Navigation Links
A link between mitochondria and tumor formation in stem cells
Date:10/10/2008

Researchers report on a previously unknown relationship between stem cell potency and the metabolic rate of their mitochondria a cell's energy makers. Stem cells with more active mitochondria also have a greater capacity to differentiate and are more likely to form tumors.

These findings, appearing this week in JBC, could lead to methods of enriching the best stem cells from a population for therapeutic use and may provide some insights into the role of stem cells in cancer.

This study, conducted by Toren Finkel and colleagues at the National Heart, Lung and Blood Institute (NHBLI), sorted mouse embryonic stem cells by their mitochondrial potential (the amount of voltage going across mitochondrial membranes, similar to how nerve activity is measured) and found that both visually and in the expression of key stem cell markers, low and high metabolism stem cells were indistinguishable.

Yet, when transplanted into mice, these two types of cells had contrasting properties, as cells with lower metabolic rates were more efficient at differentiating into other cell types while the highly metabolic cells were more prone to keep dividing and form teratomas, tumors characterized by having various tissue types mixed together.

The potential of stem cells to form teratomas remains a big obstacle in their clinical use, but these results may have at least uncovered the mechanism behind it. In fact, when Finkel and colleagues administered the mitochondrial inhibitor rapamycin to high metabolism stem cells, their teratoma capacity decreased significantly.

While this work was done with mouse cells, the researchers believe a similar relationship holds true in human stem cells. Thus, developing methods to remove highly metabolic stem cells from a population could improve their safety.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1

Related biology news :

1. Stabilizing force for good communication between neurons and muscle cells found
2. New book rethinks the relationship between sulfur and crops
3. University professor stresses links between US Navy sonar and whale strandings
4. New study indicates link between weight gains during pregnancy and dieting history
5. Researchers note differences between people and animals on calorie restriction
6. International TGen-led team finds link between brain protein and Alzheimers disease
7. Collaboration between researchers yields more comprehensive portrait of brain cancer
8. Rhode Island Hospital study finds link between obesity, type 2 diabetes and neurodegeneration
9. Distinguishing between 2 birds of a feather
10. Study finds connections between genetics, brain activity and preference
11. Building bridges between the clinic and the laboratory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... NEW YORK and POINT ROBERTS, Washington ... global news source covering leading sectors including technology and tech ... Personal Privacy marketplace featuring master pickpocket and security consultant ... wallet is stolen and talks about the Wocket™ biometric smart ...
(Date:1/22/2015)... N.C. , Jan. 22, 2015 Infinisource has launched ... of the G2 model. The G2 sets a higher standard ... iSolved human capital management solution. With plug-and-play installation, touch screen ... time clock provides a robust time collection solution for the ...
(Date:12/19/2014)... 18, 2014 Research and Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ... 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - ... http://photos.prnewswire.com/prnh/20130307/600769 Following the ... fingerprint reading feature with the iPhone 5S. It is ...
Breaking Biology News(10 mins):Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3Infinisource's NXG series sets new time clock standard 2iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2
... their existence without thousands of proteins performing myriad vital ... the study of protein structure and function can lead ... disorders. For example, the discovery of insulin’s role in ... treatment based on insulin injections. Yet, despite enormous research ...
... a paper that will be published online in advance of ... and colleagues (The Salk Institute and HHMI) demonstrate that ... as in animals. , "These findings will influence our thinking ... to understand why cells use them as signaling compartments," noted ...
... Center researchers helps explain how “memory” T cells protect ... today in Proceedings of the National Academy of Science ... organs where immune cells reside and proliferate, but also ... spread of an invading virus occurs. , After becoming ...
Cached Biology News:Weizmann Institute scientists develop a general 'control switch' for protein activity 2Weizmann Institute scientists develop a general 'control switch' for protein activity 3How 'memory' T cells curb the spread of viruses throughout the body 2
(Date:1/22/2015)... Switzerland (PRWEB) January 22, 2015 Selexis ... characterized mammalian Research Cell Banks (RCBs) used for drug ... Research Cell Banks will include Next-Generation Sequencing ... genetic architecture de-risks biologic manufacturing by ensuring the integrity ...
(Date:1/22/2015)... Nueva Jersey , 22 de enero de 2015 ... Research abre hoy su llamada a nominaciones para 2015. ... científica ha hecho, o tiene el potencial para hacer, ... Las nominaciones se aceptarán hasta el 15 de marzo ...
(Date:1/22/2015)... 2015  Varian Medical Systems (NYSE: VAR ), world ... its commitment to sustainability with inclusion on a prestigious list ... ranked healthcare equipment company among the Corporate Knights Global 100 ... Forum at Davos, Switzerland . ...
(Date:1/22/2015)...  Derma Sciences, Inc. (Nasdaq: DSCI ), ... care, announces that AMNIOEXCEL® and AMNIOMATRIX®, amniotic allografts ... the Premier, Inc. Regenerative Skin Grafting contract portfolio. ... and AMNIOMATRIX® product lines, which continue to be ...
Breaking Biology Technology:Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Varian Honored Among World's 100 Most Sustainable Corporations 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5
... time again for the half-year roundup of stock market results for ... the results from the first quarter, it was pretty dismal for ... Nasdaq National Market down 8 percent , Nasdaq Biotech down 16% ... great trend. As you can see below, the results for the ...
... profound impact on farming much the same as people would ... dot-com businesses, though many might not realize it. , , ... family farm in Loyal, WI, will showcase the latest technology ... on Tuesday, July 12, and runs thru Thursday, July 14. ...
... Crosse, Wis. - Merkle Inc. , has ... a data quality software solution, to modify their data ... customers the ability to customize and aggregate information, cleanse ... and provide association and householding capabilities. Users also have ...
Cached Biology Technology:Midwest large cap life sciences mostly outperform market 2Midwest large cap life sciences mostly outperform market 3Farmers explore technology at Wisconsin event 2
In Western blotting antibodies recognize 94 K protein band, which corresponds to S-layer protein...
High affinity antibodies recognizes HSP70 protein from human cardiac tissue. Could be used for Westerb blotting application, ELISA....
The VersArray hybridization chamber is used for manual (coverslip) hybridization of microarrays. The chamber accommodates 2 slides and is watertight to allow incubation of slides in a water bath. Dim...
... PROTECT FROM LIGHT. Useful in cell activation experiments when ... by TLC. Soluble in DMSO or EtOH. ... mM stock in DMSO is recommended. Microliter amounts of ... with rapid mixing (e.g. 10 μl into 5 ml ...
Biology Products: