Navigation Links
A new line of defense: Researchers find cattle vaccine works to reduce E. coli O157:H7
Date:8/6/2012

MANHATTAN, KAN. -- A commercial vaccine for cattle can effectively reduce levels of E. coli by more than 50 percent, a Kansas State University study has found. The vaccine is also effective using two doses instead of the recommended three doses, which can help cut costs for the beef industry.

David Renter, associate professor of epidemiology, is the principal investigator on a project that researched the effectiveness of products used to prevent the shedding of E. coli O157:H7 in cattle. The research appears in a recent online version of the journal Vaccine and helps improve current preventative methods for addressing food safety concerns.

While E. coli O157:H7 does not affect cattle, it causes foodborne disease in humans. Vaccines and other products may be given to cattle to help prevent the spread of the bacteria.

"We wanted to test how well these products work to control E. coli O157:H7 in a commercial feedlot with a large population of cattle that were fed in the summer and may be expected to have a high level of E. coli O157:H7," Renter said.

Other Kansas State University researchers involved include T.G. Nagaraja, university distinguished professor of microbiology; Nora Bello, assistant professor of statistics; Charley Cull, doctoral student in pathobiology, Oakland, Neb.; and Zachary Paddock, doctoral student in pathobiology, Manhattan, Kan. Abram Babcock, an August 2010 Kansas State University doctoral graduate, also was involved in the research.

Using a commercial feedlot setting, the researchers studied more than 17,000 cattle during an 85-day period. They studied two products: a vaccine and a low-dose direct-fed microbial.

"What's unique about this study is the number of animals we used, the research setting and that we used commercial products in the way that any cattle producer could use them," Renter said. "We didn't want it to be any different than the way somebody would use the products in a commercial feedlot."

The researchers found that the vaccine reduced the number of cattle that were shedding E. coli O157:H7 in feces by more than 50 percent. E. coli shedding was reduced by more than 75 percent among cattle that were high shedders of E. coli. While the vaccine label suggests that it is given in three doses, the researchers found that two doses of the vaccine significantly reduced E. coli.

"Showing that level of efficacy with two doses is really important because a shift to two doses from three could significantly cut costs for the beef industry," Renter said. "In terms of logistics, it can be difficult for commercial feedlot production systems to vaccinate animals three times. Both of these benefits help when considering how the vaccine can be adopted and implemented in the industry."

The researchers also discovered that the low-dose direct-fed microbial product did not work as well as the vaccine. Renter said while the study used a lower dose of the direct-fed microbial and could find no evidence that it reduced E. coli shredding, it is possible that the direct-fed microbial product is more effective at a higher dose.

"This vaccine is an option for reducing E. coli," Renter said. "We have shown that this vaccine works and that it is a tool that could be adopted in the industry."


'/>"/>
Contact: David Renter
drenter@k-state.edu
785-532-4801
Kansas State University
Source:Eurekalert

Related biology news :

1. Iowa State, Ames Lab researchers invent new tool to study single biological molecules
2. Wayne State researchers working to improve genetic analysis, disorder detection
3. Superbird stuns researchers
4. Massachusetts Eye and Ear researchers discover elusive gene that causes a form of blindness from birth
5. Researchers monitor red tides in Chesapeake Bay
6. BUSM researchers find link between childhood abuse and age at menarche
7. Researchers dig through the gene bank to uncover the roots of the evolutionary tree
8. Researchers find new gene mutation associated with congenital myopathy
9. NASA and university researchers find a clue to how life turned left
10. To understand childhood obesity, researchers look to inactive, fat rats
11. Researchers study knee stress at tissue, cellular levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2017)... 18, 2017  Socionext Inc., a global expert in SoC-based imaging ... server, the M820, which features the company,s hybrid codec technology. A ... Tera Probe, Inc., will be showcased during the upcoming Medtec Japan ... at the Las Vegas Convention Center April ... Click here for ...
(Date:4/13/2017)... According to a new market research report "Consumer IAM Market by ... Service, Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast to ... USD 14.30 Billion in 2017 to USD 31.75 Billion by 2022, at ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
Breaking Biology News(10 mins):
(Date:6/20/2017)... ... 20, 2017 , ... Do More with OHAUS , With the launch of ... in the weighing industry, to extending its expertise across the entire laboratory to a ... and more, allowing for its customers to 'Do More' in the lab. ...
(Date:6/19/2017)... ... 2017 , ... EDETEK, Inc., a clinical technology company focused ... two new additions of its award-winning cloud-based platform CONFORM™: Information Hub and Clinical ... Annual Meeting in Chicago, IL, June 19-22, 2017. , “Modern clinical trials use ...
(Date:6/16/2017)... Lexington, Massachusetts (PRWEB) , ... June 16, 2017 ... ... in medical device compliance and commercialization, has just announced two more sessions of ... of the series will focus on the world of online templates for design ...
(Date:6/15/2017)... , ... June 15, 2017 , ... ... auxin herbicides give farmers new options for managing Palmer amaranth and other broadleaf ... (WSSA) say special precautions are necessary. Auxin herbicides are known to drift and ...
Breaking Biology Technology: