Navigation Links
A new avenue to better medicines: Metal-peptide complexes
Date:7/9/2012

Researchers at the RUB and from Berkeley have used metal complexes to modify peptide hormones. In the Journal of the American Chemical Society, they report for the first time on the three-dimensional structure of the resulting metal-peptide compounds. "With this work, we have laid the molecular foundation for the development of better medicines" says Prof. Raphael Stoll from the Faculty of Chemistry and Biochemistry at the Ruhr-University. The team examined hormones that influence the sensation of pain and tumour growth.

Peptide hormones have many functions in the body

Hormones consisting of amino acids, the peptide hormones, convey bodily sensations such as pain and hunger, but also transmit growth signals. One example of this is insulin, which is important for the control of blood sugar levels. In interaction with specific receptors, the G-protein-coupled receptors, peptide hormones transport their messages to the cells. The hormones can be specifically chemically modified so that their effect changes, for example pain tolerance is lowered, or tumour growth inhibited. The German-Californian group of researchers has now found a new way to modify peptide hormones.

Metal complexes react with various peptide hormones

The first time they used a metal complex, namely, a rhodium compound, which reacts with the amino acid tyrosine. The precious metal rhodium is used as a catalyst in the synthesis of highly complex medicinal substances in the research laboratory as well as in industrial plants. Among other things, the researchers analysed the peptide hormone encephalin, which is important for the sensation of pain, and octreotide. The latter is a synthetic derivative of the growth hormone somatostatin, approved as a medicinal substance and already used in the treatment of certain tumours. The reaction with the metal complex was highly selective. Although the hormones consist of hundreds of atoms, the rhodium c
'/>"/>

Contact: Prof. Dr. Nils Metzler-Nolte
nils.metzler-nolte@rub.de
49-234-322-4153
Ruhr-University Bochum
Source:Eurekalert

Page: 1 2

Related biology news :

1. Physics confirms sprinters are performing better than ever before
2. Not-so-precious: Stripping gold from AFM probes allows better measurement of picoscale forces
3. Screening horticultural imports: New models assess plant risk through better analysis
4. Arsenic for better drugs and cleaner crops
5. Better looking birds have more help at home with their chicks
6. Evaluation of microscopy techniques may help scientists to better understand ancient plants
7. New Tool Helps Drug Developers Optimize Their Research and Target Development for Better Results and a Stronger Competitive Edge
8. Better plants for biofuels
9. Better housing conditions for zebrafish could improve research results
10. Bigger gorillas better at attracting mates and raising young
11. Modern hybrid corn makes better use of nitrogen, study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... October 2014 Psychological stress and stress-related psychiatric disorders ... diseases, but the molecular mechanisms underlying this ... contribute to the development of targeted preventive ... these devastating diseases. This work is presented ... in Berlin., Now an international group of ...
(Date:10/17/2014)... news release is available in German . ... millions of sperms every day in order to reproduce? And ... are the topic of the latest issue of the research ... 2014). The evolutionary biologist Steven Ramm from Bielefeld University Bielefeld ... it is not unusual for a female to copulate with ...
(Date:10/16/2014)... Virginia Institute of Marine Science have received a ... to identify the streams and wetlands most vulnerable ... help local governments and citizens conserve these important ... dataset of tidal-marsh observations first gathered by VIMS ... baseline can today,s researchers accurately map the slow ...
Breaking Biology News(10 mins):Researchers find why depression and aging linked to increased disease risk 2Sperm wars 2EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3
... On April 15, 2010 , Dr. Stipkala joined a panel ... hosted by the University of South Carolina ,s NanoCenter in ... capitalists from all over the Southeast who are active in the nanotechnology ... Dr. Stipkala and ...
... Bethesda, MD The Genetics Society of America is ... selected for poster awards at the 51st Annual Drosophila ... were selected for first, second and third place awards ... undergraduate. This was the first time that undergraduate student ...
... YORK (April 25, 2010) -- Researchers at the ... Psychiatry at Weill Cornell Medical College discovered that ... behaviors. The genetically altered mice, which behaved much ... disorder (OCD), could help scientists design new therapies ...
Cached Biology News:Dr. Jeremy M. Stipkala, Patent Attorney, Speaks on USC NanoCenter Panel 2Genetics Society of America announces award recipients at 51st Annual Drosophila Conference 2Weill Cornell researchers find that a single gene is responsible for OCD-like behaviors in mice 2Weill Cornell researchers find that a single gene is responsible for OCD-like behaviors in mice 3Weill Cornell researchers find that a single gene is responsible for OCD-like behaviors in mice 4
(Date:10/22/2014)... DUBLIN , Oct. 22, 2014 ... "Organic Electronics Market by Material, by Application, Geography ... report to their offering. Organic electronics, ... a branch of material science which deals with small ... as organic because small molecules and polymers are carbon ...
(Date:10/20/2014)... 2014 Convey Computer , the ... from Iowa State University won first place in the ... Convey HC-2ex, the team’s solution achieved the highest overall ... the second place finisher. , Experts from all segments ... month long challenge, using a variety of design tools, ...
(Date:10/20/2014)... Oct. 20, 2014  GenVec, Inc. (NASDAQ: GNVC ... , Ph.D., from its board of directors effective on October ... 2003, and served as its chairman from June 2006 to ... Nominating and Corporate Governance and Audit Committees of the board.  ... a decade of dedicated service to GenVec, and its stockholders," ...
(Date:10/20/2014)... Local veterinary surgeon, Dr. Tim McCarthy is ... donor stem cells for dogs with osteoarthritis. Dr. McCarthy ... performed clinical stem cell therapy for 7 years. The ... a single injection of donor stem cells into one ... and inflammation in the treated joints. , Candidates ...
Breaking Biology Technology:Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 2Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 3Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3Zola P. Horovitz To Retire From GenVec Board 2Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2
... China, May 15, 2012 BGI, one of ... Roche GS FLX+ System has been successfully installed at its ... existing array of short read sequencing technologies and enhance BGI,s ... developed by 454 Life Sciences, a Roche Company, features the ...
... (Santa Barbara, Calif.) Imagine an LED light with 20 ... that can generate, transmit, and store data 100 times faster ... planet be if we could turn waste heat into electricity, ... more efficient, and more accessible? The (IEE) at ...
... 14, 2012  More than one billion people worldwide have a ... the ability of the lens in the eye to change ... others struggle with trying to read menus and newspapers. Maybe ... this change in vision, which often begins around age 40, ...
Cached Biology Technology:BGI Installs Roche GS FLX+ System to Enhance Long Read Sequencing Capabilities for Genome and Transcriptome Research 2BGI Installs Roche GS FLX+ System to Enhance Long Read Sequencing Capabilities for Genome and Transcriptome Research 3Oracle chairman Jeff Henley makes $50 million gift to UC Santa Barbara 2Oracle chairman Jeff Henley makes $50 million gift to UC Santa Barbara 3Oracle chairman Jeff Henley makes $50 million gift to UC Santa Barbara 4New Daily Disposable Multifocal Contact Lenses from CooperVision Offer Comfort, Performance, Health, and Convenience to Fit Your Life 2New Daily Disposable Multifocal Contact Lenses from CooperVision Offer Comfort, Performance, Health, and Convenience to Fit Your Life 3
Biotin d anti-mouse Tim-1...
Mouse monoclonal [1-N-14] to Adenovirus Type 7 hexon C11 Immunogen: Purified Adenovirus type 7 Specificity: This antibody is specific for Adenovirus type 7 hexon C11....
Request Info...
... is the main excitatory neurotransmitter in the ... considered to act only on the ligand-gated ... that are involved in the fast excitatory ... to regulate enzymes producing second messengers via ...
Biology Products: