Navigation Links
A powder to enhance NMR signals
Date:12/12/2013

Nuclear Magnetic Resonance (NMR) Spectroscopy is an extremely powerful non-destructive technique for the characterization of molecules. Widely used by chemists from its origin, it is now essential in the synthesis and analysis laboratories and sees its scope extended in biological laboratories.

Coupled with NMR, Dynamic Nuclear Polarization (DNP) allows, thanks to polarizing agents, the enhancement of NMR signals from a wide range of molecules resulting in the significant reduction of the NMR acquisition time. It shows therefore strong advantages over "classical" NMR and possibly over X-ray diffraction techniques used to characterize proteins on synchrotron type equipments.

NMR has also known an impressive development in the medicine with the development of Magnetic Resonance Imaging (MRI).

Up to now, the DNP has been efficiently applied to MRI for the early diagnosis of cancers in small animals (rats and porks) in preclinical studies and more recently to 30 human patients having prostate cancers. However, MRI using DNP can not be generalized to human diagnosis as polarizing agents used to activate biological tracers/contrast agents need to be quantitatively separated from the polarized solution before human injection and image acquisition. This technical hurdle is now fixed.

In this context, an innovative powder for the easy polarization of many molecules, including biological tracers, was developed in the frame of a European collaboration involving the Laboratory of Chemistry, Catalysis, Polymers and Processes (UMR 5265-LC2P2), the European Center for high field NMR (UMR 5280, CRMN-Lyon) and ETH Zurich. These innovative "powders" open perspectives for the fast characterization of complex systems by means of solid state NMR using DNP but also in the field of medical imaging for early cancer diagnosis using MRI. In this latter field, the aforementioned materials can deliver a solution of polarized biological tracers /contrast
'/>"/>

Contact: Maud Charaf
maud.charaf@universite-lyon.fr
33-437-374-316
Lyon Science Transfert - Universit de Lyon
Source:Eurekalert

Page: 1 2

Related biology news :

1. ASBMB wins National Science Foundation grant to enhance K-12 science education
2. JRC and US NOAA enhance cooperation on climate, weather, oceans and coasts
3. Resveratrol may be a natural exercise performance enhancer: U of A medical research
4. Pitt develops biodegradable artery graft to enhance bypass surgeries
5. Study identifies pathway to enhance usefulness of EGFR inhibitors in lung cancer treatment
6. Enhanced royal jelly produces jumbo queen bee larvae
7. Ken Bierly of the Oregon Watershed Enhancement Board to receive ESA Regional Policy Award
8. Potential drug molecule shows enhanced anti-HIV activity
9. Partnership enhances biology teaching at California community colleges
10. MedNet Solutions Announces Latest Enhancements To Its iMedNet EDC eClinical Solution
11. Surface analysis techniques for advanced materials enhance Mazovias research potential
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... , Nov. 20, 2014   Atmel® Corporation ... microcontroller (MCU) and touch technology solutions, today launched the ... with the widest V cc range from ... accuracy and faster I 2 C bus communication speeds, ... EEPROM memory making them ideal for consumer, industrial, computer, ...
(Date:11/18/2014)... , Nov. 17, 2014 The Parenteral Drug Association ... regulatory agencies will speak and at least seven more will ... at the Omni Shoreham Hotel in Washington D.C. ... again to have significant support from the regulatory agencies in ... Europe in our effort to help advance the ...
(Date:11/12/2014)... , Nov. 12, 2014 Crossmatch™, a ... that its U.are.U ® fingerprint readers have been ... in Central Mexico . The bakery ... to eliminate payroll issues caused by employees clocking in ... the U.are.U fingerprint readers, Montparnasse relied on paper timecards ...
Breaking Biology News(10 mins):Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2
... of Rochester Medical Center scientists have demonstrated a new ... sometimes dangerous E. coli bacteria. , The unique technology ... of the sensing system that also includes a silicon ... and Bioelectronics published an article on the technology in ...
... clinical trial demonstrate that high doses of an experimental ... healthy adults. , Approximately half of those volunteers ... the highest dosage of the vaccine tested in the ... predict would neutralize the virus. The National Institute of ...
... estate may be its most important feature to many ... San Diego (UCSD) and the University of Virginia have ... distributed along the chromosomes of bacteria and simpler organisms ... , In a paper published Jan. 13 online in ...
Cached Biology News:Rochester scientists develop fast-working biosensor 2H5N1 avian flu virus vaccine induces immune responses in healthy adults 2H5N1 avian flu virus vaccine induces immune responses in healthy adults 3Patterns in genome organization may partially explain how microbial cells work 2Patterns in genome organization may partially explain how microbial cells work 3
(Date:12/17/2014)... (PRWEB) December 17, 2014 Audacity, a ... agency and member of the Huntsworth Health Group, is ... its executive team. In her role, Gonzales will serve ... “We are incredibly honored to welcome a talent of ... and CEO, Gaëtan Fraikin. “She is a proven healthcare ...
(Date:12/17/2014)...   Synageva BioPharma Corp. (NASDAQ: ... rare disorders, announced today its presentation at the upcoming ... San Francisco, CA. Sanj ... present on Monday, January 12, 2015, at 9:00 a.m. ... live and may be accessed from the "Webcasts & ...
(Date:12/15/2014)... Agritech Limited (NASDAQ GS: SEED) (" Origin ", or the ... China , today announced that the Company ... 30, 2014, before the market opens on Thursday, January 8, ... January 8, 2015, at 8:00 a.m. ET / 9:00 p.m. ... To participate in the call, please dial +1-888-346-8982 in ...
(Date:12/13/2014)... The DNA Microarray market market was ... expected to grow at a CAGR of 15.2% ... TOC of the DNA Microarray for an in-depth ... help of various tables and figures. , ... consists of instrument, consumables, and services, where the ...
Breaking Biology Technology:Audacity Welcomes Healthcare Communications Expert Jamie Gonzales as Senior Vice President of Client Services 2Origin Agritech Limited to Announce Fiscal 2014 Annual Financial Results on January 8th, 2015 2Origin Agritech Limited to Announce Fiscal 2014 Annual Financial Results on January 8th, 2015 3DNA Microarray Market Is Expected to Grow at a CAGR of 15.2% from 2014 to 2019 - A Report by MicroMarket Monitor 2DNA Microarray Market Is Expected to Grow at a CAGR of 15.2% from 2014 to 2019 - A Report by MicroMarket Monitor 3DNA Microarray Market Is Expected to Grow at a CAGR of 15.2% from 2014 to 2019 - A Report by MicroMarket Monitor 4
... fusions in lysates of the yeast Saccharomyces cerevisiae using the , ... , Paul Gavin # and Mark Prescott # ... # Department of Biochemistry and Molecular ... Australia , * Technical assistance: Varian Australia Pty ...
... Overview , Affinity ... number of biological molecules. For example, antibodies may be purified based ... purified on the basis of its affinity for a monospecific antibody ... column with a relatively large volume. This note discusses the use ...
... Purpose , ... be identified and quantified more effectively and efficiently using LC/MS/MS. These ... challenges. , Overview ... safety organizations worldwide are placing great importance on the identification and ...
Cached Biology Technology: Monitoring fluorescence resonance energy transfer (FRET) between GFP, fusions in lysates of the yeast Saccharomyces cerevisiae using the , Varian, Cary Eclipse 2 Monitoring fluorescence resonance energy transfer (FRET) between GFP, fusions in lysates of the yeast Saccharomyces cerevisiae using the , Varian, Cary Eclipse 3 Monitoring fluorescence resonance energy transfer (FRET) between GFP, fusions in lysates of the yeast Saccharomyces cerevisiae using the , Varian, Cary Eclipse 4Use of ZipTip Pipette Tips for Microscale Affinity Mass Spectrometry 2Use of ZipTip Pipette Tips for Microscale Affinity Mass Spectrometry 3Identification of Insecticides and Herbicides by LC/MS/MS Using the API 2000 LC/MS/MS System 2
... and Freedom EVO384R are fast multi-channel pipetting ... three different sizes, with a multi-channel head ... significant time saving, with true parallel processing ... of your assays with the Freedom EVOware ...
... Aminopropylsilane is perhaps the ... chemistry for microarray experiments. ... for Microarrays provide a ... for printing PCR products ...
Collected from animals that are 16 to 18 months old. Sterile, Cell culture tested, ID clarifier: USA Origin...
... P450 (CYP450) metabolite postulated to play an ... vasculature. In rat cerebral microvessels, 20-HETE is ... 20-HETE is excreted mainly as the glucuronide ... pg/ml in human urine) is about 10-fold ...
Biology Products: