Navigation Links
A pesky bacterial slime reveals its survival secrets
Date:1/7/2011

ngineering at Harvard.

As the Aizenberg lab studies materials and wetting, the engineers immediately recognized the significance of what they were observing. It turns out that biofilm has an unprecedented liquid-repellent surface, thereby revealing a critical clue to what may be responsible for its broad antimicrobial resistance.

Nature offers numerous examples of water-resistant surfaces, such as the lotus leaf, a longstanding inspiration for creating synthetic materials. Until now, however, no model natural systems have been found for broadly repellent materials.

While such surfaces can be manufactured, the top-down process is costly, labor intensive, and reliant on toxic chemicals and brittle structures. A biofilm, however, is living proof that only the simplest and most natural of components are requirednamely, a resilient meshwork made from proteins and polysaccharides assembled into a multi-scale, hierarchical structure.

At the same time, the finding offers a completely new perspective on how biofilms are immune to so many different types of biocides. Even the most sophisticated biochemical strategy will be ineffective if a biocide cannot enter the slime to reach the bacteria. In short, the antimicrobial activity of alcohols and other solvents becomes compromised by the strongly non-wetting behavior at clinically relevant concentrations.

The team expects that their newfound knowledge will help alert researchers to the need to consider this requirement when designing ways to destroy harmful biofilms.

"Their notorious resistance to a broad range of biocide chemistries has remained a mysterious and pressing problem despite two decades of biofilm research," says Aizenberg, a pioneer in the field of biomimicry. "By looking at it as a macroscopic problem, we found an explanation that was just slightly out of view: antimicrobials can be ineffective simply by being a non-wetting liquid that cannot penetrate into th
'/>"/>

Contact: Michael Patrick Rutter
mrutter@seas.harvard.edu
617-496-3815
Harvard University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. K-State researchers find gene-silencing nanoparticles may put end to pesky summer pest
2. Pesky aphid thrives despite weak immune system
3. Pesky fruit flies learn from experienced females: Study
4. Remarkable biological complexity of bacterial cells is focus of newly released book
5. TYRX AIGISRx antibacterial envelope shows low infection rate, high CIED procedure success
6. Life-saving in the bacterial world: How Campylobacter rely on Pseudomonas to infect humans
7. Insulin may reduce several inflammatory factors induced by bacterial infection
8. Antibacterial peptide could aid in treating soldiers burn wound infections
9. Management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis
10. Mining bacterial genomes reveals valuable hidden drugs
11. In the ring: Researchers fighting bacterial infections zero in on microorganisms soft spots
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A pesky bacterial slime reveals its survival secrets
(Date:7/9/2014)... an associate professor of plant pathology and microbiology ... awarded the 2014 Alexopoulos Prize by the ... advancing the science of mycology the study of ... lichens, plant pathogens, and medically important fungi. , The ... early-career mycologist. Stajich received the award last month in ...
(Date:7/9/2014)... Research Centre (CNIO) have discovered that NANOG, an essential ... in stratified epitheliathose that form part of the epidermis ... vaginain adult organisms. According to the conclusions of the ... this factor could also play a role in the ... oesophagus and skin. , The pluripotency factor NANOG is ...
(Date:7/9/2014)... the puzzle behind nature,s ability to split the ... the development of artificial photosynthesis for clean, green ... international collaboration of scientists led by researchers with ... the SLAC National Accelerator Laboratory. , Working ... world,s most powerful x-ray laser, the researchers were ...
Breaking Biology News(10 mins):UC Riverside plant pathologist receives national recognition 2CNIO scientists discover that pluripotency factor NANOG is also active in adult organisms 2Postcards from the photosynthetic edge 2Postcards from the photosynthetic edge 3
... of Technology have created a new sampling device that ... pneumonia each year. Called PneumoniaCheck, the device created ... of diagnosing pneumonia, which is a major initiative of ... Pneumonia, an inflammation of the lungs, kills about ...
... a method based on geographic positioning systems that allowed ... in a way similar to how geographers characterize mountain ... that reflects how "rugged" the surface of the tooth ... the shearing molars in insect eaters and omnivores to ...
... 18, 2011) -- A University of Arizona College of ... robots for planetary exploration will be featured in a ... "WaveLengths." The robots will be featured on the ... MST on public television KUAT Channel 6. "WaveLengths" is ...
Cached Biology News:A better way to diagnose pneumonia 2A better way to diagnose pneumonia 3UMass Amherst biologists use GPS to 'map' bats teeth to explore evolutionary adaptations to diet 2Planetary exploration robots to be featured on science program 'WaveLengths' 2
(Date:1/15/2014)... JOSE, California , January 15, 2014 ... cancer, today announced the appointment of Thomas C Reynolds MD, ... 20 years, development experience gained in the biotechnology industry, most ... "I am delighted to welcome Tom at this transformative time ...
(Date:1/15/2014)... Reston, VA (PRWEB) January 15, 2014 ... education have continued their sponsorship of an annual competition ... interest in, and access to, innovative STEM study. The ... , TEAMS: Tests of Engineering Aptitude, Mathematics, and ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider of ... of tinnitus. Patients listen to sound therapy that is ... of weeks to months, their tinnitus volume decreases. , AudioNotch ... Music and Notched White Noise. Now, AudioNotch is pleased to ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider of ... regulatory, business, and media events in the United States ... former associate Virginia Cox , JD, is returning to the ... Virginia Cox re-joins 3D after more than two years of ...
Breaking Biology Technology:Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Former FDA Associate Commissioner Returns To 3D Communications 2
... Wis. - Building the Merge Healthcare ... explains, will mean offshoring 150 jobs to a "more ... reduce 28 percent of the financially troubled medical imaging ... Japan to regain the competitive edge marks the centerpiece ...
... people, a natural biological response to the phrase securities law ... the outside of the cornea wall, coupled with a dull ... my best to stick to the essentials. As a result, ... company is raising capital, it is important to contact an ...
... Wisconsin organizers of Make Mine a $Million ... May as Wisconsin does its part to take one ... , ,Although the date of the awards program has ... including Make Mine a $Million members - soon will ...
Cached Biology Technology:Merge offshoring jobs to "more cost-effective" workforce 2Merge offshoring jobs to "more cost-effective" workforce 3Securities compliance is part of raising capital 2Securities compliance is part of raising capital 3Securities compliance is part of raising capital 4Make Mine a $Million shoots for May program 2Make Mine a $Million shoots for May program 3