Navigation Links
A loose grip provides better chemotherapy
Date:2/4/2011

Researchers at Case Western Reserve University have developed a little bomb that promises a big bang for cancer patients.

Preliminary tests show an anti-cancer drug loosely attached to gold nanoparticles starts accumulating deep inside tumors within minutes of injection and can be activated for an effective treatment within two hours. The same drug injected alone takes two days to gather and attacks the tumor from the surface a far less effective route.

The work, titled "Deep Penetration of a PDT Drug into Tumors by Noncovalent Drug-Gold Nanoparticle Conjugates," is published today in the online edition of the Journal of the American Chemical Society.

Speeding anti-cancer drugs directly into tumors enables patients to receive lower doses of the toxic chemicals, thereby saving healthy tissue from damage and other harsh side effects suffered in traditional chemotherapy.

"We hope to lower the dosage by at least a factor of 10," said Clemens Burda, a professor of chemistry at Case Western Reserve and the senior author of the paper.

The key to success? The scientists tied an anti-cancer drug to golden missiles using a weak chemical interaction called a noncovalent bond. In molecule construction, a covalent bond is a heavy rope lashed and knotted; a noncovalent bond is a shoestring tied in a bow.

"Very often, additions to chemical systems change properties of the components of the system," Burda said. Attempts by his and other research groups to use covalent bonds for drug delivery have resulted in such complications and less than hoped-for results.

The researchers, who come from a breadth of disciplines, found that by using a noncovalent bond to attach the drug to coated gold, they eliminated interference among the desired properties of each component.

Burda's group sought to simplify the process by using materials that have well-known properties.

Gold nanoparticles have large surface areas that permit packing a lot in a tiny space. The element is inert inside the body and at less than 5 nanometers across, or less than 1/10,000 the width of a human hair, the particles quickly flow out of the blood stream and across cancer cell membranes to accumulate inside tumors.

A coat of polyethylene glycol links tightly to the gold while providing cargo space to attach other materials.

The coated gold provides an environment to physically prevent activation of the photodynamic therapy drug silicon phthalocyanine, preventing unintended toxic exposures to healthy tissues.

The loosely-held drug is released from the nanoparticle through the attraction of the drug to the lipid membrane of cancer cells. Laser light switches on the freed silicon phthalocyanine, which breaks down and kills cancer cells, shrinking the tumor.

After delivering the drug, the nanoparticles pass through the kidneys and clear the body within a week.


'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Related biology news :

1. New technology provides first view of DNA damage within entire human genome
2. Cord blood cell transplantation provides improvement for severely brain-injured child
3. In the lab, engineers novel liquid provides a solid fix for broken bones
4. Research provides new leads in the case against drug-resistant biofilms
5. TB-drugome provides new targets for anti-tuberculosis drug discovery
6. Study provides treatment hope for long term effects of brain trauma
7. 100-million-year-old mistake provides snapshot of evolution
8. UF research provides new understanding of bizarre extinct mammal
9. Study provides data that can inform Atlantic sturgeon recovery efforts
10. Protein provides link between calcium signaling in excitable and non-excitable cells
11. Going green: New program provides vital support for plant scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... and BANGALORE, India , April 28, 2016 ... a product subsidiary of Infosys (NYSE: INFY ), ... a global partnership that will provide end customers ... mobile banking and payment services.      (Logo: ... innovation area for financial services, but it also plays a ...
(Date:4/19/2016)... , UAE, April 20, 2016 ... be implemented as a compact web-based "all-in-one" system solution ... the biometric fingerprint reader or the door interface with ... of modern access control systems. The minimal dimensions of ... ID readers into the building installations offer considerable freedom ...
(Date:4/13/2016)... -- IMPOWER physicians supporting Medicaid patients in Central ... in telehealth thanks to a new partnership with higi. ... patients can routinely track key health measurements, such as ... when they opt in, share them with IMPOWER clinicians ... retail location at no cost. By leveraging this data, ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... A person commits a crime, and the detective ... the criminal down. An outbreak of foodborne illness ... (FDA) uses DNA evidence to track down the bacteria that ... It,s not. The FDA has increasingly used a complex, cutting-edge ... illnesses. Put as simply as possible, whole genome sequencing is ...
(Date:6/23/2016)... Calif. , June 23, 2016  The Prostate Cancer Foundation ... increasingly precise treatments and faster cures for prostate cancer. Members of the Class ... across 15 countries. Read More About the Class of ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry Network for ... Design Lab . Located in Pasadena, Calif., the Design Lab’s mission is to ... are designed, built and brought to market. , The Design Lab is Supplyframe’s ...
(Date:6/23/2016)... , June 23, 2016 Apellis Pharmaceuticals, ... 1 clinical trials of its complement C3 inhibitor, ... and multiple ascending dose studies designed to assess ... of subcutaneous injection in healthy adult volunteers. ... either as a single dose (ranging from 45 ...
Breaking Biology Technology: