Navigation Links
A possible cause of Parkinson's disease discovered
Date:2/1/2011

"Nucleolus", or small nucleus, is the term coined by early biologists for the tiny structure within the nucleus which they saw under the microscope. In this structure within the nucleus, RNA molecules and proteins are assembled to form ribosomes, the true protein factories of cells.

Defective nucleoli have been implicated in several rare hereditary diseases, most recently also in neurodegenerative disorders such as Alzheimer's and Huntington's disease. Despite intense research efforts around the world, the molecular causes of Parkinson's disease are still unclear. Under the leadership of Dr. Rosanna Parlato, scientists from the departments of Professor Dr. Guenther Schuetz and Professor Dr. Ingrid Grummt at DKFZ have investigated whether the demise of nucleoli also plays a role in this disease, which is also known as "shaking palsy".

The investigators studied dopamine-producing neurons in the brain of Parkinson's disease patients under the microscope. When Parkinson's disease occurs, this type of cells malfunctions and dies, causing the characteristic palsy symptoms. Indeed, the majority of nucleoli in these cells were found to be defective.

This discovery caused the group to investigate whether disrupted nucleoli may really cause Parkinson's-like symptoms or whether this was only an incidental finding. To this end, they modified the DNA of mice in such a way that the dopamine-producing cells of the experimental animals could only form defective nucleoli. These mice showed symptoms resembling Parkinson's disease, such as characteristically impaired movements. In addition, the dopamine-producing neurons in their brain died prematurely.

In order to find out why these symptoms occur, the researchers took a closer look at all functions of the genetically modified cells. And they found an important change: The activity of the mTOR enzyme, a key regulator of intracellular signaling pathways, was reduced in the genetically modif
'/>"/>

Contact: Dr. Sibylle Kohlstaedt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Bacteria possible cause of preterm births
2. Globally sustainable fisheries possible with co-management
3. Grow your own transplant may be possible for men with type 1 diabetes
4. Findings suggest new cause, possible treatment for multiple sclerosis
5. Supercomputer makes it possible to develop a Brazilian Global Climate System Model
6. Cheaper, more effective treatment of type 1 Gaucher disease possible
7. Possible alternate therapy for adults with poorly controlled asthma
8. Study finds possible persistence switch for tuberculosis
9. Warrior worms discovered in snails; UCSB scientists see possible biomedical applications
10. VCU study: Team uncovers possible risk gene for schizophrenia
11. Possible discovery of earliest animal life pushes back fossil record
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Standards and Technology (NIST) need a special tool ... prove that necessity is truly the mother of ... Lorna De Leoz and Stephen Stein, NIST chemists ... is the study of the abundant, often-branched sugar ... and lipids and influence cellular processes, including immunity, ...
(Date:7/11/2014)... international team of researchers, including scientists from the Max ... a reported a major step in understanding photosynthesis, the ... maintains the oxygen in its atmosphere and which is ... earth. , The researchers report the first direct ... namely the step in which a specific protein complex, ...
(Date:7/11/2014)... mesenchymal stem cells can stimulate neurogenesis in the brain ... (AD) and improve tissue and function injury under the ... the therapeutic effect of adipose-derived stem cells (ADSCs) transplantation ... oxidative injury and neurogenesis in the brain of AD ... Life Sciences, Tsinghua University, China transplanted ADSCs into the ...
Breaking Biology News(10 mins):A first direct glimpse of photosynthesis in action 2
... This release is available in <A HREF=",http://chinese.eurekalert.org/zh/pub_releases/2009-05/bc-pmp051909.php,">Chinese . ... in plants is able to take on a similar ... in the open access journal BMC Microbiology . ... in E. coli cells, polar regions keeping ...
... has been thrown on how humans choose their partners, ... European Society of Human Genetics today (Monday May 25). ... Immunogenetics and Histocompatibility Laboratory at the University of Parana, ... with diverse major histocompatibility complexes (MHCs) were more likely ...
... Molecular Medicine (MDC) Berlin-Buch, Germany, have gained crucial insight ... the sensory neurons of mice, the neurobiologists and pain ... were able to directly elucidate, for the first time, ... were able to show that neurons develop their sensitivity ...
Cached Biology News:Plant Min protein sits tight and rescues E. coli 2Opposites attract -- how genetics influences humans to choose their mates 2Investigating the development of mechanosensitivity 2
(Date:7/10/2014)... Senior supply chain management executives from ... the challenges of “Reducing Cost, Lead Time, & Defects ... sourcing. Describing the partnership of the Bio Supply Management ... Institute ( SCMI) of the University of San ... the Kroc Institute of Peace and Justice in San ...
(Date:7/10/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/s3bqj2/photonic ... "International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, ... report to their offering. ... photonic integration traces its roots in the latter ... photonic integration went unexplored and unfulfilled for several ...
(Date:7/10/2014)... published today in the journal PNAS (Proceedings of ... time of day and sleep deprivation have a significant ... when looking at the best time of day to ... and for administering medicines effectively. , Researchers from the ... London, investigated the links between sleep deprivation, body clock ...
(Date:7/10/2014)... shelled out for crude 3-D glasses, polarized glasses, ... These basic devices, used to trick the brain ... be rendered obsolete with the introduction of new ... , TAU doctoral students Yuval Yifat, Michal Eitan, ... based on nanoantennas that could be used for ...
Breaking Biology Technology:Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Time of day crucial to accurately test for diseases, new research finds 2Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3
... Investors to Attend Conference, MONTREAL, Sept. 12 ... announced that Mr. Pierre Laurin, President,and Chief Executive ... Investor Summit on September 16, 2008 at 16:00 ... Hopkins InterContinental Hotel in San Francisco., More ...
... Exosome Diagnostics, Inc. today,announced the appointment of ... this role, Dr. Skog will oversee the research ... diagnostics that can,identify cancer-specific genetic mutations., Dr. ... Exosome Diagnostics,core technology that has been licensed exclusively ...
... Catalyst,Pharmaceutical Partners, Inc. (Nasdaq: CPRX ), ... prescription drugs,for the treatment of drug addiction and ... into definitive agreements with,institutional investors to sell 1,488,332 ... $3.00 per share in a registered direct common ...
Cached Biology Technology:ProMetic to present at Merriman Curhan Ford's Investor Summit 2008 on September 16th 2Catalyst Pharmaceutical Partners, Inc. Announces a $4.5 Million Registered Direct Common Stock Offering 2Catalyst Pharmaceutical Partners, Inc. Announces a $4.5 Million Registered Direct Common Stock Offering 3
OptiBuffer is a fully optimised medium, designed for,the electroporation of eukaryotic cells. OptiBuffer,improves both transfection efficiencies and survival,rates over PBS or other standard culture...
... Whether your protein is in solution or ... using MALDI-TOF/TOF mass spectrometry. Proteins will be digested ... weights (mass) of the peptides are determined by ... top 10 peaks (peptides) from MALDI-TOF will be ...
EZ-Tn5™ Transposase is designed for use with our pMOD™ series of vectors as well as any EZ-Tn5™ transposon system....
Request Info...
Biology Products: