Navigation Links
A powder to enhance NMR signals
Date:12/12/2013

Nuclear Magnetic Resonance (NMR) Spectroscopy is an extremely powerful non-destructive technique for the characterization of molecules. Widely used by chemists from its origin, it is now essential in the synthesis and analysis laboratories and sees its scope extended in biological laboratories.

Coupled with NMR, Dynamic Nuclear Polarization (DNP) allows, thanks to polarizing agents, the enhancement of NMR signals from a wide range of molecules resulting in the significant reduction of the NMR acquisition time. It shows therefore strong advantages over "classical" NMR and possibly over X-ray diffraction techniques used to characterize proteins on synchrotron type equipments.

NMR has also known an impressive development in the medicine with the development of Magnetic Resonance Imaging (MRI).

Up to now, the DNP has been efficiently applied to MRI for the early diagnosis of cancers in small animals (rats and porks) in preclinical studies and more recently to 30 human patients having prostate cancers. However, MRI using DNP can not be generalized to human diagnosis as polarizing agents used to activate biological tracers/contrast agents need to be quantitatively separated from the polarized solution before human injection and image acquisition. This technical hurdle is now fixed.

In this context, an innovative powder for the easy polarization of many molecules, including biological tracers, was developed in the frame of a European collaboration involving the Laboratory of Chemistry, Catalysis, Polymers and Processes (UMR 5265-LC2P2), the European Center for high field NMR (UMR 5280, CRMN-Lyon) and ETH Zurich. These innovative "powders" open perspectives for the fast characterization of complex systems by means of solid state NMR using DNP but also in the field of medical imaging for early cancer diagnosis using MRI. In this latter field, the aforementioned materials can deliver a solution of polarized biological tracers /contrast agents free from any impurity and therefore injectable to humans.


'/>"/>

Contact: Maud Charaf
maud.charaf@universite-lyon.fr
33-437-374-316
Lyon Science Transfert - Universit de Lyon
Source:Eurekalert

Related biology news :

1. ASBMB wins National Science Foundation grant to enhance K-12 science education
2. JRC and US NOAA enhance cooperation on climate, weather, oceans and coasts
3. Resveratrol may be a natural exercise performance enhancer: U of A medical research
4. Pitt develops biodegradable artery graft to enhance bypass surgeries
5. Study identifies pathway to enhance usefulness of EGFR inhibitors in lung cancer treatment
6. Enhanced royal jelly produces jumbo queen bee larvae
7. Ken Bierly of the Oregon Watershed Enhancement Board to receive ESA Regional Policy Award
8. Potential drug molecule shows enhanced anti-HIV activity
9. Partnership enhances biology teaching at California community colleges
10. MedNet Solutions Announces Latest Enhancements To Its iMedNet EDC eClinical Solution
11. Surface analysis techniques for advanced materials enhance Mazovias research potential
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... Sweden , April 28, 2016 First ... M (139.9), up 966% compared with the first quarter of 2015 ... profit totaled SEK 589.1 M (loss: 18.8) and the operating margin ... 7.12 (loss: 0.32) Cash flow from operations was SEK ... The 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. ...
(Date:4/15/2016)... DUBLIN , April 15, 2016 ... of the,  "Global Gait Biometrics Market 2016-2020,"  report ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,The global gait ... CAGR of 13.98% during the period 2016-2020. ... movement angles, which can be used to compute ...
(Date:3/29/2016)... March 29, 2016 LegacyXChange, Inc. ... "LEGX" and SelectaDNA/CSI Protect are pleased to announce our ... in a variety of writing instruments, ensuring athletes signatures ... created collectibles from athletes on LegacyXChange will be assured ... the DNA. Bill Bollander , CEO ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... and RESEARCH TRIANGLE PARK, N.C. , ... UTHR ) announced today that Martine Rothblatt ... Therapeutics will provide an overview and update on the ... Annual Health Care Conference. The presentation will ... a.m. Eastern Time, and can be accessed via a ...
(Date:4/27/2016)... ... 2016 , ... A compact PET scanner called NuPETâ„¢ has ... Resonance Imaging) in existing third-party MRI systems. PET and MRI are complementary imaging ... Simultaneous PET/MRI imaging offers a solution to many challenges that face researchers who ...
(Date:4/27/2016)... 27, 2016 ReportsnReports.com adds ... specific focus on US, EU, China ... to the healthcare business intelligence collection of its ... Complete report on the Flow Cytometry market spread ... with 282 tables and figures is now available ...
(Date:4/26/2016)... ... April 26, 2016 , ... Heidelberg Instruments, a ... technology innovation for its Volume Pattern Generator (VPG) line of lithography systems. The ... photomasks as well as a solution for mid volume direct write lithography applications. ...
Breaking Biology Technology: