Navigation Links
A hot species for cool structures
Date:7/21/2011

A fungus that lives at extremely high temperatures could help understand structures within our own cells. Scientists at the European Molecular Biology Laboratory (EMBL) and Heidelberg University, both in Heidelberg, Germany, were the first to sequence and analyse the genome of a heat-loving fungus, and used that information to determine the long sought 3-dimensional structure of the inner ring of the nuclear pore. The study was published today in Cell.

The fungus Chaetomium thermophilum lives in soil, dung and compost heaps, at temperatures up to 60oC. This means its proteins including some which are very similar to our own have to be very stable, and the Heidelberg scientists saw this stability as an advantage.

"There are a number of structures that we couldn't study before, because they are too unstable in organisms that live at more moderate temperatures," explains Peer Bork, who led the genome analysis at EMBL. "Now with this heat-loving fungus, we can."

The scientists compared the fungus' genome and proteome to those of other eukaryotes organisms whose cells have a nucleus and identified the proteins that make up the innermost ring of the nuclear pore, a channel that controls what enters and exits a cell's nucleus. Having identified the relevant building blocks, the scientists determined the complex 3D structure of that inner ring for the first time.

"This work shows the power of interdisciplinary collaborations," says Ed Hurt, who led the structural and biochemical analyses at Heidelberg University: "the nuclear pore is an intricate biological puzzle, but by combining bioinformatics with biochemistry and structural biology, we were able to solve this piece of it for the first time."

The scientists have made C. thermophilum's genome and proteome publicly available, and are confident that these will prove valuable for studying other eukaryotic structures and their interactions, as well as
'/>"/>

Contact: Sonia Furtado
sonia.furtado@embl.de
European Molecular Biology Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. UBC graduate student discovers key to bifocals in mangrove fish species
2. Marquesas Islands in French Polynesia yield 18 new species of rare ferns and flowering plants
3. Enzymes for cell wall synthesis conserved across species barriers
4. Acidifying oceans could hit California mussels, a key species
5. Jewel beetles, obtained from local people, turn out to be 4 species unknown to science
6. Most of worlds missing species live in known hotspots
7. Prodigal plankton species makes first known migration from Pacific to Atlantic via Pole
8. Ancient species of mayfly had short, tragic life
9. New study supports Darwins hypothesis on competition between species
10. Ecology biased against non-native species?
11. Climate change allows invasive weed to outcompete local species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/xclcvw/biometrics_market ) ... Market in Japan 2014-2018" report to their ... The integration of biometrics and smart ... upgradation of the driver,s license is one of ... the aforementioned projects, biometrics is being used as ...
(Date:12/5/2014)... PROVO, Utah , Dec. 4, 2014  Tute ... has raised $2.3 million in Series A1 funding led ... angel investors also participated in the investment round. ... as the healthcare community adopts next-generation sequencing and seeks ... disease," said Reid Robison , MD MBA, and ...
(Date:12/3/2014)... Ariz. , Dec. 2, 2014 As ... hand readers, Inception Technologies is pleased to announce the ... easier for customers to collect the workforce data that ... problems that have been left by existing readers. Many ... user interface, connectivity and modern technology. Older models force ...
Breaking Biology News(10 mins):Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Inception Technologies to Release New Biometric Reader 2
... study to conserve and restore endangered horse mussel reefs ... University,s marine research and outreach centre in Portaferry in ... Biological Sciences, will provide scientific and technological research to ... restore it. Horse mussel reefs are important to ...
... one of the major threats to biodiversity and in ... human health. For their effective management it is important ... highest risk of being invaded. The first map ... Union was published in the Wiley-Blackwell journal Diversity ...
... Amsterdam, The Netherlands, January 22, 2009 A growing ... to delay age-related cognitive decline, including in some cases ... published in the January 2009 issue of the ... PhD, of the Center for Cellular Neurobiology; Neurodegeneration Research ...
Cached Biology News:Queen's University Belfast works to save Strangford horse mussels 2
(Date:12/13/2014)... The “Global Synthetic Biology Market (2013-2018)”, analyses ... and challenges. , The global synthetic biology market ... Fisher Scientific, Inc. (U.S.), DuPont (U.S.), and Royal ... approximately ~65% of the total synthetic biology market. ... Report @ http://www.marketsandmarkets.com/Market-Reports/synthetic-biology-market-889.html , Thermo Fisher ...
(Date:12/13/2014)...  Vermillion, Inc. (NasdaqCM: VRML), a bio-analytical solutions company focused ... Veronica G. H. Jordan , Ph.D., and David ... bringing the total number of directors to eight, seven ... LaFrance , Chairman, President, and Chief Executive Officer of ... appointments of Veronica and David to our board of ...
(Date:12/13/2014)... SAN ANTONIO , Dec. 12, 2014 /PRNewswire/ ... presentation of data at the San Antonio Breast Cancer ... epoetin alfa plus best supportive care (BSC) versus BSC ... breast cancer receiving standard chemotherapy. This non-inferiority trial did ... out a 15 percent or greater increase in the ...
(Date:12/12/2014)... Pittcon is pleased to announce ... over 2,000 technical presentations offered in symposia, oral ... program covers a wide range of applications such ... discovery, environmental, food science, fuels/energy, genomics, lab management, ... The Technical Program begins on Sunday, March 8 ...
Breaking Biology Technology:Synthetic Biology Market to HIt $5.6304 Billion by 2018 - New Research Report by MarketsandMakets 2Synthetic Biology Market to HIt $5.6304 Billion by 2018 - New Research Report by MarketsandMakets 3Vermillion Strengthens Board of Directors with Appointments of Veronica Jordan, Ph.D., and David Schreiber 2Vermillion Strengthens Board of Directors with Appointments of Veronica Jordan, Ph.D., and David Schreiber 3Data from the EPO-ANE-3010 Study Evaluating Epoetin Alfa Presented at San Antonio Breast Cancer Symposium 2Data from the EPO-ANE-3010 Study Evaluating Epoetin Alfa Presented at San Antonio Breast Cancer Symposium 3Data from the EPO-ANE-3010 Study Evaluating Epoetin Alfa Presented at San Antonio Breast Cancer Symposium 4Data from the EPO-ANE-3010 Study Evaluating Epoetin Alfa Presented at San Antonio Breast Cancer Symposium 5Data from the EPO-ANE-3010 Study Evaluating Epoetin Alfa Presented at San Antonio Breast Cancer Symposium 6Data from the EPO-ANE-3010 Study Evaluating Epoetin Alfa Presented at San Antonio Breast Cancer Symposium 7Data from the EPO-ANE-3010 Study Evaluating Epoetin Alfa Presented at San Antonio Breast Cancer Symposium 8Data from the EPO-ANE-3010 Study Evaluating Epoetin Alfa Presented at San Antonio Breast Cancer Symposium 9Data from the EPO-ANE-3010 Study Evaluating Epoetin Alfa Presented at San Antonio Breast Cancer Symposium 10Data from the EPO-ANE-3010 Study Evaluating Epoetin Alfa Presented at San Antonio Breast Cancer Symposium 11Data from the EPO-ANE-3010 Study Evaluating Epoetin Alfa Presented at San Antonio Breast Cancer Symposium 12Pittcon Announces a Diverse 2015 Technical Program - Renowned Speakers, Special Symposia and Co-programming 2Pittcon Announces a Diverse 2015 Technical Program - Renowned Speakers, Special Symposia and Co-programming 3
... of person to staff customer support centers. These specialists must ... of a complicated computer system, and then be able to ... Finding these very talented people is not an easy task, ... high degree of technical aptitude. But there is more to ...
... of Fiserv, Inc. has announced the launch ... self-funded health care market. , , Fiserv Health ... administration services for self-funded medical, dental, vision and disability ... now has an integrated suite of medical management programs ...
... named to the top five in the "specialty niche" ... KLAS , a provider of healthcare information technology (HIT) ... score for all time and attendance system vendors scoring ... Performance award. , , KLAS provides the ...
Cached Biology Technology:Hope For Some U.S. Tech Workers 2Hope For Some U.S. Tech Workers 3Fiserv Launches Avidyn Health to Target Healthcare Costs 2API Receives Top 5 Recognition in "Best In KLAS" Awards 2
...
Ultra-sensitive, non-radioactive detection of rat Osteopontin...
Agarose-LE, 250 g. Suitable for soft agarose cloning. Nuclease-free.Gel point (1.5%): 36 1.5 C, EEO (-mr): 1200 g/cm2. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Request Info...
Biology Products: