Navigation Links
A new line of defense: Researchers find cattle vaccine works to reduce E. coli O157:H7
Date:8/6/2012

MANHATTAN, KAN. -- A commercial vaccine for cattle can effectively reduce levels of E. coli by more than 50 percent, a Kansas State University study has found. The vaccine is also effective using two doses instead of the recommended three doses, which can help cut costs for the beef industry.

David Renter, associate professor of epidemiology, is the principal investigator on a project that researched the effectiveness of products used to prevent the shedding of E. coli O157:H7 in cattle. The research appears in a recent online version of the journal Vaccine and helps improve current preventative methods for addressing food safety concerns.

While E. coli O157:H7 does not affect cattle, it causes foodborne disease in humans. Vaccines and other products may be given to cattle to help prevent the spread of the bacteria.

"We wanted to test how well these products work to control E. coli O157:H7 in a commercial feedlot with a large population of cattle that were fed in the summer and may be expected to have a high level of E. coli O157:H7," Renter said.

Other Kansas State University researchers involved include T.G. Nagaraja, university distinguished professor of microbiology; Nora Bello, assistant professor of statistics; Charley Cull, doctoral student in pathobiology, Oakland, Neb.; and Zachary Paddock, doctoral student in pathobiology, Manhattan, Kan. Abram Babcock, an August 2010 Kansas State University doctoral graduate, also was involved in the research.

Using a commercial feedlot setting, the researchers studied more than 17,000 cattle during an 85-day period. They studied two products: a vaccine and a low-dose direct-fed microbial.

"What's unique about this study is the number of animals we used, the research setting and that we used commercial products in the way that any cattle producer could use them," Renter said. "We didn't want it to be any different than the way somebody would use the products in a commercial feedlot."

The researchers found that the vaccine reduced the number of cattle that were shedding E. coli O157:H7 in feces by more than 50 percent. E. coli shedding was reduced by more than 75 percent among cattle that were high shedders of E. coli. While the vaccine label suggests that it is given in three doses, the researchers found that two doses of the vaccine significantly reduced E. coli.

"Showing that level of efficacy with two doses is really important because a shift to two doses from three could significantly cut costs for the beef industry," Renter said. "In terms of logistics, it can be difficult for commercial feedlot production systems to vaccinate animals three times. Both of these benefits help when considering how the vaccine can be adopted and implemented in the industry."

The researchers also discovered that the low-dose direct-fed microbial product did not work as well as the vaccine. Renter said while the study used a lower dose of the direct-fed microbial and could find no evidence that it reduced E. coli shredding, it is possible that the direct-fed microbial product is more effective at a higher dose.

"This vaccine is an option for reducing E. coli," Renter said. "We have shown that this vaccine works and that it is a tool that could be adopted in the industry."


'/>"/>
Contact: David Renter
drenter@k-state.edu
785-532-4801
Kansas State University
Source:Eurekalert

Related biology news :

1. Iowa State, Ames Lab researchers invent new tool to study single biological molecules
2. Wayne State researchers working to improve genetic analysis, disorder detection
3. Superbird stuns researchers
4. Massachusetts Eye and Ear researchers discover elusive gene that causes a form of blindness from birth
5. Researchers monitor red tides in Chesapeake Bay
6. BUSM researchers find link between childhood abuse and age at menarche
7. Researchers dig through the gene bank to uncover the roots of the evolutionary tree
8. Researchers find new gene mutation associated with congenital myopathy
9. NASA and university researchers find a clue to how life turned left
10. To understand childhood obesity, researchers look to inactive, fat rats
11. Researchers study knee stress at tissue, cellular levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/4/2017)... , Oct. 4, 2017  GCE Solutions, a global clinical ... data and document anonymization solution on October 4, 2017. Shadow is ... field to comply with policy 0070 of the European Medicines Agency ... data. ... GCE Solutions ...
(Date:8/15/2017)... 15 2017   ivWatch LLC , a medical device company ... today announced receipt of its ISO 13485 Certification, the global standard ... Organization for Standardization (ISO®). ... Model 400 Continuous Monitoring device for the early detection of IV ... "This is an important milestone for ...
(Date:6/30/2017)... Today, American Trucking Associations announced Seeing ... and eye tracking software, became the newest member ... "Artificial intelligence and advanced sensing algorithms ... driver,s attentiveness levels while on the road.  Drivers ... fatigue and prevent potential accidents, which could lead ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... HILLS, Calif. , Oct. 11, 2017  SkylineDx today ... (ICR) and University of Leeds ... risk-stratify patients with multiple myeloma (MM), in a multi-centric Phase ... University of Leeds is the sponsor ... and ICR will perform the testing services to include high-risk ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights ... (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... process optimization firm for the life sciences and healthcare industries, announces a presentation ... San Francisco. , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will ...
(Date:10/9/2017)... Arizona (PRWEB) , ... October 09, 2017 , ... ... Kindred, a four-tiered line of medical marijuana products targeting the needs of consumers ... and packaging of Kindred takes place in Phoenix, Arizona. , As operators of ...
Breaking Biology Technology: