Navigation Links
A hydrogel that knows when to go
Date:5/7/2014

e gel," he said. The links begin to form at the same time as the gel, but crosslinking takes up to a half-hour to complete.

The hydrogel is designed for stability over its long-term use as a scaffold for cells to take root and proliferate. But it's also designed for its own timely destruction.

"I came up with the idea a few years ago, but it's finally all come together," said Watson, who is pursuing both a Rice doctorate and a medical degree in a joint program with nearby Baylor College of Medicine. "These chemical crosslinks are attached by phosphate ester bonds, which can be degraded by catalysts in particular, alkaline phosphatase -- that are naturally produced by bone tissue.

"The catalysts are naturally present in your body at all times, in low levels. But in areas of newly formed bone, they actually get to much higher levels," he said. "So what we get is a semismart material for bone-tissue engineering. As new bone is formed, the gel should degrade more quickly in that area to allow even more space for bone to form."

The fine balancing act took a lot of expertise from his colleagues and co-authors, including Paul Engel, chair of Rice's Department of Chemistry, and F. Kurtis Kasper, a senior faculty fellow in bioengineering. "It looks like we may have just decided to try something and found that, hey, it worked! But that wasn't the case," said Watson, describing the months and years it took to refine the hydrogel. Engel's help with the sophisticated chemistry was especially valuable, he said.

Watson expects that the material degradation can be tuned to match various bone growth rates.

"Optimizing the degradation kinetics is nontrivial and may be better suited for a biotech company," he said. "We focus more on the performance of the hydrogels and the underlying molecular mechanisms"


'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Pumping iron: A hydrogel actuator with mussel tone
2. Stem cell proliferation and differentiation observed within hydrogel
3. Morphing DNA hydrogel flows like liquid but remembers its original shape
4. The nose knows in asthma
5. Internet helps ensure mother knows best when it comes to preventing childhood obesity
6. Amiigo Unveils Fitness Tracker That Knows What Exercise Youre Performing
7. The nose knows: Gene therapy restores sense of smell in mice
8. How a common fungus knows when to attack
9. The electronic nose knows when your cantaloupe is ripe
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A hydrogel that knows when to go
(Date:8/12/2015)... , Aug. 12, 2015  New research ... can attack Android phones to steal users, fingerprints. ... increasing availability of fingerprint scanners on mobile devices, ... concern. To secure biometrics on mobile devices, HYPR ... augment these convenient authentication systems with strong cryptographic ...
(Date:8/10/2015)... The latest 364 page report from business intelligence ... border security market . Visiongain assesses that ... Now: Border security is hard to achieve and harder ... issue you need to know about - and more importantly, ... how this will impact your company and the border security ...
(Date:8/5/2015)... August 5, 2015 According to ... Management Market by Software, Services, Vertical (BFSI, Airport, IT & ... - Global Forecast to 2020", published by MarketsandMarkets, defines ... globally into various segments. The global PIAM Market is ... $546.2 Million by 2019, at a CAGR of 14.9 ...
Breaking Biology News(10 mins):HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 3Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 2Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 3Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 4Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 5Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 6Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 7Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 8Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 9Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4
... orchestrated by a spectrum of signals from hormones within ... cytokinins originate in the roots of plants, and their ... leaves stimulates plant development. Though these phytohormones have been ... their transportation within plants was previously poorly understood. ...
... PA, February 20, 2014 Schizophrenia has long been known ... of the population. Researchers have been following two paths in ... they studied common gene variants that, individually, only increase the ... likelihood of developing schizophrenia from a 10 out of a ...
... fruits and vegetables are associated with higher Body Mass ... households, according to American University researchers in the journal ... significant, association between the prices of fruit and vegetables ... lead author and assistant professor of public administration and ...
Cached Biology News:Roots to shoots: Hormone transport in plants deciphered 2Gathering the clues to rare gene variants contributing to schizophrenia 2High cost of fruits, vegetables linked to higher body fat in young children 2
(Date:8/28/2015)... ... August 28, 2015 , ... Proove Biosciences ... the International Spine Intervention Society’ s 23rd Annual Scientific Meeting (ASM). ... 2015. With a focus on evidence-based research and clinical application, the event gathered ...
(Date:8/28/2015)... 28, 2015 /PRNewswire/ - RepliCel Life Sciences Inc. ... company focused on the development of autologous cell ... ended June 30, 2015, corporate highlights, and near-term ... are available at www.sedar.com ,  www.edgar.com ... "RepliCel expects to launch its RCS-01 treatment ...
(Date:8/28/2015)... (PRWEB) , ... August 28, 2015 , ... Since the initial launch of FireflySci Inc. ... quirky humor and excellent customer service. Images such as the Fonz in a lab ... add some flavor to the humdrum spectroscopy field. , FireflySci is proud to ...
(Date:8/27/2015)... ... August 27, 2015 , ... Capital Edge Consulting , a ... is pleased to announce their ranking as one of the top 5000 companies listed ... private companies across the nation. , “It is truly an honor to be recognized ...
Breaking Biology Technology:Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 2Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 3Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 4RepliCel Reports Second Quarter 2015 Financial Results 2RepliCel Reports Second Quarter 2015 Financial Results 3RepliCel Reports Second Quarter 2015 Financial Results 4RepliCel Reports Second Quarter 2015 Financial Results 5Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 2Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 3
... NEW YORK, July 21 /PRNewswire-Asia-FirstCall/ ... ), ("the Company" or "AOBO"), a pharmaceutical,company dedicated ... of a broad range of prescription and over ... AOBO was honorably elected as one of,the "Top ...
... LEXINGTON, Mass., July 21 Heejin Lee, an MIT PhD ... his work on a silicone-based combination product recently launched by ... ISSAC Award for Innovation recognizes and promotes the achievements of ... development of silicone-based combination products. Combination products are a new ...
... ... Details Productivity Gains, Process Improvements Realized with Quantros Accreditation and Compliance Excellence Solution ... San Francisco, CA ... and professional services solutions for the healthcare industry , announced today the highly ...
Cached Biology Technology:American Oriental Bioengineering Honorably Elected a Top 20 Most Competitive Public Pharmaceutical Company in China 2$10,000 ISSAC Award for Innovation Presented to MIT PhD 2Quantros ACE Helps East Jefferson General Hospital Achieve Best-in-Class Performance 2Quantros ACE Helps East Jefferson General Hospital Achieve Best-in-Class Performance 3
... Transformation Buffer Set are convenient methods for ... for simple and highly efficient DNA transformation. ... for heat shocking and related procedures. Instead, ... adding DNA to Z-Competent cells and incubating ...
... Diagnostics Universal Amplicon Detection Assay ... in the qualitative detection and ... in vitro nucleic acid ... not to be used in ...
Propidium Iodide: {3,8-diamino-5-[3-(diethylmethylammonio)propyl]-6-phenylphenanthridinium diodide}. Antifade Solution: p-Phenylenediamine and glycerol in PBS solution. 2.5ug/mL Propidium Iodide (PI)...
Apoptosis Detection Systems and Reagents...
Biology Products: