Navigation Links
A new method to identify mutated genes in human diseases
Date:3/27/2008

Researchers from the University of Turin, Italy and the University of Nijmegen, The Netherlands, have devised a new method that may help the medical community to determine the genetic basis of many common diseases. Their findings are described in an article published March 21st in the open-access journal PLoS Computational Biology.

Thousands of human diseases originate from mutations in one or more genes. Identification of mutated genes is a crucial first step towards understanding the molecular mechanisms at the origin of diseases and devising a treatment. In many cases, we do not know the identity of the affected gene, only a chromosomal region (typically containing hundred of genes) in which the mutation is located.

The research group, led by Ferdinando Di Cunto and Paolo Provero, analyzed gene expression data (patterns of gene activity in tissues and cell lines) from thousands of published experiments to identify genes showing patterns comparable to the ones of mutated genes in similar diseases. The study identified candidate genes for 81 diseases, including various forms of epilepsy and muscular dystrophy

As in all such analyses, the results must be verified experimentally. However, the task of understanding the molecular basis of many diseases could be significantly simplified by the results of this work.


'/>"/>

Contact: Mary Kohut
Press@plos.org
415-568-3457
Public Library of Science
Source:Eurekalert

Page: 1

Related biology news :

1. New method to estimate sea ice thickness
2. Powerful yet reliable proteomics techniques are the focus of a new methods book
3. RNA-based methods for developmental studies are featured in Cold Spring Harbor Protocols
4. Stowers Proteomics Center devises method for assigning probabilities to human protein interactions
5. New method developed to identify genetic determinants of Alzheimers disease
6. Feinstein researchers develop new genetic method and identify novel genes for schizophrenia
7. New book presents methods to poke and prod individual molecules
8. Team of scientists develops non-invasive method to track nerve-cell development in live human brain
9. Cold Spring Harbor Protocols highlights a method that captures cell growth and activity
10. From brains to behavior: Cold Spring Harbor Protocols features methods for neuroscience research
11. Contraception: progress brings hope for new methods for men
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... TEANECK, N.J. , May 16, 2017  Veratad ... leading provider of online age and identity verification solutions, ... the K(NO)W Identity Conference 2017, May 15 thru May ... Ronald Regan Building and International Trade Center. ... across the globe and in today,s quickly evolving digital ...
(Date:5/6/2017)... , May 5, 2017 ... just announced a new breakthrough in biometric authentication ... exploits quantum mechanical properties to perform biometric authentication. These ... smart semiconductor material created by Ram Group and ... finance, entertainment, transportation, supply chains and security. Ram ...
(Date:4/19/2017)... ALBANY, New York , April 19, 2017 /PRNewswire/ ... highly competitive, as its vendor landscape is marked by ... in the market is however held by five major ... and Safran. Together these companies accounted for nearly 61% ... majority of the leading companies in the global military ...
Breaking Biology News(10 mins):
(Date:5/22/2017)... ... May 22, 2017 , ... ... leaders of the Maryland Biohealth community in developing and issuing recommendations to grow ... U.S. BioHealth Innovation Hub by 2023. , The recommendations are ...
(Date:5/21/2017)... LOS ANGELES, CA (PRWEB) , ... May 19, ... ... at the annual meeting and educational conference of the American Association of Bioanalysts ... at the Galleria Hotel in Houston. The conference reinforces AAB’s commitment to excellence ...
(Date:5/19/2017)... ... May 19, 2017 , ... In response to the strong ... Biodex Medical Systems, Inc. announces the release of their Gait Trainer 3 with an ... with a biomedical system to aid in rehabilitating individuals with cerebral palsy, traumatic brain ...
(Date:5/18/2017)... ... May 18, 2017 , ... ... 28, 2017 at the Prince Of Wales Private Hospital. The procedure was performed ... C6-C7. The patient failed conservative treatments prior to undergoing surgery. , The AxioMed ...
Breaking Biology Technology: