Navigation Links
A new kind of rat model
Date:9/13/2007

Two neuroscientists at the University of Wisconsin-Milwaukee (UWM) are working with local company PhysioGenix to investigate a novel animal model the company has developed for researching diseases like depression, anxiety, schizophrenia and ADHD.

The models are genetically altered rats, originally created by researchers at the Medical College of Wisconsin (MCW) as a way to clone genes related to human diseases. Called consomic rats, they were produced by replacing a single chromosome from the genetic background of a diseased rat with the same chromosome from a normal rat.

In theory, if the new strain is cured of a disease, then the genes responsible for the disease are either on the transferred chromosome or somehow related to it. Consomic rats can be used to rapidly identify new genes and cellular targets associated with certain diseases and to develop and test the efficacy of new drug therapies.

In fact, the consomic rats have already proved useful in studies of cardiovascular disease and hypertension the main reason for their development.

The process of identifying which genes are the players in certain complex diseases or behaviors is much quicker using consomic rats than by traditional gene-hunting methods, says Steven Nye, director of genomics at PhysioGenix and principal investigator of the National Institutes of Health grant for commercializing the consomic rats.

PhysioGenix, a spin-off company founded by researchers at MCW, has contracted with UWM Psychology Professors Rodney Swain and Fred Helmstetter to characterize the rats behaviors in a battery of psychological tests to confirm whether chromosome substitution improves their conditions.

The task is daunting, considering there are 44 strains of consomic rats and potentially hundreds of psychological tests to choose from.

Currently, Swain and Helmstetter are probing their efficacy in identifying the genetic roots of psychological di
'/>"/>

