Navigation Links
A longer lasting tumor blocker
Date:4/28/2009

On the heels of dismaying reports that a promising antitumor drug could, in theory, shorten patients' long-term survival, comes a promising study by a Japanese team of researchers that suggests a potentially better option. The study appears in the May 11 issue of the Journal of Experimental Medicine (online April 27).

Many cancer treatments work by disrupting the formation of new blood vessels that feed growing tumors. Agents that block a vessel-promoting factor called VEGF have shown promise in human clinical trials. But recent studies in mice show that when treatment stops, tumor growth rapidly resumes. Now, Yoshiaki Kubota and colleagues find that blocking a different molecule, called M-CSF, suppressed tumor growth even after treatment was stopped.

Kubota and his team compared the efficacy of inhibitors against M-CSF and VEGF in mice with a certain kind of bone tumor. Three weeks of anti-VEGF treatment suppressed tumor growth but, similar to other recent reports, the tumors bounced back when the drug treatment was curtailed. Tumor growth in mice on a similar regiment of an M-CSF inhibitor remained suppressed in the absence of drug.

Another distinction between the two inhibitors was the type of vessel growth that was blocked. Blocking VEGF prevented dangerous vessels from growing such as those that feed tumors. But it also stopped beneficial vessels from growing, such as those that help injured tissues heal. Blocking M-CSF, on the other hand, only impeded bad vessel growth.

Most likely, the antiM-CSF treatment had a lasting effect because it resulted in damage to the scaffolding that surrounds cancerous vessels, robbing the tumors of the structural support they need to grow. Meanwhile, the scaffold of mice treated with anti-VEGF remained intact.

M-CSF levels soar in patients with osteosarcoma (a malignant bone cancer), breast cancer and prostate cancer, making these cancers potentially the most responsive to M-CSF-blocking drugs Whether or not other types of cancer rely more on M-CSF than on VEGF for their blood supply remains unknown.


'/>"/>

Contact: Amy Maxmen
amaxmen@rockefeller.edu
Rockefeller University Press
Source:Eurekalert

Related biology news :

1. Turtles no longer turned into souvenirs
2. Inactivity of proteins behind longer shelf life when freezing
3. No longer a gray area: Our hair bleaches itself as we grow older
4. Shorter wait means longer life for kidney transplant candidates
5. Living longer thanks to the longevity gene
6. For fats, longer may not be better
7. Deprived of a sense of smell, worms live longer
8. Formula discovered for longer plant life
9. The mystery of mass extinctions is no longer murky
10. Mouse study: When it comes to living longer, its better to go hungry than go running
11. Antioxidant users dont live longer, analysis of studies concludes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... , Apr. 11, 2017 Research and ... Market 2017-2021" report to their offering. ... The global eye tracking market to grow at a ... report, Global Eye Tracking Market 2017-2021, has been prepared based on ... covers the market landscape and its growth prospects over the coming ...
(Date:4/5/2017)... April 5, 2017 Today HYPR Corp. ... the server component of the HYPR platform is officially ... the end-to-end security architecture that empowers biometric authentication across ... has already secured over 15 million users across the ... of connected home product suites and physical access represent ...
(Date:3/30/2017)... , March 30, 2017 The research team ... for three-dimensional (3D) fingerprint identification by adopting ground breaking 3D fingerprint ... new realm of speed and accuracy for use in identification, crime ... affordable cost. ... A ...
Breaking Biology News(10 mins):
(Date:5/24/2017)... ... May 24, 2017 , ... Today, the ... Water Recovery’s Advanced Biological Nutrient Recovery (ABNR™) technology at its 4,000,000 gallon per ... plant upgrade to sustainably meet current and future nutrient discharge regulations. The ABNR ...
(Date:5/24/2017)... 23, 2017 As Ebola resurfaces in the ... and 20 suspected cases now reported, a new analysis of ... showed a correlation between the 2014 and 2017 outbreaks of ... sharply in 2012-13, which preceded the 2014 outbreak. An analysis ... gene Replikin counts in 2014-15, which again precedes the current ...
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... ... celebrates this month its 20th anniversary, marking the occasion with a strong presence ... the meeting’s Welcome Reception and further extends an invitation to all attendees to ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... applications, has announced a facility expansion to accommodate its rapid growth. , The ... new workspace and renovation of the existing areas. The expansion includes, a state-of-the-art ...
Breaking Biology Technology: