientists map one of most important proteins in life -- and cancer
4. Measuring the number of protein molecules inside cells
5. National Xenopus resource at the MBL innovates new way to study proteins
6. Cell membrane proteins give up their secrets
7. Proteins hands enable bacteria to establish infection, research finds
8. SLU scientists hit delete: Removing regions of shape-shifting protein explains how blood clots
9. CNIO scientists develop technology to redirect proteins towards specific areas of the genome
10. Research reveals how key controller protein is switched on
11. Cellular defence against fatal associations between proteins and DNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... USA A new GSA Bulletin study ... lower Rio Puerco and Chaco Wash in northern New ... from salt cedar and willow, investigators were able to ... greater. They then combined this data with aerial imagery, ... history of these arroyos. , Arroyos are deep, oversized ...
(Date:9/18/2014)... icy moon of Uranus, is one of the most ... Despite its relatively small size, Miranda appears to have ... the formation of at least three remarkable and unique ... These coronae are visible in Miranda,s southern hemisphere, and ... corona, the largest, has ridges and troughs with up ...
(Date:9/18/2014)... robotic system that can operate inside the bore of ... of a biomedical research partnership program at Brigham and ... if the robot, in conjunction with real-time MRI images, ... costly, and less discomforting for the patient. The novel ... therapies with greater precision. , Developed by a team ...
Breaking Biology News(10 mins):Tree rings and arroyos 2Tree rings and arroyos 3Tree rings and arroyos 4Tree rings and arroyos 5Tree rings and arroyos 6Tree rings and arroyos 7Miranda: An icy moon deformed by tidal heating 2Miranda: An icy moon deformed by tidal heating 3Miranda: An icy moon deformed by tidal heating 4Miranda: An icy moon deformed by tidal heating 5Miranda: An icy moon deformed by tidal heating 6Miranda: An icy moon deformed by tidal heating 7Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 3Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 4Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 5
... release is available in French . , Frank Kachanoff ... would make people more aggressive, not less. After all, dont football ... game in hopes of pumping them up? And what about our ... dares take their meat away from them? Wouldnt that go for ...
... as part of an insect birth control program helps ... new approach that combines the planting of pest-resistant cotton ... eliminated of the world,s most destructive cotton pests from ... Nov. 7 advance online publication of the journal ...
... tracking the flow of information in a cell preparing to ... coordinates and regulates the dynamics of shape change necessary for ... The protein, called 14-3-3, sits at an intersection where ... cell shape change and, ultimately, the splitting that allows for ...
Cached Biology News:Caveman behavioral traits might kick in at Thanksgiving table before eating 2New insect birth control strategy zaps cotton pests 2New insect birth control strategy zaps cotton pests 3New insect birth control strategy zaps cotton pests 4Johns Hopkins researchers reshape basic understanding of cell division 2
(Date:9/19/2014)... SPRINGS, Florida , September 19, 2014 ... companies release latest developments, patents and results of studies ... GNSZ), Eli Lilly and Company (NYSE: LLY ... Celgene Corporation (NASDAQ: CELG ) and Arena ... GNSZ), a leader in developing prodrug therapeutics for the ...
(Date:9/19/2014)... Dublin ... announced the addition of the  "Micro Market Monitor ... offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , , ... fastest-growing segments in the chromatography market. The market ... expected to reach $2.0 billion by 2019, at ...
(Date:9/18/2014)... Washington, USA (PRWEB) September 18, 2014 ... Representatives of a bill designed to stimulate development and ... jobs is being praised by leaders of SPIE, ... bill, the Revitalizing American Manufacturing and Innovation (RAMI) Act, ... The bill’s authors have said they are optimistic that ...
(Date:9/18/2014)... 2014 /PRNewswire-iReach/ -- DeepResearchReports.com adds "2014 Deep Research ... and "2014 Deep Research Report on Global and ... database. Photo - http://photos.prnewswire.com/prnh/20140918/147058 ... Global and China Acetic Acid Industry" is a ... China and Global Acetic Acid Market. ...
Breaking Biology Technology:Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 2Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 3Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 4Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 5Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 6Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 7Micro Market Monitor : Global Pre-packed Chromatography Columns 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 3Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 2Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 3Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 4
... will make the,following changes to the S&P 500 and S&P MidCap 400 indices:, ... removed from the S&P 500 after the close ... today,s close of trading General Growth Properties had a market ... -- S&P MidCap 400 constituent Cephalon Inc. (Nasdaq: CEPH ...
... /Xinhua-PRNewswire-FirstCall/ -- BMP,Sunstone Corporation (Nasdaq: BJGP ) ... to the technical difficulties encountered on,today,s conference call, ... November 12, 2008. On this call, BMP Sunstone ... technical difficulties prevented the,Company from addressing all questions ...
... Flu Strains A & B In,15 Minutes, Each ... becomes ill with "the,flu." Misdiagnosis of the flu is ... of this, overuse and unnecessary,use of antibiotics may be ... This flu season, a new rapid flu test ...
Cached Biology Technology:Standard & Poor's Announces Changes to U.S. Indices 2Standard & Poor's Announces Changes to U.S. Indices 3BMP Sunstone to Host Follow-Up 3Q08 Conference Call Due to Technical Difficulties Encountered on Tuesday's Call 2BMP Sunstone to Host Follow-Up 3Q08 Conference Call Due to Technical Difficulties Encountered on Tuesday's Call 3MultiVu Video Feed: New Rapid Test to Diagnose Flu May Help With Upcoming Flu Season 2
... offer all of the features of a ... with Koehler illumination, a centerable condenser and ... is the workhorse of Motic's range of ... need for re-focusing following a change in ...
... high-throuput screening of a biological systems phenotype, ... changes in the expression levels of the ... studied, classified and compared to each other, ... a glance. Automatized scanning of the hybridized ...
... RNA gel stain is a sensitive ... fluorescence when bound to RNA and low ... use with either formaldehyde/agarose or polyacrylamide gels ... A 500 µL unit size (S-7564) and ...
Rabbit polyclonal to Esa1 ( Abpromise for all tested applications)....
Biology Products: