Navigation Links
A powerful new technology to identify HIV inhibitors

This release is available in German.

EASY-HIT** is a new cell-based assay system for simple and reliable testing of HIV inhibitors. This system was developed under the leadership of Professor Ruth Brack-Werner at the Institute of Virology. At the heart of the system are cultured human cells that allow HIV to enter and replicate efficiently and that signal HIV infection by producing a red fluorescent protein. The EASY-HIT technology can be used to identify HIV-inhibitors, measure the potency of their inhibitory activity and to detect the stage of replication targeted by the inhibitor.

The researchers validated their technology with a panel of currently used anti-HIV drugs and then went on to identify 5 new HIV inhibitors. They also showed that this technology can be used to detect anti-HIV activities in raw plant extracts. The researchers are currently using this system to explore numerous biological specimens for anti-HIV activities and have already discovered novel unexpected sources of antiviral activities.

Stephan Kremb, first author of the manuscript, summarizes, "We expect the versatile and robust EASY-HIT system to identify new targets against HIV and new sources of HIV-inhibitors". "Our technology has many applications in HIV research and pharmaceutical drug design", adds Ruth Brack-Werner.

HIV was first discovered in the early 1980s and described as the causative agent of AIDS. As there is no cure for HIV infection as yet, HIV-infected individuals require life-long treatment with antiviral drugs. The problems with currently available therapies include drug side-effects, the emergence of resistant viruses and the cost of long-term treatment. "It is our particularly hope that the EASY-HIT technology will promote the development of new strategies for HIV treatment in areas with limited resources", states Ruth Brack-Werner.


Contact: Sven Winkler
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health

Related biology news :

1. Powerful supercomputer peers into the origin of life
2. Ancient terror bird used powerful beak to jab like boxer
3. Powerful genome barcoding system reveals large-scale variation in human DNA
4. Powerful new method allows scientists to probe gene activation
5. Innovative Document Security Technology Proves Powerful in Avoiding Counterfeit Products
6. Powerful new molecular GPS helps probe aging and disease processes
7. Powerful nutrient cocktail can put kids with Crohns into remission
8. Changing climate likely to make super weed even more powerful
9. InVitria to Unveil Powerful Cell Culture Media Component ZAP-CHO
10. Collaboration leads to success: Most powerful computer of its kind in western N.Y. available worldwide
11. Cancer Genomics Browser gives cancer researchers a powerful new tool
Post Your Comments:
(Date:6/9/2016)... Finland , June 9, 2016 ... National Police deploy Teleste,s video security solution to ensure the ... France during the major tournament ... data communications systems and services, announced today that its video ... Prefecture to back up public safety across the ...
(Date:6/2/2016)... , June 2, 2016 Perimeter ... Platforms, Unmanned Systems, Physical Infrastructure, Support & Other Service  ... visiongain offers comprehensive analysis of the global ... market will generate revenues of $17.98 billion in 2016. ... DVTEL Inc, a leader in software and hardware technologies ...
(Date:5/12/2016)... 12, 2016 , a brand ... overview results from the Q1 wave of its quarterly ... was consumers, receptivity to a program where they would ... health insurance company. "We were surprised to ... Michael LaColla , CEO of Troubadour Research, "primarily ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... FRANCISCO , June 23, 2016   EpiBiome ... has secured $1 million in debt financing from Silicon ... ramp up automation and to advance its drug development ... its new facility. "SVB has been an ... beyond the services a traditional bank would provide," said ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample tracking software ... State Crime Laboratory, has joined STACS DNA as a Field Application Specialist. , ... Tremblay, President and COO of STACS DNA. “In further expanding our capacity as a ...
(Date:6/23/2016)... 23, 2016 Apellis Pharmaceuticals, Inc. today ... trials of its complement C3 inhibitor, APL-2. The ... ascending dose studies designed to assess the safety, ... injection in healthy adult volunteers. Forty ... a single dose (ranging from 45 to 1,440mg) ...
(Date:6/23/2016)... LONDON , June 23, 2016 ... & Hematology Review, 2016;12(1):22-8 ... Review , the peer-reviewed journal from touchONCOLOGY, ... the escalating cost of cancer care is placing ... a result of expensive biologic therapies. With the ...
Breaking Biology Technology: