Navigation Links
A hydrogel that knows when to go
Date:5/7/2014

HOUSTON (May 7, 2014) Rice University bioengineers have created a hydrogel that instantly turns from liquid to semisolid at close to body temperature and then degrades at precisely the right pace.

The gel shows potential as a bioscaffold to support the regrowth of bone and other three-dimensional tissues in a patient's body using the patient's own cells to seed the process.

The hydrogel created in the lab of Rice bioengineer Antonios Mikos is a liquid at room temperature but, when injected into a patient, becomes a gel that would fill and stabilize a space while natural tissue grows to replace it.

The new material detailed in the American Chemical Society journal Biomacromolecules takes the state of the art a few steps further, Rice scientists said.

"This study describes the development of a novel thermogelling hydrogel for stem cell delivery that can be injected into skeletal defects to induce bone regeneration and that can be degraded and eliminated from the body as new bone tissue forms and matures," said Mikos, Rice's Louis Calder Professor of Bioengineering and Chemical and Biomolecular Engineering.

A problem with thermogelling polymers is that once they harden, they begin to collapse and then force out water, said Rice graduate student and the paper's lead author, Brendan Watson. That process, known as syneresis, defeats the purpose of defining the space doctors hope to fill with new tissue.

"If the transition gellation temperature is one or two degrees below body temperature, these polymers slowly start to expel water and shrink down until they're one-half or one-third the size. Then the defect-filling goal is no longer accomplished," he said.

Watson and his colleagues at Rice's BioScience Research Collaborative solved the problem by adding chemical cross-linkers to the gel's molecules. "It's a secondary mechanism that, after the initial thermogellation, begins to stabilize th
'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Pumping iron: A hydrogel actuator with mussel tone
2. Stem cell proliferation and differentiation observed within hydrogel
3. Morphing DNA hydrogel flows like liquid but remembers its original shape
4. The nose knows in asthma
5. Internet helps ensure mother knows best when it comes to preventing childhood obesity
6. Amiigo Unveils Fitness Tracker That Knows What Exercise Youre Performing
7. The nose knows: Gene therapy restores sense of smell in mice
8. How a common fungus knows when to attack
9. The electronic nose knows when your cantaloupe is ripe
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A hydrogel that knows when to go
(Date:7/8/2015)... NEW YORK , July 8, 2015  BD ... announced BD & Guidepoint Mentor, a new ... to Guidepoint,s expert network services. BD ... technologies to improve healthcare delivery and outcomes and, with ... start-up entrepreneur will be able to directly engage with ...
(Date:7/8/2015)... , July 8, 2015 The ... as this summer,s must have products such as wearables, smart ... as popularity for biometrics based devices continues to rapidly grow.  ... Inc. (NASDAQ: NXTD ), Google Inc. (NASDAQ: GOOG ... FIT ), GoPro, Inc. (NASDAQ: GPRO ) and ...
(Date:7/7/2015)... Calif. , July 7, 2015  Based ... market, Frost & Sullivan recognizes Credence ID, LLC ... Entrepreneurial Company of the Year Award. Credence ... to aid in its mission of offering enrollment ... populations globally. As Credence ID was formed by ...
Breaking Biology News(10 mins):BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 2Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 3Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 4Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 5Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 6Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5
... professor Karen Warkentin, working at the Smithsonian Tropical ... frog embryos at a very early developmental stage ... reported in the Nov. 7, 2008 issue of ... initial responses to the environment may be critical ...
... West Nile virus in North America over the past decade ... according to an article in the November issue of ... before its emergence in New York in 1999, has since ... Nile virus has killed hundreds of millions of birds and ...
... -- Scientists have long known that it,s possible for one ... by skipping or including certain sequences from the messenger RNA. ... as alternative splicing, is both far more prevalent and varies ... all human genes, about 94 percent, generate more than one ...
Cached Biology News:Red-eyed treefrog embryos actively avoid asphyxiation inside their eggs 2Human genes sing different tunes in different tissues 2
(Date:7/31/2015)... , July 31, 2015 China Cord ... China,s leading provider of cord blood ... cell storage services, today announced that the Company has ... U.S. Securities and Exchange Commission. The filed Form 20-F ... March 31, 2015. The Form 20-F can be accessed ...
(Date:7/30/2015)... , July 30, 2015 AACC ... to the 2015 AACC Annual Meeting & Clinical ... from July 26–30. The meeting showcased revolutionary advancements ... the ability of healthcare providers to diagnose patients ... effective medical treatment. As of ...
(Date:7/30/2015)... (PRWEB) , ... July 30, 2015 , ... The 2015 ... in-depth study on the current state of the global Propanol market with a focus ... CNPC, BASF, Eastman, Dow, Carboclor, Mitsui Chemicals, Oxea, ISU Chemical, Sanofi, Royal Dutch Shell, ...
(Date:7/30/2015)... Kan. , July 30, 2015   ... a pet therapeutics company focused on the licensing, ... companion animals, today announced that its strategic partner ... a dose confirmation study of AT-016, an adipose-derived ... for the treatment of osteoarthritis pain in dogs. ...
Breaking Biology Technology:China Cord Blood Corporation Files Its Annual Report on Form 20-F 2Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 2Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 3Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 4Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 2Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 3Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 4Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 5
... INTRODUCTION , ... the absorbance at 280 nm and calculating the concentration using ... because extinction coefficients are typically obtained using standard cuvettes with ... be done in microplates, but they have not been widely-used ...
... Corporation, 1311 Orleans Dr., Sunnyvale, CA 94089. , , , ... , This application note describes ... Probes in the Gemini XS, Gemini EM and SpectraMax M2 ... assay is much more sensitive than traditional photometer methods, such as absorbance ...
... T. Ferguson, Ph.D., ... , INTRODUCTION , This application note ... Molecular Devices to study the performance of the LIVE/DEAD ... dyes, calcein AM (cal AM) and ethidium homodimer (EthD-1), to stain ...
Cached Biology Technology:PathCheck Applied to Measurement of Protein Solutions in the SpectraMax Plus Microplate Spectrophotometer (MaxLine Application Note #26) 2PathCheck Applied to Measurement of Protein Solutions in the SpectraMax Plus Microplate Spectrophotometer (MaxLine Application Note #26) 3PathCheck Applied to Measurement of Protein Solutions in the SpectraMax Plus Microplate Spectrophotometer (MaxLine Application Note #26) 4PathCheck Applied to Measurement of Protein Solutions in the SpectraMax Plus Microplate Spectrophotometer (MaxLine Application Note #26) 5PathCheck Applied to Measurement of Protein Solutions in the SpectraMax Plus Microplate Spectrophotometer (MaxLine Application Note #26) 6PathCheck Applied to Measurement of Protein Solutions in the SpectraMax Plus Microplate Spectrophotometer (MaxLine Application Note #26) 7PathCheck Applied to Measurement of Protein Solutions in the SpectraMax Plus Microplate Spectrophotometer (MaxLine Application Note #26) 8PathCheck Applied to Measurement of Protein Solutions in the SpectraMax Plus Microplate Spectrophotometer (MaxLine Application Note #26) 9Using the NanoOrange protein kit in the Gemini XS, Gemini EM and SpectraMax M2 microplate readers (MaxLine Application Note #22) 2Using the NanoOrange protein kit in the Gemini XS, Gemini EM and SpectraMax M2 microplate readers (MaxLine Application Note #22) 3Using the NanoOrange protein kit in the Gemini XS, Gemini EM and SpectraMax M2 microplate readers (MaxLine Application Note #22) 4LIVE/DEAD Viability/Cytotoxicity Assay for Animal Cells Using the SpectraMax Gemini XS Fluorescence Microplate Reader (MaxLine Application Note #43) 2LIVE/DEAD Viability/Cytotoxicity Assay for Animal Cells Using the SpectraMax Gemini XS Fluorescence Microplate Reader (MaxLine Application Note #43) 3LIVE/DEAD Viability/Cytotoxicity Assay for Animal Cells Using the SpectraMax Gemini XS Fluorescence Microplate Reader (MaxLine Application Note #43) 4LIVE/DEAD Viability/Cytotoxicity Assay for Animal Cells Using the SpectraMax Gemini XS Fluorescence Microplate Reader (MaxLine Application Note #43) 5
... Rabbit Polyclonal to Human CELSR3 CELSR3 ... ligand. In mouse, this gene is expressed ... in adult mice and rats in brain, spinal ... been isolated from human B-cell/lung/testis, blood, brain, colon, ...
...
... focal drug delivery. Maintain bath temperature and ... line while quickly switching 4 or 8 ... 37°C at 5 ml/minute flow rates through ... Advanced auto-tuning temperature lock Designed ...
...
Biology Products: