Navigation Links
A novel mechanism for fast regulation of gene expression
Date:3/18/2014

?

Does RNA interference regulate gene expression?

But the scientists had also noticed that the two genes overlapped a bit at their tips. The tips, called the 3' UTRs (untranslated regions), don't code for protein but are transcribed into mRNA.

That got them thinking. When the two genes were transcribed into mRNA, the two ends would complement one another like the hooks and loops of a Velcro fastener. Like the hooks and loops, they would want to stick together, forming a short section of double-stranded mRNA. And double-stranded mRNA, they knew, activates biochemical machinery that degrades any mRNA molecules with the same genetic sequence.

https://www.youtube.com/watch?v=0H6EgLCYcX4&feature=youtu.be

Double-stranded RNA binds to a protein complex called Dicer that cuts it into fragments. Another protein complex, RISC, binds these fragments. One of the RNA strands is eliminated but the other remains bound to the RISC complex. RISC and its attached RNA then becomes a heat-seeking missile that finds and destroys other copies of the same RNA. If the mRNA molecules disappear, their corresponding proteins are never made.

It turned out that heat sensitivity in the fly is all about potassium channel, said Ben-Shahar. What if, he thought, the two mRNAs stuck together, the mRNA segment encoding the potassium channel was bound to RISC and other copies of the potassium channel mRNA were destroyed. This was another, potentially faster way the neurons might be controlling the excitability of their membranes.

A designer fly provides an answer

Which is it? Is regulation occurring at the gene level or the mRNA level?

To find out, the scientists made designer fruit flies that had various combinations of the genes and their sticky noncoding ends. One of these transgenic fly lines was missing the part of the gene
'/>"/>

Contact: Diana Lutz
dlutz@wustl.edu
314-935-5272
Washington University in St. Louis
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Researchers discover novel therapy for Crohns disease
2. New clinical trial explores novel noninvasive colon cancer screening test
3. Notre Dame researchers using novel method to combat malaria drug resistance
4. Unique adaptations to a symbiotic lifestyle reveal novel targets for aphid insecticides
5. Key proteins newly discovered form and function may provide novel cancer treatment target
6. Novel discovery by NUS scientists paves the way for more effective treatment of cancers
7. London researchers discover novel mechanism involved in key immune response
8. Mexican rock heroes trial novel green trading system
9. VTT and GE Healthcare developing novel biomarkers to predict Alzheimers disease
10. Cleveland Clinic researchers receive $5 million grant to discover novel pathways to heart disease
11. Novel nano-structures to realize hydrogens energy potential
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A novel mechanism for fast regulation of gene expression
(Date:9/2/2014)... Sam Kean stops by Reactions this week to debunk ... that, despite what "Shark Week" may lead you to ... http://youtu.be/KhFygIoW_MA . , Kean,s book, "The Disappearing Spoon: ... History of the World from the Periodic Table of ... 10-episode video series produced for the newly launched American ...
(Date:9/2/2014)... spiky legs and their propensity for eating anything, including ... And now research from North Carolina State University finds ... across the eastern United States. , "The good news ... kind of threat to humans," says Dr. Mary Jane ... author of a paper about the research. , The ...
(Date:9/2/2014)... N.C. -- When you accidentally touch a hot oven, ... the basic neural circuits involved in sensing and responding ... the molecular players. , Duke researchers have made a ... involved in pain in worms, and have built a ... 2 in Nature Communications , may help direct ...
Breaking Biology News(10 mins):Researchers find Asian camel crickets now common in US homes 2Surprising new role for calcium in sensing pain 2Surprising new role for calcium in sensing pain 3
... of Alzheimer,s disease reports improvement in language abilities ... the research, published today in the open access ... minutes of using this new treatment. Building ... in BioMed Central,s Journal of Neuroinflammation, ...
... to be the niche. As air and water preceded life, ... cells in many tissues and provides factors necessary to keep ... cell dependents. A team of scientists at the ... assistant professor in the Laboratory of Genetics, now suggests that ...
... the burgeoning field of interventional therapies for congenital ... Vegas July 20-23 for the Pediatric & Adult ... Medical Center in Chicago will perform live cases ... On Monday, July 21st, Dr. Ziyad M. ...
Cached Biology News:Stem cell chicken and egg debate moves to unlikely arena: the testes 2Stem cell chicken and egg debate moves to unlikely arena: the testes 3Latest advances in interventional cardiology for congenital heart disease presented 2
(Date:9/2/2014)... Massachusetts , September 2, 2014 ... to BioData,s research and lab management services  ... management service, is pleased to announce the appointment of ... Culot most recently served as VP Marketing and Business ... life science research and clinical applications. Previously, ...
(Date:9/1/2014)... 01, 2014 The Collaborative R&D ... report provides comprehensive understanding and unprecedented access to ... by the worlds leading life science companies. , ... of how and why companies enter collaborative R&D ... partner’s negotiated deals terms provides critical insight into ...
(Date:8/31/2014)... Dallas, Texas (PRWEB) August 31, 2014 ... on the current state of the Epoxy Hardener ... provides a basic overview of the industry, including ... analysis and Chinese domestic market analysis are provided ... competitive landscape of the market. A comparison between ...
(Date:8/29/2014)... Albany, New York (PRWEB) August 29, 2014 ... be valued at $5.6 billion in 2019. It ... 18.1% from 2013 to 2019, and was valued ... research report published by Transparency Market Research. , ... please visit: http://www.transparencymarketresearch.com/companion-diagnostics-market.html . , The research ...
Breaking Biology Technology:Louis Culot Appointed as BioData's CEO 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 3Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 4Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 2Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 3Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3
... Medarex, Inc. (Nasdaq: MEDX ) is ... at 8:30 a.m. Eastern Time on Thursday, April 30, ... for the first quarter of 2009.To access the call ... webcast can be accessed through the Investor Relations section ...
... Integrity Provider First to Bring IP Ownership into Discussion , ... ... LLC , the leading provider of data integrity solutions, announced today ... and only data integrity protection provider of its kind ...
... BioMS Medical Corp (TSX: MS), a leading developer in the ... Giese, President and CEO, will present at a session entitled ... technology sector" as part of the Alberta Economic Forum in ... Monday May 4th at 10:05am (Local time), ...
Cached Biology Technology:Medarex to Host Business and Financial Update Conference Call on Thursday, April 30, 2009 2Surety, LLC Joins Microsoft BioIT Alliance 2Surety, LLC Joins Microsoft BioIT Alliance 3BioMS Medical to present at Alberta Economic Forum in Geneva 2
... and affinity purification of small components ... monodisperse magnetic particles (2.8 m in ... surface activation is not required. Allows ... orientation for affinity purification of proteins. ...
ZO-2 (H-110)...
p-Bcl-2 (Thr 74)...
Derlin-2 (C-18)...
Biology Products: