Navigation Links
A new weapon in the fight against obesity and diabetes
Date:11/4/2008

This press release is available in French.

A study appearing November 5 in the journal Cell Metabolism demonstrates that a synthetic new chemical entity protects against diet-induced obesity, improves glucose tolerance and insulin sensitivity and enhances exercise endurance by enhancing fat utilization in certain target tissues.

The new chemical entity was developed by Sirtris, a a GSK company, and the research study was led by EPFL professor Johan Auwerx, MD.

Reducing calorie consumption by about 20% has been shown to slow down the aging process, improve endurance and protect against diet-induced obesity and metabolic diseases such as diabetes. A year ago, researchers demonstrated that these metabolic benefits can also occur with large doses of resveratrol, a substance naturally occurring in red wine. Researchers hypothesized that these beneficial effects result from activation of SIRT1, an enzyme that is involved in regulating certain key cellular processes, notably the efficiency and number of mitochondria the energy powerhouses of our cells.

Because dietary management and exercise rarely succeed by themselves in curbing obesity and associated metabolic disorders, interest has increased in using the SIRT1 pathway as a target for possible pharmacological intervention.

The new chemical entity announced today in Cell Metabolism was specifically designed to activate the SIRT1 pathway and assess its role in the beneficial metabolic effects found in calorie restriction and high doses of resveratrol. The new research verified the hypothesis, demonstrating that activating the SIRT1 pathway protects from diet-induced obesity and its negative metabolic consequences by primarily promoting fat consumption in skeletal muscle, liver, and brown adipose tissue.

"These results show that new synthetic SIRT1 activators can reproduce the positive metabolic effects that were previously demonstrated using resveratrol, a naturally occurring SIRT1 activator found in red wine," stated Auwerx, lead author of the paper. "But unlike resveratrol, these new chemical entities target only the SIRT1 pathway, making them more selective and potent for achieving these metabolic benefits."

To assess the new SIRT1 activator on metabolic function, mice were fed a high-fat diet over a period of 15 weeks, while receiving average drug exposures of 100 to 500 mg/kg/day. Mice on a high-fat diet treated with the higher drug dose did not become obese, and their triglyceride, cholesterol, fasting blood glucose and insulin levels were all reduced. Furthermore, they were able to run approximately twice the distance as control animals in an endurance exercise test.


'/>"/>

Contact: Johan Auwerx
johan.auwerx@epfl.ch
41-216-930-951
Ecole Polytechnique Fdrale de Lausanne
Source:Eurekalert

Related biology news :

1. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
2. Researcher working on destruction of chemical weapons
3. Francisella tularensis: Stopping a biological weapon
4. UD plant biologists uncover top wetland plants hidden weapon
5. Scripps Florida scientists awarded $1.5M to fight major water and food parasites
6. UCSB study finds physical strength, fighting ability revealed in human faces
7. Plant-eating predator to fight superweed is not magic bullet
8. Vitiligo skin disorder could yield clues in fight against melanoma
9. Anti-tumor therapy with endoscopic ultrasound may fight cancer more safely and effectively
10. Synthetic moleculues could add spice to fight against cancer
11. Potential new drug target to fight tuberculosis identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... , April 5, 2017 Today ... announcing that the server component of the HYPR platform ... for providing the end-to-end security architecture that empowers biometric ... HYPR has already secured over 15 million users ... including manufacturers of connected home product suites and physical ...
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC , ... that the United States Patent and Trademark Office (USPTO) ... covers the linking of an iris image with a ... and represents the company,s 45 th issued patent. ... is very timely given the multi-modal biometric capabilities that ...
(Date:3/30/2017)... March 30, 2017  On April 6-7, 2017, Sequencing.com ... Genome hackathon at Microsoft,s headquarters in ... will focus on developing health and wellness apps that ... Hack the Genome is the first hackathon for ... world,s largest companies in the genomics, tech and health ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia Inc ., a ... Webinar titled, “Pathology is going digital. Is your lab ready?” with Dr. Nicolas ... practices and how Proscia improves lab economics and realizes an increase in diagnostic ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are ... 5.5 million people each year. Especially those living in larger cities are affected by ... in one of the most pollution-affected countries globally - decided to take action. , ...
(Date:10/10/2017)... ... October 10, 2017 , ... San Diego-based team building and ... rebranding initiative announced today. The bold new look is part of a transformation ... moves into a significant growth period. , It will also expand its service offering ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... Dr. Bob ... at his local San Diego Rotary Club. The event entitled “Stem ... CA and had 300+ attendees. Dr. Harman, DVM, MPVM was joined by two ...
Breaking Biology Technology: