Navigation Links
A novel way found to prevent protein plaques implicated in Alzheimer's
Date:11/18/2007

NEW YORK, November 18, 2007For unknown reasons a protein called amyloid beta aggregates into toxic plaques in the brain, killing neurons. These plaques are one of the hallmarks of Alzheimers disease. Now two new animal studies show for the first time that the deadly transformation of amyloid beta into plaques can be prevented through an interaction between amyloid beta and another protein called cystatin C.

Although much work needs to be done, these new findings may open the door to new treatments for Alzheimers disease that mimic the effects of cystatin C, says Efrat Levy, Ph.D., Associate Professor in the Departments of Psychiatry and Pharmacology at New York University School of Medicine, and the lead author of the study. We are really excited by these findings because recent studies show that cystatin C is protective against a variety of insults that cause cell death in the brain. Our potential therapeutic approach focuses on keeping amyloid beta in a water soluble form, preventing its accumulation in the brain, and thus slowing, halting, or reversing disease progression, says Dr. Levy, who is also Director of the Laboratory of Molecular Pathology of Cerebral Amyloidosis at the Nathan S. Kline Institute for Psychiatric Research in Orangeburg, New York.

With support from the Alzheimers Association, Dr. Levys laboratory has already begun studies to develop a drug that will mimic the ability of cystatin C to bind to a non-pathological form of amyloid beta and thereby prevent its accumulation into plaques in the brain.

Alzheimers is estimated to affect 5 million Americans and there are no medicines that can delay or prevent the disease. Many laboratories worldwide are pursuing ways to prevent the clumping of amyloid beta as possible therapies for the disease. It isnt known whether the protein actually causes Alzheimers, but amyloid beta is one of the proteins implicated in the disease process.

The two studies appear in
'/>"/>

Contact: Pam McDonnell
Pamela.Mcdonnell@nyumc.org
212-404-3555
New York University Medical Center and School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. MGH researchers describe new way to identify, evolve novel enzymes
2. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
3. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
4. IdentiPHI Re Launches SAFmodule Software to Secure Novell(R) Networks
5. IdentiPHI Re Launches SAFmodule Software to Secure Novell(R) Networks
6. 454 Sequencing: Science paper describes a novel, highly efficient method of sequencing ancient DNA
7. Scientists discover novel way to remove iron from ferritin
8. Identification of a novel class of (not-so) small RNAs
9. Key to out-of-control immune response in lung injury found
10. Natural chemical found in broccoli helps combat skin blistering disease
11. Balzan Foundation announces 2007 winners
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2015)... 2015 According to a ... Market Forecast & Opportunities, 2020", the global biometrics market ... 14% till 2020. The biometrics market is garnering ... and review of biometric management systems. The constant ... with greater efficiency, are resulting in increasing installation ...
(Date:4/8/2015)... N.C. , April 8, 2015  Infinisource, ... solutions and services, and Morpho, a leading supplier ... partnership to produce the market,s most advanced biometrically-enabled ... Infinisource,s iSolved NXG time clock is setting a ... and labor data for the small and mid-size ...
(Date:4/2/2015)... 2015 According to preliminary estimates ... somewhat higher than 125 MSEK. This exceeds the guidance ... that revenues for Q1 2015 would be in line ... Q4 2014. The operating result for the first quarter ... interim report will as previously communicated be published on ...
Breaking Biology News(10 mins):Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3Fingerprint Cards Revises Revenues for Q1 2015 2
... pollutants into our waters and atmosphere could soon be ... Presenting their research today, 26 June, in IOP ... Universit de Technologie de Compigne, believe their work ... the exact location where pollutants have been leaked as ...
... Imaging is the first handbook of its ... visualization of microcirculation. Clearly structured throughout, this ... researcher relying on microcirculation imaging. , Author Professor ... Ireland, Galway, explores everything from basic research to ...
... , GAINESVILLE, Fla. --- The BP Deepwater Horizon oil spill ... as erosion, but there may be cause for optimism, according ... in the Proceedings of the National Academy of Sciences ... 15 to 30 feet from the shoreline and this plant ...
Cached Biology News:Maths formula leads researchers to source of pollution 2BP Deepwater Horizon oil spill exacerbated existing environmental problems in Louisiana marshes 2BP Deepwater Horizon oil spill exacerbated existing environmental problems in Louisiana marshes 3
(Date:4/30/2015)... 2015  Pfenex Inc. (NYSE MKT: PFNX) a ... biosimilar therapeutics including high value and difficult to ... previously announced underwritten public offering of 6,750,000 shares ... price of $15.50 per share. This includes the ... option to purchase up to 750,000 additional shares ...
(Date:4/30/2015)... SAINT-MALO, FRANCE (PRWEB) April 30, 2015 ... States and at http://www.lespausa.com , Phytomer’s ... to sensitive and reactive skin while battling the ... inflammation. This restorative cream is formulated with star ... derived via biotechnology in a complex of soothing ...
(Date:4/29/2015)... BALTIMORE, Maryland, USA (PRWEB) April 29, 2015 ... photonics, optical sensing, and imaging on the East Coast, ... government program managers, researchers, applications developers, and industry suppliers ... sensing and imaging for multiple applications. , The event ... security, and commercial and scientific sensing and imaging -- ...
(Date:4/29/2015)... The leading Regenerative Veterinary Medicine Company, VetStem Biopharma., ... therapy has processed more than 11,000 samples. VetStem ... treatment for horses with potentially fatal injuries to tendons ... exclusive license for adipose-derived (fat derived) stem cell technology ... in January 2004. Shortly after, the first dogs were ...
Breaking Biology Technology:Pfenex Inc. Announces Closing of Public Offering of Common Stock and Full Exercise of Underwriters' Option to Purchase Additional Shares 2Phytomer introduces DOUCEUR INTEMPORELLE Restorative Shield Cream 2Phytomer introduces DOUCEUR INTEMPORELLE Restorative Shield Cream 3SPIE DSS provides venue for collaboration vital to research, applications advances 2SPIE DSS provides venue for collaboration vital to research, applications advances 3SPIE DSS provides venue for collaboration vital to research, applications advances 4VetStem Biopharma -Regenerative Cell Therapy has processed over 11,000 samples 2
... living cell is something that has long eluded researchers; however, ... be able to do this and potentially provide a tool ... such as cancer. In a study published today, ... German Physical Society,s New Journal of Physics , researchers ...
... N.Y., May 18, 2011 BioSpecifics Technologies Corp. (NASDAQ: ... in class collagenase-based products, today announced that there will ... XIAPEX® in Europe) for the treatment of patients suffering ... of the European Societies for Surgery of the Hand ...
... N.J., May 18, 2011 Children at Paterson Public ... to the efforts of more than 200 volunteers from ... School District, and organizers from non-profit KaBOOM!. The new ... School No. 5 as well as children living in ...
Cached Biology Technology:'Critical baby step' taken for spying life on a molecular scale 2BioSpecifics Technologies Corp. Announces Data Presentations at Upcoming XVI Annual Federation of the European Societies for Surgery of the Hand Meeting 2BioSpecifics Technologies Corp. Announces Data Presentations at Upcoming XVI Annual Federation of the European Societies for Surgery of the Hand Meeting 3BioSpecifics Technologies Corp. Announces Data Presentations at Upcoming XVI Annual Federation of the European Societies for Surgery of the Hand Meeting 4Designed by Kids, Built by Volunteers: Roche, New Jersey Community Development Corporation, and KaBOOM! Build New Playground in Just One Day for Paterson Public School Children 2Designed by Kids, Built by Volunteers: Roche, New Jersey Community Development Corporation, and KaBOOM! Build New Playground in Just One Day for Paterson Public School Children 3Designed by Kids, Built by Volunteers: Roche, New Jersey Community Development Corporation, and KaBOOM! Build New Playground in Just One Day for Paterson Public School Children 4
... can be used to label ... covalently bound acridinium NHS ester ... presence of hydrogen peroxide. Acridinium ... used as a detection method ...
... assay (EMSA) is a powerful tool for ... gel shift or gel retardation, the assay ... subjected to electrophoresis, free DNA will migrate ... LightShift Chemiluminescent EMSA Kit is a nonradioactive ...
... The Guava PCA-96 systems provide automated, ... a tray of microcentrifuge tubes. This flexible ... ideal for screening in basic research, target ... Like it's smaller cousin, the Guava PCA-96 ...
... Cellomics KineticScan™ Reader is Cellomics‘ ... Solutions for Cell-based Screening". The ... ability to do both temporal ... physiological processes, dynamic distribution and ...
Biology Products: