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A molecular switch turns on the flame in 'nature's blowtorch'
Date:5/29/2008

ducts are free to leave.

After another substrate molecule and oxygen move into the active site, the cycle can repeat. The reorientation of a single peptide bond, an event called an "isomerization," thus acts as a molecular switch, moving the P450 between safe and active forms while protecting the P450 and its environment from accidental oxidative damage.


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Contact: Laura Gardner
gardner@brandeis.edu
781-736-4204
Brandeis University
Source:Eurekalert

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