Navigation Links
A mammalian clock protein responds directly to light
Date:6/30/2008

We all know that light effects the growth and development of plants, but what effect does light have on humans and animals? A new paper by Nathalie Hoang et al., published in PLoS Biology this week, explores this question by examining cryptochromes in flies, mice, and humans. In plants, cryptochromes are photoreceptor proteins which absorb and process blue light for functions such as growth, seedling development, and leaf and stem expansion. Cryptochromes are present in humans and animals as well and have been proven to regulate the mechanisms of the circadian clock. But how they work in humans and animals is still somewhat of a mystery.

When plants are exposed to blue light, they experience a reduction in flavin pigments. This reduction activates the cryptochromes and thus allows for growth and seedling development. Hoang et al. sought to study the effect of blue light on fly, animal, and human cryptochromes by exposing them to blue light and measuring the change in the number of oxidized flavins. After a prolonged exposure to blue light, the authors found that the number of flavins did in fact decrease, as they do in plants.

While this research reveals a similarity in the responses of flies, mice, humans, and plants to blue light, the decrease in flavins affects circadian rhythms differently. The mouse cryptochromes, Mcry1 and Mcry2, interact with key parts of the circadian clock: mice with these cryptochromes missing exhibited a complete loss in circadian rhythm behaviors such as wheel-running. However, this change in behavior was independent of light exposure.

Although this paper by Hoang, et al, shows that cryptochromes in animals and humans do respond to light in a similar fashion to those in plants, the question as to how exactly light effects them is still open for further research. Although cryptochromes are mainly found in the retina of the eye, they are also present in many different tissues of the body that are close to the surface. This suggests that cryptochromes may have non-visual functions, and may also affect protein levels and behavior.


'/>"/>

Contact: Natalie Bouaravong
press@plos.org
Public Library of Science
Source:Eurekalert

Related biology news :

1. First high-res 3D structures of mammalian HSP90 protein solved
2. St. Jude settles century-old debate on origin of mammalian network of lymphatic vessels
3. Venous origin of the mammalian lymphatic vasculature
4. Turning back the clock for Schwann cells
5. Molecular clock could predict risk for developing breast cancer
6. NYU dental professor discovers biological clock linking tooth growth to other metabolic processes
7. Systems biology approach identifies nutrient regulation of biological clock in plants
8. Web-Hosted Attendance on Demand(R) Introduces Innovative Web Time Clock
9. Bioclocks work by controlling chromosome coiling
10. New molecular clock from LLNL and CDC indicates smallpox evolved earlier than believed
11. Circadian clock controls plant growth hormone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/12/2016)... WearablesResearch.com , a brand of Troubadour Research & ... Q1 wave of its quarterly wearables survey. A particular ... a program where they would receive discounts for sharing ... "We were surprised to see that so many ... CEO of Troubadour Research, "primarily because there are segments ...
(Date:4/28/2016)... , April 28, 2016 First quarter 2016: ... up 966% compared with the first quarter of 2015 ... SEK 589.1 M (loss: 18.8) and the operating margin was 40% ... 0.32) Cash flow from operations was SEK 249.9 M ... revenue guidance is unchanged, SEK 7,000-8,500 M. The operating ...
(Date:4/15/2016)... April 15, 2016  A new partnership announced ... accurate underwriting decisions in a fraction of the ... priced and high-value life insurance policies to consumers ... With Force Diagnostics, rapid testing (A1C, Cotinine ... readings (blood pressure, weight, pulse, BMI, and activity ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... YORK , May 27, 2016 ... but investors playing in this space know that volatility is ... morning,s featured companies on ActiveWallSt.com: Synta Pharmaceuticals Corp. (NASDAQ: ... ), Lpath Inc. (NASDAQ: LPTN ), and Heat ... and gain access to the technical alerts for these stocks ...
(Date:5/26/2016)... Jersey and READING, England ... Indegene ( http://www.indegene.com ), a leading global ... life science, pharmaceutical and healthcare organisations and TranScrip ... innovative scientific support throughout the product lifecycle, today ... the launch of IntraScience.      (Logo: ...
(Date:5/26/2016)... -- Despite the volatility that continues to envelop ... pre-market research on ActiveWallSt.com directs the investor community,s focus on ... RDUS ), Cerus Corp. (NASDAQ: CERS ), Arrowhead ... Therapeutics Inc. (NASDAQ: FPRX ). Register with us ... http://www.activewallst.com/ On Wednesday, shares in ...
(Date:5/26/2016)... ... May 26, 2016 , ... Kinder Scientific (KinderScientific.com), a ... that position the Company for the future. Kinder Scientific announces restructured ownership ... has been appointed Chairman of the Board, Curtis D. Kinghorn has been appointed ...
Breaking Biology Technology: