Navigation Links
A new mouse model provides insight into genetic neurological disorders
Date:5/25/2009

m.biologists.org>dmm.biologists.org> mice with mutations in the GARS gene have some of the same symptoms as CMT and HMN patients. Their hope is that this mouse can be used to study what causes these diseases and how it might effectively be treated. Mice with defects in some of this protein have problem with grip strength and motor skills while symptoms are more pronounced in animals that carry the mutation in all of their protein copies. This report is the first documentation of successful breeding of animals with this mutation, giving researchers access to new materials to understand how this gene influences human neuronal diseases.

When the researchers made the same mutation in two different breeds of mice it caused two distinguishable sets of symptoms, demonstrating that the genetic background influences the effects of the GARS gene mutation. This variability in the mouse disease symptoms is also seen in humans, and may help shed light on how CMT and HMN differently affect individual patients' symptoms.


'/>"/>

Contact: Kristy Kain
kristy.kain@vanderbilt.edu
The Company of Biologists
Source:Eurekalert

Page: 1 2

Related biology news :

1. A computer for your mouse!
2. Immune cells promote blood vessel formation in mouse endometriosis
3. Cancer-resistant mouse discovered
4. Looking through the eyes of a mouse, scientists monitor circulating cells in its bloodstream
5. New chimeric mouse model for human liver diseases, drug testing
6. CSHL scientists identify and repress breast cancer stem cells in mouse tissue
7. Dissecting the genetic components of adaptation of E. coli to the mouse gut
8. Book is the first high-resolution digital mouse brain atlas designed for Web applications
9. Scientists successfully treat new mouse model of inflammatory bowel disease
10. Negligent, attentive mouse mothers show biological differences
11. Mouse study: When it comes to living longer, its better to go hungry than go running
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/18/2015)... , June 18, 2015 NXT-ID, Inc. (NASDAQ: ... focused on the growing mobile commerce market announces that its ... segment on "Money on the Mark", scheduled to air on ... June 20 th . The broadcast ... from 7:00 to 8:00pm EST. NXT-ID, Inc.,s CEO Gino ...
(Date:6/17/2015)... Germany , June 17, 2015 ... today launched new Investigator ® STR assay kits for ... the United States . The new genetic fingerprint kits ... markers (short tandem repeats or STRs) for DNA matching. They ... quality of DNA in each sample, a novel QIAGEN technology ...
(Date:6/17/2015)... BEACH GARDENS, Fla. , June 17, 2015 ... management solutions, today announced that its U.are.U ® ... Togo,s Eateries, Inc., a ... fast casual sandwich chain, to increase security, improve ... Crossmatch fingerprint readers enable instant, non-repudiable identity confirmation ...
Breaking Biology News(10 mins):NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3
... The National Institute of Neurological Disorders and Stroke (NINDS), ... a three-year, $900,000 grant to the Center for Biomedical ... The grant will fund the center,s biomarker research in ... detect changes in brain function and biochemistry. Led ...
... February 14, 2013 The 18th century natural philosopher ... as a consequence of the cumulative effort, across generations, ... view of evolution was largely abandoned with the advent ... most important traits and many medical illnesses across generations. ...
... assortment of amphibian species living in a pond, the more ... a parasitic infection that can cause severe deformities, including the ... the University of Colorado Boulder. The findings, published ... idea that greater biodiversity in larger-scale ecosystems, such as forests ...
Cached Biology News:NIH funds research to identify Parkinson's biomarkers 2NIH funds research to identify Parkinson's biomarkers 3Life experiences put their stamp on the next generation: New insights from epigenetics 2CU-Boulder amphibian study shows how biodiversity can protect against disease 2CU-Boulder amphibian study shows how biodiversity can protect against disease 3CU-Boulder amphibian study shows how biodiversity can protect against disease 4
(Date:7/6/2015)... ... July 06, 2015 , ... An optical technology ... how blood flows in the brain during stroke, providing information that could someday ... article published in the journal Neurophotonics describes work at the University ...
(Date:7/6/2015)... CA (PRWEB) , ... July 06, 2015 , ... ... in Personalized Medicine, recently hosted their 2015 bi-annual Pain Management Medical Advisory Board ... met with Proove Biosciences’ executive Research and Development team to discuss new clinical ...
(Date:7/6/2015)... , July 6, 2015  Emdeon ... into a definitive agreement to acquire Altegra ... intervention platforms that combine data aggregation and ... capabilities to achieve actionable insights and improved ... combine Altegra Health,s risk adjustment and quality ...
(Date:7/6/2015)... 29, 2015 Research ... addition of the "Biotechnology for the Non-Biotechnologist" ... for the Non-Biotechnologist, ideal for non-Scientists and Scientists ... and potential of biotechnology. Ideal for ... theory, principles, techniques, and potential of biotechnology ...
Breaking Biology Technology:Reducing Stroke Damage May be Next Application for OCT Technology Now Widely Used in Eye and Vision Healthcare 2Reducing Stroke Damage May be Next Application for OCT Technology Now Widely Used in Eye and Vision Healthcare 3Proove Biosciences Gathers Key Opinion Leaders in Pain Management for Medical Advisory Board Meeting in Palm Springs, California 2Proove Biosciences Gathers Key Opinion Leaders in Pain Management for Medical Advisory Board Meeting in Palm Springs, California 3Emdeon to Acquire Altegra Health 2Emdeon to Acquire Altegra Health 3Emdeon to Acquire Altegra Health 4
... Catholic Health Initiatives, (CHI) Institute for Research and ... have announced a joint strategic partnership to focus ... community hospitals across their system. ... clinical R&D and molecular diagnostics laboratory that supports ...
... (Nasdaq: LIFE ), a provider of innovative ... bioenergy crop company, today announced they have completed sequencing the ... SOLiD™ 4.0 System by Life Technologies. The sequence ... crop and advances its development as a high yielding, low-cost ...
... a global leader in material science and high-performance polymer ... 6 languages: English, Chinese, French, German, Japanese, and Spanish. ... Account Managers and modified customer support hours to better ... for download at http://www.zeusinc.com . ...
Cached Biology Technology:BioFortis and Catholic Health Initiatives' Center for Translational Research Announce Biorepository Information Technology Strategic Partnership to Drive Progress in Personalized Medicine 2BioFortis and Catholic Health Initiatives' Center for Translational Research Announce Biorepository Information Technology Strategic Partnership to Drive Progress in Personalized Medicine 3Life Technologies and SG Biofuels Complete Sequence of Jatropha Genome 2Life Technologies and SG Biofuels Complete Sequence of Jatropha Genome 3Life Technologies and SG Biofuels Complete Sequence of Jatropha Genome 4Zeus Catalog Available in Six Languages 2
Homo sapiens postsynaptic protein CRIPT Antigen: Recombinant Protein...
... quadrupole 1200L sets the new standard ... - incorporating the latest technologies and ... chromatography analytical needs. The Atmospheric ... Transmission Quadrupole Analyzer provide superior selectivity ...
Human Legumain Affinity Purified Polyclonal Ab...
Mouse Endoglin/CD105 Fluorescein MAb (Clone 209701)...
Biology Products: