Navigation Links
A pesky bacterial slime reveals its survival secrets
Date:1/7/2011

ngineering at Harvard.

As the Aizenberg lab studies materials and wetting, the engineers immediately recognized the significance of what they were observing. It turns out that biofilm has an unprecedented liquid-repellent surface, thereby revealing a critical clue to what may be responsible for its broad antimicrobial resistance.

Nature offers numerous examples of water-resistant surfaces, such as the lotus leaf, a longstanding inspiration for creating synthetic materials. Until now, however, no model natural systems have been found for broadly repellent materials.

While such surfaces can be manufactured, the top-down process is costly, labor intensive, and reliant on toxic chemicals and brittle structures. A biofilm, however, is living proof that only the simplest and most natural of components are requirednamely, a resilient meshwork made from proteins and polysaccharides assembled into a multi-scale, hierarchical structure.

At the same time, the finding offers a completely new perspective on how biofilms are immune to so many different types of biocides. Even the most sophisticated biochemical strategy will be ineffective if a biocide cannot enter the slime to reach the bacteria. In short, the antimicrobial activity of alcohols and other solvents becomes compromised by the strongly non-wetting behavior at clinically relevant concentrations.

The team expects that their newfound knowledge will help alert researchers to the need to consider this requirement when designing ways to destroy harmful biofilms.

"Their notorious resistance to a broad range of biocide chemistries has remained a mysterious and pressing problem despite two decades of biofilm research," says Aizenberg, a pioneer in the field of biomimicry. "By looking at it as a macroscopic problem, we found an explanation that was just slightly out of view: antimicrobials can be ineffective simply by being a non-wetting liquid that cannot penetrate into th
'/>"/>

Contact: Michael Patrick Rutter
mrutter@seas.harvard.edu
617-496-3815
Harvard University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. K-State researchers find gene-silencing nanoparticles may put end to pesky summer pest
2. Pesky aphid thrives despite weak immune system
3. Pesky fruit flies learn from experienced females: Study
4. Remarkable biological complexity of bacterial cells is focus of newly released book
5. TYRX AIGISRx antibacterial envelope shows low infection rate, high CIED procedure success
6. Life-saving in the bacterial world: How Campylobacter rely on Pseudomonas to infect humans
7. Insulin may reduce several inflammatory factors induced by bacterial infection
8. Antibacterial peptide could aid in treating soldiers burn wound infections
9. Management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis
10. Mining bacterial genomes reveals valuable hidden drugs
11. In the ring: Researchers fighting bacterial infections zero in on microorganisms soft spots
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A pesky bacterial slime reveals its survival secrets
(Date:8/20/2014)... who are poor experience higher cortisol levels in pregnancy ... the stress hormone, putting them at greater risk ... new research from the University of Colorado Denver. , ... Journal of Human Biology , is the first to ... the socioeconomic status of their mothers during pregnancy. , ...
(Date:8/20/2014)... for electronically manipulating the flight muscles of moths and ... those muscles. The work opens the door to the ... emergency response. , "In the big picture, we want ... moths for use in applications such as search and ... of electrical and computer engineering at NC State and ...
(Date:8/20/2014)... 2014  The second annual Biometrics UnPlugged Executive ... Tampa, Florida on September 15, 2014, ... Technology and Strategy at Samsung, and Philippe de ... of this year,s event is Mobility at the ... "Biometrics UnPlugged: Mobility at the Crossroads of Commerce ...
Breaking Biology News(10 mins):CU Denver researcher shows economic disparities impact infant health 2Research paves way for development of cyborg moth 'biobots' 2Biometrics UnPlugged: Mobility at the Crossroads of Commerce & Privacy to Feature Interactive Sessions with Samsung and Experian 2
... collaboration with colleagues from UC Berkeley and StrataGent Life ... pulsed microjet system engineered to deliver protein drugs into ... penetration injection systems cause. The research was published online ... Sciences. , The effort to create needle-free drug ...
... rise to a rare genetic disease, genetics researchers have ... broader role during human development, potentially in cases of ... of researchers identified two genes that contribute to Cornelia ... an estimated one in 10,000 children. The disease varies ...
... researchers from the National Human Genome Research Institute (NHGRI), ... identified a genetic variant that is a major contributor ... the April 6, 2007 issue of the journal Science. ... variant that accounts for differences in dog size is ...
Cached Biology News:Researchers design pulsed mircrojet system to deliver protein drugs without pain or bruising 2Gene found for rare disorder may reveal new pathway in mental retardation 2Researchers identify gene involved in dog size 2Researchers identify gene involved in dog size 3Researchers identify gene involved in dog size 4
(Date:8/19/2014)... (PRWEB) August 19, 2014 ... to raise $200,000 to fund a corporate lab ... , This development is a critical component ... of care to the implementation of personalized medicine ... of practicing medicine. , Indiegogo contributions will support ...
(Date:8/19/2014)... August 19, 2014 XenoTech announces ... and cost-effective metabolite production from bioactive small molecules. ... platform, the technology enables convenient and timely assessment ... to XenoTech’s Vice President of Commercial Operations, Christian ... assessing clinical risk can be measured directly by ...
(Date:8/19/2014)... 2012, the European Union (EU) mandated use of the ICH-recommended ... – responding to the increasing need to understand and manage ... many regions, the main objectives of the PBRER are to:, ... of new or emerging information on the risks of a ... potential benefits of a drug; and , Allow ...
(Date:8/19/2014)... August 19, 2014 Sales Horizons, a ... its online sales skills training course to ... , MedTech clinical staff spend the majority of their ... standalone medical center, or physician practice – providing support ... why stop there? Sales Horizons believes clinical staff are ...
Breaking Biology Technology:Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 3Beyond Metabolite Identification, Testable Quantities Now Offered by XenoTech 2Beyond Metabolite Identification, Testable Quantities Now Offered by XenoTech 3Top Five Best Practices for Developing Your Periodic Benefit Risk Evaluation Report (PBRER), New Webinar Hosted by Xtalks 2Sales Horizons Launches a New Online Sales Training Course for MedTech Clinical Staff to Develop Their Sales Skills 2Sales Horizons Launches a New Online Sales Training Course for MedTech Clinical Staff to Develop Their Sales Skills 3
... (NSF) has awarded $6.5 million to the Center for Nanotechnology ... work regarding the societal aspects of nanotechnology for another five ... its first five-year award of $6.2 million to Arizona State ... of NSF,s initiative to support research and education on nanotechnology ...
... DIEGO, Oct. 14 Sequenom, Inc. (Nasdaq: ... a new clinical advisory board focusing on retinal ... will provide guidance to Sequenom and Sequenom Center ... of retinal care molecular diagnostics. (Logo: ...
... ... ... ... longUrl, so we need to grab the first one. for (var r in data.results) { first_result = data.results[r]; break; ...
Cached Biology Technology:Arizona State University awarded $6.5 million to study nanotechnology and society 2Arizona State University awarded $6.5 million to study nanotechnology and society 3Sequenom Announces Formation of Ophthalmology Clinical Advisory Board 2Sequenom Announces Formation of Ophthalmology Clinical Advisory Board 3Sequenom Announces Formation of Ophthalmology Clinical Advisory Board 4Sequenom Announces Formation of Ophthalmology Clinical Advisory Board 5The World Market for Diabetes Treatments Now Available at ReportsandReports 2The World Market for Diabetes Treatments Now Available at ReportsandReports 3The World Market for Diabetes Treatments Now Available at ReportsandReports 4The World Market for Diabetes Treatments Now Available at ReportsandReports 5The World Market for Diabetes Treatments Now Available at ReportsandReports 6The World Market for Diabetes Treatments Now Available at ReportsandReports 7The World Market for Diabetes Treatments Now Available at ReportsandReports 8The World Market for Diabetes Treatments Now Available at ReportsandReports 9
OmniSlide Heated Wash Module. 2 independent chambers with precise temperature control from ambient of 5C to 70C. Each chamber holds 1 slide rack (20 slides). Includes 2 x Wash Sleeves, 1 x Slide R...
... bioassays for interferons are cytopathic effect inhibition assays, ... Sample types include; tissue culture supernatents; serum from ... assays, one unit is defined as the quantity ... cytopathic effect of viral infection by 50%. ...
... interferons are cytopathic effect inhibition assays, also known ... include; tissue culture supernatents; serum from PK studies ... unit is defined as the quantity of interferon ... of viral infection by 50%. All ...
OmniSlide thermal Cycler for slide applications. 20 slide capacity. Humidity Chamber. Slide Rack can be transferred directly to Wash Module to avoid handling individual slides....
Biology Products: