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A protein called cFLIP makes tumor cells in breast cancer resistant to treatments
Date:12/14/2010

This release is available in Spanish.

Researchers at the Andalusian Institute for Molecular Biology and Regenerative Medicine (CABIMER) and the University of Granada found that cFLIP an inhibitor of death ligand-induced apoptosis is not only essential in breast tumor cells resistance to TRAIL treatments (a death ligand with a potent therapeutic potential against cancer), but this protein is also key to the survival of such cancer cells.

Researchers proved that a variation in the expression of this protein may lead to the normal development of breast epithelium. This is an important finding to be considered in the design of cFLIP-targeted therapies against cancer.

The research conducted by Rosario Yerbes Cadenas, PhD candidate at the University of Granada, was led by professor Abelardo Lpez Rivas, of CABIMER, and was aimed at analysing the potential of cFLIP inhibitors in cancer therapies.

At present, TRAIL is a death-ligand of the TNF family, with significant therapeutic potential against cancer, basically due to its ability to induce apoptosis in cancer cells without displaying significant toxicity toward normal cells. However, there are tumor cells that are resistant to TRAIL-induced apoptosis for unknown causes.

A Key Component

This study analysed the role of cFLIP in breast cancer cells' resistance to TRAIL-induced apoptosis. Thus, researchers concluded that cFLIP is key in these cells' resistance to TRAIL. Such conclusion was drawn from the evidence that the inhibition of their expression through treatments with Doxorubicin (anthracycline, widely used in chemotherapy) or with SAHA (Histone deacetylases inhibitor), as well as the silencing of its expression through cFLIP siRNA oligos (small interfering RNA), resulted in the sensitisati
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Contact: Rosario Yerbes Cadenas
Rosario.yerbes@cabimer.es
34-954-467-934
University of Granada
Source:Eurekalert

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