Navigation Links
A powerful new technology to identify HIV inhibitors

This release is available in German.

EASY-HIT** is a new cell-based assay system for simple and reliable testing of HIV inhibitors. This system was developed under the leadership of Professor Ruth Brack-Werner at the Institute of Virology. At the heart of the system are cultured human cells that allow HIV to enter and replicate efficiently and that signal HIV infection by producing a red fluorescent protein. The EASY-HIT technology can be used to identify HIV-inhibitors, measure the potency of their inhibitory activity and to detect the stage of replication targeted by the inhibitor.

The researchers validated their technology with a panel of currently used anti-HIV drugs and then went on to identify 5 new HIV inhibitors. They also showed that this technology can be used to detect anti-HIV activities in raw plant extracts. The researchers are currently using this system to explore numerous biological specimens for anti-HIV activities and have already discovered novel unexpected sources of antiviral activities.

Stephan Kremb, first author of the manuscript, summarizes, "We expect the versatile and robust EASY-HIT system to identify new targets against HIV and new sources of HIV-inhibitors". "Our technology has many applications in HIV research and pharmaceutical drug design", adds Ruth Brack-Werner.

HIV was first discovered in the early 1980s and described as the causative agent of AIDS. As there is no cure for HIV infection as yet, HIV-infected individuals require life-long treatment with antiviral drugs. The problems with currently available therapies include drug side-effects, the emergence of resistant viruses and the cost of long-term treatment. "It is our particularly hope that the EASY-HIT technology will promote the development of new strategies for HIV treatment in areas with limited resources", states Ruth Brack-Werner.


Contact: Sven Winkler
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health

Related biology news :

1. Powerful supercomputer peers into the origin of life
2. Ancient terror bird used powerful beak to jab like boxer
3. Powerful genome barcoding system reveals large-scale variation in human DNA
4. Powerful new method allows scientists to probe gene activation
5. Innovative Document Security Technology Proves Powerful in Avoiding Counterfeit Products
6. Powerful new molecular GPS helps probe aging and disease processes
7. Powerful nutrient cocktail can put kids with Crohns into remission
8. Changing climate likely to make super weed even more powerful
9. InVitria to Unveil Powerful Cell Culture Media Component ZAP-CHO
10. Collaboration leads to success: Most powerful computer of its kind in western N.Y. available worldwide
11. Cancer Genomics Browser gives cancer researchers a powerful new tool
Post Your Comments:
(Date:11/2/2015)...  SRI International has been awarded a contract of ... to the National Cancer Institute (NCI) PREVENT Cancer Program ... modern testing and support facilities, and analytical instrumentation to ... studies to evaluate potential cancer prevention drugs. ... Drug Development Program is an NCI-supported pipeline to bring ...
(Date:10/29/2015)... JOLLA, Calif. , Oct. 29, 2015  The ... a new report titled, "DNA Synthesis and Biosecurity: Lessons ... well the Department of Health and Human Services guidance ... issued in 2010. --> ... but it also has the potential to pose unique ...
(Date:10/29/2015)... Mich. , Oct. 29, 2015  Rubicon ... Genomics for U.S. distribution of its DNA library ... kit and Rubicon,s new ThruPLEX Plasma-seq kit. ThruPLEX ... enable the preparation of NGS libraries for liquid ... for diagnostic and prognostic applications in cancer and ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... 24, 2015 /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ: ... the remaining 11,000 post-share consolidation (or 1,100,000 pre-share ... "Series B Warrants") subject to the previously disclosed ... 23, 2015, which will result in the issuance ... to the issuance of such shares, there will ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... InSphero AG, ... 3D cell culture models, has promoted Melanie Aregger to serve as Chief Operating Officer. ... Aregger served on the management team and was promoted to Head of ...
(Date:11/24/2015)... LOS ANGELES , Nov. 24, 2015 ... a biotechnology company focused on the discovery, development and ... Marban , Ph.D., Chief Executive Officer, is scheduled to ... December 1, 2015 at 10:50 a.m. EST, at The ... York City . . ...
(Date:11/24/2015)... NEW YORK , November 24, 2015 ... in a European healthcare ... in which the companies will work closely together in identifying ... of unmet medical need. The collaboration is underpinned by a ... LSP fund. This is the first investment by Bristol-Myers Squibb ...
Breaking Biology Technology: