Navigation Links
A new ally in the battle against cocaine addiction
Date:1/2/2010

A recent study shows that a bacterial protein may help cocaine addicts break the habit.

Cocaine esterase (CocE) is a naturally-occurring bacterial enzyme that breaks down cocaine, thereby reducing its addictive properties. The efficacy of CocE in animals and its suitability for treatment of addiction has been limited by its short half-life in the body.

A recent study, published in the Journal of Pharmacology and Experimental Therapeutics and reviewed by Faculty of 1000 Medicine's Friedbert Weiss, demonstrates that a more stable version of CocE, double mutant or DM CocE, significantly decreased the desire for cocaine and prevented death from cocaine overdose.

In the study, rats were trained to self-administer cocaine by pressing a button in their cage, mimicking the need for regular doses of the drug during addiction. Rats treated with the double mutant form of CocE pressed the button to receive cocaine less often, suggesting that DM-CocE broke down the drug and dampened addiction.

DM-CocE decreased the rats' urge for cocaine but not for an addictive analogue, highlighting the degree of specificity for cocaine. Weiss notes that the DM-CocE enzyme also provides "long-lasting protection" against the toxic effects of a potentially lethal dose.

Though the effects of CocE can be overcome by a sufficiently large dose of cocaine, the present findings suggest that CocE has great promise as a drug abuse treatment.

Weiss says, "These therapeutic approaches may therefore not be "fail-safe" for reducing cocaine intake by determined users" but "long-acting forms of CocE represent potentially valuable treatment approaches not only for the prevention of cocaine-induced toxicity but also for ongoing cocaine abuse in humans."


'/>"/>

Contact: Steve Pogonowski
press@f1000.com
Faculty of 1000: Biology and Medicine
Source:Eurekalert

Page: 1

Related biology news :

1. Stem cells battle for space
2. Nanoparticle-based battlefield pain treatment moves a step closer
3. Battle of the sexes benefits offspring, says research
4. The battle for CRTC2: How obesity increases the risk for diabetes
5. Queens scientists find new way to battle MRSA
6. Carbon sinks losing the battle with rising emissions
7. Researchers identify potential new weapon in battle against HIV infection
8. Color My Pyramid nutrition education program battles obesity in DC schools
9. In Vietnam, alongside progress, a battle for life
10. LSU and Ohio State battle on football field, collaborate in research field
11. In promiscuous antelopes, the battle of the sexes gets flipped
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... , April 13, 2017 According to a ... Identity Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment ... the IAM Market is expected to grow from USD 14.30 Billion in ... Rate (CAGR) of 17.3%. ... MarketsandMarkets Logo ...
(Date:4/6/2017)... , April 6, 2017 ... RFID, ANPR, Document Readers, by End-Use (Transportation & Logistics, ... Facility, Oil, Gas & Fossil Generation Facility, Nuclear Power), ... Educational, Other) Are you looking for a ... sector? ...
(Date:4/3/2017)... , April 3, 2017  Data captured ... engineering platform, detected a statistically significant association ... prior to treatment and objective response of ... potential to predict whether cancer patients will ... treatment, as well as to improve both pre-infusion ...
Breaking Biology News(10 mins):
(Date:4/21/2017)... ... April 21, 2017 , ... Having worked on the design ... is pleased to introduce it to top lab design architects from around the country ... and VP of Industrial Design and Engineering Greg Casey will be at the show, ...
(Date:4/21/2017)... ... April 21, 2017 , ... The impressively wide ... of researchers, engineers, product developers, and industry suppliers gathered last week for ... SPIE, the international society for optics and photonics , the event drew nearly ...
(Date:4/21/2017)... ... April 21, 2017 , ... Frederick Innovative ... range of emerging bio and technology start-ups, is hosting “Celebration Friday” (a festive ... event will start with libations and networking at 3:30 p.m. at FITCI’s 4539 ...
(Date:4/20/2017)... ... April 20, 2017 , ... ... this new webinar will explore challenging patient cases when screening for direct oral ... there may be a need for bridging parental anticoagulation especially for those at ...
Breaking Biology Technology: