Navigation Links
A new protein partnership that leads to pediatric tumor regression
Date:9/10/2009

Why are some pediatric cancers able to spontaneously regress? Prof. Michael Fainzilber and his team of the Weizmann Institute's Biological Chemistry Department seem to have unexpectedly found part of the answer. Further research towards a better understanding of the mechanism of action might hopefully lead, in the future, to the development of drugs that will be able to induce regression of certain tumors.

TrkA is a particular cell receptor well known for its "pro-life advocacies": When nerve growth factor proteins bind to TrkA receptors, it activates the receptors into promoting the growth and survival of neurons.

So when Fainzilber, together with Ph.D. student Liraz Harel, postdoctoral student Dr. Barbara Costa, technician Zehava Levy, and former Ph.D. student Dr. Marianna Tcherpakov, carried out screening tests to identify other molecules involved in this signaling cascade, it took them by surprise to learn that TrkA may not be who it seems. They found that if TrkA teams up with another molecule called CCM2 the newly-identified player in this signaling cascade they become "partners in crime," with TrkA turning into a cell killer!

However, though paradoxical, this atypical behavior may actually be rooting for life after all. This idea comes from findings concerning pediatric tumors of neural origin, specifically, medulloblastoma the most common malignant brain tumor and the second most common malignancy among children less than 20 years of age; and neuroblastoma the most common extracranial solid cancer in childhood. Neuroblastoma displays unusual behavior, being one of the few human malignancies known to demonstrate spontaneous regression in some cases, but nobody knows how or why. Studies have shown that the tumors with positive prognosis usually express TrkA, while aggressive forms of the tumor do not. However, how TrkA induces tumor regression is yet unknown, and the mechanism was an enigma.

What if CCM2 was the
'/>"/>

Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science
Source:Eurekalert

Page: 1 2

Related biology news :

1. Protein chatter linked to cancer activation
2. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
3. Researchers identify proteins involved in new neurodegenerative syndrome
4. Low levels of key protein may indicate pancreatic cancer risk
5. Structure of 450 million year old protein reveals evolutions steps
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Specific brain protein required for nerve cell connections to form and function
8. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
9. Interacting protein theory awaits test from new neutron analysis tools
10. Depression, aging, and proteins made by a virus may all play role in heart disease
11. Census of protein architectures offers new view of history of life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... circuits in the brain of mice, scientists have ... research, led by Howard Hughes Medical Institute investigator ... (MIT), reveals that the connections between the part ... an experience and the part of the brain ... are malleable. , Altering those connections can ...
(Date:8/27/2014)... pathogens posing the greatest risk to Europe based upon ... of Liverpool researchers using a ,big data, approach to ... of Infection and Global Health ranked the top 100 ... animals using a system which, they believe, will help ... the spread of infectious diseases, including as a result ...
(Date:8/27/2014)... available in German . ... most common inherited disease affecting the peripheral nervous system. ... Planck Institute of Experimental Medicine and University Medical Centre ... is impaired in rats with the disease. These cells ... as myelin, which facilitates the rapid transfer of electrical ...
Breaking Biology News(10 mins):Researchers change the emotional association of memories 2Researchers change the emotional association of memories 3Researchers change the emotional association of memories 4Big data approach identifies Europe's most dangerous human and domestic animal pathogens 2Potential therapy for incurable Charcot-Marie-Tooth disease 2
... and wild--are indifferent to sweets. A new study ... their strictly carnivorous behavior. "We took a behavioral ... senior author of the study and Associate Director ... on mammalian tongues are specialized taste bud receptors ...
... invaluable decision-making tools for public health officials. As ... 2001, models can be useful in two ways: ... infection and they can allow the comparison of ... implicit assumptions that may systematically bias their predictions, ...
... of Massachusetts Amherst have discovered a tiny biological ... helps describe how microorganisms can clean up groundwater ... also have applications in the emerging field of ... extremely small dimensions. , The findings of microbiologist ...
Cached Biology News:Field of beams - Novel system uses polarized light pulses to reveal crop health 2Researchers Discover That Microbes Can Produce Miniature Electrical Wires 2Researchers Discover That Microbes Can Produce Miniature Electrical Wires 3Researchers Discover That Microbes Can Produce Miniature Electrical Wires 4
(Date:8/27/2014)... MADISON, N.J. , Aug. 27, 2014 /PRNewswire/ ... significant potential to help physicians better identify early-stage ... progression and disability, according to a new study ... from Quest Diagnostics (NYSE: DGX ) ... of the 14-3-3eta protein outperformed conventional antibody-serum testing, ...
(Date:8/27/2014)... , Aug. 27, 2014 Reportbuyer.com ... The Graphene Opportunity - A Rational View ... Graphene The New Nanotech? A similar amount ... of applications ranging from microelectronics to water treatment, ... announced the availability of the Graphene Opportunity Report, ...
(Date:8/27/2014)... Research and Markets  has announced the addition of ... Report 2014" report to their offering. ... Report 2014 is a professional and in-depth study on ... spectrometer industry. The report provides a basic ... industry chain structure. The isotope ratio mass spectrometer market ...
(Date:8/27/2014)... 27, 2014 Riviera Beach, Florida ... the creation of the Sancilio Scientific Advisory Board ... SCI’s philosophy of looking to nature for pharmaceutical ... actions are based on sound scientific data, analyses, ... Board provides a vehicle for SCI to receive ...
Breaking Biology Technology:Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 3Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 4The Graphene Opportunity - A Rational View 2The Graphene Opportunity - A Rational View 3The Graphene Opportunity - A Rational View 4Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 2New Sancilio & Company, Inc. Scientific Board 2New Sancilio & Company, Inc. Scientific Board 3
... 26, 2011 Reportlinker.com announces that ... is available in its catalogue: ... Strategies - A Guide to ... and Biopharmaceutical Industries ...
... Our understanding of what differentiates cancer cells from normal cells ... complex signal systems of individual cells. By combing two different ... research world with a tool for studying signal paths on ... published today in PLoS One . "We also ...
... In the wake of the March 11 earthquake and ... across Japan, the award-winning undergraduate internship program NanoJapan is ... rather than having U.S. undergraduates travel to Japan for ... the opportunity to send 25-30 students to Rice University ...
Cached Biology Technology:Reportlinker Adds Technology Transfer Strategies - A Guide to Maximizing Returns Within the Pharmaceutical and Biopharmaceutical Industries 2Reportlinker Adds Technology Transfer Strategies - A Guide to Maximizing Returns Within the Pharmaceutical and Biopharmaceutical Industries 3Reportlinker Adds Technology Transfer Strategies - A Guide to Maximizing Returns Within the Pharmaceutical and Biopharmaceutical Industries 4Reportlinker Adds Technology Transfer Strategies - A Guide to Maximizing Returns Within the Pharmaceutical and Biopharmaceutical Industries 5Reportlinker Adds Technology Transfer Strategies - A Guide to Maximizing Returns Within the Pharmaceutical and Biopharmaceutical Industries 6Reportlinker Adds Technology Transfer Strategies - A Guide to Maximizing Returns Within the Pharmaceutical and Biopharmaceutical Industries 7Reportlinker Adds Technology Transfer Strategies - A Guide to Maximizing Returns Within the Pharmaceutical and Biopharmaceutical Industries 8Reportlinker Adds Technology Transfer Strategies - A Guide to Maximizing Returns Within the Pharmaceutical and Biopharmaceutical Industries 9Combo method reveals cells' signal systems 2Reverse NanoJapan: Rice to host 25-30 Japanese students 2
Phosphotyrosine IgG mouse monoclonal antibody: Alkaline Phosphatase conjugate...
Rabbit polyclonal to Myosin VIIa (rating: *****) ( Abpromise for all tested applications). entrezGeneID: 4647 SwissProtID: Q13402...
Mouse monoclonal [6E10] to LAP2 ( Abpromise for all tested applications). entrezGeneID: 7112 SwissProtID: P42166...
...
Biology Products: