Navigation Links
A mammalian clock protein responds directly to light
Date:6/30/2008

We all know that light effects the growth and development of plants, but what effect does light have on humans and animals? A new paper by Nathalie Hoang et al., published in PLoS Biology this week, explores this question by examining cryptochromes in flies, mice, and humans. In plants, cryptochromes are photoreceptor proteins which absorb and process blue light for functions such as growth, seedling development, and leaf and stem expansion. Cryptochromes are present in humans and animals as well and have been proven to regulate the mechanisms of the circadian clock. But how they work in humans and animals is still somewhat of a mystery.

When plants are exposed to blue light, they experience a reduction in flavin pigments. This reduction activates the cryptochromes and thus allows for growth and seedling development. Hoang et al. sought to study the effect of blue light on fly, animal, and human cryptochromes by exposing them to blue light and measuring the change in the number of oxidized flavins. After a prolonged exposure to blue light, the authors found that the number of flavins did in fact decrease, as they do in plants.

While this research reveals a similarity in the responses of flies, mice, humans, and plants to blue light, the decrease in flavins affects circadian rhythms differently. The mouse cryptochromes, Mcry1 and Mcry2, interact with key parts of the circadian clock: mice with these cryptochromes missing exhibited a complete loss in circadian rhythm behaviors such as wheel-running. However, this change in behavior was independent of light exposure.

Although this paper by Hoang, et al, shows that cryptochromes in animals and humans do respond to light in a similar fashion to those in plants, the question as to how exactly light effects them is still open for further research. Although cryptochromes are mainly found in the retina of the eye, they are also present in many different tissues of the body that
'/>"/>

Contact: Natalie Bouaravong
press@plos.org
Public Library of Science
Source:Eurekalert

Page: 1 2

Related biology news :

1. First high-res 3D structures of mammalian HSP90 protein solved
2. St. Jude settles century-old debate on origin of mammalian network of lymphatic vessels
3. Venous origin of the mammalian lymphatic vasculature
4. Turning back the clock for Schwann cells
5. Molecular clock could predict risk for developing breast cancer
6. NYU dental professor discovers biological clock linking tooth growth to other metabolic processes
7. Systems biology approach identifies nutrient regulation of biological clock in plants
8. Web-Hosted Attendance on Demand(R) Introduces Innovative Web Time Clock
9. Bioclocks work by controlling chromosome coiling
10. New molecular clock from LLNL and CDC indicates smallpox evolved earlier than believed
11. Circadian clock controls plant growth hormone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/7/2014)...  In conjunction with the Glendale ... Foundation of the Verdugos has announced the " GLENDALE ... $250,000 initiative to keep the Verdugo Regional Crime Lab operational ... months of existence, the Lab has processed more than 400 ... enforcement. "Because our number one priority is the ...
(Date:11/6/2014)... - Insilico Medicine, Inc, a Baltimore-based bioinformatics company ... diseases announced a research collaboration with the international ... Inc (OTC: CSBR). , "There are many companies ... Champions Oncology,s TumorGraft technology is unique in a ... experimentally generating vast amounts of valuable data. Our ...
(Date:11/4/2014)... of death at the right time might actually help ... that could help in understanding animal populations, pest control ... paper in the journal Trends in Ecology and ... conclude that the kind of positive population effect an ... mortality, depends on the size and developmental stage of ...
Breaking Biology News(10 mins):Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2When less is more: Death in moderation boosts population density in nature 2
... CAMBRIDGE, Mass. -- MIT biological engineers have developed a ... that have undergone a specific mutation. The work, ... marks the first time researchers have been able to ... a particular mutationin intact tissue. In this case, the ...
... of mangroves on the coasts of the Philippines could help ... that hit the islands annually. This is one of ... massive mangrove replanting, that J.H. Primavera from the Southeast Asian ... University, both in the Philippines, cite in a paper published ...
... soon as it,s begun promises to reduce the need for ... & Industry (C&I) magazine. Drilling is one ... off visiting their dentist every year. The new ... years from now, is based on Raman spectroscopy most commonly ...
Cached Biology News:MIT researchers offer glimpse of rare mutant cells 2Mangroves key to saving lives 2End in sight for the dreaded dentist drill 2
(Date:11/24/2014)... , November 24, 2014 Senior ... honored for dynamic leadership skills, business acumen ... and medical information products and services, congratulates Diane ... Clinical Reference and Workflow, Elsevier Clinical Solutions, for being ... Watching ® Awards issue of Profiles in ...
(Date:11/22/2014)... Denver, Colo. (PRWEB) November 21, 2014 ... of proprietary cloud based analytics and scientific testing methodologies ... a commitment for a $750,000 line of credit from ... are extremely pleased to have secured this commitment from ... Chief Executive Officer of CannLabs. “This capital will help ...
(Date:11/22/2014)... LONDON , Nov. 21, 2014  The element ... in emerging diseases, i.e., they strike without warning. Until ... advance warning of a viral outbreak, resulting in suboptimal ... to Ebola currently. Photo - ... surprise has now been removed because virus gene structural ...
(Date:11/21/2014)... (PRWEB) November 20, 2014 Offering a ... Sartorius Entris Balance promotion . The Sartorius Entris ... a durable, high accuracy, and easy-to-maintain balance entry level ... Germany. It was designed to help customer’s bridge the ... a balance that is very durable. Sartorius is the ...
Breaking Biology Technology:Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 2Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 3CannLabs Secures $750,000 Line Of Credit 2Viruses' Advantage of Surprise is Lost 2Pipette.com Announces an Extension on the Sartorius Entris Balance Promotion to the End of 2014 2
... Nov. 12 WHO and CDC have stated that ... is "suboptimal" -- often correct less than 50% of ... are not yet accurate in,our predictions of upcoming influenza ... the United States alone., As in the case ...
... China, Nov. 12 /Xinhua-PRNewswire-FirstCall/ -- China Shenghuo,Pharmaceutical ... Shenghuo" or the,"Company"), which is engaged in ... nutritional supplement and cosmetic products,in the People,s ... NYSE Alternext,US LLC (formerly the American Stock ...
... (ASX: POH; OTCQX: PPGNY) announced today that ... trial using its patented drug,delivery system, TPM, ... non steroidal,anti-inflammatory drug (NSAID), diclofenac. The trial ... topically applied Voltaren(R) gel,(1% diclofenac), one of ...
Cached Biology Technology:A New Way to Predict Outbreaks: Replikin Peptide Concentration in H5N1 Influenza Virus Genome as a Marker for Lethal Outbreaks 2A New Way to Predict Outbreaks: Replikin Peptide Concentration in H5N1 Influenza Virus Genome as a Marker for Lethal Outbreaks 3NYSE Alternext US Accepts China Shenghuo's Compliance Plan for Continued Listing 2NYSE Alternext US Accepts China Shenghuo's Compliance Plan for Continued Listing 3NYSE Alternext US Accepts China Shenghuo's Compliance Plan for Continued Listing 4Transdermal Diclofenac enters Phase 1 Clinical Trial in Humans 2
streptavidin, Alexa Fluor® 750–allophycocyanin conjugate (Alexa Fluor® 750–allophycocyanin streptavidin) *1 mg/mL*...
Biotin-OSu is used to label proteins, immunological agents, DNA and synthetic oligonucleotides. Biotin labeling is detected through enzymatically labeled avidin or streptavidin proteins that conforma...
RAT ANTI MOUSE JAM-2 Immunogen: Recombinant soluble JAM-2...
...
Biology Products: