Navigation Links
A novel way found to prevent protein plaques implicated in Alzheimer's
Date:11/18/2007

NEW YORK, November 18, 2007For unknown reasons a protein called amyloid beta aggregates into toxic plaques in the brain, killing neurons. These plaques are one of the hallmarks of Alzheimers disease. Now two new animal studies show for the first time that the deadly transformation of amyloid beta into plaques can be prevented through an interaction between amyloid beta and another protein called cystatin C.

Although much work needs to be done, these new findings may open the door to new treatments for Alzheimers disease that mimic the effects of cystatin C, says Efrat Levy, Ph.D., Associate Professor in the Departments of Psychiatry and Pharmacology at New York University School of Medicine, and the lead author of the study. We are really excited by these findings because recent studies show that cystatin C is protective against a variety of insults that cause cell death in the brain. Our potential therapeutic approach focuses on keeping amyloid beta in a water soluble form, preventing its accumulation in the brain, and thus slowing, halting, or reversing disease progression, says Dr. Levy, who is also Director of the Laboratory of Molecular Pathology of Cerebral Amyloidosis at the Nathan S. Kline Institute for Psychiatric Research in Orangeburg, New York.

With support from the Alzheimers Association, Dr. Levys laboratory has already begun studies to develop a drug that will mimic the ability of cystatin C to bind to a non-pathological form of amyloid beta and thereby prevent its accumulation into plaques in the brain.

Alzheimers is estimated to affect 5 million Americans and there are no medicines that can delay or prevent the disease. Many laboratories worldwide are pursuing ways to prevent the clumping of amyloid beta as possible therapies for the disease. It isnt known whether the protein actually causes Alzheimers, but amyloid beta is one of the proteins implicated in the disease process.

The two studies appear in
'/>"/>

Contact: Pam McDonnell
Pamela.Mcdonnell@nyumc.org
212-404-3555
New York University Medical Center and School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. MGH researchers describe new way to identify, evolve novel enzymes
2. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
3. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
4. IdentiPHI Re Launches SAFmodule Software to Secure Novell(R) Networks
5. IdentiPHI Re Launches SAFmodule Software to Secure Novell(R) Networks
6. 454 Sequencing: Science paper describes a novel, highly efficient method of sequencing ancient DNA
7. Scientists discover novel way to remove iron from ferritin
8. Identification of a novel class of (not-so) small RNAs
9. Key to out-of-control immune response in lung injury found
10. Natural chemical found in broccoli helps combat skin blistering disease
11. Balzan Foundation announces 2007 winners
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... in Khabarovsk Krai, a territory occupying the coastline of the ... of smoke mark active fires. The smoke, which appears mostly ... of Okhotsk. Taiga and tundra are found in ... depression, and deciduous forests are the natural vegetation in the ... the summer, the 2014 wildfire season appears to be more ...
(Date:9/22/2014)... warming, larger and larger areas of sea ice melt in ... the winter it is thinner and more reduced. As the ... of global warming, because reduced sea ice in the Arctic ... , "If our results are representative, then sea ice plays ... into account in future global CO2 budgets", says Dorte Haubjerg ...
(Date:9/21/2014)... of cowpea (black-eyed peas) is a fascinating example of ... fascinating is the story of the scientist behind the ... Legume of the 21st Century to serve as an ... book was recently published by the Crop Science Society ... Agriculture (IITA). , Singh has devoted his life,s work ...
Breaking Biology News(10 mins):Arctic sea ice helps remove CO2 from the atmosphere 2
... WASHINGTON, April 25, 2012 Research!America President and CEO Mary ... Departments of Labor and Health and Human Services is far ... saves lives and spurs new businesses and jobs throughout the ... level that,s $19 billion below what was mandated under last ...
... the Broad Institute of MIT and Harvard have announced ... analysis tools, is now available to the scientific community. ... Expo on Tuesday, Jill Mesirov, director of computational biology ... and tool developers to explore this beta release of ...
... LONDON, ON Patients suffering with end-stage renal disease ... at home rather than the conventional dialysis in clinics. ... the potential of more intensive dialysis completed in a ... who underwent intensive dialysis at home have better survival ...
Cached Biology News:Researchers announce GenomeSpace environment to connect genomic tools 2Researchers announce GenomeSpace environment to connect genomic tools 3
(Date:9/22/2014)... Research and Markets has announced the addition ... Report 2014" report to their offering. ... 2014 is a professional and in-depth study on the ... a focus on the Chinese situation. The ... definitions, classifications, applications and industry chain structure. The microcrystalline ...
(Date:9/22/2014)... Sept. 22, 2014  Neogen Corporation (Nasdaq: ... first quarter of its 2015 fiscal year, which ended ... to net income of $7,839,000 in the first quarter ... effective Oct. 30, 2013, earnings per share in the ... ago. First quarter revenues increased 15% to ...
(Date:9/22/2014)... -- The US markets on Friday, September ... Dow Jones Industrial Average finished at 17,279.74, up 0.08% ... The S&P 500 finished the session 0.05% lower at ... sectors finished on a positive note. The S&P 500 ... up 0.10%, with the index gaining 6.95% in the ...
(Date:9/22/2014)... , Sept. 22, 2014  Spherix Incorporated (SPEX) -- ... monetization of intellectual property, today announced that the United States ... the Company in the month of September that is part ... The issued patent is: USRE45,121 , Application number: ... , Filing date: Dec 27, 2012 The ...
Breaking Biology Technology:Global and Chinese Microcrystalline Cellulose Industry Report 2014 2Neogen reports 13% net income increase 2Neogen reports 13% net income increase 3Neogen reports 13% net income increase 4Neogen reports 13% net income increase 5Neogen reports 13% net income increase 6Neogen reports 13% net income increase 7Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 2Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 3Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 4Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 5Spherix Notified by United States Patent & Trademark Office of New Standard Essential Patent Issued to Spherix 2Spherix Notified by United States Patent & Trademark Office of New Standard Essential Patent Issued to Spherix 3
... - Last Sunday morning, in the free-wheeling environment of ... secrets and strategies from her forthcoming book, titled ... expects to publish next year. , ,In her seminar ... provided advice about maximizing efficiency and minimizing hurt feelings ...
... Just one week ago, 67 companies were nervously introducing ... business development executives, early adopters, and eager media. , ... were nearly flawless. John Patrick's FutureScan panels were smart. ... the Wi-Fi was glitch-free. , ,The DEMOgods smiled ...
... Wis. - Wisconsin's role in tackling the world's most ... the 2006 annual conference of the Wisconsin Biotechnology and ... held Oct. 12 at the GE Healthcare Institute ... Jim Doyle and former Gov. Tommy Thompson, but session ...
Cached Biology Technology:BarCamp talk turns to Internet dating 2BarCamp talk turns to Internet dating 3Basking (briefly) in the DEMOfall 2006 glow 2Wisconsin's role in health a focus of biotech event 2Wisconsin's role in health a focus of biotech event 3
Anti-Rsk2/MAPKAP Kinase 1b, #0 SK2/MAPKAP K1 beta Smartpool&t 3T3 cell lysate Non-specific Control Pool , #D 1X Universal Buffer...
Request Info...
Assay Kit formatted for flow cytometric detection of levels of phosphorylated histone H2A.X....
Request Info...
Biology Products: