Navigation Links
A new line of defense: Researchers find cattle vaccine works to reduce E. coli O157:H7
Date:8/6/2012

MANHATTAN, KAN. -- A commercial vaccine for cattle can effectively reduce levels of E. coli by more than 50 percent, a Kansas State University study has found. The vaccine is also effective using two doses instead of the recommended three doses, which can help cut costs for the beef industry.

David Renter, associate professor of epidemiology, is the principal investigator on a project that researched the effectiveness of products used to prevent the shedding of E. coli O157:H7 in cattle. The research appears in a recent online version of the journal Vaccine and helps improve current preventative methods for addressing food safety concerns.

While E. coli O157:H7 does not affect cattle, it causes foodborne disease in humans. Vaccines and other products may be given to cattle to help prevent the spread of the bacteria.

"We wanted to test how well these products work to control E. coli O157:H7 in a commercial feedlot with a large population of cattle that were fed in the summer and may be expected to have a high level of E. coli O157:H7," Renter said.

Other Kansas State University researchers involved include T.G. Nagaraja, university distinguished professor of microbiology; Nora Bello, assistant professor of statistics; Charley Cull, doctoral student in pathobiology, Oakland, Neb.; and Zachary Paddock, doctoral student in pathobiology, Manhattan, Kan. Abram Babcock, an August 2010 Kansas State University doctoral graduate, also was involved in the research.

Using a commercial feedlot setting, the researchers studied more than 17,000 cattle during an 85-day period. They studied two products: a vaccine and a low-dose direct-fed microbial.

"What's unique about this study is the number of animals we used, the research setting and that we used commercial products in the way that any cattle producer could use them," Renter said. "We didn't want it to be any different than the way somebody would use the products in a commercial feedlot."

The researchers found that the vaccine reduced the number of cattle that were shedding E. coli O157:H7 in feces by more than 50 percent. E. coli shedding was reduced by more than 75 percent among cattle that were high shedders of E. coli. While the vaccine label suggests that it is given in three doses, the researchers found that two doses of the vaccine significantly reduced E. coli.

"Showing that level of efficacy with two doses is really important because a shift to two doses from three could significantly cut costs for the beef industry," Renter said. "In terms of logistics, it can be difficult for commercial feedlot production systems to vaccinate animals three times. Both of these benefits help when considering how the vaccine can be adopted and implemented in the industry."

The researchers also discovered that the low-dose direct-fed microbial product did not work as well as the vaccine. Renter said while the study used a lower dose of the direct-fed microbial and could find no evidence that it reduced E. coli shredding, it is possible that the direct-fed microbial product is more effective at a higher dose.

"This vaccine is an option for reducing E. coli," Renter said. "We have shown that this vaccine works and that it is a tool that could be adopted in the industry."


'/>"/>
Contact: David Renter
drenter@k-state.edu
785-532-4801
Kansas State University
Source:Eurekalert

Related biology news :

1. Iowa State, Ames Lab researchers invent new tool to study single biological molecules
2. Wayne State researchers working to improve genetic analysis, disorder detection
3. Superbird stuns researchers
4. Massachusetts Eye and Ear researchers discover elusive gene that causes a form of blindness from birth
5. Researchers monitor red tides in Chesapeake Bay
6. BUSM researchers find link between childhood abuse and age at menarche
7. Researchers dig through the gene bank to uncover the roots of the evolutionary tree
8. Researchers find new gene mutation associated with congenital myopathy
9. NASA and university researchers find a clue to how life turned left
10. To understand childhood obesity, researchers look to inactive, fat rats
11. Researchers study knee stress at tissue, cellular levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/16/2016)... --  IdentyTechSolutions America LLC , a leading provider ... a cutting-edge manufacturer of software and hardware security ... integrated solutions that comprise IDT biometric readers and ... IdentyTech,s customers with combined physical identification and anti-tailgating ... theft. "We are proud to use ...
(Date:12/15/2016)... -- ... Research and Markets has announced the addition of the "Global Military ... report forecasts the global military biometrics market to grow at a CAGR ... been prepared based on an in-depth market analysis with inputs from industry ... the coming years. The report also includes a discussion of the key ...
(Date:12/8/2016)... Dec. 8, 2016 Market Research Future published a half ... global Mobile Biometric Security and Service Market is expected to grow ... Market Highlights: ... , Mobile Biometric Security and ... the increasing need of authentication and security from unwanted cyber threats. ...
Breaking Biology News(10 mins):
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... ... waist circumference, and increased serum leptin levels had a positive association with increased ... The study published in the International Neurourology Journal involved 571 Korean men ...
(Date:1/24/2017)... & Geneva, Switerland (PRWEB) , ... January 24, ... ... announce the first commercially available malaria Plasmodium falciparum culture panels with standard concentrations ... culture panels, which are available in a range of concentrations from six different ...
(Date:1/24/2017)... LAVAL, QC , Jan. 24, 2017 /PRNewswire/ - ProMetic ... the "Corporation") announced today that its orally active lead ... Medicine ("PIM") designation by the UK Medicines and Healthcare ... Syndrome ("AS"). A PIM designation is ... promising candidate for the Early Access to Medicines Scheme ...
(Date:1/24/2017)... ... 23, 2017 , ... Edward Buckler, Ph.D., a research geneticist ... Academy of Sciences Prize in Food and Agriculture Sciences. He is being honored ... Academy of Sciences (NAS) Prize in Food and Agriculture Sciences was established in ...
Breaking Biology Technology: