Navigation Links
A mechanism to explain biological 'cross-talk' between 24-hour body cycle and metabolism
Date:11/16/2007

PHILADELPHIA Its well known that the bodys energy levels cycle on a 24-hour, or circadian, schedule, and that this metabolic process is fueled by oxygen. Now, researchers at the University of Pennsylvania School of Medicine have found that a protein called Rev-erb coordinates the daily cycles of oxygen-carrying heme molecules to maintain the bodys correct metabolism.

The research appears online this week in Science Express in advance of print publication in Science.

Many studies, including this one, point to a link between the human internal clock and such metabolic disorders as obesity and diabetes. Proteins such as Rev-erb are the gears of the clock and understanding their role is important for fighting these diseases.

This is the next chapter on Rev-erb, a member of a family of cell-nucleus proteins that includes receptors for anti-diabetic drugs, explains senior author Mitchell A. Lazar, MD, PhD, Director of the Institute for Diabetes, Obesity, and Metabolism at Penn. About two years ago Lazars group discovered that Rev-erb was a critical component of the circadian clock. In this paper, they found that the activity of Rev-erb is controlled by heme.

Heme represents the body's most important way of transporting and using oxygen, which would simply bubble away in the body without being bound to heme. In a molecular baton hand-off, oxygen is transferred from heme in the bloodstream to the heme molecules found inside a cell, says Lazar, of how oxygen reaches cells to run their metabolic needs. One of the most important roles of heme inside cells is to facilitate the use of oxygen to generate energy in the process known as cellular respiration.

The findings further tie together the 24-hour cycle of the body with metabolic function. Circadian rhythms are our sleep-wake cycle and metabolism is how we process food, so it makes sense that there would be biological cross-talk between the bodys 24-hour rhythm and metaboli
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
2. Scientists find clue to mechanisms of gene signaling and regulation
3. Neural stem cell study reveals mechanism that may play role in cancer
4. New insight into the mechanisms of voltage sensing and transduction in biological processes
5. Mechanism for the in-vivo transport of siRNA
6. Scientists decipher mechanism behind antimicrobial hole punchers
7. Enhanced DNA-repair mechanism can cause breast cancer
8. Scientists enhance Mother Natures carbon handling mechanism
9. Primate behavior explained by computer agents
10. A study proposes a new universal rule to explain the equilibrium of plant populations
11. Research explains link between cholesterol and heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 2014 Research and Markets ( ... "Global Chemical Sensor Market 2015-2019" report ... http://photos.prnewswire.com/prnh/20130307/600769 One major trend upcoming ... medical sensors in biomedical applications. Chemical sensors help ... correct diagnosis during surgical procedures. The Global Chemical ...
(Date:12/15/2014)... Research and Markets ( http://www.researchandmarkets.com/research/87pph8/global_facial ... "Global Facial Recognition Market 2015-2019" report to ... Facial recognition is a technology ... system measures the overall facial feature of a ... the distance between eyes. Facial recognition is used ...
(Date:12/11/2014)... DUBLIN , Dec. 09, 2014 Research ... http://photos.prnewswire.com/prnh/20130307/600769 ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) ... Market in India 2015-2019" report to their ... in this market is the adoption of multimodal ... one characteristic of an individual for verification and ...
Breaking Biology News(10 mins):Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... for convenient, nutritious foods increases, pre-cut and packaged fruit ... to science to discover new ways to safely extend ... potential solution to vegetables, short market life may be ... technology currently in use in commercial food operations. ...
... sudden fluctuations in the weather could be developed, thanks to ... Scientists studying how tiny algae renew old or damaged cell ... suited to climates in which weather changes quickly. Researchers ... dictates how quickly they can adapt to environmental changes, such ...
... (December 13, 2011) The Wildlife Conservation Society tracked a ... equivalent of New York to Sydney and back again. , ... 2011. The animal nicknamed Jackson was tagged ... in southern Chile. WCS conservationists fitted Jackson with a small ...
Cached Biology News:Asparagus benefits from X-ray treatment 2Elephant seal travels 18,000 miles 2
(Date:12/24/2014)... Pipette.com announces their Holiday in the ... their #HolidayInTheLab pictures for a chance to win pipette-themed ... those struggling to think of a holiday gift for ... Lab Contest provides the ideal holiday presents. The #HolidayInTheLab ... pictures of their chemistree, holiday sweaters, as well as ...
(Date:12/24/2014)... , Dec. 23, 2014 Vermillion, ... focused on gynecologic disease, announced today that investors ... , Birchview Fund LLC and several Vermillion directors ... unregistered shares of Vermillion,s common stock and warrants ... in a private placement.  Under ...
(Date:12/24/2014)... 23, 2014 Sigma-Aldrich Corporation (NASDAQ: ... period under the Hart-Scott-Rodino Antitrust Improvements Act (HSR ... December 22, 2014, thereby completing the U.S. HSR ... acquisition of the Company by Merck KGaA, Darmstadt, ... another condition to closing the transaction, which remains ...
(Date:12/24/2014)... PARIS and NEW YORK ... data from its open-label pilot study of mazindol in ... Design, Development and Therapy in December 2014 . ... of mazindol in children with attention deficit/hyperactivity disorder" ( ... 2014 Dec 1;8:2321-2332. eCollection 2014 ) ...
Breaking Biology Technology:Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3
... of visible light and zinc oxide nanorods for destroying ... at the Asian Institute of Technology (AIT). Nanorods grown ... been found to be effective in killing both gram ... has immense possibilities for affordable and environmentally friendly water ...
... May 12, 2011 Stem Cell Assurance, Inc. (SCLZ.PK) ... for Registration of Securities on Form 10 pursuant to Section ... 10 includes audited financial statements as of December 31, 2009 ... this filing, effective July 11, 2011, the Company will become ...
... May 12, 2011 The Maryland Academy of Sciences ... recipients of its Annual Awards which recognize the accomplishments ... Dr. Ian Appelbaum, Associate Professor of Physics at the ... (OYS) award and Dr. Ganesh Sriram, Assistant Professor in ...
Cached Biology Technology:Exposing ZnO nanorods to visible light removes microbes 22011 Outstanding Young Scientist and Engineer Named; Baltimore City High School Students Awarded Glass Scholarships 2
... contain 60 rabbit tissue samples arrayed on Superfrost ... slides and 1 hematoxylin and eosin (H&E) stained ... different tissues from 4 rabbit organisms, for a ... tissue sample (or core) is 1.5 mm in ...
... a wide variety of purity levels, scales and ... Purity: IG(>50%), >70%, >80% and >95% ... Length: Up to 120 residues ... acids, MAPs, KLH/BSA conjugation, and much more. ...
... Antigen sequence: H-Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH ... For our corresponding peptide ... 2 5 I-labelled ... (human) (H-1470) and ([ ...
... you to identify over 150 peptide ... protein isoforms, protein subsets, and suppress ... peptide-protein associations and relationships easily. The ... and relative protein expression analysis for ...
Biology Products: