Navigation Links
A mother's genes influence her child's aging
Date:8/22/2013

nt at birth.

In ageing research, mitochondria have been scrutinized by researchers for a long time already. The mitochondria in a cell contain thousand of copies of a circular DNA genome. These encode, for instance, proteins that are important for the enzymes of the respiratory chain. Whereas the DNA within the nucleus comes from both parents, the mitochondrial DNA only includes maternal genes, as mitochondria are transmitted to offspring via the oocyte and not via sperm cells. As the numerous DNA molecules within a cell's mitochondria mutate independently from each other, normal and damaged mtDNA molecules are passed to the next generation.

To examine which effects mtDNA damage exerts on offspring, researchers used a mouse model. Mice that inherited mutations of mtDNA from their mother not only died quicker compared to those without inherited defects, but also showed premature ageing effects like reduced body mass or a decrease in male's fertility. Moreover, these rodents were prone to heart muscle disease.

As the researchers discovered, mutations of mtDNA not only can accelerate ageing but also impair development: In mice that, in addition to their inherited defects, accumulated mutations of mtDNA during their lifetime, researchers found disturbances of brain development. They conclude that defects of mtDNA that are inherited and those that are acquired later in life add up and finally reach a critical number.

"Our findings shed light on the ageing process and strongly suggest that the mitochondria play a key role in ageing. They also show that it is important to reduce the number of mutations," says Larsson. However, the question of whether it is possible to affect the degree of mtDNA damage through, for example, lifestyle intervention is yet to be investigated. In the future, the scientists want to investigate whether a reduced number of mutations can actually increase lifespan in model organisms such as fruit flies and mice.
'/>"/>

Contact: Nils-Göran Larsson
larsson@age.mpg.de
49-221-478-89771
Max-Planck-Gesellschaft
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Bright birds make good mothers
2. Offspring of mothers stressed during pregnancy with a passive stress coping style more prone to obesity
3. Female mice exposed to BPA by mothers show unexpected characteristics
4. Privacy a problem for mothers of newborns in neonatal intensive care units, CWRU study finds
5. Nursing gerbils unravel benefit of multiple mothers in collective mammals
6. Grant funded to improve mothers nutrition before pregnancy and impact on baby
7. Infants of overweight mothers grow more slowly
8. Montreal researchers repel mortality in Malian mothers
9. Multiple genes manage how people taste sweeteners
10. Fetal stress disrupts the way genes are transmitted
11. Be happy: Your genes may thank you for it
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... DUBLIN , Jan. 22, 2015 Research and ... the addition of the "Global Wearable Technologies ... Growth, Share, Overview, Trends and Forecast 2014-2020" ... Wearable Technologies are smart devices that can be ...
(Date:12/22/2014)... Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces it has ... for the 2015 International CES debut of the Wocket™ ... will be at the NXT-ID booth January 6th and 7 ...
(Date:12/19/2014)... 18, 2014 Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) ... North America Perimeter Security Systems Market" report to their ... The North American perimeter security market is estimated to grow ... the U.S. market holds a larger share in this market, ...
Breaking Biology News(10 mins):Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3
... comprehensive marine biodiversity observation network could be established with ... assessment published in the May 2013 issue of ... major gaps in scientists, understanding of the global distribution ... climate change, pollution, habitat destruction, and overfishing. The network ...
... seafood as "sustainable" by the nonprofit Marine Stewardship Council ... consortium of researchers has found. "When consumers want ... demand: fisheries can become more sustainable or the definition ... meaninglesswith MSC seafood, the definition has been repeatedly watered ...
... a variety of essential functions such as DNA replication, ... of proteins expressed in an organism at a given ... While the genome of an organism remains relatively stable, ... cell and even within a single cell and changing ...
Cached Biology News:'Sustainable fishing' certification too lenient and discretionary, study finds 2'Sustainable fishing' certification too lenient and discretionary, study finds 3Metabolic fingerprinting: Using proteomics to identify proteins in gymnosperm pollination drops 2
(Date:1/22/2015)... Switzerland (PRWEB) January 22, 2015 Selexis ... characterized mammalian Research Cell Banks (RCBs) used for drug ... Research Cell Banks will include Next-Generation Sequencing ... genetic architecture de-risks biologic manufacturing by ensuring the integrity ...
(Date:1/22/2015)... Jan. 22, 2015   Cypher Genomics, Inc., ... (NASDAQ: SQNM ), the leading molecular ... next generation noninvasive prenatal tests (NIPT). Through this ... called Mantis™, to advance analysis of clinically-relevant fetal ...
(Date:1/22/2015)... , Jan. 22, 2015  Derma Sciences, Inc. (Nasdaq: ... focused on advanced wound care, announces that AMNIOEXCEL® ... have been added to the Premier, Inc. Regenerative ... opportunity for the AMNIOEXCEL® and AMNIOMATRIX® product lines, ...
(Date:12/24/2014)... and NEW YORK , Dec. 24, 2014 ... advancing patient care in critical areas, announced the closing of ... and warrants to purchase up to an aggregate 3,500,000 shares ... share and $.01 per warrant.  The warrants have a per ...
Breaking Biology Technology:Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3
... ... ... Writers Association named medical writer, Rita Buckley, Writer/Owner of medical writing firm ... received the awards for The Lehman Series Expert Panel on Weight Loss Surgery, published ...
... the ability of researchers to examine biological specimens, ... recent advances in X-ray diffraction methods have helped ... While significant progress has been made in ... techniques rely on fluorescent labeling technologies, which prohibit ...
... BioMed Realty Trust, Inc. (NYSE: BMR ) today announced that its ... per share of common stock, representing a 7.1% increase over the company,s first quarter ... annualized dividend of $0.60 per common share. , ... BioMed also announced that its board of directors has declared a dividend ...
Cached Biology Technology:Medical Writer Rita Buckley Wins Awards for Excellence in Medical Communication 2Medical Writer Rita Buckley Wins Awards for Excellence in Medical Communication 3Researchers use X-ray diffraction microscope to reveal 3-D internal structure of whole cell 2Researchers use X-ray diffraction microscope to reveal 3-D internal structure of whole cell 3BioMed Realty Trust Declares Second Quarter 2010 Common Stock and Preferred Stock Dividends 2BioMed Realty Trust Declares Second Quarter 2010 Common Stock and Preferred Stock Dividends 3