Navigation Links
A novel therapeutic advancement in the search for heart muscle progenitor cells
Date:11/26/2012

CPCs, which are typically only found in fetal development, can become all of the different cell types of the heart and can integrate into heart muscle tissue after injection.

An estimated 17 million people die from cardiovascular disease each year. Although mortality rates are declining, heart attacks are still among the most frequent causes of death in the developed world. Often, the cause of a heart attack is the closure of a coronary artery that supplies blood to the heart, which kills heart muscle cells. Cardiomyocytes, which are the heart muscle cells responsible for the contraction of the heart, are not able to regenerate after a heart attack. The massive loss of cells and tissue, and the highly restricted regeneration capacity of the adult heart, lead to an impaired blood supply throughout the body that drastically affects a patient's quality of life. To restore the heart's function after a major heart attack, clinicians require functionally mature cardiomyocytes that perform like the native cells in the adult heart to replace the cells that were killed.

The production of such functional cardiomyocytes from well-defined cardiovascular progenitor cells (CPCs) is the focus of the research team led by Prof. Dr. Katja Schenke-Layland from the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB in Stuttgart and her colleagues, Dr. Ali Nsair of the University of California Los Angeles (UCLA) and Prof. Dr. Robb MacLellan of the University of Washington in Seattle, who have now succeeded in identifying such cells in a mouse model. The work, which could revolutionize the treatment of heart disease, was recently published in the journal PLoS ONE (PLoS ONE7 (10):e45603, doi:10.1371/journal.pone.0045603).

Development of heart muscle cells from precursor cells

Myocardial cells as well as endothelial cells and smooth muscle cells develop from CPCs during the embryonic development of humans a
'/>"/>

Contact: Katja Schenke-Layland
katja.schenke-layland@igb.fraunhofer.de
49-711-970-4082
Fraunhofer-Gesellschaft
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Researchers discover novel therapy for Crohns disease
2. New clinical trial explores novel noninvasive colon cancer screening test
3. Notre Dame researchers using novel method to combat malaria drug resistance
4. Unique adaptations to a symbiotic lifestyle reveal novel targets for aphid insecticides
5. Key proteins newly discovered form and function may provide novel cancer treatment target
6. Novel discovery by NUS scientists paves the way for more effective treatment of cancers
7. London researchers discover novel mechanism involved in key immune response
8. Mexican rock heroes trial novel green trading system
9. VTT and GE Healthcare developing novel biomarkers to predict Alzheimers disease
10. Cleveland Clinic researchers receive $5 million grant to discover novel pathways to heart disease
11. Novel nano-structures to realize hydrogens energy potential
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A novel therapeutic advancement in the search for heart muscle progenitor cells
(Date:12/17/2014)... Dec. 16, 2014 Research and Markets ... of the "Global Chemical Sensor Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 One major ... demand for medical sensors in biomedical applications. Chemical ... quick and correct diagnosis during surgical procedures. The ...
(Date:12/15/2014)... , Dec. 12, 2014 Research and Markets ... addition of the "Global Facial Recognition Market ... http://photos.prnewswire.com/prnh/20130307/600769 Facial ... of individuals. Facial recognition system measures the overall ... jaw edges, mouth, and the distance between eyes. ...
(Date:12/11/2014)... Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the ... 2015-2019" report to their offering. ... is the adoption of multimodal biometric systems. Multimodal ... an individual for verification and identification purposes. This ...
Breaking Biology News(10 mins):Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... snuggle can prematurely end a love affair, as new evidence ... a smokers risk of an early heart attack. Researchers say ... population has a gene defect that delivers a one-two punch ... with this common gene variant experienced a heart attack around ...
... chance Lake Mead, a key source of water for millions ... by 2021 if climate changes as expected and future water ... at Scripps Institution of Oceanography, UC San Diego. ... River system has no buffer to sustain the population of ...
... U.S. Department of Homeland,Security (DHS) announced today ... international visitors arriving at San Francisco,International Airport ... the,department,s upgrade from two- to 10-fingerprint collection ... more accurately and,efficiently establishing and verifying visitors, ...
Cached Biology News:Cigarette after Valentine snuggle deadlier for some 2Cigarette after Valentine snuggle deadlier for some 3Lake Mead could be dry by 2021 2Lake Mead could be dry by 2021 3DHS Begins Collecting 10 Fingerprints From International Visitors at San Francisco International Airport 2
(Date:12/24/2014)... -- China Biologic Products, Inc. (NASDAQ: CBPO, "China ... plasma-based biopharmaceutical company in China ... Taibang Biological Products Co. Ltd., has received Good ... and Drug Administration (the "CFDA") for its new ... the Company,s public filings, the CFDA inspected this ...
(Date:12/24/2014)... PARIS and NEW YORK ... data from its open-label pilot study of mazindol in ... Design, Development and Therapy in December 2014 . ... of mazindol in children with attention deficit/hyperactivity disorder" ( ... 2014 Dec 1;8:2321-2332. eCollection 2014 ) ...
(Date:12/22/2014)... , Dec. 22, 2014 GenomeDx Biosciences ... Decipher Prostate Cancer Classifier, a genomic test for prostate ... node-negative, high-risk men managed by radical prostatectomy without adjuvant ... prostatectomy is relatively uncommon, using tumor genomics to identify ... metastatic disease is an important advance. The study has ...
(Date:12/19/2014)... PA (PRWEB) December 19, 2014 ... leading developer and manufacturer of needle-free injection technology, ... agreement with Immunomic Therapeutics, Inc. (“ITI”) for ITI ... device with its LAMP™ vaccine platform. , ... an exclusive Worldwide license to the Biojector®-2000 that ...
Breaking Biology Technology:China Biologic Receives GMP Certification for New Coagulation Factor Facility 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3
... Data published in July 7, 2009 Issue ... Sciences, , , QUEBEC CITY, July 7 /PRNewswire-FirstCall/ - ... a global biopharmaceutical company focused on endocrine therapy and oncology, ... of the National Academy of Sciences (PNAS), of new data ...
... , THE WOODLANDS, Texas, July 7 Lexicon ... biopharmaceutical company focused on discovering and developing breakthrough treatments for ... 2 clinical trial of LX1032 , the ... carcinoid syndrome . LX1032 is designed ...
... ... and investigators at the Burnham Institute for Medical Research at Lake Nona (Burnham) announced ... microbial compounds that have potential as tools for biological research and ultimately the discovery ... ...
Cached Biology Technology:AEterna Zentaris: New Data Published on its Ghrelin Antagonist Compound, AEZS-123 (JMV2959), Supports its Use in Alcohol Addiction 2AEterna Zentaris: New Data Published on its Ghrelin Antagonist Compound, AEZS-123 (JMV2959), Supports its Use in Alcohol Addiction 3AEterna Zentaris: New Data Published on its Ghrelin Antagonist Compound, AEZS-123 (JMV2959), Supports its Use in Alcohol Addiction 4Lexicon Initiates Phase 2 Clinical Trial of LX1032 in Patients With Carcinoid Syndrome 2Lexicon Initiates Phase 2 Clinical Trial of LX1032 in Patients With Carcinoid Syndrome 3Lexicon Initiates Phase 2 Clinical Trial of LX1032 in Patients With Carcinoid Syndrome 4Burnham Institute for Medical Research and Magellan BioScience Group, Inc. Announce Drug Discovery Collaboration 2Burnham Institute for Medical Research and Magellan BioScience Group, Inc. Announce Drug Discovery Collaboration 3
... form culture flask is designed for culturing organisms requiring ... has a heavy beaded rim to protect against chipping ... is 38mm and takes a No. 6.5 rubber stopper. ... heat source smaller than the base of the flask. ...
... to achieve in many bacterial strains due ... restriction and modification (R-M) systems that cleave ... TypeOne™ Restriction Inhibitor provides a powerful method ... with type I R-M systems. Developed ...
... cassette is designed to allow chloramphenicol ... prokaryotic promoter gb2 driving the gene ... modified version of the Em7 promoter. ... the generally used Tn5 promoter. A ...
Includes a choice of any 3 EasySep mouse selection kits and EasySep magnet...
Biology Products: