Navigation Links
A new strategy required in the search for Alzheimer's drugs?
Date:5/24/2013

In the search for medication against Alzheimer's disease, scientists have focused among other factors on drugs that can break down Amyloid beta (A-beta). After all, it is the accumulation of A-beta that causes the known plaques in the brains of Alzheimer's patients. Starting point for the formation of A-beta is APP. Alessia Soldano and Bassem Hassan (VIB/KU Leuven) were the first to unravel the function of APPL the fruit-fly version of APP in the brain of healthy fruit flies.

Alessia Soldano (VIB/KU Leuven): "We have discovered that APPL ensures that brain cells form a good network. We now have to ask ourselves the question whether this function of APPL is also relevant to Alzheimer's disease."

Bassem Hassan (VIB/KU Leuven): "Since we show that APP and APPL show similar activities in cultured cells, we suspect that APP in the human brain functions in the same manner as APPL in the brain of fruit flies. Hopefully we can use this to ask and eventually answer the question whether A-beta or APP itself is the better target for new drugs."

Plaques in the brain: cause or effect

The brain of a person with Alzheimer's disease is very recognizable due to the so-called plaques. A plaque is an accumulation of proteins that are primarily made up of Amyloid beta (A-beta), a small structure that splits off from the Amyloid Precursor Protein (APP). We have been dreaming for a long time of a drug that can break down A-beta, but we should be asking ourselves whether this is really the best strategy. After all, it is not yet clear whether the plaques are a cause or effect of Alzheimer's disease. In order to answer this question, it is important to determine the function of APP in healthy brains.

Optimum communication between brain cells

Alessia Soldano and Bassem Hassan study APPL, the fruit-fly version of APP. APPL is found throughout the fruit-fly brain, but primarily in the so-called alpha-beta neurons that are vital to learning processes and memory. The alpha-beta neurons must form functional axons for optimum functioning. Axons are tendrils projecting from the neuron, which are essential for communication between neurons. The VIB scientists had previously shown that APPL is important for memory in flies. Now, they have discovered that in the developing brain of a fruit fly APPL ensures that the axons are long enough and grow in the correct direction. APPL is therefore essential in the formation of a good network of neurons. The question is whether or not it is a good strategy to target a protein with such an important function in the brain in order to combat Alzheimer's disease.


'/>"/>

Contact: Sooike Stoops
sooike.stoops@vib.be
32-924-46611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Related biology news :

1. President, CEO Leppävuori, VTT: Finland should create a national bioeconomy strategy
2. Antitoxin strategy may help target other pathogens
3. Can you hear me now? New strategy discovered to prevent hearing loss
4. An economical, effective and biocompatible gene therapy strategy promotes cardiac repair
5. Coppers previously unknown exit strategy
6. New gene therapy strategy boosts levels of deficient protein in Friedreichs ataxia
7. US Navy defends renewable fuels strategy in Industrial Biotechnology Journal
8. Scientists uncover strategy able to dramatically reduce chemotherapys side effects
9. Limiting TV time -- Effective strategy for preventing weight gain in children
10. Rare cliffhanging plant species uses unique reproductive strategy
11. Texas Biomed files patent for a novel HIV vaccine strategy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/6/2017)... , Feb. 6, 2017 According to ... are driving border authorities to continue to embrace ... there are 2143 Automated Border Control (ABC) eGates ... deployed at more than 163 ports of entry ... to 2016 achieving a combined CAGR of 37%. ...
(Date:2/2/2017)... NEW YORK , Feb. 2, 2017  EyeLock ... has released a new white paper " What You ... The problem of ensuring user authenticity is a ... protect the authentication of users. However, traditional authentication schemes ... Biometric authentication offers an elegant ...
(Date:1/30/2017)...   Invitae Corporation (NYSE: NVTA ... today announced that it will report its fourth quarter ... on Monday, February 13, 2017, and Invitae,s management team ... p.m. Eastern / 1:45 p.m. Pacific. ... financial results, guidance, and recent developments and will spend ...
Breaking Biology News(10 mins):
(Date:2/21/2017)... ... February 21, 2017 , ... ... Liquid Biopsy System , a fully automated benchtop system for collecting intact circulating ... is being launched at the Molecular Medicine Tri Conference (Tri-Con) Annual Meeting 2017 ...
(Date:2/21/2017)... (PRWEB) , ... February 21, ... ... the Life -Sciences division, Treximo will pair its $200M operational capacity with ... consulting and project management in areas affecting quality and operational management. ...
(Date:2/21/2017)... -- Lexus, a returning partner of the Amgen Tour of California ... partner of the men,s and women,s events for the next five ... Tour of California will mark the start ... professional cycling teams in the world racing from Northern to ... Breakaway from Heart Disease TM Women,s Race empowered with ...
(Date:2/21/2017)... Research and Markets has announced the addition of the ... Forecast to 2025" report to their offering. ... The Global Bioplastics & Biopolymers ... over the next decade to reach approximately $8.9 billion by 2025. ... forecasts for all the given segments on global as well as ...
Breaking Biology Technology: