Navigation Links
A hot species for cool structures
Date:7/21/2011

A fungus that lives at extremely high temperatures could help understand structures within our own cells. Scientists at the European Molecular Biology Laboratory (EMBL) and Heidelberg University, both in Heidelberg, Germany, were the first to sequence and analyse the genome of a heat-loving fungus, and used that information to determine the long sought 3-dimensional structure of the inner ring of the nuclear pore. The study was published today in Cell.

The fungus Chaetomium thermophilum lives in soil, dung and compost heaps, at temperatures up to 60oC. This means its proteins including some which are very similar to our own have to be very stable, and the Heidelberg scientists saw this stability as an advantage.

"There are a number of structures that we couldn't study before, because they are too unstable in organisms that live at more moderate temperatures," explains Peer Bork, who led the genome analysis at EMBL. "Now with this heat-loving fungus, we can."

The scientists compared the fungus' genome and proteome to those of other eukaryotes organisms whose cells have a nucleus and identified the proteins that make up the innermost ring of the nuclear pore, a channel that controls what enters and exits a cell's nucleus. Having identified the relevant building blocks, the scientists determined the complex 3D structure of that inner ring for the first time.

"This work shows the power of interdisciplinary collaborations," says Ed Hurt, who led the structural and biochemical analyses at Heidelberg University: "the nuclear pore is an intricate biological puzzle, but by combining bioinformatics with biochemistry and structural biology, we were able to solve this piece of it for the first time."

The scientists have made C. thermophilum's genome and proteome publicly available, and are confident that these will prove valuable for studying other eukaryotic structures and their interactions, as well as general adaptations to life in hot places. Such knowledge could potentially lead to new biotechnology applications.


'/>"/>

Contact: Sonia Furtado
sonia.furtado@embl.de
European Molecular Biology Laboratory
Source:Eurekalert

Related biology news :

1. UBC graduate student discovers key to bifocals in mangrove fish species
2. Marquesas Islands in French Polynesia yield 18 new species of rare ferns and flowering plants
3. Enzymes for cell wall synthesis conserved across species barriers
4. Acidifying oceans could hit California mussels, a key species
5. Jewel beetles, obtained from local people, turn out to be 4 species unknown to science
6. Most of worlds missing species live in known hotspots
7. Prodigal plankton species makes first known migration from Pacific to Atlantic via Pole
8. Ancient species of mayfly had short, tragic life
9. New study supports Darwins hypothesis on competition between species
10. Ecology biased against non-native species?
11. Climate change allows invasive weed to outcompete local species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2017)... TOKYO , Feb. 1, 2017  Central ... innovative and meaningful advances worldwide, The Japan Prize ... Japan Prize, who have pushed the envelope in ... Information and Communication. Three scientists are being recognized ... outstanding achievements that not only contribute to the ...
(Date:1/31/2017)... CAMBRIDGE, Mass. , Jan. 31, 2017 /PRNewswire-USNewswire/ ... develop novel therapies for the treatment of bacterial ... generation set of antibacterial candidates from Pro Bono ... the increased prevalence of multi-drug resistant forms of ... by Cantab Anti Infectives Ltd, a PBB group ...
(Date:1/26/2017)... 2017  Crossmatch, a leading provider of security and ... at combatting fraud, waste and abuse in assistance operations ... Action on Disaster Relief conference in Panama ... agencies and foreign assistance organizations throughout Latin ... are a largely unacknowledged problem in the foreign assistance ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... CA (PRWEB) , ... February 22, 2017 , ... ... a free AFM Luncheon for all SPIE attendees and Park ... CA, just one block from the San Jose Convention Center. The luncheon will ...
(Date:2/22/2017)... ... February 22, 2017 , ... ProMIS Neurosciences (“ProMIS” or the ... diseases, today announced it has issued a scientific white paper entitled “Results from ... series of commentaries from ProMIS’s scientific team offering insight into the Company’s product ...
(Date:2/22/2017)... , Feb. 22, 2017 Origin (Origin Agritech, LLC, ... trait and seed provider, and Arcadia (Arcadia ... that develops and commercializes agricultural productivity traits and nutritional products, today ... corn biotechnology product developed in China to ... regulatory trials. ...
(Date:2/22/2017)... and SAN DIEGO , Feb. ... "Company") (OTCQB:CELZ) announced today expansion of its translational ... cell product through establishment of laboratory facilities in ... at the San Diego BioLabs facility, a biotechnology ... Novartis, and Sanofi. In November 2016, ...
Breaking Biology Technology: