"Now you can see all those differences that you couldn't see before," explains Mahajan, whose primary appointment is in the Carver College of Medicine.
Previous studies have compared the abundance of single proteins in the fovea, macula, and periphery. The UI choroid-RPE map corroborates findings from these studies, while also opening a whole, new avenue of research into thousands of proteins that may be involved in vision loss. Mahajan likens it to a leap from the first topological drawings of a landscape to the detailed satellite images we have now.
"We were able to identify thousands of proteins simultaneously and develop a map that shows what are the patterns of proteins that make these regions unique. This has helped explain why certain genes are associated with macular degeneration, and helps point us to new treatment targets," says Skeie, who earned her undergraduate and master's degrees at the UI and is the study's first author.
|Contact: Richard Lewis|
University of Iowa