Navigation Links
A new cellular garbage control pathway with relevance for human neurodegenerative diseases
Date:7/18/2014

This news release is available in German.

Proteins, the components of our body that execute, control and organize basically all functions in our cells, are made out of strings of amino acids, which like an origami - are folded into specific and complex three-dimensional structures according to their desired functions. However, since folding and maintaining of such structures is highly sensitive to cellular or environmental stress, proteins can potentially misfold or form clumps (aggregates). Such undesired protein waste can be toxic for cells and may even lead to cell death. Because several human neurodegenerative diseases are known to be linked to an accumulation of abnormal protein aggregates, basic science aimed to understand how cells remove cellular garbage is elementary for designing strategies for a potential prevention or cure of such disorders.

Scientists in the laboratory of Stefan Jentsch at the MPIB now successfully used baker's yeast for screening for new cellular waste disposal pathways. Kefeng Lu, a postdoctoral researcher from China, discovered a new class of helper proteins (termed CUET proteins) present both in yeast and humans that recognize cellular garbage earmarked for disposal by an attached label in the form of the ubiquitously existing protein known as "ubiquitin". Importantly, these newly identified helper proteins channel the cellular garbage by a "self-eating" pathway (autophagy) to the lysosome, a compartment of cells dedicated for destruction and recycling. The Max Planck scientists could also show that a toxic protein related to the abnormal, aggregate-forming protein "huntingtin" of patients with the neurodegenerative Huntington's disease is efficiently destroyed by the newly identified pathway. Remarkably, this pathway seems specific
'/>"/>

Contact: Anja Konschak
konschak@biochem.mpg.de
0049-898-578-2824
Max Planck Institute of Biochemistry
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Why anandamide can increase intracellular Ca2+ concentration?
2. Cellular defence against fatal associations between proteins and DNA
3. Cellular gates for sodium and calcium controlled by common element of ancient origin
4. Cellular team players
5. Researchers discover Trojan Horse method of penetrating cellular walls without harm
6. Family of proteins plays key role in cellular pump dynamics
7. Scientists capture most detailed images yet of humans tiny cellular machines
8. Which came first, bi- or tricellular pollen? New research updates a classic debate
9. UNC researchers link aging to cellular interactions that occur across generations
10. Organization of cellular photosystems
11. Protein rescues stuck cellular factories
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A new cellular garbage control pathway with relevance for human neurodegenerative diseases
(Date:11/6/2014)... groundbreaking paper from a team of Florida State University ... plants could adapt to and survive environmental swings such ... the latest issue of the journal The Plant ... of DNA and proteins) is organized in a cell ... genes are turned on and others are turned off. ...
(Date:11/6/2014)... 2014 - Insilico Medicine, Inc, a Baltimore-based bioinformatics ... related diseases announced a research collaboration with the ... Oncology, Inc (OTC: CSBR). , "There are many ... but Champions Oncology,s TumorGraft technology is unique in ... regimen experimentally generating vast amounts of valuable data. ...
(Date:11/5/2014)... de Janeiro, Brazil -Individuals show great diversity in their ... males and females greatly differ in their perceptual evaluation ... of smell tests. , Sex differences in ... behaviors and may be connected to one,s perception of ... emotions. Thus, women,s olfactory superiority has been suggested to ...
Breaking Biology News(10 mins):Maize analysis yields whole new world of genetic science 2Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2The female nose always knows: Do women have more olfactory neurons? 2
... University of Michigan and Shanghai Jiao Tong University ... fund renewable energy and biomedical research projects involving ... the renewable-energy program is to develop new technologies ... on climate change. The biomedical collaboration will spur ...
... University Park, Pa. -- A mass spectrometer ... history of the Earth system will join other ... Laboratory, thanks to a $724,000 grant through the ... Fantle, assistant professor of geoscience, is the principal ...
... NC If scientists have identified some two million ... the tree of life that unites them all? A ... state-of-the-art knowledge about the evolutionary relationships among living things. ... scientists store, share, and study evolutionary trees was ...
Cached Biology News:U-M joins with Chinese university to jointly fund renewable energy and biomedical research projects 2New aid to biogeochemical research slated for materials characterization lab 2Database gives access to the latest findings about the tree of life 2Database gives access to the latest findings about the tree of life 3
(Date:11/22/2014)... Colo. (PRWEB) November 21, 2014 ... proprietary cloud based analytics and scientific testing methodologies relating ... commitment for a $750,000 line of credit from an ... extremely pleased to have secured this commitment from one ... Executive Officer of CannLabs. “This capital will help accelerate ...
(Date:11/22/2014)... November 22, 2014 The “Chiral ... Preparative), by Material (Metal, Glass, Plastic), by Application ... SFC] - Forecast to 2018” analyses and studies ... in North America, Europe, Asia, and Rest of ... and 15 figures spread through 135 pages and ...
(Date:11/22/2014)... --   , ... KLOX    Mariano Rodriguez ... bestellt    KLOX ist bestens vorbereitet, ... Behandlungssystems zur Wundheilung zu beginnen    , ... erfreut, die folgenden personellen Veränderungen anzukündigen: ...
(Date:11/21/2014)... USA (PRWEB) November 19, 2014 The ... our lives was shared with more than 200 primary ... postgraduate students from the University of Otago Physics Department ... . The Otago students, members of the university’s OSA/SPIE ... Zealand in early September, giving children from small, rural ...
Breaking Biology Technology:CannLabs Secures $750,000 Line Of Credit 2Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 2Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 3Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 4Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 5KLOX Technologies meldet Neubesetzung von Führungspositionen 2KLOX Technologies meldet Neubesetzung von Führungspositionen 3KLOX Technologies meldet Neubesetzung von Führungspositionen 4KLOX Technologies meldet Neubesetzung von Führungspositionen 5Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3
... 7, 2011 IBM,s (NYSE: IBM ) announcement ... seek out and destroy drug-resistant bacteria caps off a ... Earlier this week, scientists from IBM Research ... nanoparticles that are physically attracted like magnets to MRSA ...
... 7, 2011 Wound Management Technologies, Inc., ( OTCQB: ... advanced wound care solutions, today announced that its Pharma ... within key international markets, has received new orders for ... In Lebanon, the subsidiary just completed a $50,000 order ...
... 5, 2011 A new drug is effective in preventing ... to the disease. These patients with basal cell nevus ... locally invasive or metastatic, according to a discussion presented by ... annual meeting of the American Association for Cancer Research (AACR). ...
Cached Biology Technology:IBM's MRSA Infection-Fighting Nanotechnology Caps Century of Healthcare Innovation 2IBM's MRSA Infection-Fighting Nanotechnology Caps Century of Healthcare Innovation 3IBM's MRSA Infection-Fighting Nanotechnology Caps Century of Healthcare Innovation 4WNDM Secures Additional International Sales; $150 K in New Orders for 2011 2WNDM Secures Additional International Sales; $150 K in New Orders for 2011 3New drug is effective against the most common form of skin cancer 2
RNA polymerase sigma 70 Immunogen: Recombinant, full length protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Anti-Dardarin Immunogen: Synthetic peptide from rat LRRK2. Available Date: 38814...
Rat monoclonal to UGGT ( Abpromise for all tested applications)....
... Rabbit polyclonal to MSY2/YBOX2 ( ... Antigen: Synthetic ... to the C-terminus of Human MSY2/YBOX2. ... is proprietary) (Peptide ...
Biology Products: