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A loose grip provides better chemotherapy
Date:2/4/2011

surface areas that permit packing a lot in a tiny space. The element is inert inside the body and at less than 5 nanometers across, or less than 1/10,000 the width of a human hair, the particles quickly flow out of the blood stream and across cancer cell membranes to accumulate inside tumors.

A coat of polyethylene glycol links tightly to the gold while providing cargo space to attach other materials.

The coated gold provides an environment to physically prevent activation of the photodynamic therapy drug silicon phthalocyanine, preventing unintended toxic exposures to healthy tissues.

The loosely-held drug is released from the nanoparticle through the attraction of the drug to the lipid membrane of cancer cells. Laser light switches on the freed silicon phthalocyanine, which breaks down and kills cancer cells, shrinking the tumor.

After delivering the drug, the nanoparticles pass through the kidneys and clear the body within a week.


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Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Page: 1 2

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