Navigation Links
A new cellular garbage control pathway with relevance for human neurodegenerative diseases
Date:7/18/2014

This news release is available in German.

Proteins, the components of our body that execute, control and organize basically all functions in our cells, are made out of strings of amino acids, which like an origami - are folded into specific and complex three-dimensional structures according to their desired functions. However, since folding and maintaining of such structures is highly sensitive to cellular or environmental stress, proteins can potentially misfold or form clumps (aggregates). Such undesired protein waste can be toxic for cells and may even lead to cell death. Because several human neurodegenerative diseases are known to be linked to an accumulation of abnormal protein aggregates, basic science aimed to understand how cells remove cellular garbage is elementary for designing strategies for a potential prevention or cure of such disorders.

Scientists in the laboratory of Stefan Jentsch at the MPIB now successfully used baker's yeast for screening for new cellular waste disposal pathways. Kefeng Lu, a postdoctoral researcher from China, discovered a new class of helper proteins (termed CUET proteins) present both in yeast and humans that recognize cellular garbage earmarked for disposal by an attached label in the form of the ubiquitously existing protein known as "ubiquitin". Importantly, these newly identified helper proteins channel the cellular garbage by a "self-eating" pathway (autophagy) to the lysosome, a compartment of cells dedicated for destruction and recycling. The Max Planck scientists could also show that a toxic protein related to the abnormal, aggregate-forming protein "huntingtin" of patients with the neurodegenerative Huntington's disease is efficiently destroyed by the newly identified pathway. Remarkably, this pathway seems specific for aggregated proteins like huntingtin and appears to be more potent than previously discovered cellular garbage disposal mechanisms.

Because the identified cellular disposal mechanism operates in yeast as well, the researches will now take full advantage of its powerful experimental possibilities to investigate this pathway further. A detailed analysis of this mechanism will be crucial to understand how aggregate-forming proteins lead to human diseases and may help to develop concepts for possible disease preventions.


'/>"/>

Contact: Anja Konschak
konschak@biochem.mpg.de
0049-898-578-2824
Max Planck Institute of Biochemistry
Source:Eurekalert  

Related biology news :

1. Why anandamide can increase intracellular Ca2+ concentration?
2. Cellular defence against fatal associations between proteins and DNA
3. Cellular gates for sodium and calcium controlled by common element of ancient origin
4. Cellular team players
5. Researchers discover Trojan Horse method of penetrating cellular walls without harm
6. Family of proteins plays key role in cellular pump dynamics
7. Scientists capture most detailed images yet of humans tiny cellular machines
8. Which came first, bi- or tricellular pollen? New research updates a classic debate
9. UNC researchers link aging to cellular interactions that occur across generations
10. Organization of cellular photosystems
11. Protein rescues stuck cellular factories
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A new cellular garbage control pathway with relevance for human neurodegenerative diseases
(Date:4/5/2017)... Today HYPR Corp. , leading innovator ... of the HYPR platform is officially FIDO® Certified ... architecture that empowers biometric authentication across Fortune 500 enterprises ... over 15 million users across the financial services industry, ... product suites and physical access represent a growing portion ...
(Date:4/3/2017)... , April 3, 2017  Data captured ... engineering platform, detected a statistically significant association ... prior to treatment and objective response of ... potential to predict whether cancer patients will ... treatment, as well as to improve both pre-infusion ...
(Date:3/30/2017)... NEW YORK , March 30, 2017 ... by type (physiological and behavioral), by technology (fingerprint, AFIS, ... recognition, voice recognition, and others), by end use industry ... travel and immigration, financial and banking, and others), and ... Europe , Asia Pacific ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... States multicenter, prospective clinical study that demonstrates the accuracy of the FebriDx® ... identifying clinically significant acute bacterial and viral respiratory tract infections by testing ...
(Date:10/12/2017)... ... October 12, 2017 , ... AMRI, a ... biotechnology industries to improve patient outcomes and quality of life, will now be ... are being attributed to new regulatory requirements for all new drug products, including ...
(Date:10/11/2017)... ... 2017 , ... At its national board meeting in North ... the co-founder, CEO and chief research scientist of Minnesota-based Advanced Space Technology and ... ARCS Alumni Hall of Fame . ASTER Labs is a technology development ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
Breaking Biology Technology: