Navigation Links
A hydrogel that knows when to go
Date:5/7/2014

HOUSTON (May 7, 2014) Rice University bioengineers have created a hydrogel that instantly turns from liquid to semisolid at close to body temperature and then degrades at precisely the right pace.

The gel shows potential as a bioscaffold to support the regrowth of bone and other three-dimensional tissues in a patient's body using the patient's own cells to seed the process.

The hydrogel created in the lab of Rice bioengineer Antonios Mikos is a liquid at room temperature but, when injected into a patient, becomes a gel that would fill and stabilize a space while natural tissue grows to replace it.

The new material detailed in the American Chemical Society journal Biomacromolecules takes the state of the art a few steps further, Rice scientists said.

"This study describes the development of a novel thermogelling hydrogel for stem cell delivery that can be injected into skeletal defects to induce bone regeneration and that can be degraded and eliminated from the body as new bone tissue forms and matures," said Mikos, Rice's Louis Calder Professor of Bioengineering and Chemical and Biomolecular Engineering.

A problem with thermogelling polymers is that once they harden, they begin to collapse and then force out water, said Rice graduate student and the paper's lead author, Brendan Watson. That process, known as syneresis, defeats the purpose of defining the space doctors hope to fill with new tissue.

"If the transition gellation temperature is one or two degrees below body temperature, these polymers slowly start to expel water and shrink down until they're one-half or one-third the size. Then the defect-filling goal is no longer accomplished," he said.

Watson and his colleagues at Rice's BioScience Research Collaborative solved the problem by adding chemical cross-linkers to the gel's molecules. "It's a secondary mechanism that, after the initial thermogellation, begins to stabilize th
'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Pumping iron: A hydrogel actuator with mussel tone
2. Stem cell proliferation and differentiation observed within hydrogel
3. Morphing DNA hydrogel flows like liquid but remembers its original shape
4. The nose knows in asthma
5. Internet helps ensure mother knows best when it comes to preventing childhood obesity
6. Amiigo Unveils Fitness Tracker That Knows What Exercise Youre Performing
7. The nose knows: Gene therapy restores sense of smell in mice
8. How a common fungus knows when to attack
9. The electronic nose knows when your cantaloupe is ripe
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A hydrogel that knows when to go
(Date:12/17/2014)... 16, 2014  Automation is fundamentally transforming the ... than at international borders. Over the past decade, ... allowed veteran travelers to self process through border ... Kiosks at an increasing number of airports, seaports, ... According to Maxine Most , Principal ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced ... the APAC Region 2015-2019"  report to their offering. ... this market is advances in technology. With continuous ... biometric solutions to the latest standard that meets ...
(Date:12/11/2014)... N.C. , Dec. 10, 2014  That blood pressure ... quite a while. Hypertension – the medical term for high ... the early 1800s, and the inflatable cuff that,s used in ... doesn,t, however, mean there,s nothing new about hypertension, its triggers ... long-held beliefs about the condition and the best ways to ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... world of the developing brain, neural stem cells give rise ... neurons then migrate along the stem cell fibers up to ... have discovered a key mechanism of this migration one ... processes and diseases, including cancer. The finding, the ...
... increases in consumption of sugar-sweetened beverages over the ... Type 2 diabetes mellitus, led nutritional epidemiologists at ... on Aging (USDA HNRCA) at Tufts University and ... consumption and insulin resistance, a precursor to Type ...
... years ago, "ultraconserved elements" were discovered in the genomes of ... pairs in length or longer -- some are over 700 ... the three species. They have been perfectly conserved since the ... some 85 million years ago. These and other ...
Cached Biology News:Neural stem cell study reveals mechanism that may play role in cancer 2Neural stem cell study reveals mechanism that may play role in cancer 3Neural stem cell study reveals mechanism that may play role in cancer 4Sugary drinks, not fruit juice, may be linked to insulin 2Sugary drinks, not fruit juice, may be linked to insulin 3Ultraconserved elements in the genome: Are they indispensable? 2Ultraconserved elements in the genome: Are they indispensable? 3Ultraconserved elements in the genome: Are they indispensable? 4
(Date:12/24/2014)... December 23, 2014 The ... such as its definition, classification, application and ... specification, manufacturing process, and product cost structure. ... applications. The analysis also covers upstream raw ... industry development trend and proposals. In the ...
(Date:12/24/2014)... Diego, CA (PRWEB) December 23, 2014 ... where their Twitter followers can submit their #HolidayInTheLab ... themselves and their lab mates. , For those struggling ... lab mates, the Pipette.com Holiday in the Lab Contest ... Pipette.com Twitter followers to send pictures of ...
(Date:12/24/2014)... -- PharmaBoardroom,s new report, , Healthcare ... for free download , digs deep into this vibrant ... the sector today. One area where ... developing a homegrown pharmaceutical manufacturing base, even if the government,s ... way off. A cursory comparison with neighboring Morocco ...
(Date:12/24/2014)... YORK , Dec. 23, 2014  NeuroLifeSciences announced ... mazindol in children with attention deficit/hyperactivity disorder published in ... . The paper, titled "Pilot Phase ... disorder" ( Konofal et al, Drug Des ... ) shows that mazindol might be an effective, ...
Breaking Biology Technology:Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3
... May 14, 2012   USHIFU, LLC (US HIFU), a ... ultrasound (HIFU) technologies, announced today that Mark Carol, ... chief development officer. With more than 25 years ... Dr. Carol will focus on continued development of ...
...  /PRNewswire-Asia/ -- 3SBio Inc. (NASDAQ: SSRX ) ("3SBio" ... on researching, developing, manufacturing and marketing biopharmaceutical products, today ... ended March 31, 2012. First ... net revenues increased by 24.5% over the first quarter ...
... at Nanyang Technological University (NTU), it comes in the form of ... kills them without the need for antibiotics. The killer coating, ... and fungi that it comes in contact with, is now being ... specialising in animal care products. The next step is ...
Cached Biology Technology:US HIFU Adds Mark Carol, MD, As Chief Development Officer 2US HIFU Adds Mark Carol, MD, As Chief Development Officer 3US HIFU Adds Mark Carol, MD, As Chief Development Officer 43SBio Inc. Announces Unaudited First Quarter 2012 Results 23SBio Inc. Announces Unaudited First Quarter 2012 Results 33SBio Inc. Announces Unaudited First Quarter 2012 Results 43SBio Inc. Announces Unaudited First Quarter 2012 Results 53SBio Inc. Announces Unaudited First Quarter 2012 Results 63SBio Inc. Announces Unaudited First Quarter 2012 Results 73SBio Inc. Announces Unaudited First Quarter 2012 Results 83SBio Inc. Announces Unaudited First Quarter 2012 Results 93SBio Inc. Announces Unaudited First Quarter 2012 Results 103SBio Inc. Announces Unaudited First Quarter 2012 Results 11NTU scientists invent superbug killers 2NTU scientists invent superbug killers 3
Edited by I.H. Pawlowitzki, J.H. Edwards and E.A. Thompson (1997) • This volume covers: Linkage in dominant recessive and oligogenic disease, Model free (non-parametric) methods, Tools for gene ...
... Cloning is the most ... cloning PCR products. TOPO ... Blunt TOPO vectors are ... with topoisomerase I. This ...
... TOPO Cloning is the ... for cloning PCR products. ... Zero Blunt TOPO vectors ... activated with topoisomerase I. ...
ready-to-use solution...
Biology Products: