Navigation Links
A mechanism to explain biological 'cross-talk' between 24-hour body cycle and metabolism
Date:11/16/2007

PHILADELPHIA Its well known that the bodys energy levels cycle on a 24-hour, or circadian, schedule, and that this metabolic process is fueled by oxygen. Now, researchers at the University of Pennsylvania School of Medicine have found that a protein called Rev-erb coordinates the daily cycles of oxygen-carrying heme molecules to maintain the bodys correct metabolism.

The research appears online this week in Science Express in advance of print publication in Science.

Many studies, including this one, point to a link between the human internal clock and such metabolic disorders as obesity and diabetes. Proteins such as Rev-erb are the gears of the clock and understanding their role is important for fighting these diseases.

This is the next chapter on Rev-erb, a member of a family of cell-nucleus proteins that includes receptors for anti-diabetic drugs, explains senior author Mitchell A. Lazar, MD, PhD, Director of the Institute for Diabetes, Obesity, and Metabolism at Penn. About two years ago Lazars group discovered that Rev-erb was a critical component of the circadian clock. In this paper, they found that the activity of Rev-erb is controlled by heme.

Heme represents the body's most important way of transporting and using oxygen, which would simply bubble away in the body without being bound to heme. In a molecular baton hand-off, oxygen is transferred from heme in the bloodstream to the heme molecules found inside a cell, says Lazar, of how oxygen reaches cells to run their metabolic needs. One of the most important roles of heme inside cells is to facilitate the use of oxygen to generate energy in the process known as cellular respiration.

The findings further tie together the 24-hour cycle of the body with metabolic function. Circadian rhythms are our sleep-wake cycle and metabolism is how we process food, so it makes sense that there would be biological cross-talk between the bodys 24-hour rhythm and metabolic function, says Lazar. Indeed, scientists already recognize that getting too much or too little sleep increases the risk of diabetes. The newly discovered circadian/metabolic link could be the focus of a new generation of diabetes treatments.

The Penn group worked with scientists at GlaxoSmithKline, who demonstrated that the Rev-erb protein can physically bind to heme in the test tube. The Penn scientists then found that heme, by regulating the activity of Rev-erb, reduces the amount of glucose produced by liver cells.

Whats exciting about this is that it puts heme in a central role in the metabolic regulation of the cell, says Lazar. Not only is it a key component in making energy, but also in the pathway for turning off glucose production. Excessive glucose production by the liver is a major cause of high blood sugar in diabetes.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Related biology news :

1. Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
2. Scientists find clue to mechanisms of gene signaling and regulation
3. Neural stem cell study reveals mechanism that may play role in cancer
4. New insight into the mechanisms of voltage sensing and transduction in biological processes
5. Mechanism for the in-vivo transport of siRNA
6. Scientists decipher mechanism behind antimicrobial hole punchers
7. Enhanced DNA-repair mechanism can cause breast cancer
8. Scientists enhance Mother Natures carbon handling mechanism
9. Primate behavior explained by computer agents
10. A study proposes a new universal rule to explain the equilibrium of plant populations
11. Research explains link between cholesterol and heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... 2017 The report "Video Surveillance ... Servers, Storage Devices), Software (Video Analytics, VMS), and Service ... Forecast to 2022", published by MarketsandMarkets, the market was ... projected to reach USD 75.64 Billion by 2022, at ... base year considered for the study is 2016 and ...
(Date:3/24/2017)... , Mar 24, 2017 Research and ... Access System Market Analysis & Trends - Industry Forecast to 2025" ... ... to grow at a CAGR of around 15.1% over the next ... This industry report analyzes the market estimates and forecasts for all ...
(Date:3/22/2017)... VILNIUS, Lithuania , March 21, 2017 /PRNewswire/ ... identification and object recognition technologies, today announced the ... development kit (SDK), which provides improved facial recognition ... safety cameras on a single computer. The new ... algorithms to improve accuracy, and it utilizes a ...
Breaking Biology News(10 mins):
(Date:9/22/2017)... ... 22, 2017 , ... The Academy of Model Aeronautics (AMA) ... 29, 2017, to promote AMA’s programs, member services, and the model aviation hobby. ... but not limited to model aviation and other RC activities. , Thousands are ...
(Date:9/21/2017)... ... (PRWEB) September 21, 2017 , ... The 3rd ... to review the latest knowledge on these products, which are increasingly used in ... the impact of Biostimulants on Plant Nutrition, Abiotic Stresses, Plant Growth and Development, ...
(Date:9/21/2017)... ... September 21, 2017 , ... When a downtown ... response was swift and efficient thanks to the continuing efforts of members of ... of more than 50 stakeholders, including officials from area counties and cities, Renewable ...
(Date:9/20/2017)... (PRWEB) , ... September 20, 2017 , ... ... today that it has appointed Vishwas Paralkar to the role of chief scientific ... targeting technology. He will report to Cybrexa’s president and CEO, Per Hellsund. , ...
Breaking Biology Technology: