Navigation Links
A new light shed on genetic regulation's role in the predisposition to common diseases
Date:9/2/2012

Genetic disease risk differences between one individual and another are based on complex aetiology. Indeed, they may reflect differences in the genes themselves, or else differences at the heart of the regions involved in the regulation of these same genes.

By gene regulation we mean the decision that the cell makes as to when, where and at what level to activate or suppress the expression of a gene. In theory, two people could thus share a gene that is perfectly identical and yet show differences in their predisposition to a disease due to genetic differences concerning the regulation (overexpression or underexpression) of this same gene.

Numerous teams are currently trying to draw up a map of regions involved in gene regulation. Not an easy task, but invaluable since it allows us to understand all the genetic causes that can explain the predisposition to certain diseases.

Working with twins

Emmanouil Dermitzakis, Louis-Jeantet Professor at the Faculty of Medicine and member of the NCCR Frontiers in Genetics and the Institute of Genetics and Genomics of Geneva (IGE3), is a specialist in what is called the genetics of complex traits. With an international team co-led by Professor Tim Spector (Kings College), Professor Mark McCarthy (Oxford University) and Dr. Panos Deloukas (Wellcome Trust Sanger Institute), he publishes a study highlighting thousands of these genetic variants that seem to explain individual differences in gene expression.

For this work, the researchers used samples of three different tissue types (adipose tissue, skin and blood cells) collected from more than 800 homozygotic (identical) and dizygotic twins.

"Identifying variants which control the activity of many genes is a greater challenge than we anticipated but we are developing appropriate tools to uncover them and understand their contribution to disease," comments Panos Deloukas. "Modern human genetics combined with samples donated by the participants in s
'/>"/>

Contact: Emmanouil Dermitzakis
emmanouil.dermitzakis@unige.ch
41-223-795-483
Universit de Genve
Source:Eurekalert

Page: 1 2

Related biology news :

1. AGU journal highlights -- 31 August 2012
2. Shedding new light on one of diabetes most dangerous complications
3. Fast food restaurant lighting and music can reduce calorie intake and increase satisfaction
4. Biomass characterization technology research highlighted in Industrial Biotechnology journal
5. Athletic field paint steals spotlight from the grass it covers
6. Research on wood formation sheds light on plant biology
7. Origami inspires research into materials that self-assemble when exposed to light
8. Team receives $22.5 million to shed light on the immune system
9. Imaging study sheds new light on alcohol-related birth defects
10. Scientists shed light on glowing materials
11. Studies shed light on why species stay or go in response to climate change
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... digital distribution of media will have lower carbon ... when file sizes are large. , That,s the ... Journal of Industrial Ecology that looked at ... as PlayStation3. Researchers found that Blu-ray Discs delivered ... than game files downloaded over broadband Internet. For ...
(Date:9/2/2014)... [Brown University] It,s hard to comprehend how bad ... has become without knowing what it was before people ... rate was 10 times lower than scientists had thought, ... worse. , Extinctions are about 1,000 times more frequent ... came along. The explanation from lead author Jurriaan de ...
(Date:9/2/2014)... All human cells contain essentially the same DNA sequence ... shapes and functions of cells in the different parts ... DNA contains the same construction master plan, an additional ... possible DNA programs are active. This mechanism involves modifications ... small chemical groups (e.g. methylation). It acts on top ...
Breaking Biology News(10 mins):Extinctions during human era worse than thought 2Extinctions during human era worse than thought 3Throwing a loop to silence gene expression 2
... blocks sperm. Evidence suggests that human male fertility ... and their receptors are present in the male reproductive ... there has been no genetic test to clarify mechanisms. ... issue, Sun et al. characterize the phenotype of mice ...
... a modest beneficial effect of anakinra for rheumatoid arthritis ... and its use with other biologic medications. Rheumatoid ... as one in 100 people worldwide. It affects the ... of a new breed of arthritis drugs licensed in ...
... who received a daily nutritional supplement for three months had a ... compared to children who did not receive the supplementation, according to ... Wasting (defined as a certain deviation that a child,s weight ... same height in a reference group) is characterized by the loss ...
Cached Biology News:February 2009 highlights from Biology of Reproduction 2Anakinra for rheumatoid arthritis: A modest benefit with some risk 2Nutritional supplementation program helps prevent weight loss among children in African country 2Nutritional supplementation program helps prevent weight loss among children in African country 3
(Date:9/2/2014)... , Sept. 2, 2014  Technology Applications International ... that its wholly-owned subsidiary Renuell Int,l, Inc. has signed ... and Space Administration ("NASA") at the Johnson Space Center ... See photos: tapplic.com/houstonphotos/ ... are very pleased to announce our latest, exclusive agreement ...
(Date:9/2/2014)... September 02, 2014 Opertech Bio, ... highly efficient, cost effective approach to sensory evaluation, ... 8,820,265 by the U.S. Patent and Trademark Office, ... , “Opertech’s taste evaluation technology called ... automated high throughput system for rapid characterization of ...
(Date:9/2/2014)... 2, 2014  Xencor, Inc. (NASDAQ: ... monoclonal antibodies for the treatment of autoimmune diseases, ... the appointment of Debra Zack , M.D., ... of Lloyd Rowland , senior vice president, ... "Debra,s expertise in biologics clinical development and ...
(Date:9/2/2014)...  Synthetic Biologics, Inc. (NYSE MKT: SYN), a ... targeting specific pathogens that cause serious infections and ... preclinical toxicology study of SYN-004. Per U.S. Food ... was required to move the Company,s lead anti-infective, ... effects of Clostridium difficile (C. difficile), ...
Breaking Biology Technology:Technology Applications International Corporation Subsidiary Enters Into Additional Exclusive Agreement with NASA at a Signing Ceremony at the Johnson Space Center In Houston, Texas 2Technology Applications International Corporation Subsidiary Enters Into Additional Exclusive Agreement with NASA at a Signing Ceremony at the Johnson Space Center In Houston, Texas 3Opertech Bio Receives U.S. Patent for High-Throughput Taste Evaluation Technology 2Xencor Appoints Debra Zack, M.D., Ph.D., Vice President, Clinical Development and Lloyd Rowland, Senior Vice President, Chief Compliance Officer and General Counsel 2Xencor Appoints Debra Zack, M.D., Ph.D., Vice President, Clinical Development and Lloyd Rowland, Senior Vice President, Chief Compliance Officer and General Counsel 3Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 2Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 3Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 4Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 5
... Guidance and Remains on Track for Four Product Launches ... 9:00 a.m. EDT EATONTOWN, N.J., April 30 Osteotech, ... the emerging field of biologic products for regenerative healing, ... 31, 2009."During the first quarter, we continued to make ...
... Accomplished regulatory executive enhances Nfocus device development team.PALO ALTO, ... Neuromedical Inc. announced today the appointment of accomplished ... the role of Vice President of Regulatory Affairs. "Bob ... experience to Nfocus , having served 18 of ...
... shows potential for pirfenidone role in treatment of patients with ... in HCV -- Strong data from 14-day triple combination study ... InterMune, Inc. (Nasdaq: ITMN ) today announced ... 2009. InterMune reported a net loss for ...
Cached Biology Technology:Osteotech Reports First Quarter 2009 Financial Results 2Osteotech Reports First Quarter 2009 Financial Results 3Osteotech Reports First Quarter 2009 Financial Results 4Osteotech Reports First Quarter 2009 Financial Results 5Osteotech Reports First Quarter 2009 Financial Results 6Osteotech Reports First Quarter 2009 Financial Results 7Osteotech Reports First Quarter 2009 Financial Results 8Nfocus Neuromedical Appoints Robert O'Holla to Head Regulatory 2InterMune Reports First Quarter 2009 Financial Results and Business Highlights 2InterMune Reports First Quarter 2009 Financial Results and Business Highlights 3InterMune Reports First Quarter 2009 Financial Results and Business Highlights 4InterMune Reports First Quarter 2009 Financial Results and Business Highlights 5InterMune Reports First Quarter 2009 Financial Results and Business Highlights 6InterMune Reports First Quarter 2009 Financial Results and Business Highlights 7InterMune Reports First Quarter 2009 Financial Results and Business Highlights 8InterMune Reports First Quarter 2009 Financial Results and Business Highlights 9InterMune Reports First Quarter 2009 Financial Results and Business Highlights 10InterMune Reports First Quarter 2009 Financial Results and Business Highlights 11InterMune Reports First Quarter 2009 Financial Results and Business Highlights 12InterMune Reports First Quarter 2009 Financial Results and Business Highlights 13
... QRT-PCR Mixes are formulated for use in ... SYBR Green. One-step QRT-PCR mixes offer a ... The pipetting steps are minimised, making the ... ,The 2x ABsolute QRT-PCR Mix is supplied ...
... of environmental and pathophysiological stressful conditions trigger ... known as heat shock proteins (HSPs), more ... The Hsp90 family of proteins in ... beta, Grp94, and Trap-1 (Hsp75). It was ...
... bespoke, cost-effective solutions for complex protein processing and production ... experience to help you develop a solution to your ... , do ... transfer all methodology to your own ...
... The Schleicher & Schuell BioScience Arraying ... dedicated to custom protein and nucleic ... project teams, comprised of R&D, Engineering, ... closely with collaborators every step of ...
Biology Products: