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A new signaling pathway of the immune system is elucidated
Date:3/31/2011

th death of keratinocytes, the predominant cells of the epidermis in charge of protecting the skin against environmental damage. This effect is dependent on the TNF signaling pathways.

The research reported allows us to reshape our thinking about how chronic proliferative dermatitis arises in humans, as well as opening new avenues of therapeutic intervention in the TNF-alpha signalling pathway. Moreover, a potential source of this disease may arise from mutations in a critical region of the linear ubiquitin ligase complex (LUBAC) allowing identification of patients that may respond well to targeted therapy. "In patients suffering from chronic proliferative dermatitis with unclear origin, it is now possible to specifically look for a mutation in LUBAC components", suggests Ivan Dikic.


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Contact: Ivan Dikic
ivan.dikic@biochem2.de
49-696-301-5652
Goethe University Frankfurt
Source:Eurekalert

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