Navigation Links
A novel mechanism for fast regulation of gene expression
Date:3/18/2014

if you warm neurons in culture, he said, the neurons will fire more rapidly. And if the culture is cooled down, the neurons slow down. Neurons in an organism, however, behave differently from those in a dish. Usually the organism is able to cushion its nervous system from heat stress, at least within limits. But nobody knew how they did this.

As a fruit fly scientist, Ben-Shahar was aware that there are mutations in fruit flies that make them bad at buffering heat stress, and this provided a starting point for his research.

One of these genes is actually called seizure, because flies with a broken copy of this gene are particularly sensitive to heat. Raising the temperature even 10 degrees sends them into seizures. "They seize very fast, in seconds," Ben-Shahar said.

"When we looked at seizure (sei) we noticed that there is another gene on the opposite strand of the double-stranded DNA molecule called pickpocket 29 (ppk29)," Ben-Shahar said. This was interesting because seizure codes for a protein "gate" that lets potassium ions out of the neuron and pickpocket 29 codes for a gate that lets sodium ions into the neuron.

Neurons are "excitable" cells, he said, because they tightly control the gradients of potassium and sodium across their cell membranes. Rapid changes in these gradients cause a nerve to "fire," to stop firing, and to repolarize, so that it can fire again.

The scientists soon showed that transcription of these genes is coordinated. When the flies are too hot, they make more transcripts of the sei gene and fewer of ppk29. And when the flies cooled down, the opposite happened. If the central dogma held in this case, the neurons might be buffering the effects of heat by altering the expression of these genes.

One problem with this idea, though, is that gene transcription is slow and the flies, remember, seize in seconds. Was this mechanism fast enough to keep up with sudden changes in the environment
'/>"/>

Contact: Diana Lutz
dlutz@wustl.edu
314-935-5272
Washington University in St. Louis
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Researchers discover novel therapy for Crohns disease
2. New clinical trial explores novel noninvasive colon cancer screening test
3. Notre Dame researchers using novel method to combat malaria drug resistance
4. Unique adaptations to a symbiotic lifestyle reveal novel targets for aphid insecticides
5. Key proteins newly discovered form and function may provide novel cancer treatment target
6. Novel discovery by NUS scientists paves the way for more effective treatment of cancers
7. London researchers discover novel mechanism involved in key immune response
8. Mexican rock heroes trial novel green trading system
9. VTT and GE Healthcare developing novel biomarkers to predict Alzheimers disease
10. Cleveland Clinic researchers receive $5 million grant to discover novel pathways to heart disease
11. Novel nano-structures to realize hydrogens energy potential
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A novel mechanism for fast regulation of gene expression
(Date:8/28/2014)... FASEB MARC (Maximizing Access to Research Careers) ... the American College of Sports Medicine,s Conference on ... in Miami, Florida. These awards are meant ... and scientists from underrepresented groups into the mainstream ... the participation of young scientists at the American ...
(Date:8/28/2014)... than 25 million kilometres of new roads will be ... slice into Earth,s last wildernesses, where they bring an ... , Now, an ambitious study has created a ,global ... try to balance the competing demands of development and ... ,environmental-values, layer that estimates that natural importance of ecosystems ...
(Date:8/28/2014)... and Alaska totaled 515 million board feet in volume ... more than 10 percent compared to the first quarter ... Station reported today. During this same period, West coast ... board feet. , The total value of these log ... million in the same quarter, while the total value ...
Breaking Biology News(10 mins):Study shows where on the planet new roads should and should not go 2Study shows where on the planet new roads should and should not go 3West coast log exports up, lumber exports down in second quarter of 2014 2
... #1 FOR IMMEDIATE RELEASE Wine in a box? Think ... Chemistry In a surprise discovery that ... gauche alternative to bottles, scientists in Canada are reporting that ... substances that contribute odors to wine and can lower its ...
... not only effect the environment via their exhaust pipes. ... with getting from a to b that we rarely ... Research Letters , Monday, June 8, 2009, researchers from ... University of California, Berkeley, have created a framework to ...
... , GREENVILLE, S.C., June 3 Integrated Biometrics, a leading ... Charles Johnson to its sales staff. Johnson is a ... and had previously worked at Integrated Biometrics in 2006. ... Chair of the local ASIS Chapter. , , "As ...
Cached Biology News:American Chemical Society's Weekly PressPac -- June 3, 2009 2American Chemical Society's Weekly PressPac -- June 3, 2009 3American Chemical Society's Weekly PressPac -- June 3, 2009 4American Chemical Society's Weekly PressPac -- June 3, 2009 5American Chemical Society's Weekly PressPac -- June 3, 2009 6American Chemical Society's Weekly PressPac -- June 3, 2009 7American Chemical Society's Weekly PressPac -- June 3, 2009 8American Chemical Society's Weekly PressPac -- June 3, 2009 9American Chemical Society's Weekly PressPac -- June 3, 2009 10More than just the tailpipe 2Integrated Biometrics Adds Security Industry Veteran to Sales Staff 2
(Date:8/28/2014)... 2014  Next month, executives from clinical trial marketing firm ... beginning with Patient-Centered Clinical Trials 2014 , to be ... , September 4-5. Patient recruitment experts Bonnie A. ... will share insights on the benefits of employing an ... – from media to mobile apps – can be used ...
(Date:8/28/2014)... by a Florida State University research team has led ... temperature, emit white light, and convert photon energy directly ... a butterfly. , Biwu Ma, associate professor in the ... College of Engineering, created the molecule in a lab ... that his creation has many other unique capabilities. , ...
(Date:8/28/2014)... Boston, MA (PRWEB) August 28, 2014 ... of wholesale construction materials, selected SoundConnect ... of their cloud based audio and web conferencing ... configured to support PrimeSource’s employees’ needs. SoundConnect ... technologies. , PrimeSource Building Products will be ...
(Date:8/27/2014)... Austin, TX (PRWEB) August 27, 2014 ... $6 million in Series B funding and secured Otter ... and investment capital will accelerate commercialization of GGI’s Agriplier™ ... multiple crop types. , “Since our first meeting, ... commitment to the biological product space,” said Alan Sobba, ...
Breaking Biology Technology:BBK Worldwide Leads Sessions at Key September Events 2Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2PrimeSource Chooses SoundConnect as Collaboration Provider 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3
... Schneider Nationals vice president of application development, ... world's leading Information technology (IT) leaders by Computerworld, an ... demonstrate technology leadership in resolving pressing business problems. Honorees, ... issue of Computerworld and will be honored at ...
... network crash last week left many University of ... exactly was wrong with their e-mail. The Division ... UWs networks, experienced a system-wide crash last Friday that ... , ,According to Brian Rust, spokesperson for DoIT, ...
... days is an exercise in faith. Every day, more and more job ... , ,At the same time, lots of people we know are still ... jobs we've spotted, they say to us: "Yes, I saw that job ... ) you wrote to me about but I'm not pursuing it. It ...
Cached Biology Technology:Schneider Vice President Honored as Top IT Leader by Computerworld 2Router Failure and Software Crash UW-Madison Network 2Pity the Midwest Technology Sales Guy 2Pity the Midwest Technology Sales Guy 3Pity the Midwest Technology Sales Guy 4Pity the Midwest Technology Sales Guy 5
... The Gene Pulser Xcell ... V, 50-60 Hz, is used ... This system includes the main ... (25-3,275 microfarad range) or square-wave ...
... software is used on Macintosh operating ... of any DNA sequence up to ... placement of primers and GC clamps ... gel electrophoresis (DGGE), constant denaturing gel ...
... RNAi Services offer you a full ... studies. B-Bridges advanced design parameters, effective ... ensure that you obtain quality results ... Design Service utilizes their proprietary B-Algo ...
... Solution Polymorphic DNA Technologies offers a ... complete solution for SNP discovery by performing ... primers, PCR amplification, DNA sequencing and data ... SNP discovery, Polymorphic uses the gold standard ...
Biology Products: