Navigation Links
A protein couple controls flow of information into the brain's memory center
Date:7/24/2014

These molecules, which have similar counterparts in humans, affect the connections between nerve cells and influence the transmission of nerve signals into the hippocampus, an area of the brain that plays a significant role in learning processes and the creation of memories. The results of the study have been published in the journal Neuron.

Brain function depends on the active communication between nerve cells, known as neurons. For this purpose, neurons are woven together into a dense network where they constantly relay signals to one another. However, neurons do not form direct contacts with each other. Instead they are separated by an extremely narrow gap, known as the synapse. This gap is bridged by 'neurotransmitters', which carry nerve signals from one cell to the next.

Docking stations

Specific molecular complexes in the cell's outer shell, so-called 'receptors', receive the signal by binding the neurotransmitters. This triggers an electrical impulse in the receptor-bearing cell and thus the nerve signal has moved on one neuron further.

In the current study, a team led by Dr Jakob von Engelhardt focused on the 'AMPA' receptors. These bind the neurotransmitter 'glutamate' and are particularly common in the brain. "We looked at AMPA receptors in an area of the brain, which constitutes the main entrance to the hippocampus," explains von Engelhardt, who works for the DZNE and DKFZ. "The hippocampus is responsible for learning and memory formation. Among other things it processes and combines sensory perception. We therefore asked ourselves how the flow of information into the hippocampus is controlled."

A pair of helpers

Dr von Engelhardt's research team specifically focused on two protein molecules: 'CKAMP44' and 'TARP Gamma-8'. These proteins are present, along with AMPA receptors, in the 'granule' cells, which are neurons that receive signals from areas outsi
'/>"/>

Contact: Dirk Förger
dirk.foerger@dzne.de
0049-228-433-02260
DZNE - German Center for Neurodegenerative Diseases
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Protein evolution follows a modular principle
2. High matrix metalloproteinase-9 expression induces microangiogenesis after cerebral infarction
3. Scientists map one of most important proteins in life -- and cancer
4. Measuring the number of protein molecules inside cells
5. National Xenopus resource at the MBL innovates new way to study proteins
6. Cell membrane proteins give up their secrets
7. Proteins hands enable bacteria to establish infection, research finds
8. SLU scientists hit delete: Removing regions of shape-shifting protein explains how blood clots
9. CNIO scientists develop technology to redirect proteins towards specific areas of the genome
10. Research reveals how key controller protein is switched on
11. Cellular defence against fatal associations between proteins and DNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2015)... , June 25, 2015  TAKE Solutions Ltd., ... patent by the United States Patent and Trademark Office ... This process leverages TAKE Solutions, Clinical Accelerators to reduce ... 50% (when compared to standardization without the accelerators), thus ... At the heart of the ...
(Date:6/24/2015)... , June 24, 2015 Biometry authentication ... emerging biometric password solution one face in. ... one face in, entering the expanding ... and affordable multifactor-authentication biometric answer to the password ... provided in partnership with KeyLemon, one face in ...
(Date:6/18/2015)... NEW YORK , June 18, 2015 ... in US$ Million by the following Product Segments, which ... Immunoassay Systems, Chemiluminescence Immunoassay Systems, Radio Immunoassay Systems, and ... for the US, Canada , ... Asia-Pacific , Latin America ...
Breaking Biology News(10 mins):TAKE Solutions Awarded Patent By USPTO 2KeyLemon Announces Partnership With Biometric Password Solution onefacein 2Global Immunoassay Systems Market 2Global Immunoassay Systems Market 3Global Immunoassay Systems Market 4Global Immunoassay Systems Market 5Global Immunoassay Systems Market 6Global Immunoassay Systems Market 7Global Immunoassay Systems Market 8Global Immunoassay Systems Market 9Global Immunoassay Systems Market 10Global Immunoassay Systems Market 11Global Immunoassay Systems Market 12Global Immunoassay Systems Market 13Global Immunoassay Systems Market 14Global Immunoassay Systems Market 15Global Immunoassay Systems Market 16Global Immunoassay Systems Market 17Global Immunoassay Systems Market 18Global Immunoassay Systems Market 19Global Immunoassay Systems Market 20Global Immunoassay Systems Market 21Global Immunoassay Systems Market 22Global Immunoassay Systems Market 23Global Immunoassay Systems Market 24Global Immunoassay Systems Market 25Global Immunoassay Systems Market 26Global Immunoassay Systems Market 27Global Immunoassay Systems Market 28Global Immunoassay Systems Market 29
... termites use vibrations to choose the wood they eat ... in homes and also may provide insights into the ... most noise but have some signals that trigger attention ... entomologist Theo Evans says laboratory experiments have found that ...
... A team of Fox Chase Cancer Center scientists led ... genetic mutation that keeps a mouse strain from developing ... The report by Kappes and his colleagues appears in ... first discovered the mice with this naturally occurring defect ...
... 2,or ACC2, appears to turn the adipose or fat ... the animals can eat more and weigh less,than their ... appears online today in the Proceedings of the National,Academy ... mice bred to lack ACC2," said Dr. Salih,Wakil, chair ...
Cached Biology News:Termites feed through good vibrations 2Fox Chase Cancer Center scientists identify immune-system mutation 2Lack of enzyme turns fat cells into fat burners 2
(Date:6/30/2015)... , June 30, 2015  The University of ... Biosciences (CCE/Bio) and UC San Diego Extension announced ... be held Aug.  12 – 14, 2015, at ... three-day workshop provides an intense exposure to best ... and is well-suited to biologists, process engineers and ...
(Date:6/30/2015)... ... June 30, 2015 , ... Smarter ... — a revolutionary new archwire that allows orthodontists to simultaneously apply different forces ... the efficacy of SmartArch. “We’re thrilled about taking SmartArch one step closer to ...
(Date:6/29/2015)... ... , ... The global microfluidics market is expected to grow ... 2020). The market is mainly driven by the rising geriatric population, growing Asian ... of adequate healthcare and research infrastructure in emerging markets, dearth of skilled professionals ...
(Date:6/29/2015)... June 29, 2015 According to a ... XNA), by Application (Diagnostics, Therapeutics, R&D), by Technology (SELEX, Other ... Companies, CRO) - Global Forecast to 2020", published by MarketsandMarkets, ... by 2020 from $107.56 Million in 2015, at a CAGR ... ables and 67 F igures spread through ...
Breaking Biology Technology:UC San Diego Extension to Offer Third Annual Microbial Fermentation Workshop 2New case studies for SmartArch orthodontic archwire paves way to product launch later this year 2Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 2Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 3Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 4Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 5Aptamers Market Worth $244.93 Million by 2020 2Aptamers Market Worth $244.93 Million by 2020 3Aptamers Market Worth $244.93 Million by 2020 4
... PRINCETON, New Jersey and SAN DIEGO,California, September 8 , ... for Continuous Process,Chemistry Technologies and for Further Global Expansion, ... investment of $3.3M,by a group of private and financial ... Graphisoft and Dave Tapolczay, CEO of Medical,Research Council Technology ...
... announced that it has appointed A.J. Whalen as Solutions Director. ... ... 8, 2008 -- www.symphony-consulting.com [Symphony Management Consulting] announced ... , , ,Mr. Whalen joins Symphony from Wellesley Information Services ...
... Cell Therapeutics, Inc.,(CTI) (Nasdaq: CTICD ; ... a letter from the Listing Qualifications Staff of ... is not in compliance with the,$50,000,000 minimum market ... Marketplace Rule 4450(b)(1)(A). Furthermore, the Company does not,comply ...
Cached Biology Technology:World Leader in Bench-Top Flow Chemistry Instruments ThalesNano, Inc. Closes Funding Round 2Symphony Managemnt Consulting Hires New Solutions Director 2CTI Receives NASDAQ Letter 2CTI Receives NASDAQ Letter 3