Navigation Links
A hot species for cool structures
Date:7/21/2011

A fungus that lives at extremely high temperatures could help understand structures within our own cells. Scientists at the European Molecular Biology Laboratory (EMBL) and Heidelberg University, both in Heidelberg, Germany, were the first to sequence and analyse the genome of a heat-loving fungus, and used that information to determine the long sought 3-dimensional structure of the inner ring of the nuclear pore. The study was published today in Cell.

The fungus Chaetomium thermophilum lives in soil, dung and compost heaps, at temperatures up to 60oC. This means its proteins including some which are very similar to our own have to be very stable, and the Heidelberg scientists saw this stability as an advantage.

"There are a number of structures that we couldn't study before, because they are too unstable in organisms that live at more moderate temperatures," explains Peer Bork, who led the genome analysis at EMBL. "Now with this heat-loving fungus, we can."

The scientists compared the fungus' genome and proteome to those of other eukaryotes organisms whose cells have a nucleus and identified the proteins that make up the innermost ring of the nuclear pore, a channel that controls what enters and exits a cell's nucleus. Having identified the relevant building blocks, the scientists determined the complex 3D structure of that inner ring for the first time.

"This work shows the power of interdisciplinary collaborations," says Ed Hurt, who led the structural and biochemical analyses at Heidelberg University: "the nuclear pore is an intricate biological puzzle, but by combining bioinformatics with biochemistry and structural biology, we were able to solve this piece of it for the first time."

The scientists have made C. thermophilum's genome and proteome publicly available, and are confident that these will prove valuable for studying other eukaryotic structures and their interactions, as well as general adaptations to life in hot places. Such knowledge could potentially lead to new biotechnology applications.


'/>"/>

Contact: Sonia Furtado
sonia.furtado@embl.de
European Molecular Biology Laboratory
Source:Eurekalert

Related biology news :

1. UBC graduate student discovers key to bifocals in mangrove fish species
2. Marquesas Islands in French Polynesia yield 18 new species of rare ferns and flowering plants
3. Enzymes for cell wall synthesis conserved across species barriers
4. Acidifying oceans could hit California mussels, a key species
5. Jewel beetles, obtained from local people, turn out to be 4 species unknown to science
6. Most of worlds missing species live in known hotspots
7. Prodigal plankton species makes first known migration from Pacific to Atlantic via Pole
8. Ancient species of mayfly had short, tragic life
9. New study supports Darwins hypothesis on competition between species
10. Ecology biased against non-native species?
11. Climate change allows invasive weed to outcompete local species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... March 31, 2016   ... or the "Company") LegacyXChange is excited to ... its soon to be launched online site for trading ... ) will also provide potential shareholders a sense ... technology to an industry that is notorious for fraud. ...
(Date:3/22/2016)... PROVO and SANDY, Utah ... (NSO), which operates the highest sample volume laboratory in ... Tute Genomics and UNIConnect, leaders in clinical sequencing informatics ... the launch of a project to establish the informatics ... NSO has been contracted by the ...
(Date:3/15/2016)... Yissum Research Development Company of the Hebrew University ... University, announced today the formation of Neteera Technologies ... biological indicators. Neteera Technologies has completed its first round ... Neteera,s ... from sweat ducts, enables reliable and speedy biometric identification, ...
Breaking Biology News(10 mins):
(Date:5/5/2016)... CA (PRWEB) , ... May 05, 2016 , ... ... closed on a definitive agreement to acquire Algynomics, a research-stage pain diagnostics company. ... data to identify individuals at increased risk for the development of chronic pain, ...
(Date:5/4/2016)... ... May 05, 2016 , ... CereScan, the nation’s leader in ... during National Stroke Awareness Month in May. An infographic created by CereScan ... CereScan will donate $1 up to a maximum of $3,000 through users ...
(Date:5/4/2016)... New York, NY (PRWEB) , ... May 04, 2016 , ... ... neurofibromatosis (NF), a genetic disorder that causes tumors to grow on nerves throughout the ... treatment or cure. , Through numerous community events held during the month of May, ...
(Date:5/3/2016)... PUNE, India , May 3, 2016 ... Type (DNA Chip (Genomics, Drug Discovery, Gene ... Chips), End user (Academics Institutes, Diagnostics Centers), ... 2020" published by MarketsandMarkets, the market is ... 2020 from USD 7.63 Billion in 2015, ...
Breaking Biology Technology: