Navigation Links
A miR boost enables acute leukemia cells to mature
Date:4/3/2009

cks DNMT1 also, but indirectly," Garzon says.

The miR, it turns out, targets another protein called Sp1 that boosts production of the DNMT1 protein.

Thus, low levels of the miR may result in lots of Sp1 protein and of DNMT1, which busily adds the chemical units that silences genes. High levels of the miR, on the other hand, may keep the amount of Sp1 low, so there is little DNMT1 and much less gene silencing.

"Our paper explains why this miR is a powerful demethylating agent," Garzon says. "It shows that putting this miR back into leukemia cell lines and leukemia cells from patients causes a drop in global DNA methylation and reactivates protective tumor suppressor genes, which allows the cells to differentiate and mature."


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Therapeutic cloning gets a boost with new research findings
2. Major NSF grant boosts UNH research on hormonal genomics
3. New MegaMatcher Accelerator Boosts Speed for High-Volume Biometric Identification and Database Duplicate Searching
4. High CO2 boosts plant respiration, potentially affecting climate and crops
5. Research project to boost European fish farming
6. A little wine boosts omega-3 in the body: Researchers find a novel mechanism for a healthier heart
7. Tropical forest carbon monitoring gets big boost
8. Shrimp trawling may boost mercury in red snapper, study suggests
9. Supercomputer provides massive computational boost to biomedical research at TGen
10. Boost from McGill, Gates Foundation helps Africans control pharma research
11. Diabetes researcher gets $5M boost
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A miR boost enables acute leukemia cells to mature
(Date:10/28/2014)... from the National University of Singapore (NUS) have discovered ... breeding and laying direct developing eggs in live bamboo ... white spotted bush frog ( Raorchestes chalazodes ). ... two species known to adopt this novel reproductive strategy. ... London,s Biological Journal of the Linnean Society , ...
(Date:10/27/2014)... punch with a pair of papers that detail how ... Collagen is the most common protein in mammals, a ... support cells and hold organs together. Discovering its secrets ... and cosmetic and reconstructive medicine. , The Rice lab ... a decade, teasing out the details of how it ...
(Date:10/27/2014)... – October 28, 2014 – A new randomized controlled ... blend of collagen and calcium, KoACT®, was far superior ... leaching of calcium from bones and rebuilding new bone ... at: http://www.ncbi.nlm.nih.gov/pubmed/25314004 , ahead of print in ... research was conducted by Bahram H. Arjmandi, PhD, RDN, ...
Breaking Biology News(10 mins):NUS researchers discover for the first time that a rare bush frog breeds in bamboo 2NUS researchers discover for the first time that a rare bush frog breeds in bamboo 3'Sticky' ends start synthetic collagen growth 2'Sticky' ends start synthetic collagen growth 3New RCT: KoACT® beats calcium and vitamin D for optimal bone strength 2
... would happen if a fast-food restaurant reduces the calories ... decreasing the portion size of French fries? Would children ... beverage? Researchers at Cornell University, Dr. Brian Wansink and ... McDonald,s restaurants to answer that question. Prior to ...
... predict sinkholes? What do ancient ambers reveal about paleochemotaxonomy? ... us understand current global warming? Did trilobites venture into ... above sea level? What does the 27 March 2013 ... you reconstruct snapshots of a catastrophic radial current? What ...
... The wild bison roaming Catalina Island are a major attraction ... Island,s most popular destination every year. But managing the number ... endanger the health of the rest of the Island has ... new study by the Catalina Island Conservancy scientists, published in ...
Cached Biology News:Healthier Happy Meals 2New geology research explores intriguing questions 2New geology research explores intriguing questions 3New geology research explores intriguing questions 4New geology research explores intriguing questions 5New geology research explores intriguing questions 6New geology research explores intriguing questions 7New geology research explores intriguing questions 8New geology research explores intriguing questions 9Study finds Catalina Island Conservancy contraception program effectively manages bison population 2
(Date:10/30/2014)... , Oct. 30, 2014 Isis Pharmaceuticals, Inc. (NASDAQ: ... announced that management will present a company overview at the ... a.m. ET in Boston, MA. ... on the "Investors & Media" section of the Company,s website, ... Isis website within 48 hours and will be archived for ...
(Date:10/27/2014)... North Carolina (PRWEB) October 27, 2014 ... invited earlier this month to sit down with Bryan Hamilton, ... from RPG Solutions to discuss talent in the Research Triangle ... topics that were highlighted at the roundtable include ... the Triangle, the significance of work/life balance and the unique ...
(Date:10/27/2014)... 27, 2014 The “Molecular Diagnostic ... Microbiology), Technology (PCR, INAAT, DNA Sequencing), End User ... Software) - Global Forecast to 2018” provides a ... opportunities, current market trends, and strategies impacting the ... and forecasts of the revenue and share analysis. ...
(Date:10/27/2014)... Janssen Biotech, Inc. and the Crohn,s ... the launch of Get Your Full ... designed to provide resources for people living with ... of nutrition and appropriate therapy in managing IBD. ... with this release, please click: http://www.multivu.com/players/English/7261131-janssen-ccfa-get-your-full-course-for-ibd-wellness-with-sunny-anderson/ ...
Breaking Biology Technology:Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 3Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 2Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 3Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 4Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 5Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 2Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 3Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 4
... , , , ... ("Rib-X" or the "Company"), a development-stage company focused on ... the treatment of acute care antibiotic-resistant infections, today announced ... the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy ...
... ... MGi scientific camera is being launched into space today as part of ... Naval research Laboratory (NRL) chose the Rolera MGi because of its high ... NASA will transmit the data to the NRL, which will then distribute ...
... In the news release, "Clinical Therapeutics Announces ... for a Refocused Pediatric,Adolescent, & Maternal Therapeutics Section" issued ... PR Newswire, we are advised by a representative,of the ... England",to "Bridgewater, New Jersey" and the contact number has ...
Cached Biology Technology:Rib-X Pharmaceuticals to Present at the 49th ICAAC 2Rib-X Pharmaceuticals to Present at the 49th ICAAC 3Rib-X Pharmaceuticals to Present at the 49th ICAAC 4First Spaceborne Hyperspectral Imager Will Use QImaging Rolera-MGi EMCCD Camera 2/C O R R E C T I O N -- Clinical Therapeutics/ 2/C O R R E C T I O N -- Clinical Therapeutics/ 3/C O R R E C T I O N -- Clinical Therapeutics/ 4/C O R R E C T I O N -- Clinical Therapeutics/ 5