Navigation Links
A new indicator for breast cancer relapse identified
Date:6/19/2012

This press release is available in Spanish.

Researchers at the IMIM (Institut de Recerca Hospital del Mar) have proven that the absence of the 14-3-3 protein sigma in breast cancer cells is directly associated with these cells' capacity to activate the signalling of a protein complex called NF-kB, which is related to tumour progression. The activation of NF-kB in tumours was also identified as the best indicator for relapse in breast cancer patients, compared to other parameters currently used, such as the presence of affected ganglions or the tumour's size and degree. The investigators have also described a group of genes that are activated in breast cancer cells and that are also associated with a poor prognosis in other types of tumours.

Previous studies had detected that the 14-3-3 protein sigma was not present in the tumours of many breast cancer patients. They have now discovered that 'the lack of this protein does not in itself establish a prognosis factor for these types of cancer, although the NF-kB complex is an essential requirement for it to remain active chronically, as it is associated with tumour invasion and metastasis or, stated differently, the progression of the tumour', comments Llus Espinosa, study coordinator and researcher in the IMIM stem cells and cancer research group.

Breast cancer is most common among women in Western countries and relapse and metastasis are the fatal consequences of this disease. Identifying the mechanisms involved in the survival of breast cancer cells and their ability to colonise other tissues are crucial issues for improving treatment. With the participation of some 100 patients, this study analysed the possible usefulness of determining the lack of the 14-3-3 sigma and/or the activation of NF-kB in tumour cells as a factor in prognosis and diagnosis, as well as for future clinical and therapeutic a
'/>"/>

Contact: Marta Calsina
mcalsina@imim.es
34-933-160-680
IMIM (Hospital del Mar Research Institute)
Source:Eurekalert

Page: 1 2

Related biology news :

1. AAO-HNS releases updated Clinical Indicators
2. Researchers identify need to sample multiple tumor zones in breast cancer
3. UCSB anthropologists finds high levels of omega-3 fatty acids in breast milk of Amerindian women
4. Cardio fitness levels of breast cancer patients may affect survival
5. Newly discovered breast milk antibodies help neutralize HIV
6. Breast-fed babies gut microbes contribute to healthy immune systems
7. Heparin-like compounds inhibit breast cancer metastasis to bone
8. Blocking DNA: HDAC inhibitor targets triple negative breast cancer
9. Study sheds new light on importance of human breast milk ingredient
10. Molecule found that inhibits estrogen, key risk factor for endometrial and breast cancers
11. MicroRNA controls malignancy and resistance of breast cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... French . ... project, led by the Research Institute of the McGill ... new oral medication is showing significant progress in restoring ... now, this inherited retinal disease that causes visual impairment ... untreatable. The study is published today in the scientific ...
(Date:7/11/2014)... 2014--Researchers at the Department of Energy,s Oak Ridge ... presented by R&D Magazine in recognition of the ... recognize the tremendous value of our National Labs," ... development at the National Labs continues to help ... the scientific and technological innovations necessary to remain ...
(Date:7/11/2014)... Research awarded Michael F. Holick, PhD, MD, of Boston ... V. Avioli Award. Holick, a professor of medicine, physiology ... the understanding of vitamin D and its role in ... of the American Society for Bone and Mineral Research ... research. It is named for ASBMR,s first president and ...
Breaking Biology News(10 mins):MUHC researcher unveils novel treatment for a form of childhood blindness 2ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4BUSM's Michael F. Holick receives American Society for Bone and Mineral Research award 2
... for more than 50 years as one of the ... disorder. However, scientists have never been entirely sure ... from Cardiff University scientists suggests a possible mechanism for ... of the illness and potentially more effective treatments. ...
... obese people become salt sensitive and hypertensive has been ... They,ve documented a chain of events in which excess ... to retain more sodium and, consequently, more fluid and ... cardiologist at MCG,s Georgia Prevention Institute. Their findings ...
... carbon dioxide continues to burgeon in the atmosphere causing the ... to remove the excess gas from the atmosphere and store ... Gislason of the University of Iceland has been studying the ... basalt and presented his findings today to several thousand geochemists ...
Cached Biology News:Connection elucidated between obesity, salt sensitivity and high blood pressure 2Storing carbon dioxide deep underground in rock form 2
(Date:7/11/2014)... 11, 2014 /PRNewswire-iReach/ -- Maxim Peptide, a website that ... used solely in scientific experiments, is currently celebrating its ... business, Maxim Peptide, which was created by the founders ... and updated website that now features a special deals ... updated with fascinating articles about peptide research, including a ...
(Date:7/11/2014)... 11, 2014 EPFL and the University of  ... appointment of John P. Donoghue . The American ... Geneva . The new Wyss Center ... Geneva , has named as its ... John P. Donoghue , founder of Brown University,s Institute ...
(Date:7/10/2014)... 2014 Women in the West ... an additional family planning option. Sayana® Press has ... all levels of the health system and in ... widely used contraceptive—Pfizer’s Depo-Provera® (depot medroxyprogesterone acetate)—with the ... the first of four African countries expected to ...
(Date:7/10/2014)... Terascala, the industry leader in HPC management ... vice president of product management for Flexera Software, has ... Terascala’s software when combined with leading compute and storage ... and most reliable solutions for processing big data. , ... and broaden its product portfolio. His leadership in startups ...
Breaking Biology Technology:Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6Terascala Expands Executive Team 2Terascala Expands Executive Team 3
... ALS Lab Presents on Therapy Development StrategyCAMBRIDGE, Mass., ... (ALS TDI) has announced the 2009 launch of ... two-hour, interactive seminar is designed to inform and ... worldwide efforts to discover and develop effective treatments ...
... -- Genesis,Pharmaceuticals Enterprises, Inc. (OTC Bulletin Board: GNPH) ("Genesis" ... operations in the,People,s Republic of China, today announced its ... 2009 ended December 31, 2008. , , ... -- Revenue was $32.9 million, up 24.1% ...
... potential) of stem cells and accelerates development of ... announces today the introduction of its GT(TM) Flow ... Summit to be held in New York, NY. ... validated, scalable technology for customizing the biological activity ...
Cached Biology Technology:Seminar Will Bring ALS Researchers to Patient Groups 2Seminar Will Bring ALS Researchers to Patient Groups 3Genesis Pharmaceuticals Reports Results for the Second Quarter of its Fiscal Year 2009 2Genesis Pharmaceuticals Reports Results for the Second Quarter of its Fiscal Year 2009 3Genesis Pharmaceuticals Reports Results for the Second Quarter of its Fiscal Year 2009 4Genesis Pharmaceuticals Reports Results for the Second Quarter of its Fiscal Year 2009 5Genesis Pharmaceuticals Reports Results for the Second Quarter of its Fiscal Year 2009 6Genesis Pharmaceuticals Reports Results for the Second Quarter of its Fiscal Year 2009 7Genesis Pharmaceuticals Reports Results for the Second Quarter of its Fiscal Year 2009 8Genesis Pharmaceuticals Reports Results for the Second Quarter of its Fiscal Year 2009 9Genesis Pharmaceuticals Reports Results for the Second Quarter of its Fiscal Year 2009 10Genesis Pharmaceuticals Reports Results for the Second Quarter of its Fiscal Year 2009 11Genesis Pharmaceuticals Reports Results for the Second Quarter of its Fiscal Year 2009 12Genesis Pharmaceuticals Reports Results for the Second Quarter of its Fiscal Year 2009 13Genesis Pharmaceuticals Reports Results for the Second Quarter of its Fiscal Year 2009 14Genesis Pharmaceuticals Reports Results for the Second Quarter of its Fiscal Year 2009 15Genesis Pharmaceuticals Reports Results for the Second Quarter of its Fiscal Year 2009 16MaxCyte Introduces the GT(TM) Flow Transfection System for Application with Autologous and Allogeneic Stem Cell Therapies 2MaxCyte Introduces the GT(TM) Flow Transfection System for Application with Autologous and Allogeneic Stem Cell Therapies 3
...
...
...
DryStrip aligners, 4. Category: Electrophoresis Systems & Standards & Reagents, IEF & SDS-PAGE & 2-D Electrophoresis, Multiphor II Kits & Components and Accessories....
Biology Products: