Navigation Links
A powder to enhance NMR signals
Date:12/12/2013

Nuclear Magnetic Resonance (NMR) Spectroscopy is an extremely powerful non-destructive technique for the characterization of molecules. Widely used by chemists from its origin, it is now essential in the synthesis and analysis laboratories and sees its scope extended in biological laboratories.

Coupled with NMR, Dynamic Nuclear Polarization (DNP) allows, thanks to polarizing agents, the enhancement of NMR signals from a wide range of molecules resulting in the significant reduction of the NMR acquisition time. It shows therefore strong advantages over "classical" NMR and possibly over X-ray diffraction techniques used to characterize proteins on synchrotron type equipments.

NMR has also known an impressive development in the medicine with the development of Magnetic Resonance Imaging (MRI).

Up to now, the DNP has been efficiently applied to MRI for the early diagnosis of cancers in small animals (rats and porks) in preclinical studies and more recently to 30 human patients having prostate cancers. However, MRI using DNP can not be generalized to human diagnosis as polarizing agents used to activate biological tracers/contrast agents need to be quantitatively separated from the polarized solution before human injection and image acquisition. This technical hurdle is now fixed.

In this context, an innovative powder for the easy polarization of many molecules, including biological tracers, was developed in the frame of a European collaboration involving the Laboratory of Chemistry, Catalysis, Polymers and Processes (UMR 5265-LC2P2), the European Center for high field NMR (UMR 5280, CRMN-Lyon) and ETH Zurich. These innovative "powders" open perspectives for the fast characterization of complex systems by means of solid state NMR using DNP but also in the field of medical imaging for early cancer diagnosis using MRI. In this latter field, the aforementioned materials can deliver a solution of polarized biological tracers /contrast agents free from any impurity and therefore injectable to humans.


'/>"/>

Contact: Maud Charaf
maud.charaf@universite-lyon.fr
33-437-374-316
Lyon Science Transfert - Universit de Lyon
Source:Eurekalert

Related biology news :

1. ASBMB wins National Science Foundation grant to enhance K-12 science education
2. JRC and US NOAA enhance cooperation on climate, weather, oceans and coasts
3. Resveratrol may be a natural exercise performance enhancer: U of A medical research
4. Pitt develops biodegradable artery graft to enhance bypass surgeries
5. Study identifies pathway to enhance usefulness of EGFR inhibitors in lung cancer treatment
6. Enhanced royal jelly produces jumbo queen bee larvae
7. Ken Bierly of the Oregon Watershed Enhancement Board to receive ESA Regional Policy Award
8. Potential drug molecule shows enhanced anti-HIV activity
9. Partnership enhances biology teaching at California community colleges
10. MedNet Solutions Announces Latest Enhancements To Its iMedNet EDC eClinical Solution
11. Surface analysis techniques for advanced materials enhance Mazovias research potential
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... UBM,s Advanced Design and Manufacturing event in ... and evolving technology through its 3D Printing and Smart ... the expo portion of the event and feature a ... on trending topics within 3D printing and smart manufacturing. ... will take place June 13-15, 2017 at the Jacob K. ...
(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" or ... independent Directors Mr. Robin D. Richards and Mr. ... the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer said," ... and benefiting from their considerable expertise as we move forward ...
(Date:4/4/2017)... YORK , April 4, 2017   EyeLock ... today announced that the United States Patent and Trademark ... patent broadly covers the linking of an iris image ... same transaction) and represents the company,s 45 th ... latest patent is very timely given the multi-modal biometric ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... 21, 2017 , ... Building on the success of the inaugural RAADfest last ... very latest developments in radical life extension. RAADfest combines cutting edge science presented for ... of personal development, making it the largest most comprehensive and inclusive super longevity event ...
(Date:6/22/2017)... , ... June 22, 2017 , ... ... results to clients throughout the biopharma and life sciences industries, continue to be ... is seeing. Tunnell’s Kip Wolf will be speaking on “The State of Information ...
(Date:6/20/2017)... ... June 20, 2017 , ... CTNext , Connecticut’s ... has formed a Higher Education Entrepreneurship Advisory Committee to implement the recommendations of ... other high-ranking representatives from 35 higher education institutions across the state over the ...
(Date:6/20/2017)... ... June 20, 2017 , ... National executive search firm, ... extensive assay development and biomarker expertise, as VP of Scientific Affairs at Cambridge ... in bio-analytical assay development and sample testing services. The organization acts as a ...
Breaking Biology Technology: