Navigation Links
A new DNA vaccine induces a Th2 immune response in Alzheimer's disease mice
Date:10/29/2013

Amyloid-beta (Aβ) active immunization in Alzheimer's disease can increase the rate of Aβ clearance, and delay cognitive dysfunction, but it is easy to induce meningoencephalitis, which may be related to activation of Th1 lymphocytes. To enhance anti-Aβ antibody generation and induce a Th2 immune response, Prof. Yunpeng Cao and team from the First Affiliated Hospital of China Medical University, China constructed a new DNA vaccine p(Aβ310)10-C3d-p28.3 encoding ten repeats of Aβ310 and three copies of C3d-p28 as a molecular adjuvant. The researchers administered this adjuvant intramuscularly to female C57BL/6J mice at 810 weeks of age, and found that the p(Aβ310)10-C3d-p28.3 vaccine induced high titers of anti-amyloid-β antibodies, which bound to Aβ plaques in APP/PS1 transgenic mouse brain tissue, demonstrating that the vaccine is effective against plaques in a mouse model of Alzheimer's disease. Moreover, the vaccine elicited a predominantly IgG1 humoral response and low levels of interferon-γ in ex vivo cultured splenocytes, indicating that the vaccine could shift the cellular immune response towards a Th2 phenotype. This indicated that the vaccine did not elicit a detrimental immune response and had a favorable safety profile. These findings were published in the Neural Regeneration Research (Vol. 8, No. 27, 2013).


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert

Page: 1

Related biology news :

1. Queens scientists seek vaccine for Pseudomonas infection
2. In search for a vaccine, IU biologist receives $2.3 million to explore chlamydia genomics
3. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
4. SFU HIV/AIDS vaccine research gets financial boost
5. Researchers identify Achilles heel of dengue virus, target for future vaccines
6. AAPS National Biotechnology Conference to highlight innovative vaccines
7. Army study: DNA vaccine and duck eggs protect against hantavirus disease
8. Sensitive test helps improve vaccine safety
9. Overweight? Theres a vaccine for that
10. Vaccine and antibiotics stabilized so refrigeration is not needed -- NIH study
11. Scripps Research Institute wins $77 million to develop AIDS vaccine center
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, a ... authentication solutions, today announced that it has been ... Research Projects Activity (IARPA) to develop next-generation Presentation ... "Innovation has been a driving force ... program will allow us to innovate and develop ...
(Date:4/5/2017)... 5, 2017  The Allen Institute for Cell Science ... a one-of-a-kind portal and dynamic digital window into the ... the first application of deep learning to create predictive ... lines and a growing suite of powerful tools. The ... and future publicly available resources created and shared by ...
(Date:3/30/2017)... LOS ANGELES , March 30, 2017  On ... Hack the Genome hackathon at ... This exciting two-day competition will focus on developing health ... experience. Hack the Genome is ... has been tremendous. The world,s largest companies in the ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... and Bethesda, MD (PRWEB) , ... April 20, ... ... Innovation announce the formation of a unique intellectual property (IP) sharing and commercialization ... of their most promising inventions. A main component of this effort is bringing ...
(Date:4/20/2017)... For today, Stock-Callers.com redirects investors, attention to Biotechnology, ... research aimed at treating diseases and medical conditions. Under evaluation ... (NASDAQ: KERX), Kite Pharma Inc. (NASDAQ: KITE), and ZIOPHARM Oncology ... complimentary research reports on these stocks now at: ... http://stock-callers.com/registration Biostage ...
(Date:4/19/2017)... ... 18, 2017 , ... Alisa Wright, founder and CEO of Singota Solutions ... of Pharmacy in Lafayette, Indiana. , The Distinguished Alumni Award was established in ... and other scientific endeavors. , Wright began her career in the pharmaceutical industry ...
(Date:4/19/2017)... , ... April 19, 2017 , ... ... Series A-1 financing round. This event adds to several other early achievements at ... Executive and Scientific Teams. , ThermaGenix will use proceeds from the ...
Breaking Biology Technology: