Navigation Links
A mechanism to explain biological 'cross-talk' between 24-hour body cycle and metabolism
Date:11/16/2007

PHILADELPHIA Its well known that the bodys energy levels cycle on a 24-hour, or circadian, schedule, and that this metabolic process is fueled by oxygen. Now, researchers at the University of Pennsylvania School of Medicine have found that a protein called Rev-erb coordinates the daily cycles of oxygen-carrying heme molecules to maintain the bodys correct metabolism.

The research appears online this week in Science Express in advance of print publication in Science.

Many studies, including this one, point to a link between the human internal clock and such metabolic disorders as obesity and diabetes. Proteins such as Rev-erb are the gears of the clock and understanding their role is important for fighting these diseases.

This is the next chapter on Rev-erb, a member of a family of cell-nucleus proteins that includes receptors for anti-diabetic drugs, explains senior author Mitchell A. Lazar, MD, PhD, Director of the Institute for Diabetes, Obesity, and Metabolism at Penn. About two years ago Lazars group discovered that Rev-erb was a critical component of the circadian clock. In this paper, they found that the activity of Rev-erb is controlled by heme.

Heme represents the body's most important way of transporting and using oxygen, which would simply bubble away in the body without being bound to heme. In a molecular baton hand-off, oxygen is transferred from heme in the bloodstream to the heme molecules found inside a cell, says Lazar, of how oxygen reaches cells to run their metabolic needs. One of the most important roles of heme inside cells is to facilitate the use of oxygen to generate energy in the process known as cellular respiration.

The findings further tie together the 24-hour cycle of the body with metabolic function. Circadian rhythms are our sleep-wake cycle and metabolism is how we process food, so it makes sense that there would be biological cross-talk between the bodys 24-hour rhythm and metabolic function, says Lazar. Indeed, scientists already recognize that getting too much or too little sleep increases the risk of diabetes. The newly discovered circadian/metabolic link could be the focus of a new generation of diabetes treatments.

The Penn group worked with scientists at GlaxoSmithKline, who demonstrated that the Rev-erb protein can physically bind to heme in the test tube. The Penn scientists then found that heme, by regulating the activity of Rev-erb, reduces the amount of glucose produced by liver cells.

Whats exciting about this is that it puts heme in a central role in the metabolic regulation of the cell, says Lazar. Not only is it a key component in making energy, but also in the pathway for turning off glucose production. Excessive glucose production by the liver is a major cause of high blood sugar in diabetes.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Related biology news :

1. Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
2. Scientists find clue to mechanisms of gene signaling and regulation
3. Neural stem cell study reveals mechanism that may play role in cancer
4. New insight into the mechanisms of voltage sensing and transduction in biological processes
5. Mechanism for the in-vivo transport of siRNA
6. Scientists decipher mechanism behind antimicrobial hole punchers
7. Enhanced DNA-repair mechanism can cause breast cancer
8. Scientists enhance Mother Natures carbon handling mechanism
9. Primate behavior explained by computer agents
10. A study proposes a new universal rule to explain the equilibrium of plant populations
11. Research explains link between cholesterol and heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/15/2016)... 15, 2016  Synthetic Biologics, Inc. (NYSE MKT: ... on the gut microbiome, today announced the pricing ... of its common stock and warrants to purchase ... price to the public of $1.00 per share ... from the offering, excluding the proceeds, if any ...
(Date:6/27/2016)... Research and Markets has announced the addition of the "Biometrics ... The report forecasts the biometrics market ... CAGR of 12.28% during the period 2016-2020. The ... inputs from industry experts. The report covers the market landscape and ... a discussion of the key vendors operating in this market. ...
(Date:6/21/2016)... , June 21, 2016 NuData ... the new role of principal product architect and ... the director of customer development. Both will report ... technical officer. The moves reflect NuData,s strategic growth ... response to high customer demand and customer focus ...
Breaking Biology News(10 mins):
(Date:12/5/2016)... HAMILTON, Bermuda , Dec. 5, 2016 ... leading clinical-stage biopharmaceutical company focused on the treatment of ... of intepirdine for the treatment of Alzheimer,s disease will ... Disease (CTAD) Meeting on Friday, December 9, 2016 in ... CTAD will show results of both simple and complex ...
(Date:12/5/2016)... , ... December 05, 2016 , ... ... to soon resume cervical and lumbar disc production, company President, Jake Lubinski will ... who are implanting the AxioMed disc in Cologne and Karlsruhe to discuss the ...
(Date:12/5/2016)... NxGen MDx announced today that it brought its NxGen Informed ... been able to improve customer service through shortened turnaround times and at ... , CEO of NxGen MDx. ... A decrease in turnaround times by ... job opportunities at the Grand Rapid headquarters. The NxGen Informed ...
(Date:12/4/2016)... ... December 02, 2016 , ... A proposed five-year extension ... federally funded research and development is welcome news for the photonics community, say ... , As part of the National Defense Authorization Act (NDAA) compromise agreement finalized ...
Breaking Biology Technology: