Navigation Links
A new DNA vaccine induces a Th2 immune response in Alzheimer's disease mice
Date:10/29/2013

Amyloid-beta (Aβ) active immunization in Alzheimer's disease can increase the rate of Aβ clearance, and delay cognitive dysfunction, but it is easy to induce meningoencephalitis, which may be related to activation of Th1 lymphocytes. To enhance anti-Aβ antibody generation and induce a Th2 immune response, Prof. Yunpeng Cao and team from the First Affiliated Hospital of China Medical University, China constructed a new DNA vaccine p(Aβ310)10-C3d-p28.3 encoding ten repeats of Aβ310 and three copies of C3d-p28 as a molecular adjuvant. The researchers administered this adjuvant intramuscularly to female C57BL/6J mice at 810 weeks of age, and found that the p(Aβ310)10-C3d-p28.3 vaccine induced high titers of anti-amyloid-β antibodies, which bound to Aβ plaques in APP/PS1 transgenic mouse brain tissue, demonstrating that the vaccine is effective against plaques in a mouse model of Alzheimer's disease. Moreover, the vaccine elicited a predominantly IgG1 humoral response and low levels of interferon-γ in ex vivo cultured splenocytes, indicating that the vaccine could shift the cellular immune response towards a Th2 phenotype. This indicated that the vaccine did not elicit a detrimental immune response and had a favorable safety profile. These findings were published in the Neural Regeneration Research (Vol. 8, No. 27, 2013).


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert

Page: 1

Related biology news :

1. Queens scientists seek vaccine for Pseudomonas infection
2. In search for a vaccine, IU biologist receives $2.3 million to explore chlamydia genomics
3. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
4. SFU HIV/AIDS vaccine research gets financial boost
5. Researchers identify Achilles heel of dengue virus, target for future vaccines
6. AAPS National Biotechnology Conference to highlight innovative vaccines
7. Army study: DNA vaccine and duck eggs protect against hantavirus disease
8. Sensitive test helps improve vaccine safety
9. Overweight? Theres a vaccine for that
10. Vaccine and antibiotics stabilized so refrigeration is not needed -- NIH study
11. Scripps Research Institute wins $77 million to develop AIDS vaccine center
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... 2015 According to a new ... Assessment Type (Pen & Paper Based, Hosted, Biometrics), Service, ... Academic Research), Vertical and Region - Global Forecast to ... to grow from USD 2.4 Billion in 2015 to ... Growth Rate (CAGR) of 25.6% from 2015 to 2020. ...
(Date:8/24/2015)...  Based on its recent analysis of the biometric products ... Biometrics Company of the Year Award. DERMALOG is the leading ... Africa . It has particularly gained prominence ... one of the largest biometric mass applications in the world, ... Bank of Nigeria with its biometric ...
(Date:8/19/2015)... , Aug. 19, 2015  VOXX International Corporation ... has entered into a Definitive Agreement to purchase ... iris authentication market leader EyeLock through an acquiring ... have a controlling interest in the acquiring entity. ... completion of due diligence.  Expanding on its existing ...
Breaking Biology News(10 mins):Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 2Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 3Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 4Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 2Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 3Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 4Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 5Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 6VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 2VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 3VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 4VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 5
... down the biological trigger that gives rise to ... that can cause blindness and deafness. The findings ... lead to new treatments for osteoporosis and other ... Lawrence Livermore and Lawrence Berkeley national laboratories, the ...
... the common cold because there is scant evidence they ... the risks, according to a new systematic review of ... in the treatment of acute upper respiratory tract infections," ... the University of Auckland, New Zealand. "The implications for ...
... immunologists studying mast cells, known to play a central ... hormone-like molecule that can kill these cells by programming ... The findings move researchers another step closer to understanding ... researchers develop new treatments for allergy and inflammatory responses ...
Cached Biology News:Researchers track down cause of a disfiguring bone disorder 2Researchers track down cause of a disfiguring bone disorder 3Doctors should stop prescribing antibiotics for the common cold, review advises 2VCU study shows hormone-like molecule kills cells that cause inflammation in allergic disease 2
(Date:9/2/2015)... -- Research and Markets ( ... PharmaBiotech,s new report "Biochips and Microarrays - ... This report is an analysis of ... report starts with a description of technologies as ... array comparative genomic hybridization (CGH), copy number variation ...
(Date:9/2/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cqsxmg/gene_therapy ) ... "Gene Therapy - Technologies, Markets and Companies" ... therapy are difficult to estimate as there is only ... in China since 2004. Gene ... estimates are based on epidemiology of diseases to be ...
(Date:9/2/2015)... Mass. (PRWEB) , ... September 02, 2015 , ... ... includes development of botanical and plant-derived compounds. BCC Research reveals in its ... past 2020 because this market defines the category and generates the most market ...
(Date:9/2/2015)... Aytu BioScience, Inc. (OTCQB: AYTU), a specialty ... related conditions, announced today that it has closed the ... financing, raising a total of $5.175 million, which includes ... Josh Disbrow , Chief Executive Officer ... intended to be used to conduct clinical studies for ...
Breaking Biology Technology:Global Biochips and Microarrays Technologies, Markets and Companies Report 2015 with Market Size in 2014 and Projected Value for the Years 2019 and 2024 2Global Gene Therapy Market Study 2015-2024 - Technologies, Markets and Companies Analysis 2Plant-derived Compounds Poised to Assume Greater Role in Global Drug Markets, According to BCC Research 2Plant-derived Compounds Poised to Assume Greater Role in Global Drug Markets, According to BCC Research 3Aytu BioScience Completes $5.175 Million Private Placement 2Aytu BioScience Completes $5.175 Million Private Placement 3
... 13 ,Exelixis, Inc. (Nasdaq: EXEL ) today announced ... common stock. The net proceeds of the,offering are approximately ... shares in the offering are being sold by,Exelixis. Exelixis ... up to an additional 1,050,000 shares of common stock. ...
... PITTSBURGH, Sept. 13 The Pittsburgh Life ... region,s life,sciences industry on a fast track ... and Chief Executive Officer, Renal Solutions, Inc., ... Initiatives, UPMC, John,L. Miclot, President and Chief ...
... September 13 In order,to meet its obligations under ... ("Shire") (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ) is,publishing today ... June 2007,in accordance with International Financial Reporting Standards (IFRS). ... 2007, Shire announced its results in,respect of the same ...
Cached Biology Technology:The Pittsburgh Life Sciences Greenhouse Elects Four New Members to Its Board of Directors 2The Pittsburgh Life Sciences Greenhouse Elects Four New Members to Its Board of Directors 3IFRS Information - First Half of 2007 2IFRS Information - First Half of 2007 3IFRS Information - First Half of 2007 4IFRS Information - First Half of 2007 5IFRS Information - First Half of 2007 6IFRS Information - First Half of 2007 7IFRS Information - First Half of 2007 8IFRS Information - First Half of 2007 9IFRS Information - First Half of 2007 10IFRS Information - First Half of 2007 11IFRS Information - First Half of 2007 12IFRS Information - First Half of 2007 13IFRS Information - First Half of 2007 14IFRS Information - First Half of 2007 15IFRS Information - First Half of 2007 16IFRS Information - First Half of 2007 17IFRS Information - First Half of 2007 18IFRS Information - First Half of 2007 19IFRS Information - First Half of 2007 20IFRS Information - First Half of 2007 21IFRS Information - First Half of 2007 22IFRS Information - First Half of 2007 23IFRS Information - First Half of 2007 24IFRS Information - First Half of 2007 25IFRS Information - First Half of 2007 26IFRS Information - First Half of 2007 27IFRS Information - First Half of 2007 28IFRS Information - First Half of 2007 29IFRS Information - First Half of 2007 30IFRS Information - First Half of 2007 31IFRS Information - First Half of 2007 32IFRS Information - First Half of 2007 33
ANTI S. ENTERID LPS...
B.D. Hames and D.M. Glover (1996) • This issue covers T-Cell antigen receptor genes; T-Lymphocyte signal transduction; B-Cell activation antibody engineering and the complement system and other ...
Request Info...
RABBIT ANTI PORCINE CARBOXYPEPTIDASE B...
Biology Products: