Navigation Links
A new treatment option for alcohol dependence: Reduced consumption rather than abstinence
Date:4/11/2013

Philadelphia, PA, April 11, 2013 A potential new treatment for alcoholism called nalmefene is effective and safe for reducing alcohol consumption in alcohol dependent individuals, says a new study published this week in Biological Psychiatry.

Traditionally, abstinence has been regarded as the primary treatment goal for alcohol dependence, and current pharmacological treatments for alcoholism are approved only for relapse prevention. However, relapse rates remain high and a goal of abstinence is unacceptable to many patients. To address these concerns and provide opportunities for improved patient outcomes, new evidence-based treatments are necessary.

"Our new findings may mark a true paradigm shift in the treatment of men and women who suffer from alcohol related disorders. While abstinence should be the best bet, a reduction in consumption may be a valuable alternative for the many patients who cannot attain abstinence or are not (yet) capable of doing so," said Dr. Karl Mann at Central Institute of Mental Health in Germany, who led the research.

Mann and his colleagues conducted a clinical trial to investigate the effectiveness of nalmefene in reducing alcohol consumption. They recruited 604 alcohol-dependent patients, half of whom were randomized to receive nalmefene, while the other half received visually-identical placebo pills. Neither patients nor their doctors knew which treatment they were receiving. Patients were instructed to take one tablet on each day they perceived a risk of drinking alcohol, and were followed by the study investigators for 24 weeks.

What they found is promising. Nalmefene was significantly better than placebo in reducing alcohol consumption and it improved patients' clinical status and liver enzymes. It was also generally well-tolerated, with most side effects characterized as mild or moderate and quickly resolved.

"With nalmefene, we seem to be able to 'block the buzz' which
'/>"/>

Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Page: 1 2

Related biology news :

1. Stem cells enable personalised treatment for bleeding disorder
2. Breakthrough cancer-killing treatment has no side-effects
3. Measuring ultrasound for better treatment of muscle injuries
4. Vitamin P as a potential approach for the treatment of damaged motor neurons
5. Researchers discover brain cancer treatment using genetic material from bone marrow cells
6. Drug for erectile disorder show promise in the treatment of obesity
7. Beckers Spine Review Releases List of 50 Spine Surgeons & Specialists Researching Biologics for Spine Treatments
8. Discovery could yield treatment for cocaine addicts
9. Novel treatment approach for bladder pain using a herpes simplex virus vector reported
10. Political strife undermines HIV treatment
11. Early antiretroviral treatment reduces viral reservoirs in HIV-infected teens
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... environmental impact recently scored a major win. In August, ... bags, and Governor Jerry Brown is expected to sign ... without a fight, according to an article in ... the American Chemical Society. , Alexander Tullo, a senior ... its first small victory in 1990 when Nantucket became ...
(Date:9/17/2014)... the human retinoblastoma protein gene are a leading cause ... turned to fruit fly eyes to unlock the secrets ... paper featured on the cover of the current issue ... State University researchers provide the first detailed examination of ... the human cancer gene, said Irina Pushel, MSU undergraduate ...
(Date:9/17/2014)... crime unit designed to fight food fraud in ... being passed off as beef scientists from Germany ... describe their approach, which represents a vast improvement over ... Food Chemistry . , Hans-Ulrich Humpf and colleagues note ... But they also say that adding, for example, horse ...
Breaking Biology News(10 mins):Abnormal properties of cancer protein revealed in fly eyes 2
... Detroit automaker, it appears that nature prefers to build its ... combining advanced computational modeling and cutting-edge experiments by molecular biologists ... the most stable parts of a protein are also the ... Sept. 13 issue of the journal Structure. , Nature refuses ...
... are miniature labs that can be swallowed like a ... Their function is to screen for, detect, and ... still at a single-cell size in early development stages. ... and water. , Engineering researchers at McMaster University will ...
... the event of a large-scale smallpox bioterrorist attack in ... researchers at Fred Hutchinson Cancer Research Center that appears ... Instead, the current U.S. government policy of post-release surveillance, ... and close contacts would be sufficient to thwart an ...
Cached Biology News:Protein folding: Building a strong foundation 2Nano-devices hold promise for early-stage cancer detection 2Nano-devices hold promise for early-stage cancer detection 3Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack 2Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack 3Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack 4Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack 5
(Date:9/18/2014)... Sept. 18, 2014 Research and ... "Global N-acetylcysteine Industry Report 2014" report ... N-acetylcysteine Industry Report 2014 is a professional and ... global N-acetylcysteine industry. The report provides ... classifications, applications and industry chain structure. The N-acetylcysteine ...
(Date:9/18/2014)... Sept. 18, 2014  U.S. biotech company Kultevat ... exclusive license for technology developed by the Donald ... in plants, including for applications in production of natural ... The technology was developed under the direction of ... and former president of the Danforth Plant Science Center, ...
(Date:9/18/2014)... Pennsylvanie, 18 septembre 2014 Mapi, ... en 1974, a été depuis 40 ans ... évaluations cliniques traditionnelles par des évaluations recentrées ... sur les impacts économiques des traitements. ... A cours d,une récente conférence ...
(Date:9/18/2014)... dysplasia is a group of rare diseases that ... cartilage. Its onset hits at the fetal stage ... in the gene encoding fibroblast growth factor receptor ... of skeletal dysplasia, thanatophoric dysplasia (TD), a skeletal ... and is often lethal, and achondroplasia (ACH), which ...
Breaking Biology Technology:Global N-acetylcysteine Industry Report 2014 2Kultevat obtains license of gene switch technology 21974 - 2014 - Mapi fĂȘte ses 40 ans 2Researchers use iPS cells to show statin effects on diseased bone 2Researchers use iPS cells to show statin effects on diseased bone 3
... their voracious appetite for wood, rendering houses to dust and ... provide the biochemical means to a greener biofuel future. ... mine of microbes that have now been tapped as a ... or waste biomass to valuable biofuels. , The ...
... will utilise technologies not currently available. An example of ... as interconnects for computer chips. This is now a ... nanotechnology researchers within the Materials Ireland Polymer Research Centre ... develop such junction structure nanotubes used various different methods ...
... us, in us and for us. Imagine them seeking out ... place. Just as a car is a combination of a ... etc, nanomachines too need to be constructed from a range ... of actuator to open and close things, to absorb shock, ...
Cached Biology Technology:DOE JGI plumbs termite guts to yield novel enzymes for better biofuel production 2DOE JGI plumbs termite guts to yield novel enzymes for better biofuel production 3DOE JGI plumbs termite guts to yield novel enzymes for better biofuel production 4DOE JGI plumbs termite guts to yield novel enzymes for better biofuel production 5Understanding of actuator properties of carbon nanotubes bring micro machines closer 2
Human PDGF, CF...
... For the ultimate in utility and ... to meet the needs of the researcher. ... interior dimensions or as sheet material that ... enclosures. These isolators are autoclavable and non-cytotoxic ...
... The mycobacteria in Complete Freund's adjuvant ... injection site which enhances the immuneresponse. For ... used for the initial injections; Incomplete Freund's ... Antigens (preferably in saline) are typically mixed ...
The ELISA Kit for Hepatitis B Surface Antigen (HBsAg) is an in vitro enzyme immunoassay for the detection of HBsAg in human serum or plasma....
Biology Products: