Navigation Links
A link between mitochondria and tumor formation in stem cells
Date:10/10/2008

Researchers report on a previously unknown relationship between stem cell potency and the metabolic rate of their mitochondria a cell's energy makers. Stem cells with more active mitochondria also have a greater capacity to differentiate and are more likely to form tumors.

These findings, appearing this week in JBC, could lead to methods of enriching the best stem cells from a population for therapeutic use and may provide some insights into the role of stem cells in cancer.

This study, conducted by Toren Finkel and colleagues at the National Heart, Lung and Blood Institute (NHBLI), sorted mouse embryonic stem cells by their mitochondrial potential (the amount of voltage going across mitochondrial membranes, similar to how nerve activity is measured) and found that both visually and in the expression of key stem cell markers, low and high metabolism stem cells were indistinguishable.

Yet, when transplanted into mice, these two types of cells had contrasting properties, as cells with lower metabolic rates were more efficient at differentiating into other cell types while the highly metabolic cells were more prone to keep dividing and form teratomas, tumors characterized by having various tissue types mixed together.

The potential of stem cells to form teratomas remains a big obstacle in their clinical use, but these results may have at least uncovered the mechanism behind it. In fact, when Finkel and colleagues administered the mitochondrial inhibitor rapamycin to high metabolism stem cells, their teratoma capacity decreased significantly.

While this work was done with mouse cells, the researchers believe a similar relationship holds true in human stem cells. Thus, developing methods to remove highly metabolic stem cells from a population could improve their safety.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1

Related biology news :

1. Stabilizing force for good communication between neurons and muscle cells found
2. New book rethinks the relationship between sulfur and crops
3. University professor stresses links between US Navy sonar and whale strandings
4. New study indicates link between weight gains during pregnancy and dieting history
5. Researchers note differences between people and animals on calorie restriction
6. International TGen-led team finds link between brain protein and Alzheimers disease
7. Collaboration between researchers yields more comprehensive portrait of brain cancer
8. Rhode Island Hospital study finds link between obesity, type 2 diabetes and neurodegeneration
9. Distinguishing between 2 birds of a feather
10. Study finds connections between genetics, brain activity and preference
11. Building bridges between the clinic and the laboratory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... Increasing adoption in ... to drive biometric systems market in ... According to a recently released TechSci Research ... biometric systems market in Saudi Arabia ... CAGR of over 22% through 2020. The market ...
(Date:4/13/2015)... According to a recently ... & Opportunities, 2020", the global biometrics market is ... till 2020. The biometrics market is garnering attention ... review of biometric management systems. The constant development ... greater efficiency, are resulting in increasing installation of ...
(Date:4/9/2015)... April 9, 2015 Synaptics Inc. (NASDAQ: SYNA ... today that it will report financial results for the ... 2015, after the close of market. The company will ... at 2:00 p.m. PT (5:00 p.m. ET), during which ... participate on the live call, analysts and investors should ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2Synaptics to Report Third Quarter Results on April 23 2
... 19, 2012) A study comparing whether endothelial colony-forming cells ... umbilical cord blood are more proliferative and better for forming ... placenta are more vasculogenic., The study, carried out by researchers ... recent issue of Cell Medicine [2(3)] and is ...
... ON Humans get most of the blame for climate ... natural forces. Now, scientists from the University of Toronto and ... one potential cause of the cooling trend of the past ... chemistry of the world,s oceans. "Seawater chemistry is characterized ...
... enable greater reliance on renewable biomass resources for power ... of biomass with coal offer unique advantages, but also ... available and in development to improve the characteristics of ... peer-reviewed journal from Mary Ann Liebert, Inc. . ...
Cached Biology News:Blood vessel forming potential of stem cells from human placenta and umbilical cord blood 2Scientists connect seawater chemistry with climate change and evolution 2Strategies to improve renewable energy feedstocks 2
(Date:5/28/2015)... London (PRWEB) May 28, 2015 ... Computer Aided Engineering software, announced today it is ... (PSRI). CD-adapco will provide state-of-the-art engineering simulation tools ... share their expertise and experiences in analyzing particle ... industry members and advance the understanding of flow ...
(Date:5/28/2015)... (PRWEB) May 28, 2015 Glenn Keet, ... The Changing Landscape of EMR/EHR Clinical Data Integration with ... taking place in Washington, DC on June 14th-18th. , ... of integrating EMR/EHR systems with EDC, and will examine ... brought by eSource and electronic health records/electronic medical records ...
(Date:5/28/2015)... (PRWEB) May 28, 2015 Global ... a point to ask his audiences if they ... trends including robotics, solar cells, fuel cells, rapid ... printers, advanced battery storage technology, driverless cars, artificial ... high-quality but inexpensive online education. , While ...
(Date:5/28/2015)... Virginia (PRWEB) May 28, 2015 ... LLC announced today that Roger L. Williams, MD, ... consultant. NDA Partners Premier Experts are top tier ... to bring extraordinary value to the company’s clients. ... solutions to help clients successfully develop their medical ...
Breaking Biology Technology:CD-adapco and PSRI Chartering New Course in Particle Flow Simulations 2Clinovo Presents at the DIA 2015 51st Annual Meeting in Washington, DC on June 14th-18th 2Futurist Jack Uldrich to Deliver 4 Keynote Addresses in June 2Former CEO and Chair of the Council of Experts at the USP, Roger L. Williams, MD, Joins NDA Partners as a Premier Expert Consultant 2
... LOUIS, Aug. 27 Missouri Coalition for,Lifesaving Cures ... far-,reaching initiative petition filed last week by opponents ... worded and scientifically unsound that it,would exclude Missourians ... syndromes from its definition of "human." In ...
... Drug Royalty LP 2 (DRC) announced,today the ... worldwide,royalty interest in PEG-INTRON for $92.5M. DRC will ... certain royalty recognition levels be met.,PEG-INTRON (peginterferon alpha-2b), ... is marketed worldwide by Schering-Plough Corporation (SGP). ...
... 27 NovaQuest has,made a strategic investment ... specializing in respiratory,disorders. The investment was part ... million) in the Montreal-based company. Last ... partnering group,of Quintiles Transnational, helps TOPIGEN accelerate ...
Cached Biology Technology:New Initiative Has Shocking Effect: Thousands of Missourians with Abnormal Chromosome Structures Are Not Human 2Drug Royalty Corporation (DRC) Announces Acquisition Regarding PEG-INTRON(R) From Enzon Pharmaceuticals, Inc. (ENZN) 2NovaQuest Advances 'Virtual Development' Model With Strategic Investment in TOPIGEN Pharmaceuticals 2
... The user-friendly Eppendorf Thermomixer R ... preparations that require shaking, heating, and ... greatly expanded its application and temperature ... can each accommodate 24 micro test ...
Mouse monoclonal antibody raised against a partial recombinant PDE2A. NCBI Entrez Gene ID = PDE2A...
... can be used to test the crossreactivity ... sera that are commonly used as blocking ... spots for 19 different protein preparations on ... crossreactivity and species specificity, QC of purified ...
... sufficient materials for 1,464 array sample elements. , , ... , Blocker BSA in PBS (10X): 50 ml , ... Saline: 8 packs , 10% Tween-20: 2 x 10 ... x 25 ml , SuperSignal West Pico Stable Peroxide: ...
Biology Products: