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A pocketful of uranium
Date:2/12/2009

ted a new protein that can bind uranium instead of nickel. Only three amino acids had to be changed. In the specially designed cavity, the uranyl group has six binding partners that surround it equatorially. In addition, there are spaces for the two terminal oxygen atoms of uranyl.

This NikR mutant only binds to DNA in the presence of uranyl, not in the presence of nickel or other metal ions. This confirms its selectivity for uranyl and may make it useful for the detection of uranyl and nuclear waste bioremediation. It also represents the first step towards developing potential protein- or peptide-based agents for treatment of uranium poisoning.


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Contact: Chuan He
chuanhe@uchicago.edu
773-702-5061
Wiley-Blackwell
Source:Eurekalert  

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A pocketful of uranium
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