Navigation Links
A new nuance to neurons
Date:8/23/2011

re was actually any difference between them. In the past, many scientists hypothesized that the difference was simply a matter of location the recycling ones come into play when an electrical impulse arrives simply because they happen to be at the right spot for release.

But some scientists pondered whether the identity of the vesicles determines their behavior and not the other way around that the recycling ones are in the right spot because they are the ones destined to be released. It's sort of like asking whether a soccer player is a goalie because he happens to block shots near the goal, or because he's designated to be the goalie.

The new work essentially shows that goalies block shots because they're goalies.

Proteins Determine the Fate

In their paper, Edwards and his colleagues show that vesicles in the two different pools contain different proteins and that these differences determine how they behave. Using a technique for labeling proteins with glowing molecules derived from jellyfish, they were able to show that a protein called VAMP7 is present at high levels in the resting pool rather than the recycling pool, which contains more of other synaptic vesicle proteins.

This shows that the body makes and maintains different pools of vesicles containing different proteins for different purposes: release or some other function. According to Edwards, the observation has far-reaching implications for our understanding of how neurotransmitters are packaged, transported and released from neurons.

"What's happening is not a simple, monolithic process," he said.

The observation gives new insight into the function of the brain at the most basic, microscopic level. It also may help unravel some of the secrets of neurological diseases, aspects of which may be related to how vesicles are produced and released.

According to Edwards, resting vesicles are involved in a separate not-well-unde
'/>"/>

Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-4608
University of California - San Francisco
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Stabilizing force for good communication between neurons and muscle cells found
2. Mediator in communication between neurons and muscle cells found
3. Protecting neurons could halt Alzheimers, Parkinsons diseases
4. How mirror neurons allow us to learn and socialize by going through the motions in the head
5. Researchers generate functional neurons from somatic cells
6. UCLA stem cells scientists make electrically active motor neurons from iPS cells
7. ORNL, St. Jude track neurons to predict and prevent disease
8. Basic guides to PCR, labeling neurons featured in Cold Spring Harbor Protocols
9. Phasic firing of dopamine neurons is key to brains prediction of rewards
10. Alzheimer cell death in Zebrafish: Demise of neurons observed live for the first time
11. Impaired transport in neurons triggers prion disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A new nuance to neurons
(Date:3/2/2015)... 2, 2015  Businesses have a new option ... Tharon Rankins Enterprises has announced the launch of ... way for businesses to protect their customers, personal ... Beconux is a biometric transaction processing ... similarly to an ATM machine, the new system ...
(Date:2/24/2015)... NEW YORK , Feb. 24, 2015 This report ... Thousands by the following Segments: Face Biometrics, and Voice Biometrics. The ... , Japan , Europe ... & Africa , and Latin ... period 2013 through 2020. Also, a seven-year historic analysis is provided ...
(Date:2/18/2015)... 2015  Cepheid (NASDAQ: CPHD ) today announced ... and invited investors to participate via webcast. , Cowen ... Tuesday, March 3, 2015 at 11.20 a.m. Eastern Time ... FL Wednesday, March 4, 2015 at 10.25 a.m. ... live webcasts for these events, please visit Cepheid,s website at ...
Breaking Biology News(10 mins):Personal Data Protection Company Launches New Product 2World Face and Voice Biometrics Industry 2World Face and Voice Biometrics Industry 3World Face and Voice Biometrics Industry 4World Face and Voice Biometrics Industry 5World Face and Voice Biometrics Industry 6World Face and Voice Biometrics Industry 7World Face and Voice Biometrics Industry 8World Face and Voice Biometrics Industry 9World Face and Voice Biometrics Industry 10World Face and Voice Biometrics Industry 11World Face and Voice Biometrics Industry 12World Face and Voice Biometrics Industry 13World Face and Voice Biometrics Industry 14World Face and Voice Biometrics Industry 15World Face and Voice Biometrics Industry 16Cepheid to Webcast Upcoming Financial Presentations 2
... Southampton Centre for Biomedical Research, established by the ... the University of Southampton, have been awarded 17m ... research facilities. The funding, which is ... NHS and university partnerships, has secured the future ...
... Ga. A research team from Rollins College in Florida ... the source of the coral-killing pathogen that causes white pox ... in the Caribbean, elkhorn coral was listed for protection under ... to white pox disease. The team,s findings have just been ...
... fecal material -- in particular, dog fecal material -- may ... Detroit,s wintertime air, says a new University of Colorado Boulder ... four Midwestern cities in the experiment, two cities had significant ... feces being the most likely source. "We found ...
Cached Biology News:Southampton researchers awarded $28 million to progress pioneering nutrition and respiratory research 2Human pathogen killing corals in the Florida Keys 2Human pathogen killing corals in the Florida Keys 3New CU-Boulder study reveals bacteria from dog feces in outdoor air of urbanized air 2New CU-Boulder study reveals bacteria from dog feces in outdoor air of urbanized air 3
(Date:3/3/2015)... SAN DIEGO , March 3, 2015  Halozyme Therapeutics, ... the Barclays 2015 Global Healthcare Conference in Miami, ... ET/10:05 a.m. PT. David A. Ramsay , Chief Financial ... will be webcast through the "Investors" section of Halozyme,s corporate ... made available for 90 days following the event. To access ...
(Date:3/3/2015)... LEXINGTON, Ky. (PRWEB) March 03, 2015 ... aligning their schedules for one event: the Alltech REBELation ... USA, from May 17-20. Now in its 31st year, ... people from 70 countries, and the opportunity to join ... week, March 7 at 11:59 p.m. EST, at which ...
(Date:3/3/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/rcv4lq/gene_therapy ... Therapy Market, 2015 - 2025" report to their ... report provides an extensive study on the marketed and ... carried out in this field for over a decade ... in Asian markets; one approved in the EU). There ...
(Date:3/3/2015)... March 3, 2015 /CNW/- SQI Diagnostics Inc. (TSX:V: SQD), ... technologies and products for advanced microarray diagnostics, today ... CFE  to its Management team. In his capacity ... its transition from a development stage to a ... advance the Company,s capital market strategy and to ...
Breaking Biology Technology:Halozyme Therapeutics To Present At The Barclays 2015 Global Healthcare Conference 2World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 2World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 3World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 4Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 2Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 3Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 4Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 5Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 6Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 7SQI Diagnostics Appoints Chief Financial Officer 2SQI Diagnostics Appoints Chief Financial Officer 3
... 8, at approximately 11:26 a.m. EDT, the space shuttle Atlantis ... 39A, for one last mission. While the STS-135 flight marks ... trip may open a new era of research into infectious ... Nickerson, and Roy Curtiss III, along with their colleagues at ...
... Showcasing new tools for widespread development of ... National Institute of Standards and Technology (NIST) have demonstrated ... of an engineered mechanical object down to the quantum ... a Nature paper posted online July 6,* ...
... 2011 ,   ... development and marketing of gene signature-based,diagnostic assays based ... a Research Agreement with Johnson & Johnson,Pharmaceutical Research ... the agreement Skyline,using its proprietary knowledge and technologies ...
Cached Biology Technology:Final countdown: Atlantis to carry next-generation vaccine candidate on last space voyage 2Final countdown: Atlantis to carry next-generation vaccine candidate on last space voyage 3Final countdown: Atlantis to carry next-generation vaccine candidate on last space voyage 4NIST mechanical micro-drum cooled to quantum ground state 2NIST mechanical micro-drum cooled to quantum ground state 3NIST mechanical micro-drum cooled to quantum ground state 4Skyline Diagnostics Establishes Research Collaboration With Janssen 2
MpV17 transgene, murine homolog, glomerulosclerosis...
GEL FILTRATION CAL KIT HMW, 1 EA. *Category: Gel Filtration Gels....
... custom siRNA service provides the premium quality ... research. Custom siRNAs can be readily ordered ... target sequence, or by providing the sense ... Ambion's Silencer Validated and ...
Human FGF R2 (alpha isoforms) MAb (Clone 98706)...
Biology Products: