Navigation Links
A novel mechanism for fast regulation of gene expression
Date:3/18/2014

?

Does RNA interference regulate gene expression?

But the scientists had also noticed that the two genes overlapped a bit at their tips. The tips, called the 3' UTRs (untranslated regions), don't code for protein but are transcribed into mRNA.

That got them thinking. When the two genes were transcribed into mRNA, the two ends would complement one another like the hooks and loops of a Velcro fastener. Like the hooks and loops, they would want to stick together, forming a short section of double-stranded mRNA. And double-stranded mRNA, they knew, activates biochemical machinery that degrades any mRNA molecules with the same genetic sequence.

https://www.youtube.com/watch?v=0H6EgLCYcX4&feature=youtu.be

Double-stranded RNA binds to a protein complex called Dicer that cuts it into fragments. Another protein complex, RISC, binds these fragments. One of the RNA strands is eliminated but the other remains bound to the RISC complex. RISC and its attached RNA then becomes a heat-seeking missile that finds and destroys other copies of the same RNA. If the mRNA molecules disappear, their corresponding proteins are never made.

It turned out that heat sensitivity in the fly is all about potassium channel, said Ben-Shahar. What if, he thought, the two mRNAs stuck together, the mRNA segment encoding the potassium channel was bound to RISC and other copies of the potassium channel mRNA were destroyed. This was another, potentially faster way the neurons might be controlling the excitability of their membranes.

A designer fly provides an answer

Which is it? Is regulation occurring at the gene level or the mRNA level?

To find out, the scientists made designer fruit flies that had various combinations of the genes and their sticky noncoding ends. One of these transgenic fly lines was missing the part of the gene
'/>"/>

Contact: Diana Lutz
dlutz@wustl.edu
314-935-5272
Washington University in St. Louis
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Researchers discover novel therapy for Crohns disease
2. New clinical trial explores novel noninvasive colon cancer screening test
3. Notre Dame researchers using novel method to combat malaria drug resistance
4. Unique adaptations to a symbiotic lifestyle reveal novel targets for aphid insecticides
5. Key proteins newly discovered form and function may provide novel cancer treatment target
6. Novel discovery by NUS scientists paves the way for more effective treatment of cancers
7. London researchers discover novel mechanism involved in key immune response
8. Mexican rock heroes trial novel green trading system
9. VTT and GE Healthcare developing novel biomarkers to predict Alzheimers disease
10. Cleveland Clinic researchers receive $5 million grant to discover novel pathways to heart disease
11. Novel nano-structures to realize hydrogens energy potential
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A novel mechanism for fast regulation of gene expression
(Date:7/31/2015)... , 31 de julio de 2015 ... (ICG-10,  www.icg-10.org ) del 22 al 25 de octubre ... La conferencia celebra su décimo aniversario este ... convertido en una de las reuniones anuales más influyentes ... es una de las conferencias científicas más dinámicas, entusiastas ...
(Date:7/31/2015)... 2015 La 10e Conférence internationale sur ... par le BGI du 22 au 25 octobre ... Chine. La conférence célèbre son 10e ... l,ICG est devenue l,une des réunions annuelles mondiales ... et c,est aussi la plus dynamique, la plus ...
(Date:7/31/2015)... , 31. Juli 2015 Die 10. internationale ... von BGI veranstaltet und findet vom 22. bis ... , statt. Die Konferenz ... ihrem Start 2006 ist die ICG weltweit zu ... geworden. Sie ist eines der dynamischsten, enthusiastischsten und ...
Breaking Biology News(10 mins):La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 3La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3
... rubbed on the skin to reduce signs of aging and ... the first evidence of one of vitamin E,s normal body ... tears in the plasma membranes that protect cells from outside ... University researchers report in the journal Nature Communications ., ...
... is an adorable doe-eyed bat with a dark side it ... Tsang, a PhD student in ecology and evolutionary biology at The ... to a revolutionary way to help fund her research into how ... viruses can spread from flying foxes to humans by tracing the ...
... Researchers at the University of Delaware are examining tiny ... not only how these organisms adapt to the severe cold, ... The National Science Foundation study, led by Adam Marsh, ... Ocean, and Environment, also will compare the process of temperature ...
Cached Biology News:Scientists identify an innate function of vitamin E 2Crowdfunding science: Student raises cash online to follow a flying fox 2Crowdfunding science: Student raises cash online to follow a flying fox 3Will Antarctic worms warm to changing climate? 2Will Antarctic worms warm to changing climate? 3
(Date:8/31/2015)... 31, 2015 LabStyle Innovations Corp. (OTCQB: ... today announced it recently closed a round of ... used to support the global rollout and initial ... cloud-based, diabetes management solution that includes novel software ... glucose monitoring device, and for working capital purposes. ...
(Date:8/31/2015)... , ... August 31, 2015 , ... ... a high priority in the drug development approval process. Thus, innovator companies must ... year, Regis Technologies, Inc., a Chicago-based CMO, has been hosting multiple educational panels ...
(Date:8/31/2015)... ... 2015 , ... There’s a new treatment option for excessive menstrual bleeding – ... FDA approved system in the last 14 years, and the only endometrial ablation product ... rate of 66%, the high Patient Satisfaction rate of 98%, and the fastest procedure ...
(Date:8/30/2015)... England , August 31, 2015 ... Wartezeit   einer Frau   für chirurgische   Behandlung ... Alter von 7-90   werden für eine   ... soll 1200 Frauen behandeln und die Anzahl ausgebildeter Chirurgen ... Astellas gab heute bekannt, dass  Action on ...
Breaking Biology Technology:LabStyle Innovations Closes $2.5 Million Funding to Support Global Rollout of Dario Diabetes Management Solution 2LabStyle Innovations Closes $2.5 Million Funding to Support Global Rollout of Dario Diabetes Management Solution 3LabStyle Innovations Closes $2.5 Million Funding to Support Global Rollout of Dario Diabetes Management Solution 4Regis Shares Expert Advice on Impurities in Drug Development 2Regis Shares Expert Advice on Impurities in Drug Development 3U.S. FDA Approves Minerva Endometrial Ablation System 2U.S. FDA Approves Minerva Endometrial Ablation System 3Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 2Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 3Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 4Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 5
... into why and how nanowires take the form they ... future electronic components. PhD student Peter Krogstrup from the ... the sensational new theoretical model, which is developed in ... One of the most important components in future electronic ...
... How would you like to store all the films ever ... Magnets made of just a few metallic atoms could make ... also recently been proposed as components for spintronics devices. There,s ... been seen to work at temperatures a few hairs above ...
... Group, Inc.  (OTC Bulletin Board: MDXG ), ... biomaterial-based products and bioimplants processed from human amniotic membrane, ... 31, 2010. Full Year 2010 ResultsIn ... with the calendar year. Its prior fiscal year was ...
Cached Biology Technology:Major advance in understanding how nanowires form 2Heavy metals open path to high temperature nanomagnets 2MiMedx Group Announces 2010 Results 2MiMedx Group Announces 2010 Results 3MiMedx Group Announces 2010 Results 4MiMedx Group Announces 2010 Results 5MiMedx Group Announces 2010 Results 6MiMedx Group Announces 2010 Results 7
Our Histology, Immunohistochemistry and tissue arrays services include samples processing, different type of staning, histollogical stains, image analysis, tissue arrays, immunohistochemistry, etc....
Mouse monoclonal antibody to PDK2 - pyruvate dehydrogenase kinase, isoenzyme 2...
... of an N-terminal FLAG® fusion and a ... from bicistronic mRNA. Two genes can ... transcription of a single message from the ... protein-protein interaction studies, multi-subunit proteins, and cloning ...
Mouse monoclonal antibody raised against a partial recombinant CALCOCO2. NCBI Entrez Gene ID = CALCOCO2...
Biology Products: