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A new spin on drug delivery
Date:7/9/2010

ses "hydrodynamic effects that uniquely occur when fluids flow along curved paths. Flow under these conditions is known to generate vortices. Cells carried by such flow experience rotation and spinning that help expose the majority area of its surface to the electric field. " Having the gene delivery done by flows in curved paths is key in the gene delivery as opposed to the traditionally used, electroporation in static solution or in straight channels. "A spiral-shaped channel design yields a two-fold increase than a straight channel and an even larger factor compared to in static solution," he added.

By using fluorescence microscopy, they were able to "map" the area on the cell surface that was subjected to electroporation, and determine the extent of the DNA entry into the cell.

Lu explained the conventional delivery using a cuvette-type of device with static cell suspension produces DNA delivery confined to a narrow zone on the cell surface. However, when electroporation is applied to flowing cells in a spiral or curved channel , the images "appear dramatically different with the DNA delivery uniformly distributed over the entire cell surface."


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Contact: Lynn Nystrom
tansy@vt.edu
540-231-4371
Virginia Tech
Source:Eurekalert  

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