Contact: Steven Nye
snye@PhysioGenix.com
University of Wisconsin - Milwaukee
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. Study Models Impact Of Anthrax Vaccine
2. Scientists identify new model Of NK cell development
3. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
4. Genrate: a generative model that finds and scores new genes and exons in genomic microarray data
5. Molecular models advance the fight against malaria
6. NYU and MSKCC research provides model for understanding chemically induced cancer initiation
7. Genetic therapy reverses nervous system damage in animal model of inherited human disease
8. Disease progression model of pancreatic cancer developed by Penn researchers
9. A new way to share models of biological systems
10. Understanding biases in epidemic models important when making public health predictions
11. Climate model links higher temperatures to prehistoric extinction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2008)...the U.S. Environmental Protection Agency (EPA) ann...ersity of Kentucky (UK) to investigate how the siz...y to enter the brain. This is the largest EPA Sci...to the University of Kentucky as well as the large...echnology research. , "Nanotechnology is an exc...
(Date:8/20/2008)...e controls numerous biological processes including...EN is frequently lost or mutated; in fact, alterat...f human cancer that PTEN has become one of the mos... Now, a study led by researchers at Beth Israel De...l School provides important new insights into PTEN...
(Date:8/20/2008)...itute (NHGRI), part of the National Institutes of ...in grants to develop innovative sequencing technol... a person,s DNA as a routine part of biomedical re...ehensively sequence any person,s genome is the typ...sonalized medicine where healthcare providers can ...
(Date:8/19/2008)...researchers began studying the environmental fate ... energy industry for decades, they did not expect ...s capable of converting hydrocarbons into natural ...aking processknown as anaerobic hydrocarbon metabo...n from older, more mature oil reservoirs like thos...
Breaking Biology News(10 mins):$2M grant awarded to University of Kentucky for research on nanoparticles and human health 2New insights into the regulation of PTEN tumor suppression function 2NHGRI seeks DNA sequencing technologies fit for routine laboratory and medical use 2NHGRI seeks DNA sequencing technologies fit for routine laboratory and medical use 3NHGRI seeks DNA sequencing technologies fit for routine laboratory and medical use 4NHGRI seeks DNA sequencing technologies fit for routine laboratory and medical use 5OU researchers isolate microorganisms that convert hydrocarbons to natural gas 2OU researchers isolate microorganisms that convert hydrocarbons to natural gas 3Neogen Launches Quickest Test Available for Tetracyclines in Milk 3257 1Neogen Launches Quickest Test Available for Tetracyclines in Milk 3257 2Kidney Cancer Drug Linked to Higher Rate of Heart Problems 11780 1Kidney Cancer Drug Linked to Higher Rate of Heart Problems 11780 2Kidney Cancer Drug Linked to Higher Rate of Heart Problems 11780 3Kidney Cancer Drug Linked to Higher Rate of Heart Problems 11780 4The Female Health Company Reports 37 25 Revenue Growth and Record Profits for First Quarter of FY2008 11777 1The Female Health Company Reports 37 25 Revenue Growth and Record Profits for First Quarter of FY2008 11777 2The Female Health Company Reports 37 25 Revenue Growth and Record Profits for First Quarter of FY2008 11777 3The Female Health Company Reports 37 25 Revenue Growth and Record Profits for First Quarter of FY2008 11777 4The Female Health Company Reports 37 25 Revenue Growth and Record Profits for First Quarter of FY2008 11777 5CryoLife to Present at Roth Capital Partners 20th Annual Orange County 28OC 29 Growth Stock Conference 3255 1CryoLife to Present at Roth Capital Partners 20th Annual Orange County 28OC 29 Growth Stock Conference 3255 2
...esearchers are calling for tighter controls on the...eefs, in letters to the international journal Scie...tists, including a team from the Department of Zoo...ion by governments to halt the unsustainable plund...s tropical coral reefs have battled for survival a...
...ertain variants of a simple sugar ameliorate Alzhe...udy by Canadian researchers. Although the new stud...uld lead to new therapies that prevent or delay th...show that some types of a sugar called cyclohexane...ulation of amyloid รข deposits, a hallmark of Alzhe...
...y sampling sea life in a heavily fished region off... jellyfish have actually overtaken fish in terms o.... The findings represent a careful quantitative an...n" after intense fishing in the area in the last f...ierley, of the University of St. Andrews, and his ...
...esearchers studying mutually beneficial interactio...ly gut microorganisms have shown that two common o...mount of calories harvested from a class of carboh... conducted in previously germ-free mice, colonizat...atter mice. Scientists at Washington University Sc...
Other Biology News:Researchers appeal for new regulations to save coral reefs from live fish trade 2Researchers appeal for new regulations to save coral reefs from live fish trade 3A sweet solution for Alzheimer's disease? 2A sweet solution for Alzheimer's disease? 3Jellyfish dominate fish in over-harvested Namibian waters 2Gut microbes' partnership helps body extract energy from food, store it as fat 2Gut microbes' partnership helps body extract energy from food, store it as fat 3Gut microbes' partnership helps body extract energy from food, store it as fat 4
(Date:8/20/2008)...FirstCall/ -- Eli Lilly and,Company (NYSE: LLY ) ...ion,of SGX Pharmaceuticals, Inc. (Nasdaq: SGXP ),...n drug discovery and development in the area,of on...s Special,Stockholders Meeting, in which a majorit... agreement with Lilly. Under the agreement, Lilly ...
(Date:8/20/2008)... and Caregivers, Grassroots ...ewswire-USNewswire/ -- Inc. Magazine has,named Sen...an for,low-income seniors, the number one fastest-...rt of Inc.,s annual list of the country,s 500 fast...1,000 percent from 2004 to 2007., "This is a rewa...
(Date:8/20/2008)...ll/ -- CEL-SCI CORPORATION,(Amex: CVM ) reports f...ing,June 30, 2008., The Company,s loss from opera...76,679 versus a loss of $3,776,263 during the same...ns for the nine months ended June 30, 2008,was $7,...e nine months in,2007., The net loss per common s...
(Date:8/20/2008).../ -- Huifeng Bio-Pharmaceutical,Technology, Inc (O...producer of plant extracts and pharmaceutical raw ... and food production, today announced it will,be i... August 19-21 in Rio,de Janeiro, Brazil., "Unpara...volved in the,pharmaceutical raw materials industr...
Breaking Biology Technology:Lilly Announces Completion of SGX Acquisition 2Inc. Magazine Names Senior Whole Health the Number One Fastest-Growing Private Company in US 2Inc. Magazine Names Senior Whole Health the Number One Fastest-Growing Private Company in US 3CEL-SCI CORPORATION Reports Third Quarter 2008 Financial Results 2CEL-SCI CORPORATION Reports Third Quarter 2008 Financial Results 3CEL-SCI CORPORATION Reports Third Quarter 2008 Financial Results 4CEL-SCI CORPORATION Reports Third Quarter 2008 Financial Results 5Huifeng Bio-Pharmaceutical (HFGB) to Attend CPhI South America 2008 Pharmaceutical Conference; The First CPhI Conference to be held in the Emerging Market of Brazil 2
..., , , , , , , High-qu...lows , efficient gene silencing in eukaryot... endogenous mRNA. This effect, termed RNA interfe...cing in functional genomics studies. Now, QIAGEN o...hesis service that includes a range of modificatio...
..., , , , , , , , ,...ation of RNA using the QuantiTect SYBR Green RT-PC...ng HotStarTaq DNA Polymerase with , a uniqu...scriptases. Sensiscript , RT is designed fo...ript , RT provides highly efficient reverse...
..., , , , , , , For pur...smid or cosmid DNA , , Features an...U/g plasmid DNA , Yields of up to 10 mg...y of plasmid DNA , Fast and simple proc... * Actual yields depend on plasmid copy number...
... , , , , , , , Fran...GEN GmbH, Hilden, Germany , , Prim...making genetic modification , of neuronal c...allenging , ( 1 ). Recently, Krichevsky and...enes in primary rat hippocampal and cortical neuro...
Other Biology Technology:Custom and library siRNA for efficient gene silencing 2Custom and library siRNA for efficient gene silencing 3Custom and library siRNA for efficient gene silencing 4Custom and library siRNA for efficient gene silencing 5EndoFree Plasmid Kits 2EndoFree Plasmid Kits 3EndoFree Plasmid Kits 4Efficient DNA transfection of primary CNS neurons using TransMessenger , Transfection Reagent 2Efficient DNA transfection of primary CNS neurons using TransMessenger , Transfection Reagent 3Efficient DNA transfection of primary CNS neurons using TransMessenger , Transfection Reagent 4Efficient DNA transfection of primary CNS neurons using TransMessenger , Transfection Reagent 5Efficient DNA transfection of primary CNS neurons using TransMessenger , Transfection Reagent 6
Hucal Agx Antigen Expression Service Specificity: Hucal Agx
The 1-D PAGE Cleavable ICAT Reagent Application Kit for Targeted Protein ID and Quantitation combines SDS PolyAcrylamide Gel Electrophoresis (PAGE), isotope-coded affinity tag chemistry, and cleavabl
Antibody Purification Specificity: Antibody Purification
Ultra-sensitive, non-radioactive detection of rat Big Endothelin-1 (Big ET-1)
Biology Products: