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A new weapon in the fight against obesity and diabetes
Date:11/4/2008

reproduce the positive metabolic effects that were previously demonstrated using resveratrol, a naturally occurring SIRT1 activator found in red wine," stated Auwerx, lead author of the paper. "But unlike resveratrol, these new chemical entities target only the SIRT1 pathway, making them more selective and potent for achieving these metabolic benefits."

To assess the new SIRT1 activator on metabolic function, mice were fed a high-fat diet over a period of 15 weeks, while receiving average drug exposures of 100 to 500 mg/kg/day. Mice on a high-fat diet treated with the higher drug dose did not become obese, and their triglyceride, cholesterol, fasting blood glucose and insulin levels were all reduced. Furthermore, they were able to run approximately twice the distance as control animals in an endurance exercise test.


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Contact: Johan Auwerx
johan.auwerx@epfl.ch
41-216-930-951
Ecole Polytechnique Fdrale de Lausanne
Source:Eurekalert

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