Navigation Links
A new nuance to neurons
Date:8/23/2011

pecialized cells with very long extensions sometimes a meter or more in length.

Down these spaghetti-like nerve fibers travel electrical impulses, which will cause the neuron to release some of these tiny vesicle sacs, spilling their chemical contents into the synapse, a gap between the nerve ending and the next neuron. The chemicals then seep over to the adjoining neuron, sometimes triggering it to fire in turn.

This basic game of neurotransmission is played trillions of times over by the 10 billion or so neurons in the human brain. Some neurons are so active that they fire as many as 100 times a second, requiring mechanisms to sustain these high rates.

The vesicles play a crucial role in this process because they allow neurons to fire when ready. Neurons use the vesicles to package the chemicals and transport them in advance so that they can release as soon as an electrical impulse arrives. Since the release sites are far away from the cell center, the vesicles must recycle locally to maintain high rates of release.

For years, scientists have observed that while all vesicles appear identical, they actually exist in two different pools. The smaller pool, found at the extreme land's end of the neuron, holds the ones that release neurotransmitters when an electrical impulse arrives. After release, the vesicles are quickly recycled for continued use, and for this reason scientists have called this the "recycling" pool of vesicles.

The second pool of vesicles can be much larger, accounting for up to 80 percent of all the vesicles at a synapse. Surprisingly, these vesicles do not respond to electrical impulses. Instead they sit dormant when the signal arrives and, because of this, scientists have dubbed this the "resting" pool.

"It's not clear what they respond to or what their function is," Edwards said.

Because the vesicles in the two pools appear to be identical under the microscope, nobody knew if the
'/>"/>

Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-4608
University of California - San Francisco
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Stabilizing force for good communication between neurons and muscle cells found
2. Mediator in communication between neurons and muscle cells found
3. Protecting neurons could halt Alzheimers, Parkinsons diseases
4. How mirror neurons allow us to learn and socialize by going through the motions in the head
5. Researchers generate functional neurons from somatic cells
6. UCLA stem cells scientists make electrically active motor neurons from iPS cells
7. ORNL, St. Jude track neurons to predict and prevent disease
8. Basic guides to PCR, labeling neurons featured in Cold Spring Harbor Protocols
9. Phasic firing of dopamine neurons is key to brains prediction of rewards
10. Alzheimer cell death in Zebrafish: Demise of neurons observed live for the first time
11. Impaired transport in neurons triggers prion disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A new nuance to neurons
(Date:11/21/2014)... Nov. 19, 2014  Earlier this year Donald ... College, and one of the most prolific inventors in ... are transmitted from Smartphones to third party agencies. Spector ... has one of the earliest known patents in this ... in the military, child care, elder care and hospital ...
(Date:11/21/2014)... Nov. 20, 2014   Atmel® Corporation (NASDAQ: ... (MCU) and touch technology solutions, today launched the industry,s ... with the widest V cc range from 1.7V ... and faster I 2 C bus communication speeds, and ... memory making them ideal for consumer, industrial, computer, and ...
(Date:11/18/2014)... The Parenteral Drug Association (PDA) today confirmed that seven officials ... least seven more will participate in the upcoming 2014 PDA ... Washington D.C. , Dec. 2-4. ... the regulatory agencies in the United States ... to help advance the use of metrics in the regulatory ...
Breaking Biology News(10 mins):Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2
... bacteria exist as aggressive pathogens, causing diseases ranging from ... syndrome, others play a less malevolent role and some ... study, Cheryl Nickerson and her group at ASU,s Biodesign ... Van de Wiele and lead author Rosemarie De Weirdt ...
... participation in scientific research has deep roots in the ... has taken off spectacularly from launch pads across the ... communications technology and a sea change in a scientific ... Citizen science, crowd-sourced science, DIY research, volunteer monitoring, ...
... A study comparing whether endothelial colony-forming cells (ECFCs) derived from ... are more proliferative and better for forming new blood vessels ... vasculogenic., The study, carried out by researchers at the Indiana ... Cell Medicine [2(3)] and is freely available on-line ...
Cached Biology News:Beneficial bacteria may help ward off infection 2Beneficial bacteria may help ward off infection 3Beneficial bacteria may help ward off infection 4Beneficial bacteria may help ward off infection 5Inaugural cross-disciplinary Public Participation in Scientific Research conference 2Blood vessel forming potential of stem cells from human placenta and umbilical cord blood 2
(Date:11/23/2014)... 2014 Apiscent Labs, a privately ... chemical ingredients to the global pharmaceutical and flavor ... new website, Apiscent.com. , The Apiscent.com homepage welcomes ... design, easy navigation, rotating images and content focused ... out. , The company’s work in ...
(Date:11/22/2014)... VA (PRWEB) November 21, 2014 During ... who understood the need to surround himself with great ... CEO and entrepreneur, his friends often marveled at his ... he lived his life and -- even with his ... for the Alzheimer’s disease that would ultimately take his ...
(Date:11/22/2014)... November 21, 2014 CannLabs, Inc. ... based analytics and scientific testing methodologies relating to cannabis, ... a $750,000 line of credit from an existing stockholder ... to have secured this commitment from one of our ... of CannLabs. “This capital will help accelerate our planned ...
(Date:11/22/2014)... 2014 On November 17th Chicago start-up ... Emerging Medical Technologies Summit in San Francisco to take ... regarded among Silicon Valley investors and technology elites as ... win also positions Briteseed to move on to ... 2015 and compete with other elite innovation finalists for ...
Breaking Biology Technology:Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 2Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 3CannLabs Secures $750,000 Line Of Credit 2Insight Product Development Accelerator Member Wins MedTech Innovator Award Competition 2Insight Product Development Accelerator Member Wins MedTech Innovator Award Competition 3
... and OSLO, March 4 Pharmexa A/S and Affitech ... agreement to merge,the two companies by means of a ... Norwegian company, Affitech AS. The purpose of the merger ... vaccine business,into a company focused on the research and ...
... milestones, - Strong R&D investments, especially in EHT Dx21 and EHT ... Recruitment of 311 samples achieved for EHT Dx21, - ... Expansion of the strategic collaboration with Allergan and extension, ... of a new Management Board, - New positioning of Genomic Services ...
... highlights the importance and challenges of ... America. To move beyond the current crisis, we ... knowledge-intensive jobs, invest in "green" science and engineering ... based industries and workers. , Nanotechnologywhich some scientists ...
Cached Biology Technology:Pharmexa and Affitech to Combine Operations to Create a New Antibody Therapeutics Company 2Pharmexa and Affitech to Combine Operations to Create a New Antibody Therapeutics Company 3ExonHit Therapeutics Invested Strongly in 2008 for Pivotal 2009 Results 2ExonHit Therapeutics Invested Strongly in 2008 for Pivotal 2009 Results 3ExonHit Therapeutics Invested Strongly in 2008 for Pivotal 2009 Results 4ExonHit Therapeutics Invested Strongly in 2008 for Pivotal 2009 Results 5ExonHit Therapeutics Invested Strongly in 2008 for Pivotal 2009 Results 6ExonHit Therapeutics Invested Strongly in 2008 for Pivotal 2009 Results 7ExonHit Therapeutics Invested Strongly in 2008 for Pivotal 2009 Results 8ExonHit Therapeutics Invested Strongly in 2008 for Pivotal 2009 Results 9ExonHit Therapeutics Invested Strongly in 2008 for Pivotal 2009 Results 10ExonHit Therapeutics Invested Strongly in 2008 for Pivotal 2009 Results 11Nanotechnology: Will it drive a new innovation economy for the US? 2Nanotechnology: Will it drive a new innovation economy for the US? 3
IHC detection kit for PCNA in cells and tissues...
... Immunogen: Synthetic peptide derived from the ... protein. Specificity: Reacts with the ... Reactivity: Human Mouse (positive controls: WNT1-transfected ... lysates and mouse Mouse-1 cell lysates). ...
The pYES2 vector is designed for native expression of your protein of interest in S. cerevisiae. It contains the URA3 gene for selection in yeast and 2 origin for high-copy maintenance....
... cAMP - [125I] Direct SPA ... SPA.Includes lysis reagents that eliminate lengthy ... cAMP measurement (optional use).Range: 1.32-84.28 ng/ml ... pmol/ml).Overnight protocol.Store at 2-8 C. Category: ...
Biology Products: