Navigation Links
A new weapon in the fight against obesity and diabetes

This press release is available in French.

A study appearing November 5 in the journal Cell Metabolism demonstrates that a synthetic new chemical entity protects against diet-induced obesity, improves glucose tolerance and insulin sensitivity and enhances exercise endurance by enhancing fat utilization in certain target tissues.

The new chemical entity was developed by Sirtris, a a GSK company, and the research study was led by EPFL professor Johan Auwerx, MD.

Reducing calorie consumption by about 20% has been shown to slow down the aging process, improve endurance and protect against diet-induced obesity and metabolic diseases such as diabetes. A year ago, researchers demonstrated that these metabolic benefits can also occur with large doses of resveratrol, a substance naturally occurring in red wine. Researchers hypothesized that these beneficial effects result from activation of SIRT1, an enzyme that is involved in regulating certain key cellular processes, notably the efficiency and number of mitochondria the energy powerhouses of our cells.

Because dietary management and exercise rarely succeed by themselves in curbing obesity and associated metabolic disorders, interest has increased in using the SIRT1 pathway as a target for possible pharmacological intervention.

The new chemical entity announced today in Cell Metabolism was specifically designed to activate the SIRT1 pathway and assess its role in the beneficial metabolic effects found in calorie restriction and high doses of resveratrol. The new research verified the hypothesis, demonstrating that activating the SIRT1 pathway protects from diet-induced obesity and its negative metabolic consequences by primarily promoting fat consumption in skeletal muscle, liver, and brown adipose tissue.

"These results show that new synthetic SIRT1 activators can reproduce the positive metabolic effects that were previously demonstrated using resveratrol, a naturally occurring SIRT1 activator found in red wine," stated Auwerx, lead author of the paper. "But unlike resveratrol, these new chemical entities target only the SIRT1 pathway, making them more selective and potent for achieving these metabolic benefits."

To assess the new SIRT1 activator on metabolic function, mice were fed a high-fat diet over a period of 15 weeks, while receiving average drug exposures of 100 to 500 mg/kg/day. Mice on a high-fat diet treated with the higher drug dose did not become obese, and their triglyceride, cholesterol, fasting blood glucose and insulin levels were all reduced. Furthermore, they were able to run approximately twice the distance as control animals in an endurance exercise test.


Contact: Johan Auwerx
Ecole Polytechnique Fdrale de Lausanne

Related biology news :

1. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
2. Researcher working on destruction of chemical weapons
3. Francisella tularensis: Stopping a biological weapon
4. UD plant biologists uncover top wetland plants hidden weapon
5. Scripps Florida scientists awarded $1.5M to fight major water and food parasites
6. UCSB study finds physical strength, fighting ability revealed in human faces
7. Plant-eating predator to fight superweed is not magic bullet
8. Vitiligo skin disorder could yield clues in fight against melanoma
9. Anti-tumor therapy with endoscopic ultrasound may fight cancer more safely and effectively
10. Synthetic moleculues could add spice to fight against cancer
11. Potential new drug target to fight tuberculosis identified
Post Your Comments:
(Date:4/13/2017)... India , April 13, 2017 According to ... Proofing, Identity Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, ... MarketsandMarkets™, the IAM Market is expected to grow from USD 14.30 Billion ... Growth Rate (CAGR) of 17.3%. ... MarketsandMarkets ...
(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" or ... independent Directors Mr. Robin D. Richards and Mr. ... the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer said," ... and benefiting from their considerable expertise as we move forward ...
(Date:4/5/2017)... -- KEY FINDINGS The global market for ... of 25.76% during the forecast period of 2017-2025. The ... the growth of the stem cell market. ... INSIGHTS The global stem cell market is segmented on ... stem cell market of the product is segmented into ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... , Oct. 10, 2017 SomaGenics announced ... the NIH to develop RealSeq®-SC (Single Cell), expected to ... profiling small RNAs (including microRNAs) from single cells using ... highlights the need to accelerate development of approaches to ... "New techniques for measuring levels of ...
(Date:10/9/2017)... , Oct. 9, 2017  BioTech Holdings ... mechanism by which its ProCell stem cell therapy ... limb ischemia.  The Company, demonstrated that treatment with ... of limbs saved as compared to standard bone ... molecule HGF resulted in reduction of therapeutic effect.  ...
(Date:10/9/2017)... ... October 09, 2017 , ... The Giving Tree Wellness Center ... the needs of consumers who are incorporating medical marijuana into their wellness and ... , As operators of two successful Valley dispensaries, The Giving Tree’s two founders, ...
(Date:10/7/2017)... Seattle, WA (PRWEB) , ... ... ... the industry leader in Hi-C-based genomic technologies, launched its ProxiMeta™ Hi-C metagenome ... the ProxiMeta Hi-C kit and accompanying cloud-based bioinformatics software to perform Hi-C ...
Breaking Biology Technology: