Navigation Links
A protein couple controls flow of information into the brain's memory center
Date:7/24/2014

These molecules, which have similar counterparts in humans, affect the connections between nerve cells and influence the transmission of nerve signals into the hippocampus, an area of the brain that plays a significant role in learning processes and the creation of memories. The results of the study have been published in the journal Neuron.

Brain function depends on the active communication between nerve cells, known as neurons. For this purpose, neurons are woven together into a dense network where they constantly relay signals to one another. However, neurons do not form direct contacts with each other. Instead they are separated by an extremely narrow gap, known as the synapse. This gap is bridged by 'neurotransmitters', which carry nerve signals from one cell to the next.

Docking stations

Specific molecular complexes in the cell's outer shell, so-called 'receptors', receive the signal by binding the neurotransmitters. This triggers an electrical impulse in the receptor-bearing cell and thus the nerve signal has moved on one neuron further.

In the current study, a team led by Dr Jakob von Engelhardt focused on the 'AMPA' receptors. These bind the neurotransmitter 'glutamate' and are particularly common in the brain. "We looked at AMPA receptors in an area of the brain, which constitutes the main entrance to the hippocampus," explains von Engelhardt, who works for the DZNE and DKFZ. "The hippocampus is responsible for learning and memory formation. Among other things it processes and combines sensory perception. We therefore asked ourselves how the flow of information into the hippocampus is controlled."

A pair of helpers

Dr von Engelhardt's research team specifically focused on two protein molecules: 'CKAMP44' and 'TARP Gamma-8'. These proteins are present, along with AMPA receptors, in the 'granule' cells, which are neurons that receive signals from areas outsi
'/>"/>

Contact: Dirk Förger
dirk.foerger@dzne.de
0049-228-433-02260
DZNE - German Center for Neurodegenerative Diseases
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Protein evolution follows a modular principle
2. High matrix metalloproteinase-9 expression induces microangiogenesis after cerebral infarction
3. Scientists map one of most important proteins in life -- and cancer
4. Measuring the number of protein molecules inside cells
5. National Xenopus resource at the MBL innovates new way to study proteins
6. Cell membrane proteins give up their secrets
7. Proteins hands enable bacteria to establish infection, research finds
8. SLU scientists hit delete: Removing regions of shape-shifting protein explains how blood clots
9. CNIO scientists develop technology to redirect proteins towards specific areas of the genome
10. Research reveals how key controller protein is switched on
11. Cellular defence against fatal associations between proteins and DNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/25/2015)... BELLEVUE, Wash. , Aug. 25, 2015 /PRNewswire/ ... announced today it will unveil its "Guardian S" snake ... the National Tactical Officers Association Conference on August 30 ... S is the first-ever commercially available energetically autonomous snake ... and in-field trials and is protected by more than ...
(Date:8/20/2015)... 2015 The wearable technology market has ... and healthy. However, wearable technology has the potential ... help improve diagnostic capabilities and therapeutic outcomes. Today, ... Wearable Technologies Conference 2015 , where Barrett ... in healthcare.    "Over the past ...
(Date:8/19/2015)... HAUPPAUGE, N.Y. , Aug. 19, 2015 /PRNewswire/ ... announced that it has entered into a Definitive ... intellectual property, of iris authentication market leader EyeLock ... transaction, VOXX will have a controlling interest in ... is subject to completion of due diligence.  Expanding ...
Breaking Biology News(10 mins):Sarcos to Debut First-of-its-Kind Snake Robot 2Sarcos to Debut First-of-its-Kind Snake Robot 3Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 2Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 3VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 2VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 3VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 4VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 5
... Hole Research Center are analyzing the surprising results of the ... rainforest. , From January 2000 to July 2004, rainfall was ... of the Tapajós National Forest, in Brazil. A total of ... by 6' clear plastic panels suspended 3 to 12 feet ...
... Affymetrix Inc. (Nasdaq: AFFX - News) and Karolinska ... a strategic alliance designed to improve healthcare by ... tools for better diagnosis, prognosis, and treatment. , ... genetic analyses and measurement of gene expression in ...
... have discovered an important chemical in the brain's ... symptoms of opioid drugs like morphine and heroin. ... chemical--called a transporter--could relieve some of the early ... shaking, and jumpiness. Such drugs could become part ...
Cached Biology News:World's largest rainforest drying experiment completes first phase 2World's largest rainforest drying experiment completes first phase 3Affymetrix and the Karolinska Institutet Announce Translational Medicine Strategic Alliance 2Affymetrix and the Karolinska Institutet Announce Translational Medicine Strategic Alliance 3Key Trigger Of Opioid Withdrawal Symptoms Found 2
(Date:9/1/2015)... ... September 01, 2015 , ... Leading CEOs, CSOs, CMOs, and ... space join prominent academics and key investors for Neuro Advance Boston, October 14, ... Boston. , Neuro Advance Boston focuses on the latest developments and opportunities ...
(Date:9/1/2015)... MA (PRWEB) , ... September 01, 2015 , ... ... its new Director of Business Development, Asia Pacific. In this newly-created position, Gibbs ... the awareness and use of iLab’s suite of tools. This entails not only ...
(Date:9/1/2015)... ... September 01, 2015 , ... GenoCAD, a leading ... new version of its flagship DNA design platform, which has been enhanced to ... into numerous genetic parts, which in turn can be recombined using specific sets ...
(Date:8/31/2015)... - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today ... air emission abatement projects in North America ... for a municipality in the Southern USA ... that failed to meet the customer,s requirements. This demonstrates the value ... S. Webb , President and Chief Executive Officer.  ...
Breaking Biology Technology:Neuro Advance Boston Brings Together Leading Neuroscience Experts on October 14 at Harvard Medical School 2iLab Solutions Hires Gerard Gibbs, Director of Business Development, Asia Pacific 2iLab Solutions Hires Gerard Gibbs, Director of Business Development, Asia Pacific 3GenoCAD Releases Combinatorial Design Tool to Optimize Protein Expression and Streamline DNA Synthesis Orders 2
... Brain Metastases, PALO ALTO, Calif., Sept. 2 ... radiosurgery treatments for,multiple brain metastases using new RapidArc ... ). The MIMA Cancer Center in Melbourne,Florida and ... able to treat brain metastases more quickly and ...
... BMRN ) today announced that Jean-Jacques,Bienaime, Chief Executive ... 3rd Annual Citi Biotech Day in New York City ... Interested parties may access a live audio webcast of ... website, http://www.BMRN.com .,A replay of the call will ...
... development milestone payment to InterMune - ... to lead ITMN-191 program in Phase 2 -, BRISBANE, ... announced that InterMune has earned a $15 million,development milestone under ... NS3 protease inhibitor compound ITMN-191,(referred to as R7227 at Roche), ...
Cached Biology Technology:Brain Cancer Patients at Two Leading Hospitals Treated Using Fast and Efficient RapidArc Radiotherapy Technology from Varian Medical Systems 2Brain Cancer Patients at Two Leading Hospitals Treated Using Fast and Efficient RapidArc Radiotherapy Technology from Varian Medical Systems 3Brain Cancer Patients at Two Leading Hospitals Treated Using Fast and Efficient RapidArc Radiotherapy Technology from Varian Medical Systems 4BioMarin to Present at the Citi Biotech Day 2InterMune Earns Development Milestone in HCV Protease Inhibitor Collaboration With Roche 2InterMune Earns Development Milestone in HCV Protease Inhibitor Collaboration With Roche 3InterMune Earns Development Milestone in HCV Protease Inhibitor Collaboration With Roche 4
... is a cytidine analog that has been shown ... Immunogen: Chemical / Small Molecule conjugated ... of the ddC antiserum was determined by calculating ... moles of ddC analog at the 50% intercept ...
The Holten Safe 2010 Class II Biological Safety Cabinets provide the most ergonomical working condition of comfort while incorporating the latest technology for safety, efficiency and performance....
...
... The Holten MaxiSafe 2010 Class II ... ergonomical working condition of comfort while ... efficiency and performance.,Refined operator, environment and ... both exhausted and recirculated air.,Bottom filters ...
Biology Products: