Navigation Links
A new weapon in the fight against obesity and diabetes
Date:11/4/2008

This press release is available in French.

A study appearing November 5 in the journal Cell Metabolism demonstrates that a synthetic new chemical entity protects against diet-induced obesity, improves glucose tolerance and insulin sensitivity and enhances exercise endurance by enhancing fat utilization in certain target tissues.

The new chemical entity was developed by Sirtris, a a GSK company, and the research study was led by EPFL professor Johan Auwerx, MD.

Reducing calorie consumption by about 20% has been shown to slow down the aging process, improve endurance and protect against diet-induced obesity and metabolic diseases such as diabetes. A year ago, researchers demonstrated that these metabolic benefits can also occur with large doses of resveratrol, a substance naturally occurring in red wine. Researchers hypothesized that these beneficial effects result from activation of SIRT1, an enzyme that is involved in regulating certain key cellular processes, notably the efficiency and number of mitochondria the energy powerhouses of our cells.

Because dietary management and exercise rarely succeed by themselves in curbing obesity and associated metabolic disorders, interest has increased in using the SIRT1 pathway as a target for possible pharmacological intervention.

The new chemical entity announced today in Cell Metabolism was specifically designed to activate the SIRT1 pathway and assess its role in the beneficial metabolic effects found in calorie restriction and high doses of resveratrol. The new research verified the hypothesis, demonstrating that activating the SIRT1 pathway protects from diet-induced obesity and its negative metabolic consequences by primarily promoting fat consumption in skeletal muscle, liver, and brown adipose tissue.

"These results show that new synthetic SIRT1 activators can
'/>"/>

Contact: Johan Auwerx
johan.auwerx@epfl.ch
41-216-930-951
Ecole Polytechnique Fdrale de Lausanne
Source:Eurekalert

Page: 1 2

Related biology news :

1. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
2. Researcher working on destruction of chemical weapons
3. Francisella tularensis: Stopping a biological weapon
4. UD plant biologists uncover top wetland plants hidden weapon
5. Scripps Florida scientists awarded $1.5M to fight major water and food parasites
6. UCSB study finds physical strength, fighting ability revealed in human faces
7. Plant-eating predator to fight superweed is not magic bullet
8. Vitiligo skin disorder could yield clues in fight against melanoma
9. Anti-tumor therapy with endoscopic ultrasound may fight cancer more safely and effectively
10. Synthetic moleculues could add spice to fight against cancer
11. Potential new drug target to fight tuberculosis identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2014)... the greatest challenges in modern medicine is developing drugs ... minimal toxicity and side-effects to the patient. Such properties ... drug molecule. Ideally, the drug should have a shape ... that it binds it with high specificity. Publishing in ... synthetic amino acid that can impact the 3D structure ...
(Date:8/31/2014)... malaria diagnosis has changed very little. After taking a blood ... a glass slide, stains it with a special dye, and ... the disease. This approach gives an accurate count of how ... of disease severity but is not ideal because there ... the Singapore-MIT Alliance for Research and Technology (SMART) has now ...
(Date:8/29/2014)... recently, little has been known about what genetic changes ... of scientists, one of whom is a University of ... that genes controlling the development of the brain and ... The study was published Aug. 28 in Science ... is online at http://www.sciencemag.org/ ., The domestication of ...
Breaking Biology News(10 mins):A new synthetic amino acid for an emerging class of drugs 2A new synthetic amino acid for an emerging class of drugs 3A new way to diagnose malaria 2A new way to diagnose malaria 3New research reveals how wild rabbits were genetically transformed into tame rabbits 2New research reveals how wild rabbits were genetically transformed into tame rabbits 3
... CAMBRIDGE, Mass. (March 16, 2011) Renowned cancer researchers ... Douglas Hanahan, Director of the Swiss Institute for Experimental ... "Hallmarks of Cancer," which has influenced the study of ... a decade. Published in January 2000, their original ...
... Global Change Biology Bioenergy proposes a new method ... in bioenergy systems. CO 2 emissions resulting from ... and environmental impact studies because bioenergy is carbon- and climate- ... combustion are sequestered by growing biomass. Its climate impact has ...
... Mass., March 16, 2011 The nutritional content of ... as owner,s perceptions about them, according to a study ... School of Veterinary Medicine at Tufts University. ... humans and petschange with aging, the Association of American ...
Cached Biology News:Whitehead scientist helps revisit 'Hallmarks of Cancer' 2Whitehead scientist helps revisit 'Hallmarks of Cancer' 3Wide variety in nutritional content found in 'senior' dog foods 2Wide variety in nutritional content found in 'senior' dog foods 3
(Date:8/29/2014)... (PRWEB) August 29, 2014 Intrinsic ... 13485:2003 certified, GAMP® 5 compliant imaging core lab, ... international Phase II clinical trial to assess a ... Throughout this trial, Intrinsic Imaging will provide comprehensive ... to, protocol and charter development, site qualification, site ...
(Date:8/28/2014)... 2014 “This kit has an improved extraction ... 0 to 150 ppb,” said Mark Tess, PhD, Mycotoxin Product ... to plant owners and USDA-GIPSA inspection agencies that have a ... can take place in a matter of minutes with nothing ... test the feed and grain before accepting it, but they ...
(Date:8/28/2014)... The ability for organizations to attract top ... individuals to perform at the highest of levels, are ... to compete in this post–recession era. The pharmaceutical ... the sector increasingly focuses on the importance of employee-fit ... real results on the organization's development and the innovation ...
(Date:8/28/2014)... Aug. 28, 2014  Armetheon, Inc. ( www.armetheon.com ... mid- to late-stage cardiovascular drug candidates, today announced ... first round of financing. The Series A round ... Bioventures with participation from investors that included Atheneos ... Dr. Larry Hsu , the founder of ...
Breaking Biology Technology:Intrinsic Imaging Awarded Phase II Clinical Trial to Assess New Treatment for Non-Hodgkin’s Lymphoma 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 3
... Below is,updated text of Shire plc,s conference call notification. ... been updated from an earlier,release. Shire PLC (LSE: ... will announce third quarter 2007 earnings on,Thursday 1 November ... 12:00 GMT / 08:00 ET, Investor meeting and ...
... (Nasdaq: ARNA ) today reported financial results for ... in the third quarter of 2007 were $5.0 million, ... Total revenues in the first,nine months of 2007 were ... months of 2006. Revenues in the first nine months ...
... Sangamo,BioSciences, Inc. (Nasdaq: SGMO ) today announced that ... on Wednesday, October 24,2007 after the market closes. The ... 5:00 p.m. ET, which will be open to the ... company will review,the financial results and discuss other business ...
Cached Biology Technology:Correction: Shire plc: Third Quarter 2007 results date notification November 1, 2007 2Arena Pharmaceuticals Announces Third Quarter 2007 Financial Results 2Arena Pharmaceuticals Announces Third Quarter 2007 Financial Results 3Arena Pharmaceuticals Announces Third Quarter 2007 Financial Results 4Arena Pharmaceuticals Announces Third Quarter 2007 Financial Results 5Arena Pharmaceuticals Announces Third Quarter 2007 Financial Results 6Arena Pharmaceuticals Announces Third Quarter 2007 Financial Results 7Sangamo BioSciences Announces Third Quarter 2007 Conference Call and Webcast 2
... COOLSCOPE is an integrated digital microscope and ... computer, equipment setup, optical adjustment or software ... innovative technology, COOLSCOPE combines simplicity and advanced ... COOLSCOPE offers simultaneous viewing of a macro ...
... kit provides complete components including positive ... detection of DNA fragmentation in cultured ... of BrdU in the procedure provides ... methods. Results can be analyzed by ...
... Life Science LAS-3000 imaging system combines ... simplified user interface, providing significantly improved ... of modularities. The system is especially ... perfect standard system for Western blotting ...
... Science LAS-3000mini is a compact image ... applications, and the perfect standard system ... LAS-3000 provides significantly improved system sensitivity ... calibration standards validate that Fujis LAS-3000 ...
Biology Products: