Navigation Links
A mammalian clock protein responds directly to light
Date:6/30/2008

We all know that light effects the growth and development of plants, but what effect does light have on humans and animals? A new paper by Nathalie Hoang et al., published in PLoS Biology this week, explores this question by examining cryptochromes in flies, mice, and humans. In plants, cryptochromes are photoreceptor proteins which absorb and process blue light for functions such as growth, seedling development, and leaf and stem expansion. Cryptochromes are present in humans and animals as well and have been proven to regulate the mechanisms of the circadian clock. But how they work in humans and animals is still somewhat of a mystery.

When plants are exposed to blue light, they experience a reduction in flavin pigments. This reduction activates the cryptochromes and thus allows for growth and seedling development. Hoang et al. sought to study the effect of blue light on fly, animal, and human cryptochromes by exposing them to blue light and measuring the change in the number of oxidized flavins. After a prolonged exposure to blue light, the authors found that the number of flavins did in fact decrease, as they do in plants.

While this research reveals a similarity in the responses of flies, mice, humans, and plants to blue light, the decrease in flavins affects circadian rhythms differently. The mouse cryptochromes, Mcry1 and Mcry2, interact with key parts of the circadian clock: mice with these cryptochromes missing exhibited a complete loss in circadian rhythm behaviors such as wheel-running. However, this change in behavior was independent of light exposure.

Although this paper by Hoang, et al, shows that cryptochromes in animals and humans do respond to light in a similar fashion to those in plants, the question as to how exactly light effects them is still open for further research. Although cryptochromes are mainly found in the retina of the eye, they are also present in many different tissues of the body that are close to the surface. This suggests that cryptochromes may have non-visual functions, and may also affect protein levels and behavior.


'/>"/>

Contact: Natalie Bouaravong
press@plos.org
Public Library of Science
Source:Eurekalert

Related biology news :

1. First high-res 3D structures of mammalian HSP90 protein solved
2. St. Jude settles century-old debate on origin of mammalian network of lymphatic vessels
3. Venous origin of the mammalian lymphatic vasculature
4. Turning back the clock for Schwann cells
5. Molecular clock could predict risk for developing breast cancer
6. NYU dental professor discovers biological clock linking tooth growth to other metabolic processes
7. Systems biology approach identifies nutrient regulation of biological clock in plants
8. Web-Hosted Attendance on Demand(R) Introduces Innovative Web Time Clock
9. Bioclocks work by controlling chromosome coiling
10. New molecular clock from LLNL and CDC indicates smallpox evolved earlier than believed
11. Circadian clock controls plant growth hormone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... June 9, 2016  Perkotek an innovation leader in attendance control systems is proud ... work hours, for employers to make sure the right employees are actually signing in, ... ... ... ...
(Date:6/2/2016)... 2, 2016 The Department of Transport ... the 44 million US Dollar project, for the , ... including Personalization, Enrolment, and IT Infrastructure , to ... production and implementation of Identity Management Solutions. Numerous renowned international ... Decatur was selected for the most compliant ...
(Date:5/24/2016)... superior patient care by providing unparalleled technology to leaders of the medical imaging industry. ... recently added to the range of products distributed by Ampronix. Photo - ... ... ... ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... The immunohistochemistry (IHC) market is projected to reach ... during the forecast period of 2016 to 2021 dominated by immunohistochemistry ... the largest share of immunohistochemistry (IHC) market, by end user.   ... , , ... across 225 pages, profiling 10 companies and supported with 181 tables ...
(Date:11/30/2016)... ... November 30, 2016 , ... BEI Kimco, a ... with a flexure design that ensures high alignment accuracy by preventing unwanted shaft ... ideally suited where extreme precision is required, such as in medical equipment, laboratory ...
(Date:11/30/2016)... ALBANY, New York , November 30, 2016 /PRNewswire/ ... exceptionally consolidated as a few players hold a dominant ... Lonza Group, Charles River Laboratories International, Inc., and Merck ... global market in 2015. Transparency Market Research observes that ... they are focused on development products that are do ...
(Date:11/30/2016)... RATON, Fla. , Nov. 30, 2016 ... biotherapeutic products, is pleased to announce the addition of ... Avenue Kearney, Nebraska . The 15,200 ... business on November 29th, 2016 and brings the total ... Ileana Carlisle , BPC,s Chief Executive ...
Breaking Biology Technology: