Navigation Links
A new radiation therapy treatment developed for head and neck cancer patients
Date:8/17/2007

Most head-and-neck cancers that recur locally after prior full-dose conventional radiation therapy respond to Boron Neutron Capture Therapy (BNCT). These results were obtained in a Phase I/II study at the Helsinki University Hospital, Finland. The scientific director of the research program, professor Heikki Joensuu, University of Helsinki, considers the results clinically significant and very interesting. They open a new field for BNCT, since thus far BNCT has been evaluated only in the treatment of some brain tumours.

The follow-up results of 12 patients diagnosed with cancer of the head-and-neck and treated in a prospective clinical trial were reported in the International Journal of Radiation Oncology, Biology & Physics (online version available: www.redjournal.org). All patients had cancer of the head-and-neck that had recurred locally after surgery and conventional radiation therapy. Ten out of the 12 patients had substantial tumour shrinkage following BNCT, and in 7 cases the tumour disappeared completely. Adverse effects of treatment were moderate and resembled those of conventional radiation therapy.

The study has been expanded, and up to 30 subjects will now be allowed to enter the study protocol.

Boron neutron capture therapy (BNCT) is a form of targeted radiation treatment for cancer. It is still considered experimental. In this method a boron-containing compound (boronophenylalanine) is first infused into a peripheral vein, following which the compound accumulates in cancer tissue. Cancer is subsequently irradiated with neutrons obtained from a nuclear reactor, which causes boron atoms to split within the cancerous tissue as a result from a boron neutron capture reaction. The resulting smaller particles cause a large radiation effect within the tumour tissue, which destroys cancer cells.

The technique allows targeting of a high dosage of radiation to the tumour while al
'/>"/>

Contact: Professor Heikki Joensuu
heikki.joensuu@hus.fi
358-947-173-208
University of Helsinki
Source:Eurekalert

Page: 1 2

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Duke Experiments Boost Radiations Cancer-Killing Effects
3. Gene therapy may protect normal tissues during radiation retreatment for lung cancer
4. Jefferson researchers find nanoparticle shows promise in reducing radiation side effects
5. Radiation-killed bacteria vaccine induces broad immune response in mice
6. Radiation-armed robot rapidly destroys human lung tumors
7. One therapeutic dose of radiation causes 30 percent spongy bone loss in mice
8. Gene therapy protects mice from the effects of whole-body irradiation
9. Cancer stem cells linked to radiation resistance
10. Mars mission Risk 29: Scientists research ways to reduce radiation-induced brain damage
11. Intravenous gene therapy protects normal tissue of mice during whole-body radiation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Sweden, have explored two different ways that allow ... to the formation of oxygen molecules in photosynthesis. ... scientific journal Nature Communications . , "The ... catalysts for water oxidation, which are key components ... storage of solar energy in fuels like hydrogen, ...
(Date:7/11/2014)... increased risk of kidney injury related to the use ... mass of HES molecules, according to a report in ... International Anesthesia Research Society (IARS). , The "total mass ... on cultured human renal proximal tubule cells (PTCs), concludes ... of University Hospital Wrzburg, Austria. Other factorssuch as ...
(Date:7/11/2014)... In addition to the hippocampus, the marginal division ... and memory. What is the impact degree of ... learning and memory function? Yan Yu and his ... China found, using immunofluorescence staining, that substance P ... hippocampus and striatal marginal division of normal rats. ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2In lab studies, hydroxyethyl starch has direct harmful effects on kidney cells 2
... LONDON , February 11 De ... today announced,that it will design and roll-out East Africa,s ... part of the ongoing Rwandan National ID project,(NID). The plans for ... driver,s licence, are already underway. The first eID,documents are expected to ...
... , A few grass species provide the bulk of our ... sustainable energy and feedstock production. However there are significant barriers ... gene function and their large and complex genomes. , Now, ... international consortium led by the John Innes Centre, the US ...
... N.C. Any way you look at it -- by ... creepy crawlies called arthropods dominate planet Earth. Because of their ... figure out the family relationships that link lobsters to millipedes ... first. In a scientific and technological tour de force ...
Cached Biology News:De La Rue to Provide East Africa's First eID Project 2De La Rue to Provide East Africa's First eID Project 3First member of the wheat and barley group of grasses is sequenced 2Study finds surprising new branches on arthropod family tree 2Study finds surprising new branches on arthropod family tree 3
(Date:7/11/2014)... , July 11, 2014 /PRNewswire-iReach/ -- Maxim Peptide, a ... that are used solely in scientific experiments, is currently ... years in business, Maxim Peptide, which was created by ... a new and updated website that now features a ... has been updated with fascinating articles about peptide research, ...
(Date:7/11/2014)... MISSISSAUGA, ON , July 11, 2014 /CNW/ - ... Canada approved APTIOM TM (eslicarbazepine acetate) for use ... partial-onset seizures in patients with epilepsy who are not ... not indicated for use in patients under 18 years ... the most common neurological disorders and according to Epilepsy ...
(Date:7/10/2014)... July 10, 2014 Deep Knowledge ... Medicine Forum on ‘Commercialising Longevity Research’ and welcomed ... to the London Bioscience Innovation Center for the ... and Aging Analytics Ltd. The meeting highlighted the ... translational research for age-related disease, as well as ...
(Date:7/10/2014)... CA (PRWEB) July 10, 2014 OMICS ... Bioanalytical techniques during 18-20 August, 2014 at Double Tree ... review the recent developments in Analytical & Bioanalytical research ... globe. , Speaking on this occasion, Dr. Srinubabu Gedela, ... Analytica Acta conference is a remarkable one in bringing ...
Breaking Biology Technology:Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 3Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4
... Lione, one of,the largest intellectual property law firms in ... Addy has been named one of the Top,10 Illinois ... Politics,magazine., Intellectual property law, specifically patent law, traditionally ... practice, Ms. Addy is,among the most recognized patent attorneys ...
... Human Genome,Sciences, Inc. (Nasdaq: HGSI ) today ... its financial results for the year ended,December 31, 2007. ... 25, 2008, after the capital markets close., (Logo: ... be hosted by senior management and will be,held on ...
... Graceway Pharmaceuticals, LLC,("Graceway"), a portfolio company of ... acquired all of the assets related to Estrasorb(R),(estradiol ... (Nasdaq: NVAX ) and Allergan, Inc. ("Allergan") ... treatment of moderate to severe vasomotor,symptoms associated with ...
Cached Biology Technology:Meredith Martin Addy Named One of Top 10 Illinois 'Super Lawyers' for 2008 2Human Genome Sciences to Sponsor Conference Call to Discuss Full Year 2007 Financial Results 2Graceway Pharmaceuticals, LLC(TM) Announces Completed Acquisition of All Assets Related to Estrasorb(R) Product Line in North America From Allergan, Inc. (NYSE: AGN) and Novavax, Inc. (Nasdaq: NVAX) 2
... from 2 mM sodium phosphate buffer, pH ... D is a major lysosomal aspartyl protease ... kDa proenzyme. Overexpression of cathepsin D in ... risk of relapse and metastasis. Cathepsin D ...
Rat Hepatocytes (RH) (>3,000,000 cells)...
... Automation Buffer is a concentrated formulation of ... employing capillary action technology, as well as ... collaboration with David Brigati M.D., Department of ... This buffer is recommended for all the ...
... Intended for users requiring mass detection ... linear MALDI TOF Mass spectrometer is ... applications and for high performance mass ... QA/QC, SNP analysis, protein detection, micro-satellite ...
Biology Products: