Navigation Links
A new way to assemble cells into 3-D microtissues
Date:3/5/2009

a complementary repeating sequence of thymine and guanine (TGTGTG...) on the other, up to sequences whose base order varies over the full length of the 20-base strand of synthetic DNA. The more complex the sequences they display, the longer it takes the cells to bind together.

A third variable is the density of the DNA on the cell surface. By controlling how many artificial sugars the cells express, the researchers can control the DNA surface density. The greater the density, the faster the cells bind to one another.

Bertozzi says more variables for controlling cell assemblies are possible. "For example, it might be possible to cluster DNA strands on specific cellular structures. Thus, distribution of DNA on the cell surface might be yet another parameter we can exploit to guide cell-cell interactions."

Building complex microtissues one step at a time

By controlling these variables to assemble small cellular structures, then separating the desired structures from unwanted ones and unreacted cells and assembling more cells on the purified collection then repeating the steps again the researchers can synthesize large, complex microtissues in much the same way a synthetic organic chemist assembles a complex molecule.

Bertozzi and Gartner applied these methods to build a signaling network where one kind of cell controls the growth of a second kind of cell. They maintained the survival and replication of hematopoietic progenitor cells (a kind of stem cell for blood cells), which depend on the presence of the growth factor interleukin-3, by combining them in microtissues with CHO cells (Chinese hamster ovary cells) that were engineered to secrete interleukin-3.

When the two cell types were randomly mixed, the stem cells didn't grow. But structured microtissues built from the two cell types stimulated their own growth, forming a simple artificial signaling network that behaved much like the natural network
'/>"/>

Contact: Paul Preuss
paul_preuss@lbl.gov
510-486-6249
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Nanoparticles assemble by millions to encase oil drops
2. Texas Obesity Research Center at UH assembles researchers to discuss obesity
3. ESF EURYI award winner aims to stop cancer cells reading their own DNA
4. Newly created cancer stem cells could aid breast cancer research
5. AIDS interferes with stem cells in the brain
6. Clemson scientists shed light on molecules in living cells
7. Social habits of cells may hold key to fighting diseases
8. UF scientists reveal how dietary restriction cleans cells
9. Human derived stem cells can repair rat hearts damaged by heart attack
10. Scientists identify embryonic stem cells by appearance alone
11. Cells united against cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A new way to assemble cells into 3-D microtissues
(Date:12/24/2014)... its launch in December 2014, the 1U™ app ... trying to remember their usernames and passwords through replacing the ... To assist people who have struggled to remember usernames and ... and focuses on redefining identity, announced today that it is ...
(Date:12/19/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has ... America Perimeter Security Systems Market" report to their offering. ... North American perimeter security market is estimated to grow at ... U.S. market holds a larger share in this market, ...
(Date:12/17/2014)...  HITLAB SM announced today its completion of a ... to current U.S. Food and Drug Administration (FDA) regulations. ... and smart phone application trials utilizing the highest principles ... is determined to improve global healthcare access, quality, and ...
Breaking Biology News(10 mins):1U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2
... SAN FRANCISCO -- Researchers looking into the ... that after an eight-week program, study participants demonstrated ... gait, and increased strength and endurance. The ... VA Medical Center in Indianapolis, Indiana University-Purdue University ...
... atomic hydrogen gas the ultimate fuel for stars ... Dr Robert Braun has found.,This is the first accurate measurement ... Just after the Big Bang the Universe,s matter was almost ... together and generated galaxies, stars and planets and the ...
... a fjord in Canada scientists have found a landscape similar ... a frozen and sulphurous environment, where sulphur associated with Arctic ... for traces of life on Europa. It is ... and sulphur come together, supposedly like on Europa, Jupiter,s moon. ...
Cached Biology News:Study: In-patient, out-patient stroke rehab might benefit from yoga 2There's more star-stuff out there but it's not dark matter 2Arctic bacteria help in the search to find life on moon Europa 2
(Date:1/22/2015)... January 22, 2015 Eckert & Ziegler ... Spectrometry (AMS) services to the pharmaceutical and biotech industry, ... the company in the position of Director of Science ... broad and valuable experience in drug metabolism and bioanalysis ...
(Date:1/22/2015)... Jan. 22, 2015  Transwestern | RBJ today announces the firm ... space for Shire a leading biopharmaceutical company, at Two Ledgemont ... RBJ,s Robert Richards , president, and Brian Cohen ... the entire five-floor building at 95 Hayden Ave. ...
(Date:1/22/2015)... Jan. 22, 2015  Transwestern | RBJ today announces the firm ... space for Shire a leading biopharmaceutical company, at Two Ledgemont ... RBJ,s Robert Richards , president, and Brian Cohen ... the entire five-floor building at 95 Hayden Ave. ...
(Date:1/22/2015)... 2015 The laboratory information management systems ... a number of technological advancements due to factors such ... need to integrate healthcare systems, and increasing government support ... system integration. Key players in the market focus on ...
Breaking Biology Technology:Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 2Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 3Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 4
... Mass. , July 14 Sermo ( http://sermo.com/client ... Client Center. Based on four years of client feedback and ... meets demands for enhanced navigation, mining and monitoring of organic ... million comments and nearly 4 million votes, Sermo is rich ...
... , AKRON, Ohio , July 13 State and Federal Communications, ... report on how states are responding to the Supreme Court,s landmark decision in ... , , To ... "Citizens United Update" in the lower left of the home page. The report is ...
... of Technology announces a new type of nanopore devices that ... example to read off their sequence. In a paper entitled ... Letters ), they report a novel technique to fabricate tiny ... a thickness of only 1 atom) and they managed to ...
Cached Biology Technology:Sermo Announces New Client Center with Advanced Mining and Monitoring of Organic Physician Dialog 2Sermo Announces New Client Center with Advanced Mining and Monitoring of Organic Physician Dialog 3Report Details How States Respond to Citizens United Decision 2DNA through graphene nanopores 2
... pYD1 Yeast Display Vector is specifically designed ... the surface of Saccharomyces cerevisiae. Displayed proteins ... interact with known or putative ligands. pYD1 ... consists of two domains Aga1 and Aga2 ...
... Polyclonal Antibody against Aph-1a (Aph-1aL,S Loop ... gamma secretase is a multiprotein complex ... Pen-2; all four proteins are necessary ... secretase complex catalyzes cleavage of a ...
TGase3 (S-20)...
Mouse monoclonal [HYB 232-02] to Protein S ( Abpromise for all tested applications). entrezGeneID: 5627 SwissProtID: P07225...
Biology Products: